Cited by 153Polyamine Metabolism and ApplicationsBarrier Structure and Function StudiesGastrointestinal motility and disorders

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Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines

Guo, Xin, Rao, Jaladanki N., Liu, Lan, Zou, Tong-Tong, Turner, Douglas J., Bass, Barbara L., Wang, Jian-Ying·2003·American Journal of Physiology-Cell Physiology

DOI 10.1152/ajpcell.00015.2003

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Abstract

Maintenance of intestinal mucosal epithelial integrity requires polyamines that are involved in the multiple signaling pathways controlling gene expression and different epithelial cell functions. Integrity of the intestinal epithelial barrier depends on a complex of proteins composing different intercellular junctions, including tight junctions, adherens junctions, and desmosomes. E-cadherin is primarily found at the adherens junctions and plays a critical role in cell-cell adhesions that are fundamental to formation of the intestinal epithelial barrier. The current study determined whether polyamines regulate intestinal epithelial barrier function by altering E-cadherin expression. Depletion of cellular polyamines by alpha-difluoromethylornithine (DFMO) reduced intracellular free Ca2+ concentration ([Ca2+]cyt), decreased E-cadherin expression, and increased paracellular permeability in normal intestinal epithelial cells (IEC-6 line). Polyamine depletion did not alter expression of tight junction proteins such as zona occludens (ZO)-1, ZO-2, and junctional adhesion molecule (JAM)-1. Addition of exogenous polyamine spermidine reversed the effects of DFMO on [Ca2+]cyt and E-cadherin expression and restored paracellular permeability to near normal. Elevation of [Ca2+]cyt by the Ca2+ ionophore ionomycin increased E-cadherin expression in polyamine-deficient cells. In contrast, reduction of [Ca2+]cyt by polyamine depletion or removal of extracellular Ca2+ not only inhibited expression of E-cadherin mRNA but also decreased the half-life of E-cadherin protein. These results indicate that polyamines regulate intestinal epithelial paracellular barrier function by altering E-cadherin expression and that polyamines are essential for E-cadherin expression at least partially through [Ca2+]cyt.

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Authors: Guo, X., Rao, J. N., Liu, L., Zou, T.-T., Turner, D. J., Bass, B. L., & Wang, J.-Y.
Affiliations: University of Maryland, Baltimore (US)
ORCID: Guo, Xin
Rao, Jaladanki N.
Liu, Lan
Turner, Douglas J.
Bass, Barbara L.
Wang, Jian-Ying
Venue: American Journal of Physiology-Cell Physiology
Publisher: American Physiological Society
Published: 2003-11
Volume: 285
Issue: 5
Pages: C1174-C1187
ISSN: 0363-6143 (ISSN-L)
1522-1563
DOI: 10.1152/ajpcell.00015.2003
OpenAlex: W2109680774
Cited by: 153
References: 66
Citations by year: 2026: 2 · 2025: 4 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 11 · 2015: 9 · 2014: 9 · 2013: 6 · 2012: 9
FWCI: 3.34
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Cell Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061972, (DK-57819, DK-61972, R01DK057819)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: polyamines, adherens junctions, paracellular permeability, intestinal epithelial barrier, E-cadherin, intracellular calcium, difluoromethylornithine, spermidine, tight junctions, protein stability, IEC-6 cells
MeSH terms: Animals, Calcium, Cell Line, Cell Membrane Permeability, Epithelial Cells, Intestinal Mucosa, Polyamines, Cadherins, Adherens Junctions, Rats

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Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines

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