The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Pulmonary Embolism and Deep Vein Thrombosis in COVID-19: A Systematic Review and Meta-Analysis
Open accessAbstract
Background The association of pulmonary embolism (PE) with deep vein thrombosis (DVT) in patients with coronavirus disease 2019 (COVID-19) remains unclear, and the diagnostic accuracy of D-dimer tests for PE is unknown. Purpose To conduct meta-analysis of the study-level incidence of PE and DVT and to evaluate the diagnostic accuracy of D-dimer tests for PE from multicenter individual patient data. Materials and Methods A systematic literature search identified studies evaluating the incidence of PE or DVT in patients with COVID-19 from January 1, 2020, to June 15, 2020. These outcomes were pooled using a random-effects model and were further evaluated using metaregression analysis. The diagnostic accuracy of D-dimer tests for PE was estimated on the basis of individual patient data using the summary receiver operating characteristic curve. Results Twenty-seven studies with 3342 patients with COVID-19 were included in the analysis. The pooled incidence rates of PE and DVT were 16.5% (95% CI: 11.6, 22.9; I2 = 0.93) and 14.8% (95% CI: 8.5, 24.5; I2 = 0.94), respectively. PE was more frequently found in patients who were admitted to the intensive care unit (ICU) (24.7% [95% CI: 18.6, 32.1] vs 10.5% [95% CI: 5.1, 20.2] in those not admitted to the ICU) and in studies with universal screening using CT pulmonary angiography. DVT was present in 42.4% of patients with PE. D-dimer tests had an area under the receiver operating characteristic curve of 0.737 for PE, and D-dimer levels of 500 and 1000 μg/L showed high sensitivity (96% and 91%, respectively) but low specificity (10% and 24%, respectively). Conclusion Pulmonary embolism (PE) and deep vein thrombosis (DVT) occurred in 16.5% and 14.8% of patients with coronavirus disease 2019 (COVID-19), respectively, and more than half of patients with PE lacked DVT. The cutoffs of D-dimer levels used to exclude PE in preexisting guidelines seem applicable to patients with COVID-19. © RSNA, 2020 Supplemental material is available for this article. See also the editorial by Woodard in this issue.
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CT of Post-Acute Lung Complications of COVID-19
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Metadata
- Authors
- Suh, Y. J., Hong, H., Ohana, M., Bompard, F., Revel, M.-P., Valle, C., Gervaise, A., Poissy, J., Susen, S., Hékimian, G., Artifoni, M., Periard, D., Contou, D., Delaloye, J., Sanchez, B., Fang, C., Garzillo, G., Robbie, H., & Yoon, S. H.
- Venue
- Radiology
- Published
- 2021-02
- Volume
- 298
- Issue
- 2
- Pages
- E70-E80
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W3112786508
- Cited by
- 489
- References
- 48
- FWCI
- 17.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Suh, Y. J., Hong, H., Ohana, M., Bompard, F., Revel, M.-P., Valle, C., Gervaise, A., Poissy, J., Susen, S., Hékimian, G., Artifoni, M., Periard, D., Contou, D., Delaloye, J., Sanchez, B., Fang, C., Garzillo, G., Robbie, H., & Yoon, S. H. (2021). Pulmonary Embolism and Deep Vein Thrombosis in COVID-19: A Systematic Review and Meta-Analysis. Radiology. https://doi.org/10.1148/radiol.2020203557
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