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Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study
Open accessAbstract
Background Brain MRI parenchymal signal abnormalities have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Purpose To describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe coronavirus disease 2019 (COVID-19) infection. Materials and Methods This was a retrospective study of patients evaluated from March 23, 2020, to April 27, 2020, at 16 hospitals. Inclusion criteria were (a) positive nasopharyngeal or lower respiratory tract reverse transcriptase polymerase chain reaction assays, (b) severe COVID-19 infection defined as a requirement for hospitalization and oxygen therapy, (c) neurologic manifestations, and (d) abnormal brain MRI findings. Exclusion criteria were patients with missing or noncontributory data regarding brain MRI or brain MRI showing ischemic infarcts, cerebral venous thrombosis, or chronic lesions unrelated to the current event. Categorical data were compared using the Fisher exact test. Quantitative data were compared using the Student t test or Wilcoxon test. P < .05 represented a significant difference. Results Thirty men (81%) and seven women (19%) met the inclusion criteria, with a mean age of 61 years ± 12 (standard deviation) (age range, 8–78 years). The most common neurologic manifestations were alteration of consciousness (27 of 37, 73%), abnormal wakefulness when sedation was stopped (15 of 37, 41%), confusion (12 of 37, 32%), and agitation (seven of 37, 19%). The most frequent MRI findings were signal abnormalities located in the medial temporal lobe in 16 of 37 patients (43%; 95% confidence interval [CI]: 27%, 59%), nonconfluent multifocal white matter hyperintense lesions seen with fluid-attenuated inversion recovery and diffusion-weighted sequences with variable enhancement, with associated hemorrhagic lesions in 11 of 37 patients (30%; 95% CI: 15%, 45%), and extensive and isolated white matter microhemorrhages in nine of 37 patients (24%; 95% CI: 10%, 38%). A majority of patients (20 of 37, 54%) had intracerebral hemorrhagic lesions with a more severe clinical presentation and a higher admission rate in intensive care units (20 of 20 patients [100%] vs 12 of 17 patients without hemorrhage [71%], P = .01) and development of the acute respiratory distress syndrome (20 of 20 patients [100%] vs 11 of 17 patients [65%], P = .005). Only one patient had SARS-CoV-2 RNA in the cerebrospinal fluid. Conclusion Patients with severe coronavirus disease 2019 and without ischemic infarcts had a wide range of neurologic manifestations that were associated with abnormal brain MRI scans. Eight distinctive neuroradiologic patterns were described. © RSNA, 2020
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“MRI studies have shown brain structural and micro-structural changes in COVID-19 patients [143–146]”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [144]
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“cortical signal intensity abnormalities and unilateral FLAIR or diffusion hyper-intensities in medial the temporal lobe (MTL) [144, 146]”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [144]
In the citing paper
“structural magnetic resonance imaging of 30 in vivo severe acute cases revealed multifocal subcortical FLAIR and diffusion-weighted signal changes, compatible with oedema, particularly in the mediotemporal lobe, with an aetiological role played by haemorrhagic lesions as well (35).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [35]
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A novel coronavirus from patients with pneumonia in China, 2019
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001017 · Cited by 28,244
Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166
Hematological Problems in Pediatric Intensive Care
Revel‐Vilk, S., Cox, P. N., Robitaille, N., & Blanchette, V. S. (2013) · Pediatric and adolescent medicine · doi:10.1159/000350346 · Cited by 3,526
Neurologic features in severe SARS-CoV-2 infection
Helms, J., Kremer, S., Merdji, H., Clere-Jehl, R., Schenck, M., Kummerlen, C., Collange, O., Boulay, C., Fafi-Kremer, S., Ohana, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2008597 · Cited by 2,674
Self-citationTaylor, F., Toh, C.-H., Hoots, K., Wada, H., & Levi, M. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616068 · Cited by 2,285
A first case of meningitis/encephalitis associated with SARS-Coronavirus-2
Moriguchi, T., Harii, N., Goto, J., Harada, D., Sugawara, H., Takamino, J., Ueno, M., Sakata, H., Kondo, K., Myose, N., et al. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.03.062 · Cited by 2,024
COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features
Poyiadji, N., Shahin, G., Noujaim, D., Stone, M., Patel, S., & Griffith, B. (2020) · Radiology · doi:10.1148/radiol.2020201187 · Cited by 1,505
Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J. (2019) · Viruses · doi:10.3390/v12010014 · Cited by 1,048
Neurologic manifestations in hospitalized patients with COVID-19
Romero-Sánchez, C. M., Cicuéndez, I. D.-M., Fernández-Diaz, E. M., Sánchez‐Larsen, Á., Layos-Romero, A., García‐García, J., González, E., Peñas, I. R., Moratalla, A. B. P., Valle-Pérez, J. A. D., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009937 · Cited by 752
Neurologic alterations due to respiratory virus infections
Bohmwald, K., Gálvez, N. M. S., Ríos, M., & Kalergis, A. M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00386 · Cited by 636
Neurological complications during treatment of middle east respiratory syndrome
Kim, J.-E., Heo, J.-H., Kim, H.-O., Song, S.-H., Park, S.-S., Park, T.-H., Ahn, J.-Y., Kim, M.-K., & Choi, J.-P. (2017) · Journal of Clinical Neurology · doi:10.3988/jcn.2017.13.3.227 · Cited by 497
Reichard, R. R., Kashani, K. B., Boire, N. A., Constantopoulos, E., Guo, Y., & Lucchinetti, C. F. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02166-2 · Cited by 479
Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome
Pohl, D., Alper, G., Van Haren, K., Kornberg, A. J., Lucchinetti, C. F., Tenembaum, S., & Belman, A. L. (2016) · Neurology · doi:10.1212/wnl.0000000000002825 · Cited by 462
Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)
Arabi, Y. M., Alharthi, A. F., Hussein, J., Bouchama, A., Johani, S. A., Hajeer, A. H., Saeed, B. T., Wahbi, A. M. A., Saedy, A., Aldabbagh, T., et al. (2015) · Infection · doi:10.1007/s15010-015-0720-y · Cited by 389
Yeh, E. A., Collins, A. R., Cohen, M. E., Duffner, P. K., & Faden, H. S. (2004) · PEDIATRICS · doi:10.1542/peds.113.1.e73 · Cited by 329
Brain MRI Findings in Patients in the Intensive Care Unit with COVID-19 Infection
Kandemirli, S. G., Dogan, L., Sarikaya, Z. T., Kara, S., Akinci, C., Kaya, D., Kaya, Y., Yildirim, D., Tuzuner, F., Yildirim, M. S., et al. (2020) · Radiology · doi:10.1148/radiol.2020201697 · Cited by 298
Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis
Desforges, M., Coupanec, A. L., Stodola, J. K., Meessen-Pinard, M., & Talbot, P. J. (2014) · Virus Research · doi:10.1016/j.virusres.2014.09.011 · Cited by 281
COVID-19–associated Diffuse Leukoencephalopathy and Microhemorrhages
Radmanesh, A., Derman, A. Y., Lui, Y. W., Raz, E., Loh, J. P., Hagiwara, M., Borja, M. J., Zan, E., & Fatterpekar, G. M. (2020) · Radiology · doi:10.1148/radiol.2020202040 · Cited by 267
Neurological Implications of COVID-19 Infections
Needham, E., Chou, S., Coles, A. J., & Menon, D. K. (2020) · Neurocritical Care · doi:10.1007/s12028-020-00978-4 · Cited by 243
COVID-19-associated acute disseminated encephalomyelitis (ADEM)
Parsons, T. C., Banks, S., Bae, C., Gelber, J., Alahmadi, H., & Tichauer, M. B. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09951-9 · Cited by 229
Li, Y., Li, H., Fan, R., Wen, B., Zhang, J., Cao, X., Wang, C., Song, Z., Li, S., Li, X., et al. (2016) · Intervirology · doi:10.1159/000453066 · Cited by 203
Mahammedi, A., Saba, L., Vagal, A. S., Leali, M., Rossi, A., Gaskill, M. F., Sengupta, S., Zhang, B., Carriero, A., Bachir, S., et al. (2020) · Radiology · doi:10.1148/radiol.2020201933 · Cited by 186
Hemorrhagic Posterior Reversible Encephalopathy Syndrome as a Manifestation of COVID-19 Infection
Franceschi, A. M., Ahmed, O. A., Giliberto, L., & Castillo, M. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6595 · Cited by 162
Posterior reversible encephalopathy syndrome (PRES) as a neurological association in severe Covid-19
Kishfy, L., Casasola, M., Banankhah, P., Parvez, A., Jan, Y. J., Shenoy, A. M., Thomson, C. C., & AbdelRazek, M. A. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116943 · Cited by 94
Diagnosing autoimmune limbic encephalitis
Budhram, A., Leung, A., Nicolle, M. W., & Burneo, J. G. (2019) · Canadian Medical Association Journal · doi:10.1503/cmaj.181548 · Cited by 92
Severe cerebral involvement in adult-onset hemophagocytic lymphohistiocytosis
Radmanesh, F., Rodríguez-Pla, A., Pincus, M. D., & Burns, J. D. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.04.054 · Cited by 31
Delayed Post-hypoxic Leukoencephalopathy: A Case Series and Review of the Literature
Katyal, N., Narula, N., George, P., Nattanamai, P., Newey, C. R., & Beary, J. M. (2018) · Cureus · doi:10.7759/cureus.2481 · Cited by 27
Weston-Hurst syndrome: a rare fulminant form of acute disseminated encephalomyelitis (ADEM)
Nabi, S., Badshah, M., Ahmed, S., & Nomani, A. Z. (2016) · BMJ Case Reports · doi:10.1136/bcr-2016-217215 · Cited by 21
Research works printed but not linked: 3
- World Health Organization, Protocol: Real-time RT-PCR assays for the detection of SARS-CoV-2
- Nabi S, 2016, BMJ Case Rep, 2016
- Katyal N, 2018, Cureus, 10
Cited by
Sorted by citations
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings
Paterson, R. W., Brown, R. L., Benjamin, L. A., Nortley, R., Wiethoff, S., Bharucha, T., Jayaseelan, D. L., Kumar, G., Raftopoulos, R., Zambreanu, L., et al. (2020) · Brain · doi:10.1093/brain/awaa240 · Cited by 1,154
Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J. (2019) · Viruses · doi:10.3390/v12010014 · Cited by 1,048
Cognitive deficits in people who have recovered from COVID-19
Hampshire, A., Trender, W. R., Chamberlain, S. R., Jolly, A., Grant, J. E., Patrick, F., Mazibuko, N., Williams, S., Barnby, J. M., Hellyer, P. J., et al. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.101044 · Cited by 738
Lifting the mask on neurological manifestations of COVID-19
Pezzini, A., & Padovani, A. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0398-3 · Cited by 447
Long-Term Respiratory and Neurological Sequelae of COVID-19
Wang, F., Kream, R. M., & Stefano, G. B. (2020) · Medical Science Monitor · doi:10.12659/msm.928996 · Cited by 441
Metadata
- Authors
- Kremer, S., Lersy, F., de Sèze, J., Ferré, J.-C., Maamar, A., Carsin-Nicol, B., Collange, O., Bonneville, F., Adam, G., Martin-Blondel, G., Rafiq, M., Geeraerts, T., Delamarre, L., Grand, S., Krainik, A., For the SFNR-COVID Group, Kremer, S., Adam, G., Alleg, M., Anheim, M., Anxionnat, R., Ardellier, F.-D., Baloglu, S., Bapst, B., Benzakoun, J., Berge, J., Bolognini, F., Bonneville, F., Bornet, G., Boulay, C., Boulouis, G., Boutet, C., Brisset, J. C., Caillard, S., Carré, S., Carsin-Nicol, B., Collange, O., Comby, P.-O., Constans, J. M., David, J.-S., de Beaurepaire, I., de Sèze, J., Delamarre, L., Desal, H., Edjlali-Goujon, M., Fabre, X., Fafi-Kremer, S., Ferré, J.-C., Feuerstein, P., Henry Feugeas, M.-C., Forestier, G., Gaudemer, A., Geeraerts, T., Grand, S., Hansmann, Y., Heintz, A., Helms, J., Hemmert, C., Hmeydia, G., Jager, L., Kazémi, A., Kerleroux, B., Khalil, A., Krainik, A., Lacalm, A., Lecler, A., Lecocq, C., Lefèbvre, N., Lersy, F., Maamar, A., Martin-Blondel, G., Matthieu, M., Megdiche, I., Mertes, P.-M., Messié, J., Metanbou, S., Meyer, N., Meziani, F., Mutschler, V., Nesser, P., Oesterlé, H., Ohana, M., Oppenheim, C., Pyatigorskaya, N., Rafiq, M., Ricolfi, F., Saleme, S., Schenck, M., Schmitt, E., Schneider, F., Sebag, N., Talla Mba, Y., Thouant, P., Willaume, T., Zhu, F., Zorn, P.-E., & Cotton, F.
- Affiliations
- Hôpitaux Universitaires de Strasbourg (FR)
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Alleg, Manel
- Anheim, Mathieu
- Anxionnat, René
- Ardellier, François-Daniel
- Baloglu, Seyyid
- Bapst, Blanche
- Benzakoun, Joseph
- Berge, Jérome
- Bolognini, Federico
- Bornet, Grégoire
- Boulouis, Grégoire
- Boutet, Claire
- Brisset, Jean Christophe
- Caillard, Sophie
- Comby, Pierre-Olivier
- Constans, Jean Marc
- David, Jean-Stéphane
- Desal, Hubert
- Fabre, Xavier
- Fafi-Kremer, Samira
- Feuerstein, Philippe
- Forestier, Géraud
- Gaudemer, Augustin
- Hansmann, Yves
- Helms, Julie
- Hmeydia, Ghazi
- Jager, Lavinia
- Kerleroux, Basile
- Khalil, Antoine
- Lacalm, Audrey
- Lecler, Augustin
- Lecocq, Claire
- Mertes, Paul-Michel
- Messié, Julien
- Meyer, Nicolas
- Meziani, Ferhat
- Mutschler, Véronique
- Oesterlé, Hélène
- Oppenheim, Catherine
- Pyatigorskaya, Nadya
- Ricolfi, Frédéric
- Saleme, Suzana
- Schenck, Maleka
- Schmitt, Emmanuelle
- Schneider, Francis
- Sebag, Nathan
- Talla Mba, Yannick
- Thouant, Pierre
- Willaume, Thibault
- Zhu, François
- Zorn, Pierre-Emmanuel
- Cotton, François
- Venue
- Radiology
- Published
- 2020-11
- Volume
- 297
- Issue
- 2
- Pages
- E242-E251
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- PMC
- PMC7301613
- OpenAlex
- W3035517854
- Cited by
- 460
- References
- 28
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 35 · 2023: 64 · 2022: 80 · 2021: 163 · 2020: 89
- FWCI
- 42.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Radiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-10-EQPX-0001)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- COVID-19 pandemic, SARS-CoV-2, brain MRI findings, neurologic manifestations, altered states of consciousness, white matter hyperintensities, intracerebral hemorrhage, diffusion-weighted imaging, FLAIR, cerebral venous thrombosis, cerebral edema, brain hypometabolism
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adolescent, Adult, Aged, Brain, Child, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pneumonia, Viral, Retrospective Studies, Cohort Studies, Coronavirus Infections, Young Adult, Pandemics
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