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Cited by 254

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-α levels after prolonged running

Starkie, R. L., Rolland, J., Angus, D. J., Anderson, M. J., Febbraio, M. A.·2001·American Journal of Physiology-Cell Physiology
DOI 10.1152/ajpcell.2001.280.4.c769
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Abstract

The present study was undertaken to examine the effect of prolonged running on monocyte intracellular cytokine production and plasma cytokine concentration. Blood samples were collected 1 h before, immediately after, 2 h after, and 24 h after a competitive marathon run. There was no change in the number of cells spontaneously producing tumor necrosis factor (TNF)-α; however, there was a decrease in the number of cells producing interleukin (IL)-1α and IL-6 ( P < 0.01) postexercise. In contrast, there was an increase in the number of monocytes that responded to lipopolysaccharide stimulation by producing IL-1α, TNF-α, and IL-6 ( P < 0.01) immediately and 2 h postexercise; however, these cells contained less cytokine ( P < 0.05). Plasma IL-6, TNF-α, epinephrine, norepinephrine, and cortisol concentrations were markedly increased ( P < 0.01) postexercise. These data demonstrate that circulating monocytes are not the source of elevated levels of plasma IL-6 and TNF-α after prolonged running. In addition, it is likely that stress hormones result in a decrease in the amount of cytokine produced by LPS-stimulated cells postexercise.

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Metadata

Authors
Starkie, R. L., Rolland, J., Angus, D. J., Anderson, M. J., & Febbraio, M. A.
Venue
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Published
2001-04-01
Volume
280
Issue
4
Pages
C769-C774
ISSN
  • 0363-6143 (ISSN-L)
  • 1522-1563
DOI
10.1152/ajpcell.2001.280.4.c769
OpenAlex
W2162505253
Cited by
254
References
6
FWCI
15.70
Type
journal article
Language
en
Open access
closed

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