The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells
Abstract
To investigate the possible role of members of the mammalian transient receptor potential (TRP) channel family (TRPC1–7) in vasoconstrictor-induced Ca 2+ entry in vascular smooth muscle cells, we studied [Arg 8]-vasopressin (AVP)-activated channels in A7r5 aortic smooth muscle cells. AVP induced an increase in free cytosolic Ca 2+ concentration ([Ca 2+]i) consisting of Ca 2+ release and Ca 2+ influx. Whole cell recordings revealed the activation of a nonselective cation current with a doubly rectifying current-voltage relation strikingly similar to those described for some heterologously expressed TRPC isoforms. The current was also stimulated by direct activation of G proteins as well as by activation of the phospholipase Cγ-coupled platelet-derived growth factor receptor. Currents were not activated by store depletion or increased [Ca 2+]i. Application of 1-oleoyl-2-acetyl- sn-glycerol stimulated the current independently of protein kinase C, a characteristic property of the TRPC3/6/7 subfamily. Like TRPC6-mediated currents, cation currents in A7r5 cells were increased by flufenamate. Northern hybridization revealed mRNA coding for TRPC1 and TRPC6. We therefore suggest that TRPC6 is a molecular component of receptor-stimulated Ca 2+-permeable cation channels in A7r5 smooth muscle cells.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Li, H.-S., Xu, X.-Z. S., & Montell, C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80838-7 · Cited by 345
Cited by
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
Spassova, M. A., Hewavitharana, T., Xu, W., Soboloff, J., & Gill, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606894103 · Cited by 517
Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
TRPC Channels: Integrators of Multiple Cellular Signals
Soboloff, J., Spassova, M., Hewavitharana, T., He, L. P., Luncsford, P., Xu, W., Venkatachalam, K., van Rossum, D., Patterson, R. L., & Gill, D. L. (2007) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-34891-7_34 · Cited by 46
Metadata
- Authors
- Jung, S., Strotmann, R., Schultz, G., & Plant, T. D.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2002-02-01
- Volume
- 282
- Issue
- 2
- Pages
- C347-C359
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2053209167
- Cited by
- 230
- References
- 3
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jung, S., Strotmann, R., Schultz, G., & Plant, T. D. (2002). TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00283.2001
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