Skeletal muscle regeneration and impact of aging and nutrition

Domingues-Faria, Carla; Vasson, Marie-Paule; Goncalves-Mendes, Nicolas; Boirie, Yves; Walrand, Stephane

doi:10.1016/j.arr.2015.12.004

Cited by 157Muscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition

Skeletal muscle regeneration and impact of aging and nutrition

Domingues-Faria, Carla, Vasson, Marie-Paule, Goncalves-Mendes, Nicolas, Boirie, Yves, Walrand, Stephane·2016·Ageing Research Reviews

DOI 10.1016/j.arr.2015.12.004

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Abstract

After skeletal muscle injury a regeneration process takes place to repair muscle. Skeletal muscle recovery is a highly coordinated process involving cross-talk between immune and muscle cells. It is well known that the physiological activities of both immune cells and muscle stem cells decline with advancing age, thereby blunting the capacity of skeletal muscle to regenerate. The age-related reduction in muscle repair efficiency contributes to the development of sarcopenia, one of the most important factors of disability in elderly people. Preserving muscle regeneration capacity may slow the development of this syndrome. In this context, nutrition has drawn much attention: studies have demonstrated that nutrients such as amino acids, n-3 polyunsaturated fatty acids, polyphenols and vitamin D can improve skeletal muscle regeneration by targeting key functions of immune cells, muscle cells or both. Here we review the process of skeletal muscle regeneration with a special focus on the cross-talk between immune and muscle cells. We address the effect of aging on immune and skeletal muscle cells involved in muscle regeneration. Finally, the mechanisms of nutrient action on muscle regeneration are described, showing that quality of nutrition may help to preserve the capacity for skeletal muscle regeneration with age.

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Chronic inflammation during ageing is associated with increased pro-inflammatory cytokines TNF-α and IL-6 compared to younger individuals due to possible dysregulation in immune cell function.
“On the other hand, chronic inflammation observed during ageing is associated with an increase in pro-inflammatory cytokines (compared to younger individuals) such as TNF-α and IL-6 due to possible dysregulation in immune cell function [59,76].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [76]

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Mediterranean Diet and Quality of Life in Adults: A Systematic Review
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The Role of Omega-3 Polyunsaturated Fatty Acids and Their Lipid Mediators on Skeletal Muscle Regeneration: A Narrative Review
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Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland
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Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging
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Drosophila muscles regulate the immune response against wasp infection via carbohydrate metabolism
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“English Disease”: Historical Notes on Rickets, the Bone–Lung Link and Child Neglect Issues
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Key concepts in muscle regeneration: muscle “cellular ecology” integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function
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Acute Sarcopenia: Mechanisms and Management
Damanti, S., Senini, E., LORENZO, R. D., Merolla, A., Santoro, S., Festorazzi, C., Messina, M., Vitali, G., Sciorati, C., & Rovere, P. Q. (2024) · Nutrients · doi:10.3390/nu16203428 · Cited by 50 · see citing works
MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury
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Ginsenoside Rb1 and Rb2 Upregulate Akt/mTOR Signaling-Mediated Muscular Hypertrophy and Myoblast Differentiation
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The Role of Nutrition in the Treatment of Sarcopenia in Old Patients: From Restoration of Mitochondrial Activity to Improvement of Muscle Performance, a Systematic Review
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Age-Related Skeletal Muscle Dysfunction Is Aggravated by Obesity: An Investigation of Contractile Function, Implications and Treatment
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Impact of Western and Mediterranean Diets and Vitamin D on Muscle Fibers of Sedentary Rats
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Age-Related Changes in the Matrisome of the Mouse Skeletal Muscle
Lofaro, F. D., Cisterna, B., Lacavalla, M. A., Boschi, F., Malatesta, M., Quaglino, D., Zancanaro, C., & Boraldi, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910564 · Cited by 40 · see citing works
Sarcopenia: Current Insights into Molecular Mechanisms, Diagnostics, and Emerging Interventional Approaches
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Dehydroepiandrosterone and age-related musculoskeletal diseases: Connections and therapeutic implications
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Natural products and skeletal muscle health
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Taurine Administration Counteracts Aging-Associated Impingement of Skeletal Muscle Regeneration by Reducing Inflammation and Oxidative Stress
Barbiera, A., Sorrentino, S., Fard, D., Lepore, E., Sica, G., Dobrowolny, G., Tamagnone, L., & Scicchitano, B. M. (2022) · Antioxidants · doi:10.3390/antiox11051016 · Cited by 35 · see citing works
Morphological Regeneration and Functional Recovery of Neuromuscular Junctions after Tourniquet-Induced Injuries in Mouse Hindlimb
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Mechanical strain drives exosome production, function, and miRNA cargo in C2C12 muscle progenitor cells
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Association between Handgrip Strength and the Systemic Immune-Inflammation Index: A Nationwide Study, NHANES 2011–2014
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Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives
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Mitochondrial transplantation as a possible therapeutic option for sarcopenia
Türkel, İ., Özerkliğ, B., Yılmaz, M., Ülger, Ö., Kubat, G. B., & Tuncer, M. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02326-3 · Cited by 24 · see citing works
Mechanisms Underlying the Effects of the Green Tea Polyphenol EGCG in Sarcopenia Prevention and Management
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Comprehensive Analytics of Actovegin® and Its Effect on Muscle Cells
Reichl, F., Holdt, L. M., Teupser, D., Schütze, G. A., Metcalfe, A., Hickel, R., Högg, C., & Bloch, W. (2017) · International Journal of Sports Medicine · doi:10.1055/s-0043-115738 · Cited by 24 · see citing works
Dietary supplement intake among the elderly
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Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength
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Insights Into Transcriptome Profiles Associated With Wooden Breast Myopathy in Broilers Slaughtered at the Age of 6 or 7 Weeks
Malila, Y., Uengwetwanit, T., Thanatsang, K. V., Arayamethakorn, S., Srimarut, Y., Petracci, M., Soglia, F., Rungrassamee, W., & Visessanguan, W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.691194 · Cited by 23 · see citing works
Regenerative Repair of Volumetric Muscle Loss Injury is Sensitive to Age
Kim, J. T., Kasukonis, B. M., Dunlap, G., Perry, R. A., Washington, T. A., & Wolchok, J. C. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2019.0034 · Cited by 23 · see citing works
Dual effects of obesity on satellite cells and muscle regeneration
Geiger, A. E., Daughtry, M. R., Yen, C., Kirkpatrick, L. T., Shi, H., & Gerrard, D. E. (2020) · Physiological Reports · doi:10.14814/phy2.14511 · Cited by 21 · see citing works
Theaflavin Promotes Myogenic Differentiation by Regulating the Cell Cycle and Surface Mechanical Properties of C2C12 Cells
Qu, Z., Liu, C., Li, P., Xiong, W., Zeng, Z., Liu, A., Xiao, W., Huang, J., Liu, Z., & Zhang, S. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03744 · Cited by 22 · see citing works
Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis
Ersoy, U., Kanakis, I., Alameddine, M., Pedraza-Vázquez, G., Ozanne, S. E., Peffers, M. J., Jackson, M. J., Goljanek‐Whysall, K., & Vasilaki, A. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102980 · Cited by 22 · see citing works
Gold nanoparticles modulate macrophage polarization to promote skeletal muscle regeneration
Xu, L., Qiu, J., Ren, Q., Wang, D., Guo, A., Wang, L., Hou, K., Wang, R., & Liu, Y. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101653 · Cited by 21 · see citing works
Using polyphenol derivatives to prevent muscle wasting
Francaux, M., & Deldicque, L. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000455 · Cited by 21 · see citing works
Ginsenoside Rg5 promotes muscle regeneration via p38MAPK and Akt/mTOR signaling
Kim, R., Kim, J. W., Choi, H., Oh, J., Kim, T. H., Go, G.-Y., Lee, S.-J., & Bae, G. (2023) · Journal of Ginseng Research · doi:10.1016/j.jgr.2023.06.004 · Cited by 21 · see citing works
nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis
Montagna, C., Rizza, S., Cirotti, C., Maiani, E., Muscaritoli, M., Musarò, A., Carrı̀, M. T., Ferraro, E., Cecconi, F., & Filomeni, G. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1584-3 · Cited by 21 · see citing works
Differential expression patterns of genes associated with metabolisms, muscle growth and repair in Pectoralis major muscles of fast- and medium-growing chickens
Malila, Y., Thanatsang, K. V., Sanpinit, P., Arayamethakorn, S., Soglia, F., Zappaterra, M., Bordini, M., Sirri, F., Rungrassamee, W., Davoli, R., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275160 · Cited by 20 · see citing works
Plant-based polyphenol rich protein supplementation attenuated skeletal muscle loss and lowered the LDL level via gut microbiota remodeling in Taiwan's community-dwelling elderly
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Immune Cells and Immunosenescence
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Stiff matrices enhance myoblast proliferation, reduce differentiation, and alter the response to fluid shear stress in vitro
van Santen, V. J. B., Klein‐Nulend, J., Bakker, A. D., & Jaspers, R. T. (2022) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-021-01050-4 · Cited by 17 · see citing works
Contractile function recovery in severely injured gastrocnemius muscle of rats treated with either oleic or linoleic acid
Abreu, P., Pinheiro, C. H. D. J., Vitzel, K. F., de Vasconcelos, D. A. A., Torres, R. P., Fortes, M. A. S., Marzuca-Nassr, G. N., Mancini‐Filho, J., Hirabara, S. M., & Curi, R. (2016) · Experimental Physiology · doi:10.1113/ep085899 · Cited by 16 · see citing works
Serum vitamin D status and circulating irisin levels in older adults with sarcopenia
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Exercise, circadian rhythms, and muscle regeneration: a path to healthy aging
Su, Z., & Xiang, L. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1633835 · Cited by 15 · see citing works
Retracted
Nanoparticle‐Driven Skeletal Muscle Repair and Regeneration Through Macrophage‐Muscle Stem Cell Interaction
Xu, L., Zhang, Y., Wang, D., Ren, Q., Wang, Y., Zang, Z., Guo, A., Guo, J., Wang, L., Wang, R., et al. (2025) · Small · doi:10.1002/smll.202412611 · Cited by 14 · see citing works
A simple model of immune and muscle cell crosstalk during muscle regeneration
Kojouharov, H. V., Chen‐Charpentier, B. M., Solís, F. J., Biguetti, C. C., & Brotto, M. A. P. (2021) · Mathematical Biosciences · doi:10.1016/j.mbs.2021.108543 · Cited by 14 · see citing works
The Panax ginseng Berry Extract and Soluble Whey Protein Hydrolysate Mixture Ameliorates Sarcopenia-Related Muscular Deterioration in Aged Mice
Han, M.-J., Park, S.-J., Lee, S., & Choung, S. (2022) · Nutrients · doi:10.3390/nu14040799 · Cited by 14 · see citing works
Risk Factors for Malnutrition in Seniors Aged 75+ Living in Home Environment in Selected Regions of the Czech Republic
Brabcová, I., Trešlová, M., Bártlová, S., Vacková, J., Tóthová, V., & Motlová, L. (2016) · Central European Journal of Public Health · doi:10.21101/cejph.a4283 · Cited by 14 · see citing works
Prevalence and correlation of sarcopenia with Alzheimer’s disease: A systematic review and meta-analysis
Chen, S., Zhang, S., Zheng, Q., Miao, J., & Guo, J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318920 · Cited by 13 · see citing works
Evidence of the Autophagic Process during the Fish Immune Response of Skeletal Muscle Cells against Piscirickettsia salmonis
Valenzuela, C., Azúa, M., Álvarez, C., Schmitt, P., Ojeda, N., & Mercado, L. A. (2023) · Animals · doi:10.3390/ani13050880 · Cited by 13 · see citing works
Satellite Cells Exhibit Decreased Numbers and Impaired Functions on Single Myofibers Isolated from Vitamin B6-Deficient Mice
Komaru, T., Yanaka, N., & Kumrungsee, T. (2021) · Nutrients · doi:10.3390/nu13124531 · Cited by 12 · see citing works
Influence of Aging on Microvascular Supply of the Gluteus Medius Tendon: A Cadaveric and Histologic Study
Márquez-Arabia, W. H., Gómez-Hoyos, J., Gómez, M. G., Flórez, I. D., Gallo‐Villegas, J., Monsalve, F. J., Arias, L. F., & Martin, H. D. (2017) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2017.01.036 · Cited by 12 · see citing works
The non-saponin fraction of Korean Red Ginseng ameliorates sarcopenia by regulating immune homeostasis in 22–26-month-old C57BL/6J mice
Oh, H., Jin, H., & Lee, B.-Y. (2022) · Journal of Ginseng Research · doi:10.1016/j.jgr.2022.05.007 · Cited by 12 · see citing works
Liposome‐Enabled Nanomaterials for Muscle Regeneration
Wu, S., & Lu, J. (2025) · Small Methods · doi:10.1002/smtd.202402154 · Cited by 11 · see citing works
Adiponectin receptors activation performs dual effects on regulating myogenesis and adipogenesis of young and aged muscle satellite cells
Liu, S., Liu, H., Liu, Y., Zhang, J., Liu, Z., Zheng, Z., & Luo, E. (2022) · Cell Proliferation · doi:10.1111/cpr.13370 · Cited by 10 · see citing works
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Authors: Domingues-Faria, C., Vasson, M.-P., Goncalves-Mendes, N., Boirie, Y., & Walrand, S.
Affiliations: Université Clermont Auvergne (FR)
ORCID: Vasson, Marie-Paule
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2016-03
Volume: 26
Pages: 22-36
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2015.12.004
OpenAlex: W2193057007
Cited by: 157
References: 178
Citations by year: 2026: 8 · 2025: 21 · 2024: 17 · 2023: 21 · 2022: 22 · 2021: 18 · 2020: 12 · 2019: 10 · 2018: 14 · 2017: 8 · 2016: 6
FWCI: 0.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: skeletal muscle regeneration, muscle aging, sarcopenia, muscle stem cells, immune cells, nutrition, amino acids, omega-3 fatty acids, polyphenols, vitamin D, muscle injury repair
MeSH terms: Immunosenescence, Aging, Humans, Nutritional Status, Regeneration, Muscle Fibers, Skeletal, Sarcopenia

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Skeletal muscle regeneration and impact of aging and nutrition

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