The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-α levels after prolonged running
Abstract
The present study was undertaken to examine the effect of prolonged running on monocyte intracellular cytokine production and plasma cytokine concentration. Blood samples were collected 1 h before, immediately after, 2 h after, and 24 h after a competitive marathon run. There was no change in the number of cells spontaneously producing tumor necrosis factor (TNF)-α; however, there was a decrease in the number of cells producing interleukin (IL)-1α and IL-6 ( P < 0.01) postexercise. In contrast, there was an increase in the number of monocytes that responded to lipopolysaccharide stimulation by producing IL-1α, TNF-α, and IL-6 ( P < 0.01) immediately and 2 h postexercise; however, these cells contained less cytokine ( P < 0.05). Plasma IL-6, TNF-α, epinephrine, norepinephrine, and cortisol concentrations were markedly increased ( P < 0.01) postexercise. These data demonstrate that circulating monocytes are not the source of elevated levels of plasma IL-6 and TNF-α after prolonged running. In addition, it is likely that stress hormones result in a decrease in the amount of cytokine produced by LPS-stimulated cells postexercise.
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Cites
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297
Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humans
Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.287ad.x · Cited by 1,014
Initial events in exercise-induced muscular injury
BEN KIBLER, C. W., & ARMSTRONG, R. B. (1990) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199008000-00002 · Cited by 457 · cited 1×
“It is well recognized that repetitive eccentric contractions cause more damage to skeletal muscle than concentric contractions (1, 9, 19).”
BackgroundCarbohydrate and the cytokine response to 2.5 h of running
Nehlsen-Cannarella, S. L., Fagoaga, O. R., Nieman, D. C., Henson, D. A., Butterworth, D. E., Schmitt, R. L., Bailey, E. M., Warren, B. J., Utter, A., & Davis, J. M. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.5.1662 · Cited by 311
Influence of mode and carbohydrate on the cytokine response to heavy exertion
NIEMAN, D. C., NEHLSEN-CANNARELLA, S. L., FAGOAGA, O. R., HENSON, D. A., UTTER, A., DAVIS, J. M., WILLIAMS, F., & BUTTERWORTH, D. E. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199805000-00005 · Cited by 233
Exercise and the incidence of upper respiratory tract infections
HEATH, G. W., FORD, E. S., CRAVEN, T. E., MACERA, C. A., JACKSON, K. L., & PATE, R. R. (1991) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199102000-00002 · Cited by 175
Cited by
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909
Self-citationMuscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Self-citationImmune function in sport and exercise
Gleeson, M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00008.2007 · Cited by 1,016
Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898
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Metadata
- Authors
- Starkie, R. L., Rolland, J., Angus, D. J., Anderson, M. J., & Febbraio, M. A.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2001-04-01
- Volume
- 280
- Issue
- 4
- Pages
- C769-C774
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2162505253
- Cited by
- 254
- References
- 6
- FWCI
- 15.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Starkie, R. L., Rolland, J., Angus, D. J., Anderson, M. J., & Febbraio, M. A. (2001). Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-α levels after prolonged running. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.2001.280.4.c769
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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