Cited by 368Muscle Physiology and DisordersExercise and Physiological ResponsesMuscle metabolism and nutrition

Mechanisms of disuse muscle atrophy: role of oxidative stress

Powers, Scott K., Kavazis, Andreas N., DeRuisseau, Keith C.·2005·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Abstract

Prolonged periods of skeletal muscle inactivity lead to a loss of muscle protein and strength. Advances in cell biology have progressed our understanding of those factors that contribute to muscle atrophy. To this end, abundant evidence implicates oxidative stress as a potential regulator of proteolytic pathways leading to muscle atrophy during periods of prolonged disuse. This review will address the role of reactive oxygen species and oxidative stress as potential contributors to the process of disuse-mediated muscle atrophy. The first section of this article will discuss our current understanding of muscle proteases, sources of reactive oxygen in muscle fibers, and the evidence linking oxidative stress to disuse muscle atrophy. The second section of this review will highlight gaps in our knowledge relative to the specific role of oxidative stress in the regulation of disuse muscle atrophy. By discussing unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field.

Integrity signals

Registry

Crossref · 10.1152/ajpregu.00469.2004

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62 of 62 references verified0 citation errors · 0 not checkable

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Authors
Powers, S. K., Kavazis, A. N., & DeRuisseau, K. C.
Affiliations
University of Florida (US)
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Published
2005-02
Volume
288
Issue
2
Pages
R337-R344
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
OpenAlex
W2144577761
Cited by
368
References
62
Citations by year
2026: 6 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 19 · 2020: 14 · 2019: 17 · 2018: 18 · 2017: 16 · 2016: 28 · 2015: 16 · 2014: 24 · 2013: 19 · 2012: 24
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (R01 HL-62361, R01HL062361)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
disuse atrophy, oxidative stress, reactive oxygen species, proteolytic pathways, muscle protein loss, muscle strength
MeSH terms
Animals, Humans, Muscle Proteins, Muscular Atrophy, Peptide Hydrolases, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal

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