Cited by 126T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries

Open access
Hanna, Bola S., Wang, Gang, Galván-Peña, Silvia, Mann, Alexander O., Ramirez, Ricardo N., Muñoz-Rojas, Andrés R., Smith, Kathleen, Wan, Min +2 more·2023·Immunity

Abstract

Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T (Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations of microbiota-dependent Treg cells that promoted tissue regeneration at extra-gut sites, notably acutely injured skeletal muscle and fatty liver. Inflammatory meditators elicited by tissue damage combined with MHC-class-II-dependent T cell activation to drive the accumulation of gut-derived RORγ+ Treg cells in injured muscle, wherein they regulated the dynamics and tenor of early inflammation and helped balance the proliferation vs. differentiation of local stem cells. Reining in IL-17A-producing T cells was a major mechanism underlying the rheostatic functions of RORγ+ Treg cells in compromised tissues. Our findings highlight the importance of gut-trained Treg cell emissaries in controlling the response to sterile injury of non-mucosal tissues.

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Crossref · 10.1016/j.immuni.2023.01.033

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  • The gut microbiome regulates the activity of RORγ+ Treg cells, and dysregulation of these cells can lead to diseases such as colitis, food allergy, and colon cancer.

    “In addition, the gut microbiome regulates the activity of retinoic acid receptor-related orphan receptor gamma-positive (RORγ+) Treg cells, dysregulation of which can lead to diseases such as colitis, food allergy, and colon cancer.622,701–704”

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Authors
Hanna, B. S., Wang, G., Galván-Peña, S., Mann, A. O., Ramirez, R. N., Muñoz-Rojas, A. R., Smith, K., Wan, M., Benoist, C., & Mathis, D.
Affiliations
  • Brigham and Women's Hospital (US)
  • Pfizer (United States) (US)
Corresponding author
Mathis, Diane
Venue
Immunity
Publisher
Elsevier BV
Published
2023-04
Volume
56
Issue
4
Pages
829-846.e8
ISSN
1074-7613 (ISSN-L)
OpenAlex
W4321503800
Cited by
126
References
105
Citations by year
2026: 33 · 2025: 44 · 2024: 30 · 2023: 19
FWCI
13.75
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Pfizer
  • Deutsche Forschungsgemeinschaft (HA 8510/1)
  • National Institutes of Health
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR070334)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords
gut microbiota, tissue regeneration, skeletal muscle injury, sterile inflammation, IL-17A, MHC class II, T cell activation, stem cell proliferation and differentiation, intestinal homeostasis
MeSH terms
Gastrointestinal Microbiome, Animals, Mice, Inbred C57BL, T-Lymphocytes, Regulatory, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Microbiota

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