Cited by 1,960COVID-19 Clinical Research StudiesCOVID-19 diagnosis using AISARS-CoV-2 detection and testing

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Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing

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Xie, Xingzhi, Zhong, Zheng, Zhao, Wei, Zheng, Chao, Wang, Fei, Liu, Jun·2020·Radiology

DOI 10.1148/radiol.2020200343PMC PMC7233363

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Abstract

Some patients with positive chest CT findings may present with negative results of real-time reverse-transcription polymerase chain reaction (RT-PCR) tests for coronavirus disease 2019 (COVID-19). In this study, the authors present chest CT findings from five patients with COVID-19 infection who had initial negative RT-PCR results. All five patients had typical imaging findings, including ground-glass opacity (five patients) and/or mixed ground-glass opacity and mixed consolidation (two patients). After isolation for presumed COVID-19 pneumonia, all patients were eventually confirmed to have COVID-19 infection by means of repeated swab tests. A combination of repeated swab tests and CT scanning may be helpful for individuals with a high clinical suspicion of COVID-19 infection but negative findings at RT-PCR screening.

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Self-citation
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Background
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“This study suggests that the presence of typical CT findings in people suspected of having the virus may be useful for initial screening [91].”
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BackgroundSelf-citation
CT scan AI-aided triage for patients with COVID-19 in China
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Background
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Dawoud, M. M., Dawoud, T. M., Ali, N. Y. A., & Nagy, H. A. (2020) · The Egyptian Journal of Radiology and Nuclear Medicine · doi:10.1186/s43055-020-00359-z · Cited by 13
“So, CT is more sensitive than RT-PCR and can decrease the chance of false-negative results in the RT-PCR assay [18, 19].”
Background
Analysis and validation of a highly sensitive one-step nested quantitative real-time polymerase chain reaction assay for specific detection of severe acute respiratory syndrome coronavirus 2
Zhang, Y., Dai, C., Wang, H., Gao, Y., Li, T., Fang, Y., Shen, Z., Chen, L., Chen, Z., Ma, X., et al. (2020) · Virology Journal · doi:10.1186/s12985-020-01467-y · Cited by 13
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Method
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Comparison of HRCT Chest and RT-PCR in Diagnosis of COVID-19
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COVID-19 Underreporting in Brazil among Patients with Severe Acute Respiratory Syndrome during the Pandemic: An Ecological Study
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Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice
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Update for Anaesthetists on Clinical Features of COVID-19 Patients and Relevant Management
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Rational and practical use of imaging in COVID-19 pneumonia
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A 21st Century Evil: Immunopathology and New Therapies of COVID-19
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BackgroundMethod
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Background

Authors: Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., & Liu, J.
Affiliations: Central South University (CN)
Corresponding author: Liu, Jun
ORCID: Xie, Xingzhi
Zhong, Zheng
Zhao, Wei
Zheng, Chao
Wang, Fei
Liu, Jun
Venue: Radiology
Publisher: Radiological Society of North America (RSNA)
Published: 2020-08
Volume: 296
Issue: 2
Pages: E41-E45
ISSN: 0033-8419 (ISSN-L)
1527-1315
DOI: 10.1148/radiol.2020200343
PMC: PMC7233363
OpenAlex: W3006110666
Cited by: 1,960
References: 6
Citations by year: 2026: 16 · 2025: 24 · 2024: 75 · 2023: 136 · 2022: 282 · 2021: 575 · 2020: 850
FWCI: 60.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Radiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › COVID-19 diagnosis using AI
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
Keywords: COVID-19 pandemic, COVID-19 pneumonia, chest CT findings, ground-glass opacities, delayed diagnosis
MeSH terms: Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Vaccines, COVID-19 Testing, Adult, Aged, False Negative Reactions, Female, Humans, Male, Middle Aged, Pneumonia, Viral, Radiographic Image Interpretation, Computer-Assisted, Tomography, X-Ray Computed, Reproducibility of Results, Coronavirus Infections, Clinical Laboratory Techniques, Reverse Transcriptase Polymerase Chain Reaction, Pandemics

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Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing

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