Cited by 593Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsLipid metabolism and biosynthesis

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., Cinti, S.·2000·American Journal of Physiology-Cell Physiology

DOI 10.1152/ajpcell.2000.279.3.c670

Open this paper in CoChat — free account

Abstract

Multilocular, mitochondria-rich adipocytes appear in white adipose tissue (WAT) of rats treated with the beta3-adrenoceptor agonist, CL-316243 (CL). Objectives were to determine whether these multilocular adipocytes derived from cells that already existed in the WAT or from proliferation of precursor cells and whether new mitochondria contained in them were typical brown adipocyte mitochondria. Use of 5-bromodeoxyuridine to identify cells that had undergone mitosis during the CL treatment showed that most multilocular cells derived from cells already present in the WAT. Morphological techniques showed that at least a subpopulation of unilocular adipocytes underwent conversion to multilocular mitochondria-rich adipocytes. A small proportion of multilocular adipocytes ( approximately 8%) was positive for UCP1 by immunohistochemistry. Biochemical techniques showed that mitochondrial protein recovered from WAT increased 10-fold and protein isolated from brown adipose tissue (BAT) doubled in CL-treated rats. Stained gels showed a different protein composition of new mitochondria isolated from WAT from that of mitochondria isolated from BAT. Western blotting showed new mitochondria in WAT to contain both UCP1, but at a much lower concentration than in BAT mitochondria, and UCP3, at a higher concentration than that in BAT mitochondria. We hypothesize that multilocular adipocytes present at 7 days of CL treatment have two origins. First, most come from convertible unilocular adipocytes that become multilocular and make many mitochondria that contain UCP3. Second, some come from a cell that gives rise to more typical brown adipocytes that express UCP1.

Integrity signals

Registry

Crossref · 10.1152/ajpcell.2000.279.3.c670

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 811
Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin
Gong, D., He, Y., Karas, M., & Reitman, M. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24129 · Cited by 740
UCP3: An Uncoupling Protein Homologue Expressed Preferentially and Abundantly in Skeletal Muscle and Brown Adipose Tissue
Vidal‐Puig, A., Solanes, G., Grujić, D., Flier, J. S., & Lowell, B. B. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6740 · Cited by 711
Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization
Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., & Casteilla, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.931 · Cited by 665
Self-citation
Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.
Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635
Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats
Himms‐Hagen, J., Cui, J. Z., Danforth, E., Taatjes, D. J., Lang, S. S., Waters, B. L., & Claus, T. H. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.4.r1371 · Cited by 382
Self-citation
Brown adipose tissue in the parametrial fat pad of the mouse
Young, P., Arch, J. R. S., & Ashwell, M. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80822-4 · Cited by 377
Vascular Endothelial Growth Factor Is the Major Angiogenic Factor in Omentum: Mechanism of the Omentum-Mediated Angiogenesis
Zhang, Q.-X., Magovern, C. J., Mack, C. A., Budenbender, K. T., Ko, W., & Rosengart, T. K. (1997) · Journal of Surgical Research · doi:10.1006/jsre.1996.4983 · Cited by 365
Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.
Claffey, K. P., Wilkison, W. O., & Spiegelman, B. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42003-0 · Cited by 357
The uncoupling proteins, a review
Boss, O., Muzzin, P., & Giacobino, J.-P. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390001 · Cited by 263

Flagged first, then by citations

Show all 42 references

Research works printed but not linked: 3

Loncar D., 1991, Int J Dev Biol, 35, 321
Nedergaard J, 1995, Int J Dev Biol, 39, 827
Wynford-Thomas D, 1986, Cell Tissue Kinet, 19, 179

Sorted by citations

Items 101–200 of 588

Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue
Rogers, N. H., Landa, A., Park, S., & Smith, R. G. (2012) · Aging Cell · doi:10.1111/acel.12010 · Cited by 175
The Importance of Breast Adipose Tissue in Breast Cancer
Kothari, C., Diorio, C., & Durocher, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165760 · Cited by 181
Subcutaneous fat in normal and diseased states
Avram, A. S., Avram, M. M., & James, W. D. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.015 · Cited by 188
Wnt/β-Catenin Signaling and Obesity
Chen, N., & Wang, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00792 · Cited by 173
The brown adipocyte: update on its metabolic role
Sell, H., Deshaies, Y., & Richard, D. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.003 · Cited by 168
The Implication of Brown Adipose Tissue for Humans
Ravussin, É., & Galgani, J. E. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145209 · Cited by 173
Myocardin-Related Transcription Factor A Regulates Conversion of Progenitors to Beige Adipocytes
McDonald, M. E., Li, C., Bian, H.-J., Smith, B. D., Layne, M. D., & Farmer, S. R. (2015) · Cell · doi:10.1016/j.cell.2014.12.005 · Cited by 167
Brown adipose tissue and its therapeutic potential
Lidell, M. E., Betz, M. J., & Enerbäck, S. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12255 · Cited by 168
Beige Adipose Tissue Identification and Marker Specificity—Overview
Pilkington, A., Paz, H. A., & Wankhade, U. D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.599134 · Cited by 163
Between brown and white: Novel aspects of adipocyte differentiation
Cinti, S. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.535557 · Cited by 169
Self-citation
Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes
Li, Y., Fromme, T., Schweizer, S., Schöttl, T., & Klingenspor, M. (2014) · EMBO Reports · doi:10.15252/embr.201438775 · Cited by 165
Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis
Hoeke, G., Kooijman, S., Boon, M. R., Rensen, P. C. N., & Berbée, J. F. P. (2016) · Circulation Research · doi:10.1161/circresaha.115.306647 · Cited by 166
The role of brown adipose tissue in human obesity
Cinti, S. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.07.009 · Cited by 162
Self-citation
β3‐Adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat
Jimenez, M., Barbatelli, G., Allevi, R., Cinti, S., Seydoux, J., Giacobino, J., Muzzin, P., & Preitner, F. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03422.x · Cited by 155
Self-citation
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
Mowers, J. C., Uhm, M., Reilly, S. M., Simon, J., Leto, D. E., Chiang, S.-H., Chang, L. C., & Saltiel, A. R. (2013) · eLife · doi:10.7554/elife.01119 · Cited by 152
‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk
Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.074 · Cited by 148
Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence
Song, C. K., Vaughan, C. H., Keen‐Rhinehart, E., Harris, R. B. S., Richard, D., & Bartness, T. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00174.2008 · Cited by 146
Reduced Expression of FOXC2 and Brown Adipogenic Genes in Human Subjects with Insulin Resistance
Yang, X., Enerbäck, S., & Smith, U. (2003) · Obesity Research · doi:10.1038/oby.2003.163 · Cited by 150
Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-α
Li, P., Zhu, Z., Lu, Y., & Granneman, J. G. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00010.2005 · Cited by 143
White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways
Barquissau, V., Beuzelin, D., Pisani, D. F., Béranger, G. E., Mairal, A., Montagner, A., Roussel, B., Tavernier, G., Marques, M.-A., Moro, C., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.03.002 · Cited by 154
PVAT and Its Relation to Brown, Beige, and White Adipose Tissue in Development and Function
Hildebrand, S., Stümer, J., & Pfeifer, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00070 · Cited by 143
Human Dedifferentiated Adipocytes Show Similar Properties to Bone Marrow‐Derived Mesenchymal Stem Cells
Poloni, A., Maurizi, G., Leoni, P., Serrani, F., Mancini, S., Frontini, A., Zingaretti, M. C., Siquini, W., Sarzani, R., & Cinti, S. (2012) · Stem Cells · doi:10.1002/stem.1067 · Cited by 138
Self-citation
Effects of Wnt Signaling on Brown Adipocyte Differentiation and Metabolism Mediated by PGC-1α
Kang, S., Bajnok, L., Longo, K. A., Petersen, R. K., Hansen, J. B., Kristiansen, K., & MacDougald, O. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1272-1282.2005 · Cited by 136
Dietary polyphenols and their roles in fat browning
Silvester, A. J., Aseer, K. R., & Yun, J. W. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.028 · Cited by 136
β-Adrenergic Receptors and Regulation of Energy Expenditure: A Family Affair
Robidoux, J., Martin, T. L., & Collins, S. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121659 · Cited by 132
Brown adipose tissue—a new role in humans?
Lidell, M. E., & Enerbäck, S. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.64 · Cited by 131
Fatty acid metabolism and the basis of brown adipose tissue function
Calderón‐Domínguez, M., Mir, J. F., Fucho, R., Weber, M., Serra, D., & Herrero, L. (2015) · Adipocyte · doi:10.1080/21623945.2015.1122857 · Cited by 134
Sympathetic but not sensory denervation stimulates white adipocyte proliferation
Foster, M. T., & Bartness, T. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00197.2006 · Cited by 126
Pink Adipocytes
Cinti, S. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.05.007 · Cited by 134
Self-citation
Selective Activation of Mitogen-Activated Protein (MAP) Kinase Kinase 3 and p38α MAP Kinase Is Essential for Cyclic AMP-Dependent UCP1 Expression in Adipocytes
Robidoux, J., Cao, W., Quan, H. Y., Daniel, K. W., Moukdar, F., Bai, X., Floering, L. M., & Collins, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5466-5479.2005 · Cited by 122
Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production
Rossato, M., Granzotto, M., Macchi, V., Porzionato, A., Petrelli, L., Calcagno, A., Vencato, J., Stefani, D. D., Silvestrin, V., Rizzuto, R., et al. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.12.005 · Cited by 123
Brown Adipose Tissue and Its Role in Insulin and Glucose Homeostasis
Maliszewska, K., & Kretowski, A. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041530 · Cited by 124
The beneficial effects of brown adipose tissue transplantation
White, J. D., Dewal, R. S., & Stanford, K. I. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.06.004 · Cited by 124
Adipose Tissue: Physiology to Metabolic Dysfunction
Richard, A. J., White, U. A., Elks, C. M., & Stephens, J. M. (2020) · Europe PMC (PubMed Central) · Cited by 118
Genome-Wide Profiling of Peroxisome Proliferator-Activated Receptor γ in Primary Epididymal, Inguinal, and Brown Adipocytes Reveals Depot-Selective Binding Correlated with Gene Expression
Siersbæk, M. S., Loft, A., Aagaard, M. M., Nielsen, R., Schmidt, S. F., Petrovič, N., Nedergaard, J., & Mandrup, S. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00526-12 · Cited by 118
Brite/beige fat and UCP1 — is it thermogenesis?
Keipert, S., & Jastroch, M. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.02.008 · Cited by 120
Upregulation of AMPK during cold exposure occurs via distinct mechanisms in brown and white adipose tissue of the mouse
Mulligan, J. D., Gonzalez, A. A., Stewart, A. M., Carey, H. V., & Saupe, K. W. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.128652 · Cited by 113
Resident and migratory adipose immune cells control systemic metabolism and thermogenesis
Man, K., Kallies, A., & Vasanthakumar, A. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00804-7 · Cited by 115
EBF2 promotes the recruitment of beige adipocytes in white adipose tissue
Stine, R. R., Shapira, S. N., Lim, H., Ishibashi, J., Harms, M., Won, K., & Seale, P. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.11.001 · Cited by 114
Dynamic changes in lipid droplet-associated proteins in the “browning” of white adipose tissues
Barneda, D., Frontini, A., Cinti, S., & Christian, M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.015 · Cited by 107
Self-citation
Mechanisms underlying UCP1 dependent and independent adipocyte thermogenesis
Chang, S., Song, N., Choi, J. H., Yun, U. J., & Park, K. W. (2018) · Obesity Reviews · doi:10.1111/obr.12796 · Cited by 108
Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate
Wang, C., Bomberg, E. M., Billington, C. J., Levine, A. S., & Kotz, C. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00516.2006 · Cited by 104
Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis
Razzoli, M., Frontini, A., Gurney, A., Mondini, E., Çubuk, C., Katz, L. S., Cero, C., Bolan, P. J., Dopazo, J., Vidal‐Puig, A., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.10.005 · Cited by 106
Self-citation
Recruitment of brown fat and conversion of white into brown adipocytes: Strategies to fight the metabolic complications of obesity?
Langin, D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.008 · Cited by 107
Omega-3 fatty acids and adipose tissue biology
Kuda, O., Rossmeisl, M., & Kopecký, J. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.004 · Cited by 103
New therapeutic approaches for the treatment of obesity
Saltiel, A. R. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad1811 · Cited by 102
Mechanisms of Aging-Related Impairment of Brown Adipocyte Development and Function
Graja, A., & Schulz, T. J. (2014) · Gerontology · doi:10.1159/000366557 · Cited by 105
Role of β-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction
Plaisance, E. P., Henagan, T. M., Echlin, H., Boudreau, A., Hill, K. L., Lenard, N. R., Hasek, B. E., Orentreich∥, N., & Gettys, T. W. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00838.2009 · Cited by 95
Understanding the Biology of Thermogenic Fat: Is Browning A New Approach to the Treatment of Obesity?
Vargas‐Castillo, A., Fuentes‐Romero, R., Rodríguez-López, L. A., Torres, N., & Tovar, A. R. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.10.002 · Cited by 101
Understanding the brown adipocyte as a contributor to energy homeostasis
Chechi, K., Carpentier, A. C., & Richard, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.04.002 · Cited by 99
Thermogenic brown and beige/brite adipogenesis in humans
Cereijo, R., Giralt, M., & Villarroya, F. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.952328 · Cited by 95
Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
Weiner, J., Kranz, M., Klöting, N., Kunath, A., Steinhoff, K. G., Rijntjes, E., Köhrle, J., Zeisig, V., Hankir, M. K., Gebhardt, C., et al. (2016) · Scientific Reports · doi:10.1038/srep38124 · Cited by 98
Brown adipose tissue as an anti‐obesity tissue in humans
Chechi, K., Nedergaard, J., & Richard, D. (2013) · Obesity Reviews · doi:10.1111/obr.12116 · Cited by 98
Induction of Beige-Like Adipocytes in 3T3-L1 Cells
Asano, H., Kanamori, Y., Higurashi, S., Nara, T., Kato, K., Matsui, T., & Funaba, M. (2013) · Journal of Veterinary Medical Science · doi:10.1292/jvms.13-0359 · Cited by 93
Bone marrow–derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice
Koh, Y. J., Kang, S., Lee, H. J., Choi, T., Lee, H. S., Cho, C., & Koh, G. Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32504 · Cited by 93
Obesity: pathophysiology and therapeutic interventions
Kong, Y., Yang, H., Nie, R., Zhang, X., Zuo, F., Zhang, H., & Nian, X. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00264-9 · Cited by 89
The intake of high-fat diets induces the acquisition of brown adipocyte gene expression features in white adipose tissue
García-Ruiz, E., Reynés, B., Díaz‐Rúa, R., Ceresi, E., Oliver, P., & Palou, A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.112 · Cited by 92
Self-citation
Parallel Lineage-Tracing Studies Establish Fibroblasts as the Prevailing In Vivo Adipocyte Progenitor
Cattaneo, P., Mukherjee, D., Spinozzi, S., Zhang, L., Larcher, V., Stallcup, W. B., Kataoka, H., Chen, J., Dimmeler, S., Evans, S. Μ., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.046 · Cited by 89
Reversible physiological transdifferentiation in the adipose organ
Cinti, S. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990140 · Cited by 89
Self-citation
Single cell approaches to address adipose tissue stromal cell heterogeneity
Rondini, E. A., & Granneman, J. G. (2020) · Biochemical Journal · doi:10.1042/bcj20190467 · Cited by 90
Immunohistochemical identification of the β3-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine
De Matteis, R., Arch, J., Petroni, M., Ferrari, D., Cinti, S., & Stock, M. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802148 · Cited by 85
Self-citation
Adipose and skeletal muscle thermogenesis: studies from large animals
Fuller‐Jackson, J., & Henry, B. A. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0090 · Cited by 89
Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α
Pardo, R., Enguix, N., Lasheras, J., Felíu, J. E., Kralli, A., & Villena, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026989 · Cited by 86
Role of hormone-sensitive lipase in β-adrenergic remodeling of white adipose tissue
Mottillo, E. P., Shen, X., & Granneman, J. G. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00051.2007 · Cited by 86
The Beta3 Adrenergic Receptor in Healthy and Pathological Cardiovascular Tissues
Michel, L. Y. M., Farah, C., & Balligand, J. (2020) · Cells · doi:10.3390/cells9122584 · Cited by 83
Improved methodologies for the study of adipose biology: insights gained and opportunities ahead
Wang, Q. A., Scherer, P. E., & Gupta, R. K. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046441 · Cited by 88
In Vivo Physiological Transdifferentiation of Adult Adipose Cells
Matteis, R. D., Zingaretti, M. C., Murano, I., Vitali, A., Frontini, A., Giannulis, I., Barbatelli, G., Marcucci, F., Bordicchia, M., Sarzani, R., et al. (2009) · Stem Cells · doi:10.1002/stem.197 · Cited by 83
Self-citation
Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity
Barquissau, V., Léger, B., Beuzelin, D., Martins, F., Amri, E., Pisani, D. F., Saris, W. H. M., Astrup, A. V., Maoret, J.-J., Iacovoni, J. S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.102 · Cited by 88
The Forkhead Transcription Factor FoxC2 Inhibits White Adipocyte Differentiation
Davis, K. E., Moldes, M., & Farmer, S. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402197200 · Cited by 82
Concise Review: Adipocyte Origins: Weighing the Possibilities
Majka, S. M., Barak, Y., & Klemm, D. J. (2011) · Stem Cells · doi:10.1002/stem.653 · Cited by 81
Bone morphogenetic proteins in inflammation, glucose homeostasis and adipose tissue energy metabolism
Grgurević, L., Christensen, G. L., Schulz, T. J., & Vukičević, S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.12.009 · Cited by 84
Adipogenesis: A Necessary but Harmful Strategy
Hafidi, M. E., Buelna‐Chontal, M., Sánchez‐Muñoz, F., & Carbó, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153657 · Cited by 82
Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects
Chatree, S., Sitticharoon, C., Maikaew, P., Pongwattanapakin, K., Keadkraichaiwat, I., Churintaraphan, M., Sripong, C., Sririwichitchai, R., & Tapechum, S. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220962708 · Cited by 82
Adipokines in obesity and metabolic-related-diseases
Pestel, J., Blangero, F., Watson, J., Pirola, L., & Eljaafari, A. (2023) · Biochimie · doi:10.1016/j.biochi.2023.04.008 · Cited by 83
Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome
Poekes, L., Lanthier, N., & Leclercq, I. A. (2015) · Clinical Science · doi:10.1042/cs20150339 · Cited by 83
ASK1 signalling regulates brown and beige adipocyte function
Hattori, K., Naguro, I., Okabe, K., Funatsu, T., Furutani, S., Takeda, K., & Ichijo, H. (2016) · Nature Communications · doi:10.1038/ncomms11158 · Cited by 78
The role of adipose tissue in cancer-associated cachexia
Vaitkus, J. A., & Celi, F. S. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216683282 · Cited by 81
BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue
Hoffmann, J. M., Grünberg, J. R., CHURCH, C. D., Elias, I., Pálsdóttir, V., Jansson, J., Bosch, F., Hammarstedt, A., Hedjazifar, S., & Smith, U. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.020 · Cited by 80
Differentiation of the tumor microenvironment: are CAFs the Organizer?
Kochetkova, M., & Samuel, M. S. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.11.008 · Cited by 76
Adipokines influence the inflammatory balance in autoimmunity
Hutcheson, J. (2015) · Cytokine · doi:10.1016/j.cyto.2015.04.004 · Cited by 78
Adrenoceptors in white, brown, and brite adipocytes
Evans, B. A., Merlin, J., Bengtsson, T., & Hutchinson, D. S. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14631 · Cited by 81
Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo
Rossmeisl, M., Barbatelli, G., Flachs, P., Brauner, P., Zingaretti, M. C., Marelli, M., Janovská, P., Horáková, M., Syrový, I., Cinti, S., et al. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2002.02627.x · Cited by 75
Self-citation
Repeated Exposure to Severely Limited Sleep Results in Distinctive and Persistent Physiological Imbalances in Rats
Everson, C. A., & Szabó, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022987 · Cited by 73
Epicardial adipose tissue as a mediator of cardiac arrhythmias
Patel, K. H. K., Hwang, T., Liebers, C. S., & Ng, F. S. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00565.2021 · Cited by 77
NT-PGC-1α Protein Is Sufficient to Link β3-Adrenergic Receptor Activation to Transcriptional and Physiological Components of Adaptive Thermogenesis
Chang, J. S., Fernand, V. E., Zhang, Y., Shin, J., Jun, H., Joshi, Y., & Gettys, T. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.320200 · Cited by 75
Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes
Ariotti, N., Murphy, S., Hamilton, N., Wu, L., Green, K., Schieber, N. L., Li, P., Martin, S., & Parton, R. G. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0847 · Cited by 74
Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles
Cheng, Y., Li, J., Keipert, S., Zhang, S., Hauser, A., Graf, E., Strom, T. M., Tschöp, M. H., Jastroch, M., & Perocchi, F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.021 · Cited by 73
Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores
Rossmeisl, M., Flachs, P., Brauner, P., Sponarova, J., Matejkova, O., Prazak, T., Ruzickova, J., Bardova, K., Kuda, O., & Kopecky, J. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802855 · Cited by 71
A novel dual-targeted rosiglitazone-loaded nanoparticle for the prevention of diet-induced obesity via the browning of white adipose tissue
Hiradate, R., Khalil, I. A., Matsuda, A., Sasaki, M., Hida, K., & Harashima, H. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.10.002 · Cited by 74
Recruitment of Brown Adipose Tissue as a Therapy for Obesity-Associated Diseases
Boss, O., & Farmer, S. R. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00014 · Cited by 72
Determinants of brown adipocyte development and thermogenesis
Richard, D., Carpentier, A. C., Doré, G., Ouellet, V., & Picard, F. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.241 · Cited by 71
Two key temporally distinguishable molecular and cellular components of white adipose tissue browning during cold acclimation
Janković, A., Golić, I., Markelic, M. B., Stančić, A., Otašević, V., Buzadžić, B., Korać, A., & Korać, B. (2015) · The Journal of Physiology · doi:10.1113/jp270805 · Cited by 70
Lipid Droplets Big and Small: Basic Mechanisms That Make Them All
Klemm, R. W., & Carvalho, P. (2024) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-012624-031419 · Cited by 72
Adrenergic regulation of cellular plasticity in brown, beige/brite and white adipose tissues
Ramseyer, V. D., & Granneman, J. G. (2016) · Adipocyte · doi:10.1080/21623945.2016.1145846 · Cited by 68
Immune Modulation of Brown(ing) Adipose Tissue in Obesity
van den Berg, S. M., van Dam, A. D., Rensen, P. C. N., de Winther, M. P. J., & Lutgens, E. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1066 · Cited by 69
MicroRNA networks regulate development of brown adipocytes
Trajkovski, M., & Lodish, H. F. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.002 · Cited by 70
Molecular Aspects of Adipoepithelial Transdifferentiation in Mouse Mammary Gland
Prokesch, A., Smorlesi, A., Perugini, J., Manieri, M., Ciarmela, P., Mondini, E., Trajanoski, Z., Kristiansen, K., Giordano, A., Bogner‐Strauß, J. G., et al. (2014) · Stem Cells · doi:10.1002/stem.1756 · Cited by 66
Self-citation
Genetic and epigenetic control of adipose development
Gulyaeva, О. N., Dempersmier, J. M., & Sul, H. S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.04.016 · Cited by 68
Antiretoviral Therapy and the Lipodystrophy Syndrome, Part 2: Concepts in Aetiopathogenesis
Nolan, D. A., John, M., & Mallal, S. A. (2001) · Antiviral Therapy · doi:10.1177/135965350100600301 · Cited by 65

Authors: Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S.
Affiliations: Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa K1H 8M5, Canada; and
University of Ottawa (CA)
Institute of Normal Human Morphology-Anatomy, Faculty of Medicine, University of Ancona, 60020 Ancona, Italy
ORCID: Melnyk, A.
Cinti, S.
Venue: American Journal of Physiology-Cell Physiology
Publisher: American Physiological Society
Published: 2000-09-01
Volume: 279
Issue: 3
Pages: C670-C681
ISSN: 0363-6143 (ISSN-L)
1522-1563
DOI: 10.1152/ajpcell.2000.279.3.c670
OpenAlex: W2136040666
Cited by: 593
References: 42
Citations by year: 2026: 6 · 2025: 14 · 2024: 10 · 2023: 13 · 2022: 31 · 2021: 37 · 2020: 38 · 2019: 31 · 2018: 39 · 2017: 42 · 2016: 36 · 2015: 41 · 2014: 39 · 2013: 43 · 2012: 30
FWCI: 4.49
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Cell Physiology (publishedVersion)
PubMed (publishedVersion)
Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: white adipose tissue, CL316,243, beta3-adrenergic agonists, brown adipocyte differentiation, UCP1, UCP3, adipocyte origin, brown adipose tissue mitochondria, BrdU labeling
MeSH terms: Adipose Tissue, Adrenergic beta-Agonists, Animals, Adipose Tissue, Brown, Cell Line, Dioxoles, Immunohistochemistry, Male, Microscopy, Electron, Mitochondria, Rats, Sprague-Dawley, Adipocytes, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks