Cited by 215Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue

Bruun, Jens M., Lihn, Aina S., Madan, Atul K., Pedersen, Steen B., Schiøtt, Kirsten M., Fain, John N., Richelsen, Bjørn·2004·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00269.2003

Open this paper in CoChat — free account

Abstract

IL-8 is released from human adipose tissue. Circulating IL-8 is increased in obese compared with lean subjects and is associated with measures of insulin resistance, development of atherosclerosis, and cardiovascular disease. We studied 1) the production and release of IL-8 in vitro from paired samples of subcutaneous (SAT) and visceral (VAT) adipose tissue and 2) the production of IL-8 from whole adipose tissue, isolated adipocytes, and nonfat cells of adipose tissue. IL-8 release from VAT was fourfold higher than from SAT ( P < 0.05), and IL-8 mRNA was twofold higher in VAT compared with SAT ( P < 0.01). Dexamethasone (50 nM) attenuated IL-8 production by 50% ( P < 0.05), and IL-1β (2 μg/l) increased IL-8 production up to 15-fold ( P < 0.001). IL-8 release from whole SAT explants correlated with body mass index (BMI; r = 0.78; P < 0.001), as did IL-8 release from nonfat cells ( r = 0.79; P < 0.001). However, no correlation was found between IL-8 release from the fraction of isolated adipocytes and BMI ( r = 0.01). In conclusion, we demonstrated an increased release of IL-8 from VAT compared with SAT. Furthermore, our data suggest that the observed elevation in circulating levels of IL-8 in obese subjects is due primarily to the release of IL-8 from nonfat cells from adipose tissue. The high levels of IL-8 release from human adipose tissue and accumulation of this tissue in obese subjects may account for some of the increase in circulating IL-8 observed in obesity.

Integrity signals

Registry

Crossref · 10.1152/ajpendo.00269.2003

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)
Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,756
Adipose Tissue as an Endocrine Organ
Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
Gerszten, R. E., García-Zepeda, E. A., Lim, Y.-C., Yoshida, M., Ding, H. A., Gimbrone, M. A., Luster, A. D., Luscinskas, F. W., & Rosenzweig, A. (1999) · Nature · doi:10.1038/19546 · Cited by 1,263
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132
Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss
Bastard, J., Jardel, C., Bruckert, É., Blondy, P., Capeau, J., Laville, M., Vidal, H., & Hainque, B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6839 · Cited by 1,124
Overweight, Obesity, and Health Risk
National Task Force on the Prevention and Treatment of Obesity (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.7.898 · Cited by 963
Treatment of obesity: need to focus on high risk abdominally obese patients
Després, J., Lemieux, I., & Prud'homme, D. (2001) · BMJ · doi:10.1136/bmj.322.7288.716 · Cited by 831

Show all 31 references

Sorted by citations

Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Human epicardial adipose tissue: A review
Sacks, H. S., & Fain, J. N. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.03.019 · Cited by 986
Self-citation
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action
Yang, R.-Z., Lee, M.-J., Hu, H., Pray, J., Wu, H.-B., Hansen, B. C., Shuldiner, A. R., Fried, S. K., McLenithan, J. C., & Gong, D.-W. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00572.2004 · Cited by 884
Release of Interleukins and Other Inflammatory Cytokines by Human Adipose Tissue Is Enhanced in Obesity and Primarily due to the Nonfat Cells
Fain, J. N. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74018-3 · Cited by 702
Self-citation
Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity
Wentworth, J. M., Naselli, G., Brown, W. A., Doyle, L., Phipson, B., Smyth, G. K., Wabitsch, M., O’Brien, P. E., & Harrison, L. C. (2010) · Diabetes · doi:10.2337/db09-0287 · Cited by 636
From Blood Monocytes to Adipose Tissue-Resident Macrophages
Curat, C. A., Miranville, A., Sengenès, C., Diehl, M., Tonus, C., Busse, R., & Bouloumié, A. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1285 · Cited by 600
Monocyte Chemoattractant Protein-1 Release Is Higher in Visceral than Subcutaneous Human Adipose Tissue (AT): Implication of Macrophages Resident in the AT
Bruun, J. M., Lihn, A. S., Pedersen, S. B., & Richelsen, B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1696 · Cited by 555
Self-citation
Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters
Kim, C.-S., Park, H.-S., Kawada, T., Kim, J.-H., Lim, D., Hubbard, N. E., Kwon, B.-S., Erickson, K. L., & Yu, R. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803259 · Cited by 511
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
Elgazar-Carmon, V., Rudich, A., Hadad, N., & Lévy, R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800132-jlr200 · Cited by 510
Peroxisome Proliferator-Activated Receptor γ and Adipose Tissue—Understanding Obesity-Related Changes in Regulation of Lipid and Glucose Metabolism
Sharma, A. M., & Staels, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1268 · Cited by 483
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
Bruun, J. M., Helge, J. W., Richelsen, B., & Stallknecht, B. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00506.2005 · Cited by 437
Self-citation
Review article: Is obesity an inflammatory illness? Role of low‐grade inflammation and macrophage infiltration in human white adipose tissue
Cancello, R., & Clément, K. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01004.x · Cited by 418
Mechanisms of Glucocorticoid-Induced Insulin Resistance
Geer, E. B., Islam, J., & Buettner, C. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.10.005 · Cited by 392
Adipose Tissue and Atherosclerosis
Fantuzzi, G., & Mazzone, T. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.131755 · Cited by 383
Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity
Lee, M., Pramyothin, P., Karastergiou, K., & Fried, S. K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.029 · Cited by 399
Adipose tissue: a regulator of inflammation
Juge-Aubry, C. E., Henrichot, E., & Meier, C. A. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.009 · Cited by 353
The role of interleukins in insulin resistance and type 2 diabetes mellitus
Fève, B., & Bastard, J.-P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.62 · Cited by 343
Macrophage-Secreted Factors Impair Human Adipogenesis: Involvement of Proinflammatory State in Preadipocytes
Lacasa, D., Taleb, S., Keophiphath, M., Miranville, A., & Clement, K. (2007) · Endocrinology · doi:10.1210/en.2006-0687 · Cited by 334
Transplantation of adipose tissue and stem cells: role in metabolism and disease
Tran, T. T., & Kahn, C. R. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.20 · Cited by 335
Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects
Lihn, A. S., Bruun, J. M., He, G., Pedersen, S. B., Jensen, P. F., & Richelsen, B. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.03.002 · Cited by 321
Self-citation
Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases
Montani, J.-P., Carroll, J. F., Dwyer, T. M., Antic, V., Yang, Z., & Dulloo, A. G. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802858 · Cited by 294
Myokines and Adipokines: Involvement in the Crosstalk between Skeletal Muscle and Adipose Tissue
Li, F., Li, Y., Duan, Y., Hu, C.-A. A., Tang, Y., & Yin, Y. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.10.003 · Cited by 288
Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review
Fain, J. N. (2010) · Mediators of Inflammation · doi:10.1155/2010/513948 · Cited by 301
Self-citation
Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin
Piya, M. K., McTernan, P. G., & Kumar, S. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0498 · Cited by 266
Role of macrophage tissue infiltration in metabolic diseases
Bouloumié, A., Curat, C. A., Sengenès, C., Lolmède, K., Miranville, A., & Busse, R. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000172571.41149.52 · Cited by 268
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice
Fujisaka, S., Usui, I., Ikutani, M., Aminuddin, A., Takikawa, A., Tsuneyama, K., Mahmood, A., Goda, N., Nagai, Y., Takatsu, K., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2885-1 · Cited by 239
Inflammation and metabolic dysfunction: links to cardiovascular diseases
Taube, A., Schlich, R., Sell, H., Eckardt, K., & Eckel, J. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00907.2011 · Cited by 246
Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation
Johnston, A. W. B., Árnadóttir, S., Gudjonsson, J. E., Aphale, A., Sigmarsdottir, A., Gunnarsson, S. I., Steinsson, J. T., Elder, J. T., & Valdimarsson, H. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08655.x · Cited by 235
MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1
Strum, J. C., Johnson, J. H., Ward, J. M., Xie, H., Feild, J. A., Hester, A. G., Alford, A., & Waters, K. M. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0117 · Cited by 230
The development and endocrine functions of adipose tissue
Poulos, S. P., Hausman, D. B., & Hausman, G. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.011 · Cited by 236
Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity
Hardy, O. T., Perugini, R. A., Nicoloro, S. M. C., Gallagher-Dorval, K. A., Puri, V., Straubhaar, J., & Czech, M. (2010) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.05.013 · Cited by 229
Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: The Framingham Heart Study
Lehman, S. J., Massaro, J. M., Schlett, C. L., O’Donnell, C. J., Hoffmann, U., & Fox, C. S. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.007 · Cited by 209
Proinflammatory Cytokines in Obesity: Impact of Type 2 Diabetes Mellitus and Gastric Bypass
Catalán, V., Gómez‐Ambrosi, J., Ramírez, B., Rotellar, F., Pastor, C., Silva, C., Rodríguez, A., Gil, M. J., Cienfuegos, J. A., & Frühbeck, G. (2007) · Obesity Surgery · doi:10.1007/s11695-008-9424-z · Cited by 212
Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?
Yang, X., & Smith, U. (2007) · Diabetologia · doi:10.1007/s00125-007-0640-1 · Cited by 197
Inflammation links excess fat to insulin resistance: the role of the interleukin‐1 family
Tack, C. J., Stienstra, R., Joosten, L. A. B., & Netea, M. G. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01145.x · Cited by 199
The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction
Packer, M. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.06.055 · Cited by 213
Conjugated Linoleic Acid Promotes Human Adipocyte Insulin Resistance through NFκB-dependent Cytokine Production
Chung, S., Brown, J. M., Provo, J. N., Hopkins, R. G., & McIntosh, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508159200 · Cited by 160
Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer
Hardaway, A., Herroon, M. K., Rajagurubandara, E. N., & Podgorski, I. (2015) · Clinical & Experimental Metastasis · doi:10.1007/s10585-015-9714-5 · Cited by 160
State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training
Flynn, M. G., McFarlin, B. K., & Markofski, M. M. (2007) · American Journal of Lifestyle Medicine · doi:10.1177/1559827607300283 · Cited by 154
Stem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in stemcellness and increased commitment to an adipocyte-like phenotype
Oñate, B., Vilahur, G., Camino-López, S., Diez-Caballero, A., Ballesta‐López, C., Ybarra, J., Moscatiello, F., Herrero, J., & Badimón, L. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-625 · Cited by 160
Obesity, Visceral Fat, and NAFLD: Querying the Role of Adipokines in the Progression of Nonalcoholic Fatty Liver Disease
Mirza, M. S. (2011) · ISRN Gastroenterology · doi:10.5402/2011/592404 · Cited by 148
1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes
Gao, D., Trayhurn, P., & Bing, C. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.53 · Cited by 149
Impact of visceral adipose tissue on liver metabolism
Lafontan, M., & Girard, J. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.04.001 · Cited by 143
Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians
Nair, S., Lee, Y. H., Rousseau, E., Cam, M. C., Tataranni, P. A., Baier, L. J., Bogardus, C., & Permana, P. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1868-2 · Cited by 141
Resveratrol and inflammation: Challenges in translating pre-clinical findings to improved patient outcomes
Poulsen, M. M., Fjeldborg, K., Ørnstrup, M. J., Kjær, T. N., Nøhr, M. K., & Pedersen, S. B. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.12.024 · Cited by 138
Self-citation
Adipose Tissue: Stem Cells and Beyond
Tholpady, S. S., Llull, R., Ogle, R. C., Rubin, J. P., Futrell, J. W., & Katz, A. J. (2006) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2005.08.004 · Cited by 131
Expression of caveolin‐1 in human adipose tissue is upregulated in obesity and obesity‐associated type 2 diabetes mellitus and related to inflammation
Catalán, V., Gómez‐Ambrosi, J., Rodrı́guez, A., Silva, C., Rotellar, F., Gil, M. J., Cienfuegos, J. A., Salvador, J., & Frühbeck, G. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03021.x · Cited by 130
Intrinsic Depot-Specific Differences in the Secretome of Adipose Tissue, Preadipocytes, and Adipose Tissue–Derived Microvascular Endothelial Cells
HOCKING, S. L., Wu, L. E., Guilhaus, M., Chisholm, D. J., & James, D. E. (2010) · Diabetes · doi:10.2337/db10-0483 · Cited by 126
Prevention and treatment of type 2 diabetes: Current role of lifestyle, natural product, and pharmacological interventions
Hays, N. P., Galassetti, P. R., & Coker, R. H. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.02.003 · Cited by 125
Roles of Chemokine Ligand-2 (CXCL2) and Neutrophils in Influencing Endothelial Cell Function and Inflammation of Human Adipose Tissue
Rouault, C., Pellegrinelli, V., Schilch, R., Cotillard, A., Poitou, C., Tordjman, J., Sell, H., Clément, K., & Lacasa, D. (2013) · Endocrinology · doi:10.1210/en.2012-1415 · Cited by 119
1,25-dihydroxyvitamin D3 Protects against Macrophage-Induced Activation of NFκB and MAPK Signalling and Chemokine Release in Human Adipocytes
Ding, C., Wilding, J. P. H., & Chen, B. Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061707 · Cited by 119
The Inflammasome and Caspase-1 Activation: A New Mechanism Underlying Increased Inflammatory Activity in Human Visceral Adipose Tissue
Koenen, T. B., Stienstra, R., van Tits, L. J., Joosten, L. A. B., van Velzen, J. F., Hijmans, A., Pol, J. A., van der Vliet, J. A., Netea, M. G., Tack, C. J., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1480 · Cited by 118
AICAR stimulates adiponectin and inhibits cytokines in adipose tissue
Lihn, A. S., Jessen, N., Pedersen, S. B., Lund, S. A., & Richelsen, B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.139 · Cited by 111
Self-citation
Monocyte chemotactic protein-1 and its role in insulin resistance
Sell, H., & Eckel, J. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3281338546 · Cited by 107
The glucocorticoid receptor, not the mineralocorticoid receptor, plays the dominant role in adipogenesis and adipokine production in human adipocytes
Lee, M.-J., & Fried, S. K. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.6 · Cited by 103
Neutrophil functions in morbidly obese subjects
Brotfain, E., Hadad, N., Shapira, Y., Avinoah, E., Zlotnik, A., Raichel, L., & Lévy, R. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12631 · Cited by 98
Role of the gut in visceral fat inflammation and metabolic disorders
Lam, Y. Y., Mitchell, A. J., Holmes, A. J., Denyer, G. S., Gummesson, A., Caterson, I. D., Hunt, N. H., & Storlien, L. H. (2011) · Obesity · doi:10.1038/oby.2011.68 · Cited by 97
The Macrophage‐Specific Serum Marker, Soluble CD163, Is Increased in Obesity and Reduced After Dietary‐Induced Weight Loss
Fjeldborg, K., Christiansen, T., Bennetzen, M., Møller, H. J., Pedersen, S. B., & Richelsen, B. (2013) · Obesity · doi:10.1002/oby.20376 · Cited by 96
Self-citation
Pathways regulated by glucocorticoids in omental and subcutaneous human adipose tissues: a microarray study
Lee, M., Gong, D., Burkey, B. F., & Fried, S. K. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00231.2010 · Cited by 94
Cardiomyopathy Associated with Diabetes: The Central Role of the Cardiomyocyte
Filardi, T., Ghinassi, B., Baldassarre, A. D., Tanzilli, G., Morano, S., Lenzi, A., Basili, S., & Crescioli, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133299 · Cited by 94
Western diet regulates immune status and the response to LPS-driven sepsis independent of diet-associated microbiome
Napier, B. A., Andres-Terrè, M., Massis, L. M., Hryckowian, A. J., Higginbottom, S. K., Cumnock, K., Casey, K. M., Haileselassie, B., Lugo, K., Schneider, D. S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814273116 · Cited by 93
Searching for the link between inflammaging and sarcopenia
Wang, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101611 · Cited by 90
The biochemical function of Mg2+ in insulin secretion, insulin signal transduction and insulin resistance
Günther, T. (2010) · Magnesium Research · doi:10.1684/mrh.2009.0195 · Cited by 90
Sorghum genotype may reduce low-grade inflammatory response and oxidative stress and maintains jejunum morphology of rats fed a hyperlipidic diet
Moraes, É. A., Natal, D. I. G., Queiróz, V. A. V., Schaffert, R. E., Cecon, P. R., de Paula, S. O., Benjamin, L. D. A., Ribeiro, S. M. R., & Martino, H. S. D. (2012) · Food Research International · doi:10.1016/j.foodres.2012.07.029 · Cited by 88
Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis
Pan, X., Kaminga, A. C., Wen, S. W., & Liu, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622438 · Cited by 87
Characterization of stromal vascular fraction and adipose stem cells from subcutaneous, preperitoneal and visceral morbidly obese human adipose tissue depots
Silva, K. R., Côrtes, I., Liechocki, S., Carneiro, J. R. I., de Souza, A. A. P., Borojević, R., Maya‐Monteiro, C. M., & Baptista, L. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174115 · Cited by 93
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83
Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance
Kochumon, S., Madhoun, A. S. A., Al‐Rashed, F., Thomas, R., Sindhu, S. T. A. K., Al‐Ozairi, E., Al‐Mulla, F., & Ahmad, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-73347-y · Cited by 82
Obesity and ADHD may represent different manifestations of a common environmental oversampling syndrome: a model for revealing mechanistic overlap among cognitive, metabolic, and inflammatory disorders
Bazar, K. A., Yun, A. J., Lee, P. Y., Daniel, S. M., & Doux, J. D. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.02.042 · Cited by 76
Lipodystrophy in HIV 1-infected patients: lessons for obesity research
Villarroya, F., Domingo, P., & Giralt, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803698 · Cited by 76
Keratinocyte-derived Chemokine in Obesity
Neels, J. G., Badeanlou, L., Hester, K. D., & Samad, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018556 · Cited by 76
Plasticity of Adipose Tissue-Derived Stem Cells and Regulation of Angiogenesis
Panina, Y. A., Yakimov, A. S., Komleva, Y. K., Morgun, A. V., Lopatina, O. L., Malinovskaya, N. A., Shuvaev, А. N., Salmin, V. V., Таранушенко, Т. Е., & Salmina, A. B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01656 · Cited by 73
Visceral Fat Accumulation Induced by a High‐fat Diet Causes the Atrophy of Mesenteric Lymph Nodes in Obese Mice
Kim, C. S., Lee, S. C., Kim, Y. M., Kim, B. S., Choi, H., Kawada, T., Kwon, B. S., & Yu, R. (2008) · Obesity · doi:10.1038/oby.2008.55 · Cited by 71
Induction of Cytosolic Phospholipase A2α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early in the Course of High-Fat Feeding
Hadad, N., Burgazliev, O., Elgazar-Carmon, V., Solomonov, Y., Wueest, S., Item, F., Konrad, D., Rudich, A., & Lévy, R. (2013) · Diabetes · doi:10.2337/db12-1300 · Cited by 66
Adipokines in the treatment of diabetes mellitus and obesity
Catalán, V., Gómez‐Ambrosi, J., Rodrı́guez, A., Salvador, J., & Frühbeck, G. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560802618811 · Cited by 65
Tumor Necrosis Factor α and Glucocorticoid Synergistically Increase Leptin Production in Human Adipose Tissue: Role for p38 Mitogen-Activated Protein Kinase
Trujillo, M. E., Lee, M., Sullivan, S., Feng, J., Schneider, S. H., Greenberg, A. S., & Fried, S. K. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1901 · Cited by 65
In Morbid Obesity, Metabolic Abnormalities and Adhesion Molecules Correlate with Visceral Fat, Not with Subcutaneous Fat: Effect of Weight Loss Through Surgery
Pontiroli, A. E., Frigè, F., Paganelli, M., & Folli, F. B. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9626-4 · Cited by 60
Myokines as possible therapeutic targets in cancer cachexia
Manole, E., Ceafalan, L. C., Popescu, B. O., Dumitru, C., & Bastian, A. E. (2018) · Journal of Immunology Research · doi:10.1155/2018/8260742 · Cited by 60
A short-term diet and exercise intervention ameliorates inflammation and markers of metabolic health in overweight/obese children
Izadpanah, A., Barnard, R. J., Almeda, A. J. E., Baldwin, G. C., Bridges, S. A., Shellman, E. R., Burant, C., & Roberts, C. K. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2012 · Cited by 59
Endothelial ICAM-1 Protein Induction Is Regulated by Cytosolic Phospholipase A2α via Both NF-κB and CREB Transcription Factors
Hadad, N., Tuval, L., Elgazar-Carmon, V., Lévy, R., & Lévy, R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000193 · Cited by 59
Increased Epicardial, Pericardial, and Subcutaneous Adipose Tissue Is Associated with the Presence and Severity of Coronary Artery Calcium
Ahmadi, N., Nabavi, V., Yang, E. H., Hajsadeghi, F., Lakis, M. E., Flores, F. R., Zeb, I., Bevinal, M., Ebrahimi, R., & Budoff, M. J. (2010) · Academic Radiology · doi:10.1016/j.acra.2010.08.017 · Cited by 59
A Stratified Transcriptomics Analysis of Polygenic Fat and Lean Mouse Adipose Tissues Identifies Novel Candidate Obesity Genes
Morton, N. M., Nelson, Y. B., Michailidou, Z., Rollo, E. M. D., Ramage, L. E., Hadoke, P. W. F., Seckl, J. R., Bünger, L., Horvat, S., Kenyon, C. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023944 · Cited by 59
Ovarian Tumor Attachment, Invasion, and Vascularization Reflect Unique Microenvironments in the Peritoneum: Insights from Xenograft and Mathematical Models
Steinkamp, M. P., Winner, K. K., Davies, S., Muller, C. Y., Zhang, Y., Hoffman, R. M., Shirinifard, A., Moses, M. E., Jiang, Y., & Wilson, B. S. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00097 · Cited by 54
Impact of Adrenal Steroids on Regulation of Adipose Tissue
Infante, M., Armani, A., Mammi, C., Fabbri, A., & Caprio, M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160037 · Cited by 58
Association between physical activity energy expenditure and inflammatory markers in sedentary overweight and obese women
Lavoie, M.-È., RABASA-LHORET, R. P. R., Doucet, É., Mignault, D., Messier, L., Jp, B., & Faraj, M. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.55 · Cited by 54
Constitutive and regulated expression and secretion of interferon-γ-inducible protein 10 (IP-10/CXCL10) in human adipocytes
Herder, C., Hauner, H., Kempf, K., Kolb, H., & Skurk, T. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803432 · Cited by 50
High Sodium Intake Increases Blood Pressure and Alters Renal Function in Intrauterine Growth–Retarded Rats
Sanders, M. W., Fazzi, G., Janssen, G., Blanco, C., & de Mey, J. D. (2005) · HYPERTENSION · doi:10.1161/01.hyp.0000171475.40259.d1 · Cited by 47
The role of endothelial cells in inflamed adipose tissue
Sengenès, C., Miranville, A., Lolmède, K., Curat, C. A., & Bouloumié, A. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01853.x · Cited by 49
The forgotten key players in rheumatoid arthritis: IL-8 and IL-17 – Unmet needs and therapeutic perspectives
Gremese, E., Tolusso, B., Bruno, D., Perniola, S., Ferraccioli, G., & Alivernini, S. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.956127 · Cited by 47
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46
Differential Intra-abdominal Adipose Tissue Profiling in Obese, Insulin-resistant Women
Liu, A., McLaughlin, T., Liu, T., Sherman, A., Yee, G., Abbasi, F., Lamendola, C. A., Morton, J. M., Cushman, S. W., Reaven, G. M., et al. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9949-9 · Cited by 46
Adipose tissue expression of CCL19 chemokine is positively associated with insulin resistance
Kochumon, S., Al‐Rashed, F., Abu‐Farha, M., Devarajan, S., Tuomilehto, J., & Ahmad, R. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3087 · Cited by 45
The effect of abdominal obesity on insulin sensitivity and serum lipid and cytokine concentrations in African women
Crowther, N. J., Ferris, W. F., Ojwang, P., & Rheeder, P. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02505.x · Cited by 42
Involvement of multiple signaling pathways in the post-bariatric induction of IL-6 and IL-8 mRNA and release in human visceral adipose tissue
Fain, J. N., Bahouth, S. W., & Madan, A. K. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.02.009 · Cited by 41
Self-citation
Adipose tissue, estradiol levels, and bone health in obese men with metabolic syndrome
Ørnstrup, M. J., Kjær, T. N., Harsløf, T., Stødkilde‐Jørgensen, H., HOUGAARD, D. M., Cohen, A. S., Pedersen, S. B., & Langdahl, B. L. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0792 · Cited by 40
Self-citation
The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence
Giannattasio, S., Corinaldesi, C., Colletti, M., Luigi, L. D., Antinozzi, C., Filardi, T., Scolletta, S., Basili, S., Lenzi, A., Morano, S., et al. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-018-0977-y · Cited by 39
The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?
Sparks, L. M., Goodpaster, B. H., & Bergman, B. C. (2021) · Diabetes · doi:10.2337/dbi19-0006 · Cited by 35
Adiponectin, chemerin, cytokines, and dipeptidyl peptidase 4 are released from human adipose tissue in a depot-dependent manner: an in vitro system including human serum albumin
Svensson, H. G., Odén, B., Edén, S., & Lönn, M. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-7 · Cited by 35
Inflammation, adipokines et obésité
Clément, K., & Vignes, S. (2009) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2009.03.363 · Cited by 40
Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue
Nielsen, N. B., Højbjerre, L., Sonne, M. P., Alibegovic, A. C., Vaag, A. A., Dela, F., & Stallknecht, B. M. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.04.010 · Cited by 35

Authors: Bruun, J. M., Lihn, A. S., Madan, A. K., Pedersen, S. B., Schiøtt, K. M., Fain, J. N., & Richelsen, B.
Affiliations: Aarhus University (DK)
ORCID: Bruun, Jens M.
Pedersen, Steen B.
Richelsen, Bjørn
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2004-01
Volume: 286
Issue: 1
Pages: E8-E13
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00269.2003
OpenAlex: W2125302795
Cited by: 215
References: 31
Citations by year: 2026: 4 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 12 · 2012: 14
FWCI: 9.82
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Sundhed og Sygdom, Det Frie Forskningsråd
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: interleukin-8, visceral adipose tissue, subcutaneous adipose tissue, obesity, adipocytes, IL-8 mRNA expression, dexamethasone, IL-1β, body mass index, insulin resistance
MeSH terms: Adipose Tissue, Adult, Aerosols, Cell Differentiation, Cells, Cultured, Connective Tissue, Female, Fusarium, Humans, Middle Aged, Obesity, Morbid, RNA, Messenger, Stem Cells, Viscera, Body Mass Index, Interleukin-8, Stromal Cells, Adipocytes, Subcutaneous Tissue, Depsipeptides, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks