The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders.
Abstract
Molecular diffusion and microcirculation in the capillary network result in a distribution of phases in a single voxel in the presence of magnetic field gradients. This distribution produces a spin-echo attenuation. The authors have developed a magnetic resonance (MR) method to image such intravoxel incoherent motions (IVIMs) by using appropriate gradient pulses. Images were generated at 0.5 T in a high-resolution, multisection mode. Diffusion coefficients measured on images of water and acetone phantoms were consistent with published values. Images obtained in the neurologic area from healthy subjects and patients were analyzed in terms of an apparent diffusion coefficient (ADC) incorporating the effect of all IVIMs. Differences were found between various normal and pathologic tissues. The ADC of in vivo water differed from the diffusion coefficient of pure water. Results were assessed in relation to water compartmentation in biologic tissues (restricted diffusion) and tissue perfusion. Nonuniform slow flow of cerebrospinal fluid appeared as a useful feature on IVIM images. Observation of these motions may significantly extend the diagnostic capabilities of MR imaging.
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In the citing paper
“Diffusion MRI-based tractography has offered exclusive means to map structural connections non-invasively in animal and human brain, and is considered a very useful and powerful technique to unravel the human connectome at meso- and macro-level (Le Bihan et al. 1986; Basser et al. 1994b; Mori et al. 1999; Jones 2008; Jbabdi and Johansen-Berg 2011).”
From Diffusion MRI-based cortical connectome reconstruction: dependency on tractography procedures and neuroanatomical characteristics (2018) · cites this paper as Le Bihan et al. 1986
In the citing paper
“Diffusion-weighted MRI is the only noninvasive method available for mapping fiber architecture of tissue in vivo (Le Bihan et al., 1986; Basser et al., 1994)”
From The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains (2017) · cites this paper as Le Bihan et al., 1986
Citations
Cites
Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient
Stejskal, E. O., & Tanner, J. E. (1965) · The Journal of Chemical Physics · doi:10.1063/1.1695690 · Cited by 8,239
Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments
Carr, H. Y., & Purcell, E. M. (1954) · Physical Review · doi:10.1103/physrev.94.630 · Cited by 6,445
Use of the Stimulated Echo in NMR Diffusion Studies
Tanner, J. E. (1970) · The Journal of Chemical Physics · doi:10.1063/1.1673336 · Cited by 1,647
Restricted Self-Diffusion of Protons in Colloidal Systems by the Pulsed-Gradient, Spin-Echo Method
Tanner, J. E., & Stejskal, E. O. (1968) · The Journal of Chemical Physics · doi:10.1063/1.1670306 · Cited by 873
Cleveland, G., Chang, D. C., Hazlewood, C. F., & Rorschach, H. E. (1976) · Biophysical Journal · doi:10.1016/s0006-3495(76)85754-2 · Cited by 243
Blood flow imaging with MR: spin-phase phenomena.
von Schulthess, G. K., & Higgins, C. B. (1985) · Radiology · doi:10.1148/radiology.157.3.2997836 · Cited by 193
Self diffusion of water in frog muscle
Tanner, J. E. (1979) · Biophysical Journal · doi:10.1016/s0006-3495(79)85162-0 · Cited by 184
Restricted Diffusion in Biophysical Systems
Cooper, R. L., Chang, D. B., Young, A. C., Martin, C. J., & Ancker‐Johnson, B. (1974) · Biophysical Journal · doi:10.1016/s0006-3495(74)85904-7 · Cited by 181
McCall, D. W., Douglass, D. C., & Anderson, E. W. (1959) · The Journal of Chemical Physics · doi:10.1063/1.1730651 · Cited by 158
NMR Even Echo Rephasing in Slow Laminar Flow
Waluch, V., & Bradley, W. G. (1984) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198408000-00003 · Cited by 146
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Items 1,001–1,008 of 1,008
Whittaker, H. T., Zhu, S., Di Curzio, D. L., Buist, R., Li, X.-M., Noy, S., Wiseman, F. K., Thiessen, J. D., & Martin, M. (2018) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2018.03.010 · Cited by 12
Scattered slice shard reconstruction for motion correction in multi-shell diffusion MRI
Christiaens, D., Cordero-Grande, L., Pietsch, M., Hutter, J., Price, A. N., Hughes, E. J., Vecchiato, K., Deprez, M., Edwards, A. D., Hajnal, J. V., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2020.117437 · Cited by 4
IVIM fMRI: Brain activation with a high spatial specificity and resolution
Song, A. W., Bruce, I., Petty, C., & Chen, N.-K. (2018) · Intravoxel Incoherent Motion (IVIM) MRI · doi:10.1201/9780429427275-5 · Cited by 3
Langston, J. W., Forno, L. S., Tetrud, J., Reeves, A. G., Kaplan, J. A., & Karluk, D. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199910)46:4 · Cited by 1
40 Years of diffusion MRI in the brain: From history to emerging frontiers
Le Bihan, D. (2026) · Imaging Neuroscience · doi:10.1162/imag.a.1365
“(4). recognizing that intravoxel microscopic motion includes both molecular diffusion and microvascular flow components ( Le Bihan et al., 1986, 1988).”
Jones (1999) · doi:10.1002/(sici)1522-2594(199907)42:1
Wheeler-Kingshott (2000) · doi:10.1002/1522-2594(200011)44:5
Basser (2000) · doi:10.1002/1522-2594(200010)44:4
Metadata
- Authors
- Le Bihan, D., Breton, E., Lallemand, D., Grenier, P., Cabanis, E., & Laval-Jeantet, M.
- Affiliations
- Centre hospitalier national d'ophtalmologie des Quinze-Vingts (FR)
- Venue
- Radiology
- Published
- 1986-11
- Volume
- 161
- Issue
- 2
- Pages
- 401-407
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2129841144
- Cited by
- 3,912
- References
- 13
- Citations by year
- 2026: 85 · 2025: 118 · 2024: 128 · 2023: 158 · 2022: 151 · 2021: 201 · 2020: 175 · 2019: 157 · 2018: 187 · 2017: 199 · 2016: 167 · 2015: 170 · 2014: 166 · 2013: 160 · 2012: 127
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › NMR spectroscopy and applications
- Keywords
- intravoxel incoherent motion, diffusion MRI, perfusion MRI, apparent diffusion coefficient, restricted diffusion, capillary microcirculation, cerebrospinal fluid flow, neurological disorders, magnetic resonance imaging
- MeSH terms
- Astrocytoma, Brain Diseases, Brain Neoplasms, Cerebrovascular Circulation, Humans, Hydrocephalus, Magnetic Resonance Spectroscopy
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