Deep Learning: A Primer for Radiologists
Abstract
Deep learning is a class of machine learning methods that are gaining success and attracting interest in many domains, including computer vision, speech recognition, natural language processing, and playing games. Deep learning methods produce a mapping from raw inputs to desired outputs (eg, image classes). Unlike traditional machine learning methods, which require hand-engineered feature extraction from inputs, deep learning methods learn these features directly from data. With the advent of large datasets and increased computing power, these methods can produce models with exceptional performance. These models are multilayer artificial neural networks, loosely inspired by biologic neural systems. Weighted connections between nodes (neurons) in the network are iteratively adjusted based on example pairs of inputs and target outputs by back-propagating a corrective error signal through the network. For computer vision tasks, convolutional neural networks (CNNs) have proven to be effective. Recently, several clinical applications of CNNs have been proposed and studied in radiology for classification, detection, and segmentation tasks. This article reviews the key concepts of deep learning for clinical radiologists, discusses technical requirements, describes emerging applications in clinical radiology, and outlines limitations and future directions in this field. Radiologists should become familiar with the principles and potential applications of deep learning in medical imaging. ©RSNA, 2017
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Modern deep learning models feature millions of parameters that need to be learned from sufficiently large curated data sets in order to achieve clinical-grade accuracy, while being safe, fair, equitable and generalising well to unseen data.
“Modern DL models feature millions of parameters that need to be learned from sufficiently large curated data sets in order to achieve clinical-grade accuracy, while being safe, fair, equitable and generalising well to unseen data2–5.”
From The future of digital health with federated learning (2020) · cites this paper as [3]
Cites
Hochreiter, S., & Schmidhuber, J. (1997) · Neural Computation · doi:10.1162/neco.1997.9.8.1735 · Cited by 102,318 · see citing works
LeCun, Y., Bengio, Y., & Hinton, G. (2015) · Nature · doi:10.1038/nature14539 · Cited by 84,126 · see citing works
The perceptron: A probabilistic model for information storage and organization in the brain.
Rosenblatt, F. (1958) · Psychological Review · doi:10.1037/h0042519 · Cited by 12,280 · see citing works
Shin, H.-C., Roth, H. R., Gao, M., Lu, L., Xu, Z., Nogues, I., Yao, J., Mollura, D., & Summers, R. M. (2016) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2016.2528162 · Cited by 5,759 · see citing works
Automatic Detection of Cerebral Microbleeds From MR Images via 3D Convolutional Neural Networks
Dou, Q., Chen, H., Yu, L., Zhao, L., Qin, J., Wang, D., Mok, V. C., Shi, L., & Heng, P.-A. (2016) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2016.2528129 · Cited by 679 · see citing works
Improving Computer-Aided Detection UsingConvolutional Neural Networks and Random View Aggregation
Roth, H. R., Lu, L., Liu, J., Yao, J., Seff, A., Cherry, K., Kim, L., & Summers, R. M. (2016) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2015.2482920 · Cited by 608 · see citing works
Wolterink, J. M., Leiner, T., de Vos, B. D., van Hamersvelt, R. W., Viergever, M. A., & Išgum, I. (2016) · Medical Image Analysis · doi:10.1016/j.media.2016.04.004 · Cited by 321 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The future of digital health with federated learning
Rieke, N., Hancox, J., Li, W., Milletarì, F., Roth, H. R., Albarqouni, S., Bakas, S., Galtier, M. N., Landman, B. A., Maier-Hein, K., et al. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-00323-1 · Cited by 3,119 · see citing works
An overview of deep learning in medical imaging focusing on MRI
Lundervold, A. S., & Lundervold, A. (2019) · Zeitschrift für Medizinische Physik · doi:10.1016/j.zemedi.2018.11.002 · Cited by 2,058 · see citing works
Predicting cancer outcomes with radiomics and artificial intelligence in radiology
Bera, K., Braman, N., Gupta, A., Velcheti, V., & Madabhushi, A. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00560-7 · Cited by 819 · see citing works
Vellido, A. (2020) · Neural Computing and Applications · doi:10.1007/s00521-019-04051-w · Cited by 635 · see citing works
Pesapane, F., Volonté, C., Codari, M., & Sardanelli, F. (2018) · Insights into Imaging · doi:10.1007/s13244-018-0645-y · Cited by 479 · see citing works
Kim, D. W., Jang, H. Y., Kim, K. W., Shin, Y., & Park, S. H. (2019) · Korean Journal of Radiology · doi:10.3348/kjr.2019.0025 · Cited by 459 · see citing works
Dou, Q., So, T. Y., Jiang, M., Liu, Q., Vardhanabhuti, V., Kaissis, G., Li, Z., Si, W., Lee, H. H. C., Yu, K., et al. (2021) · npj Digital Medicine · doi:10.1038/s41746-021-00431-6 · Cited by 278 · see citing works
Deep convolutional neural networks for mammography: advances, challenges and applications
Abdelhafiz, D., Yang, C., Ammar, R., & Nabavi, S. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2823-4 · Cited by 274 · see citing works
Human–machine partnership with artificial intelligence for chest radiograph diagnosis
Patel, B. N., Rosenberg, L., Willcox, G., Baltaxe, D., Lyons, M., Irvin, J., Rajpurkar, P., Amrhein, T., Gupta, R., Halabi, S., et al. (2019) · npj Digital Medicine · doi:10.1038/s41746-019-0189-7 · Cited by 254 · see citing works
Understanding artificial intelligence based radiology studies: What is overfitting?
Mutasa, S., Sun, S., & Ha, R. (2020) · Clinical Imaging · doi:10.1016/j.clinimag.2020.04.025 · Cited by 216 · see citing works
What should medical students know about artificial intelligence in medicine?
Park, S. H., Do, K.-H., Kim, S., Park, J. H., & Lim, Y.-S. (2019) · Journal of Educational Evaluation for Health Professions · doi:10.3352/jeehp.2019.16.18 · Cited by 196 · see citing works
Fujioka, T., Kubota, K., Mori, M., Kikuchi, Y., Katsuta, L., Kasahara, M., Oda, G., Ishiba, T., Nakagawa, T., & Tateishi, U. (2019) · Japanese Journal of Radiology · doi:10.1007/s11604-019-00831-5 · Cited by 177 · see citing works
How far have we come? Artificial intelligence for chest radiograph interpretation
Kallianos, K., Mongan, J., Antani, S., Henry, T., Taylor, A., Abuya, J., & Kohli, M. (2019) · Clinical Radiology · doi:10.1016/j.crad.2018.12.015 · Cited by 173 · see citing works
A bird's-eye view of deep learning in bioimage analysis
Meijering, E. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.08.003 · Cited by 126 · see citing works
Perceptual and interpretive error in diagnostic radiology—causes and potential solutions
Degnan, A. J., Ghobadi, E. H., Hardy, P., Krupinski, E., Scali, E. P., Stratchko, L., Ulano, A., Walker, E., Wasnik, A. P., & Auffermann, W. F. (2019) · Academic Radiology · doi:10.1016/j.acra.2018.11.006 · Cited by 121 · see citing works
Generating synthetic data for medical imaging
Koetzier, L. R., Wu, J., Mastrodicasa, D., Lutz, A., Chung, M., Koszek, W. A., Pratap, J., Chaudhari, A. S., Rajpurkar, P., Lungren, M. P., et al. (2024) · Radiology · doi:10.1148/radiol.232471 · Cited by 111 · see citing works
AI-RADS: an artificial intelligence curriculum for residents
Lindqwister, A. L., Hassanpour, S., Lewis, P. J., & Sin, J. M. (2021) · Academic Radiology · doi:10.1016/j.acra.2020.09.017 · Cited by 103 · see citing works
Interventional Radiology Ex-Machina: Impact of Artificial Intelligence on Practice
Gurgitano, M., Angileri, S. A., Rodà, G. M., Liguori, A., Pandolfi, M., Ierardi, A. M., Wood, B. J., & Carrafiello, G. (2021) · La radiologia medica · doi:10.1007/s11547-021-01351-x · Cited by 100 · see citing works
Groen, A. M., Kraan, R., Amirkhan, S. F., Daams, J. G., & Maas, M. (2022) · European Journal of Radiology · doi:10.1016/j.ejrad.2022.110592 · Cited by 89 · see citing works
Pierre, K., Haneberg, A. G., Kwak, S., Peters, K. R., Hochhegger, B., Sananmuang, T., Tunlayadechanont, P., Tighe, P. J., Mancuso, A., & Forghani, R. (2023) · Seminars in Roentgenology · doi:10.1053/j.ro.2023.02.003 · Cited by 79 · see citing works
A survey on deep learning in medical ultrasound imaging
Song, K., Feng, J., & Chen, D. (2024) · Frontiers in Physics · doi:10.3389/fphy.2024.1398393 · Cited by 59 · see citing works
Wang, G., Gao, K., Liu, Q., Wu, Y., Zhang, K., Zhou, W., & Guo, C. (2023) · Journal of Medical Internet Research · doi:10.2196/49771 · Cited by 48 · see citing works
A dataset of simulated patient-physician medical interviews with a focus on respiratory cases
Fareez, F., Parikh, T., Wavell, C., Shahab, S., Chevalier, M., Good, S., De Blasi, I., Rhouma, R., McMahon, C., Lam, J.-P., et al. (2022) · Scientific Data · doi:10.1038/s41597-022-01423-1 · Cited by 39 · see citing works
Artificial intelligence in radiology: the ecosystem essential to improving patient care
Sogani, J., Allen, B., Dreyer, K., & McGinty, G. (2020) · Clinical Imaging · doi:10.1016/j.clinimag.2019.08.001 · Cited by 36 · see citing works
Haller, S., Van Cauter, S., Federau, C., Hedderich, D. M., & Edjlali, M. (2022) · Neuroradiology · doi:10.1007/s00234-021-02890-w · Cited by 33 · see citing works
Artificial intelligence and computer-aided diagnosis for colonoscopy: where do we stand now?
Kudo, S.-E., Mori, Y., Abdel-aal, U. M., Misawa, M., Itoh, H., Oda, M., & Mori, K. (2021) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2019.12.14 · Cited by 21 · see citing works
- Authors
- Chartrand, G., Cheng, P. M., Vorontsov, E., Drozdzal, M., Turcotte, S., Pal, C. J., Kadoury, S., & Tang, A.
- Affiliations
- University of Southern California (US)
- ORCID
- Venue
- RadioGraphics
- Published
- 2017-11
- Volume
- 37
- Issue
- 7
- Pages
- 2113-2131
- ISSN
- 0271-5333 (ISSN-L)
- 1527-1323
- OpenAlex
- W2767236661
- Cited by
- 1,115
- References
- 7
- Citations by year
- 2026: 75 · 2025: 90 · 2024: 150 · 2023: 198 · 2022: 146 · 2021: 163 · 2020: 137 · 2019: 112 · 2018: 42 · 2017: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiographics (publishedVersion)
- PubMed (publishedVersion)
- PolyPublie (École Polytechnique de Montréal) (submittedVersion)
- Funders
- MITACS (IT05356)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Keywords
- deep learning, convolutional neural networks, artificial neural networks, diagnostic imaging, computer-aided diagnosis, image classification, lesion detection, image segmentation, backpropagation, clinical implementation
- MeSH terms
- Machine Learning, Algorithms, Humans, Image Processing, Computer-Assisted, Learning, Radiology, Radiology Information Systems, Neural Networks, Computer
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