Mechanisms of disuse muscle atrophy: role of oxidative stress
Abstract
Prolonged periods of skeletal muscle inactivity lead to a loss of muscle protein and strength. Advances in cell biology have progressed our understanding of those factors that contribute to muscle atrophy. To this end, abundant evidence implicates oxidative stress as a potential regulator of proteolytic pathways leading to muscle atrophy during periods of prolonged disuse. This review will address the role of reactive oxygen species and oxidative stress as potential contributors to the process of disuse-mediated muscle atrophy. The first section of this article will discuss our current understanding of muscle proteases, sources of reactive oxygen in muscle fibers, and the evidence linking oxidative stress to disuse muscle atrophy. The second section of this review will highlight gaps in our knowledge relative to the specific role of oxidative stress in the regulation of disuse muscle atrophy. By discussing unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field.
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Muscle atrophy occurs from the degradation of myofibrils due to both an increase in proteolysis and a decrease in protein synthesis.
“Muscle atrophy occurs from the degradation of myofibrils due to both an increase in proteolysis and a decrease in protein synthesis82.”
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Self-citationExercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle
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Self-citationIncreased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy
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Redox homeostasis, oxidative stress and disuse muscle atrophy
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Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle
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Self-citationIron Accumulation with Age, Oxidative Stress and Functional Decline
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Calpain-1 is required for hydrogen peroxide-induced myotube atrophy
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Self-citationAdaptive Support Ventilation Prevents Ventilator-induced Diaphragmatic Dysfunction in Piglet
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Sarcopenia in Chronic Kidney Disease: Factors, Mechanisms, and Therapeutic Interventions
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Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
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Ubiquitin-proteasome pathway in skeletal muscle atrophy
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Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading
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A novel hindlimb immobilization procedure for studying skeletal muscle atrophy and recovery in mouse
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Self-citationMuscle redox signalling pathways in exercise. Role of antioxidants
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Body composition and breast cancer risk and treatment: mechanisms and impact
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Can Antioxidants Protect Against Disuse Muscle Atrophy?
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Self-citationFrailty in patients on dialysis
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Mitochondria: Inadvertent targets in chemotherapy-induced skeletal muscle toxicity and wasting?
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Mechanical ventilation promotes redox status alterations in the diaphragm
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Self-citationSarcopenia, cachexia, and muscle performance in heart failure: Review update 2016
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Self-citationSkeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease
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Redox regulation of diaphragm proteolysis during mechanical ventilation
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- Authors
- Powers, S. K., Kavazis, A. N., & DeRuisseau, K. C.
- Affiliations
- University of Florida (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2005-02
- Volume
- 288
- Issue
- 2
- Pages
- R337-R344
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2144577761
- Cited by
- 368
- References
- 62
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 19 · 2020: 14 · 2019: 17 · 2018: 18 · 2017: 16 · 2016: 28 · 2015: 16 · 2014: 24 · 2013: 19 · 2012: 24
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL-62361, R01HL062361)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- disuse atrophy, oxidative stress, reactive oxygen species, proteolytic pathways, muscle protein loss, muscle strength
- MeSH terms
- Animals, Humans, Muscle Proteins, Muscular Atrophy, Peptide Hydrolases, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal
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