The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue
Abstract
IL-8 is released from human adipose tissue. Circulating IL-8 is increased in obese compared with lean subjects and is associated with measures of insulin resistance, development of atherosclerosis, and cardiovascular disease. We studied 1) the production and release of IL-8 in vitro from paired samples of subcutaneous (SAT) and visceral (VAT) adipose tissue and 2) the production of IL-8 from whole adipose tissue, isolated adipocytes, and nonfat cells of adipose tissue. IL-8 release from VAT was fourfold higher than from SAT ( P < 0.05), and IL-8 mRNA was twofold higher in VAT compared with SAT ( P < 0.01). Dexamethasone (50 nM) attenuated IL-8 production by 50% ( P < 0.05), and IL-1β (2 μg/l) increased IL-8 production up to 15-fold ( P < 0.001). IL-8 release from whole SAT explants correlated with body mass index (BMI; r = 0.78; P < 0.001), as did IL-8 release from nonfat cells ( r = 0.79; P < 0.001). However, no correlation was found between IL-8 release from the fraction of isolated adipocytes and BMI ( r = 0.01). In conclusion, we demonstrated an increased release of IL-8 from VAT compared with SAT. Furthermore, our data suggest that the observed elevation in circulating levels of IL-8 in obese subjects is due primarily to the release of IL-8 from nonfat cells from adipose tissue. The high levels of IL-8 release from human adipose tissue and accumulation of this tissue in obese subjects may account for some of the increase in circulating IL-8 observed in obesity.
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“L. salivarius UCC118 (10 10 CFU/d for 21 d) did not affect serum IL-1a, IL-1b, IL-4, sIL-2R, sIL-6R, TNF-a or IFN-g concentrations in healthy adults aged 20 -65 years (829) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [829]
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Cites
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,756
Adipose Tissue as an Endocrine Organ
Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
Gerszten, R. E., García-Zepeda, E. A., Lim, Y.-C., Yoshida, M., Ding, H. A., Gimbrone, M. A., Luster, A. D., Luscinskas, F. W., & Rosenzweig, A. (1999) · Nature · doi:10.1038/19546 · Cited by 1,263
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132
Bastard, J., Jardel, C., Bruckert, É., Blondy, P., Capeau, J., Laville, M., Vidal, H., & Hainque, B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6839 · Cited by 1,124
Overweight, Obesity, and Health Risk
National Task Force on the Prevention and Treatment of Obesity (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.7.898 · Cited by 963
Treatment of obesity: need to focus on high risk abdominally obese patients
Després, J., Lemieux, I., & Prud'homme, D. (2001) · BMJ · doi:10.1136/bmj.322.7288.716 · Cited by 831
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Human epicardial adipose tissue: A review
Sacks, H. S., & Fain, J. N. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.03.019 · Cited by 986
Self-citationYang, R.-Z., Lee, M.-J., Hu, H., Pray, J., Wu, H.-B., Hansen, B. C., Shuldiner, A. R., Fried, S. K., McLenithan, J. C., & Gong, D.-W. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00572.2004 · Cited by 884
Fain, J. N. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74018-3 · Cited by 702
Self-citationWentworth, J. M., Naselli, G., Brown, W. A., Doyle, L., Phipson, B., Smyth, G. K., Wabitsch, M., O’Brien, P. E., & Harrison, L. C. (2010) · Diabetes · doi:10.2337/db09-0287 · Cited by 636
Metadata
- Authors
- Bruun, J. M., Lihn, A. S., Madan, A. K., Pedersen, S. B., Schiøtt, K. M., Fain, J. N., & Richelsen, B.
- Affiliations
- Aarhus University (DK)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2004-01
- Volume
- 286
- Issue
- 1
- Pages
- E8-E13
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2125302795
- Cited by
- 215
- References
- 31
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 12 · 2012: 14
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- interleukin-8, visceral adipose tissue, subcutaneous adipose tissue, obesity, adipocytes, IL-8 mRNA expression, dexamethasone, IL-1β, body mass index, insulin resistance
- MeSH terms
- Adipose Tissue, Adult, Aerosols, Cell Differentiation, Cells, Cultured, Connective Tissue, Female, Fusarium, Humans, Middle Aged, Obesity, Morbid, RNA, Messenger, Stem Cells, Viscera, Body Mass Index, Interleukin-8, Stromal Cells, Adipocytes, Subcutaneous Tissue, Depsipeptides, In Vitro Techniques
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