The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise
Abstract
AMP-activated protein kinase (AMPK) is emerging as a key signaling pathway that modulates cellular metabolic processes. In skeletal muscle, AMPK is activated during exercise. Increased myocardial substrate metabolism during exercise could be explained by AMPK activation. Although AMPK is known to be activated during myocardial ischemia, it remains uncertain whether AMPK is activated in response to the physiological increases in cardiac work associated with exercise. Therefore, we evaluated cardiac AMPK activity in rats at rest and after 10 min of treadmill running at moderate (15% grade, 16 m/min) or high (15% grade, 32 m/min) intensity. Total AMPK activity in the heart increased in proportion to exercise intensity ( P < 0.05). AMPK activity associated with the α 2-catalytic subunit increased 2.8 ± 0.4-fold ( P < 0.02 vs. rest) and 4.5 ± 0.6-fold ( P < 0.001 vs. rest) with moderate- and high-intensity exercise, respectively. AMPK activity associated with the α 1-subunit increased to a lesser extent. Phosphorylation of the Thr 172-regulatory site on AMPK α-catalytic subunits increased during exercise ( P < 0.001). There was no increase in Akt phosphorylation during exercise. The changes in AMPK activity during exercise were associated with physiological AMPK effects (GLUT4 translocation to the sarcolemma and ACC phosphorylation). Thus cardiac AMPK activity increases progressively with exercise intensity, supporting the hypothesis that AMPK has a physiological role in the heart.
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Mammalian AMP-activated protein kinase subfamily
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Cited by
Myocardial Substrate Metabolism in the Normal and Failing Heart
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Metadata
- Authors
- Coven, D. L., Hu, X., Cong, L., Bergeron, R., Shulman, G. I., Hardie, D. G., & Young, L. H.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2003-09
- Volume
- 285
- Issue
- 3
- Pages
- E629-E636
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2042124279
- Cited by
- 174
- References
- 14
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
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