Endogenous interferon-γ is required for efficient skeletal muscle regeneration
Abstract
The inflammatory response is thought to play important roles in tissue healing. The hypothesis of this study was that the inflammatory cytokine interferon (IFN)-gamma is produced endogenously following skeletal muscle injury and promotes efficient healing. We show that IFN-gamma is expressed at both mRNA and protein levels in skeletal muscle following injury, and that the time course of IFN-gamma expression correlated with the accumulation of macrophages, T-cells, and natural killer cells, as well as myoblasts, in damaged muscle. Cells of each type were isolated from injured muscle, and IFN-gamma expression was detected in each cell type. We also demonstrate that administration of an IFN-gamma receptor blocking antibody to wild-type mice impaired induction of interferon response factor-1, reduced cell proliferation, and decreased formation of regenerating fibers. IFN-gamma null mice showed similarly impaired muscle healing associated with impaired macrophage function and development of fibrosis. In vitro studies demonstrated that IFN-gamma and its receptor are expressed in the C2C12 muscle cell line, and that the IFN-gamma receptor blocking antibody reduced proliferation and fusion of these muscle cells. In summary, our results indicate that IFN-gamma promotes muscle healing, in part, by stimulating formation of new muscle fibers.
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The timing of inflammatory responses can strongly influence the kinetics and extent of muscle regeneration.
“These studies showed that the timing of inflammatory responses can have profound effects on the kinetics and extent of regeneration69, findings confirmed by experiments using antibodies to block inflammatory cytokines70,71.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [70]
Skeletal muscle Mp express iNOS mRNA at 5 days after chemically induced injury but do not express iNOS at any time-point after laceration injury.
“Studies from our own laboratory have produced contradictory data in two different mouse muscle injury models: skeletal muscle Mp express iNOS mRNA at 5 days after chemically induced injury [57] but do not express iNOS at any time-point after laceration injury (unpublished results).”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [57]
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- Authors
- Cheng, M., Nguyen, M.-H., Fantuzzi, G., & Koh, T. J.
- Affiliations
- University of Illinois Chicago (US)
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2008-05
- Volume
- 294
- Issue
- 5
- Pages
- C1183-C1191
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2141044457
- Cited by
- 214
- References
- 43
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 19 · 2023: 16 · 2022: 15 · 2021: 18 · 2020: 11 · 2019: 9 · 2018: 16 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 13 · 2013: 10 · 2012: 8
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- interferon-gamma, skeletal muscle regeneration, muscle damage, inflammation, macrophages, T cells, natural killer cells, myoblasts, IFN-gamma receptor, fibrosis, muscle cell proliferation, myoblast fusion, C2C12 myoblasts
- MeSH terms
- Interferon gamma Receptor, Animals, Cell Division, Cobra Cardiotoxin Proteins, Forelimb, Inflammation, Interferon-gamma, Intermediate Filament Proteins, Mice, Inbred C57BL, Muscle Proteins, Regeneration, Receptors, Interferon, DNA Primers, Mice, Knockout, Muscle, Skeletal, Muscle Fibers, Skeletal, Cell Culture Techniques, Reverse Transcriptase Polymerase Chain Reaction, Myoblasts, Mice
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