COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features
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Most published reports on the neurological complications of COVID-19 are limited to individual cases or small case series.
“Most published reports on the neurological complications of COVID-19 are limited to individual cases or small case series.”
From Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study (2020) · cites this paper as [5]
MRI changes in COVID-19 patients include acute necrotizing encephalopathy.
“such as acute necrotizing encephalopathy [145]”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [145]
MRI studies have shown brain structural and micro-structural changes in COVID-19 patients.
“MRI studies have shown brain structural and micro-structural changes in COVID-19 patients [143–146]”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [145]
Image studies and postmortem examination of the brain of COVID-19 patients revealed hemorrhagic lesions accompanied by neuronal injury and neuroinflammation signals.
“Image studies [12, 13] and postmortem examination [14] of the brain of COVID-19 patients also revealed hemorrhagic lesions accompanied by neuronal injury and neuroinflammation signals.”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [13]
Many neurological symptoms associated with CoV-2 infection, such as stroke or altered consciousness, are consistent with underlying vasculopathy.
“Multiple immunostaining studies reveal that ACE2 protein in the human brain is predominantly or exclusively expressed in vasculature (and specifically expressed within pericytes) (52, 53, 70), and many neurological symptoms associated with CoV-2 infection like stroke or altered consciousness are consistent with an underlying vasculopathy (71-76).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [72]
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- Authors
- Poyiadji, N., Shahin, G., Noujaim, D., Stone, M., Patel, S., & Griffith, B.
- Affiliations
- Henry Ford Health (US)
- Corresponding author
- Griffith, Brent
- Venue
- Radiology
- Published
- 2020-08
- Volume
- 296
- Issue
- 2
- Pages
- E119-E120
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- PMC
- PMC7233386
- OpenAlex
- W3013398803
- Cited by
- 1,505
- References
- 4
- Citations by year
- 2026: 20 · 2025: 22 · 2024: 64 · 2023: 79 · 2022: 180 · 2021: 408 · 2020: 729 · 2013: 1 · 2012: 1
- FWCI
- 45.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Radiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- COVID-19 pandemic, SARS-CoV-2, neuroimaging features, cerebral hemorrhage, encephalopathy
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Brain, Leukoencephalitis, Acute Hemorrhagic, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Pneumonia, Viral, Tomography, X-Ray Computed, Coronavirus Infections, Pandemics
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