CoChat
Sign Up
Cited by 311Exercise and Physiological ResponsesMuscle metabolism and nutritionSports Performance and Training

Carbohydrate and the cytokine response to 2.5 h of running

Nehlsen-Cannarella, S. L., Fagoaga, O. R., Nieman, D. C., Henson, D. A., Butterworth, D. E., Schmitt, R. L., Bailey, E. M., Warren, B. J. +2 more·1997·Journal of Applied Physiology
DOI 10.1152/jappl.1997.82.5.1662
Open this paper in CoChat — free account

Abstract

Nehlsen-Cannarella, S. L., O. R. Fagoaga, D. C. Nieman, D. A. Henson, D. E. Butterworth, R. L. Schmitt, E. M. Bailey, B. J. Warren, A. Utter, and J. M. Davis. Carbohydrate and the cytokine response to 2.5 h of running. J. Appl. Physiol. 82(5): 1662–1667, 1997.—This randomized, double-blind, placebo-controlled study was designed to determine the influence of 6% carbohydrate (C) vs. placebo (P) beverage ingestion on cytokine responses (5 total samples over 9 h) to 2.5 h of high-intensity running (76.7 ± 0.4% maximal O2uptake) by 30 experienced marathon runners. For interleukin-6 (IL-6), a difference in the pattern of change between groups was found, highlighted by a greater increase in P vs. C immediately postrun (753 vs. 421%) and 1.5 h postrun (193 vs. 86%) [ F(4,112) = 3.77, P = 0.006]. For interleukin-1-receptor antagonist (IL-1ra), a difference in the pattern of change between groups was found, highlighted by a greater increase in P vs. C 1.5 h postrun (231 vs. 72%) [ F(2,50) = 6.38, P = 0.003]. No significant interaction effects were seen for bioactive IL-6 or IL-1β. The immediate postrun plasma glucose concentrations correlated negatively with those of plasma cortisol ( r = −0.67, P < 0.001); postrun plasma cortisol ( r = 0.70, P < 0.001) and IL-6 levels ( r = 0.54, P = 0.003) correlated positively with levels of IL-1ra. Taken together, the data indicate that carbohydrate ingestion attenuates cytokine levels in the inflammatory cascade in response to heavy exertion.

Integrity signals

Registry

Crossref · 10.1152/jappl.1997.82.5.1662

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Carbohydrate ingestion during exercise blunted the exercise-induced IL-6 response, the increase in lymphocyte number as well as the cortisol.

    “Carbohydrate ingestion during exercise blunted the exercise-induced IL-6 response, the increase in lymphocyte number as well as the cortisol (204, 205).”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [205]

Cites

Flagged first, then by citations

1 of the 29 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Nehlsen-Cannarella, S. L., Fagoaga, O. R., Nieman, D. C., Henson, D. A., Butterworth, D. E., Schmitt, R. L., Bailey, E. M., Warren, B. J., Utter, A., & Davis, J. M.
Affiliations
  • Immunology Center and Department of Pathology, Loma Linda University Medical Center, Loma Linda, California 92350;
  • Loma Linda University Medical Center (US)
  • Appalachian State University (US)
  • University of South Carolina (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1997-05-01
Volume
82
Issue
5
Pages
1662-1667
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1997.82.5.1662
OpenAlex
W2115197006
Cited by
311
References
29
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 6 · 2018: 7 · 2017: 12 · 2016: 9 · 2015: 16 · 2014: 13 · 2013: 17 · 2012: 14
FWCI
17.33
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
carbohydrate intake, cytokines, interleukin-6, interleukin-1 receptor antagonist, IL-1β, cortisol, plasma glucose, marathon running, high-intensity exercise, exercise-induced inflammation
MeSH terms
Adult, Blood Glucose, Dietary Carbohydrates, Double-Blind Method, Epinephrine, Female, Humans, Hydrocortisone, Inflammation, Interleukin-1, Male, Middle Aged, Placebos, Running, Sialoglycoproteins, Interleukin-6, Cytokines, Receptors, Interleukin-1, Interleukin 1 Receptor Antagonist Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review