The proatherogenic cytokine interleukin-18 is secreted by human adipocytes
Abstract
OBJECTIVE: Interleukin (IL)-18, an important mediator of innate immunity and strong risk factor for the development of cardiovascular disease, was shown recently to be elevated in obesity. The aim of our study was to investigate whether human adipocytes produce IL-18. METHODS: Human adipose tissue was obtained from lean women undergoing elective plastic surgery and from obese individuals undergoing laparoscopic surgery (gastric banding). Preadipocytes from mammary adipose tissue were isolated and differentiated under defined adipogenic conditions. IL-18 expression was analyzed by real-time reverse transcriptase PCR, ELISA and immunocytochemistry. RESULTS: Human preadipocytes of all differentiation stages spontaneously secreted IL-18. In parallel significant amounts of IL-18 mRNA were detected. Freshly isolated mature adipocytes from subcutaneous and omental depots also released IL-18. IL-18 release from adipocytes from obese donors was about 3-fold higher compared to adipocytes from non-obese donors. CONCLUSIONS: We conclude that human adipose tissue produces IL-18 and thereby contributes to systemic IL-18 concentrations. This finding supports the concepts that adipocytes behave as primitive immune cells and that IL-18 may mediate some of the detrimental complications of obesity such as cardiovascular disease and type 2 diabetes.
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In adipose tissue, IL-18 is released by both macrophages and adipocytes in obese mice and humans.
“In the adipose tissue, the latest cytokine is released by both macrophages and adipocytes in obese mice and humans [237,238].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [238]
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- Authors
- Skurk, T., Kolb, H., Müller-Scholze, S., Röhrig, K., Hauner, H., & Herder, C.
- Affiliations
- Technical University of Munich (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Corresponding author
- Herder, Christian
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-06
- Volume
- 152
- Issue
- 6
- Pages
- 863-868
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2159226285
- Cited by
- 135
- References
- 32
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 6 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 7
- FWCI
- 10.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- IL-18, adipocytes, adipose tissue, obesity, preadipocytes, adipogenesis, cytokine production, atherosclerosis, cardiovascular disease, type 2 diabetes, innate immunity, omental adipose tissue, subcutaneous adipose tissue
- MeSH terms
- Adipose Tissue, Adult, Aged, Cell Differentiation, Female, Glycerolphosphate Dehydrogenase, Humans, Immunohistochemistry, Male, Middle Aged, Obesity, RNA, Messenger, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-18
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