Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review

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Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon

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Effects of selenium nanoparticles on growth performance, hematological, serum biochemical parameters, and antioxidant status in fish

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Inflammatory bowel diseases: pathological mechanisms and therapeutic perspectives

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Selenium-Containing Agents Acting on Cancer—A New Hope?

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Cascade targeting selenium nanoparticles-loaded hydrogel microspheres for multifaceted antioxidant defense in osteoarthritis

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Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far?

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Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection

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Ionic Selenium and Nanoselenium as Biofortifiers and Stimulators of Plant Metabolism

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Evaluation of dietary selenium, vitamin C and E as the multi-antioxidants on the methylmercury intoxicated mice based on mercury bioaccumulation, antioxidant enzyme activity, lipid peroxidation and mitochondrial oxidative stress

Moniruzzaman, M., Lee, S., Park, Y., Min, T., & Bai, S. C. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.129673 · Cited by 53 · see citing works

Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer’s Disease: A Narrative Review

Zimetti, F., Adorni, M. P., Marsillach, J., Marchi, C., Trentini, A., Valacchi, G., & Cervellati, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6695796 · Cited by 49 · see citing works

Accessory proteins of the zDHHC family of S-acylation enzymes

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A Comparison of the Beneficial Effects of Inorganic, Organic, and Elemental Nano-selenium on Nile Tilapia: Growth, Immunity, Oxidative Status, Gut Morphology, and Immune Gene Expression

Ghaniem, S., Nassef, E., Zaineldin, A. I., Bakr, A., & Hegazi, S. (2022) · Biological Trace Element Research · doi:10.1007/s12011-021-03075-5 · Cited by 49 · see citing works

Biomedical Promise of Aspergillus Flavus-Biosynthesized Selenium Nanoparticles: A Green Synthesis Approach to Antiviral, Anticancer, Anti-Biofilm, and Antibacterial Applications

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Selenium: a potent regulator of ferroptosis and biomass production

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The Immunomodulatory Effects of Selenium: A Journey from the Environment to the Human Immune System

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Three Classes of Antioxidant Defense Systems and the Development of Postmenopausal Osteoporosis

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Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-κB pathway

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Epigenetic remodeling under oxidative stress: Mechanisms driving tumor metastasis

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Selenium Nanoparticles in Protecting the Brain from Stroke: Possible Signaling and Metabolic Mechanisms

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α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance

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Effects of Regular Brazil Nut (Bertholletia excelsa H.B.K.) Consumption on Health: A Systematic Review of Clinical Trials

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Selenium in Peptide Chemistry

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Recombinant Adeno-Associated Virus Vectors for Gene Therapy of the Central Nervous System: Delivery Routes and Clinical Aspects

Słyk, Ż., Stachowiak, N., & Małecki, M. (2024) · Biomedicines · doi:10.3390/biomedicines12071523 · Cited by 39 · see citing works

Vitamin E and selenium supplementation synergistically alleviate the injury induced by hydrogen peroxide in bovine granulosa cells

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Selenium and selenoproteins: their function and development of selenium‐rich foods

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MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation

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Exploring the Link between Oxidative Stress, Selenium Levels, and Obesity in Youth

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Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation

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Dietary supplementation of black mulberry (Morus nigra) syrup improves the growth performance, innate immune response, antioxidant status, gene expression responses, and disease resistance of Nile tilapia (Oreochromis niloticus)

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Association of Urinary and Dietary Selenium and of Serum Selenium Species with Serum Alanine Aminotransferase in a Healthy Italian Population

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SELENOF is a new tumor suppressor in breast cancer

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Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?

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The roles of essential trace elements in T cell biology

Lan, L., Zhao, F., Liu, X., & Zhang, B. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18390 · Cited by 30 · see citing works

Parenteral Nutrition and Oxidant Load in Neonates

Karthigesu, K., Bertolo, R. F. P., & Brown, R. (2021) · Nutrients · doi:10.3390/nu13082631 · Cited by 30 · see citing works

Advances in the Study of the Mechanism by Which Selenium and Selenoproteins Boost Immunity to Prevent Food Allergies

Zhu, K., Yang, S., Li, T., Huang, X., Dong, Y., Wang, P., & Huang, J. (2022) · Nutrients · doi:10.3390/nu14153133 · Cited by 29 · see citing works

Mitochondria-Targetable Ratiometric Time-Gated Luminescence Probe Activated by Selenocysteine for the Visual Monitoring of Liver Injuries

Huang, Y., Song, B., Chen, K., Tang, Z., Ma, H., Kong, D., Liu, Q., & Yuan, J. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04409 · Cited by 29 · see citing works

“Alphabet” Selenoproteins: Their Characteristics and Physiological Roles

Dogaru, C. B., Muscurel, C., Duţă, C., & Stoian, I. A.-M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115992 · Cited by 29 · see citing works

Metabolomic analysis reveals biogenic selenium nanoparticles improve the meat quality of thigh muscle in heat-stressed broilers is related to the regulation of ferroptosis pathway

Huang, M.-Y., An, Y.-C., Zhang, S., Qiu, S.-J., Yang, Y., & Liu, W. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103554 · Cited by 27 · see citing works

High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure

Bhattarai, U., Xu, R. C., He, X., Pan, L., Niu, Z., Wang, D., Zeng, H., Chen, J., Clemmer, J. S., & Chen, Y. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103325 · Cited by 27 · see citing works

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis

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Propolis extract nanoparticles alleviate diabetes-induced reproductive dysfunction in male rats: antidiabetic, antioxidant, and steroidogenesis modulatory role

Boshra, A. E., Hassan, N. H., Ibrahim, S., Hassanen, E. I., Eldin, Z. E., & Ali, S. E. (2024) · Scientific Reports · doi:10.1038/s41598-024-81949-z · Cited by 26 · see citing works

Selenium Compounds and Their Bioactivities: Molecular Mechanisms and Prospects for Functional Food and Therapeutic Applications

Hou, X., Wang, Z., & Peng, M. (2025) · Plants · doi:10.3390/plants14172622 · Cited by 25 · see citing works

Selenium alleviates endoplasmic reticulum calcium depletion-induced endoplasmic reticulum stress and apoptosis in chicken myocardium after mercuric chloride exposure

Gao, P., Wang, A., Chen, X., Cui, H., Li, Y., & Fan, R. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-25970-1 · Cited by 25 · see citing works

Recent advances in the application of metallomics in diagnosis and prognosis of human cancer

Zhang, Y., He, J., Jin, J., & Ren, C. (2022) · Metallomics · doi:10.1093/mtomcs/mfac037 · Cited by 24 · see citing works

Redox-regulating nanotherapeutics potentiating ferroptosis-driven cancer treatment

Yang, X., Sun, X., Lei, J., Shi, X., Zhang, S., & Luo, C. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149518 · Cited by 24 · see citing works

Selenomethionine Ameliorates Cognitive Impairment, Decreases Hippocampal Oxidative Stress and Attenuates Dysbiosis in D-Galactose-Treated Mice

Gao, Y., Xu, Y., & Yin, J. (2022) · Antioxidants · doi:10.3390/antiox11010111 · Cited by 23 · see citing works

Research Progress on Bioactive Metal Complexes against ER-Positive Advanced Breast Cancer

Liang, Z., Liu, L., Zhou, Y., Liu, W., & Lu, Y. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01458 · Cited by 23 · see citing works

Dietary microalgal-fabricated selenium nanoparticles improve Nile tilapia biochemical indices, immune-related gene expression, and intestinal immunity

Zahran, E., Elbahnaswy, S., Ahmed, F., Risha, E., Mansour, A. T., Alqahtani, A. S., Awadin, W. F., & Sebaei, M. G. E. (2024) · BMC Veterinary Research · doi:10.1186/s12917-024-03966-4 · Cited by 22 · see citing works

Elemental Influence: The Emerging Role of Zinc, Copper, and Selenium in Osteoarthritis

Amhare, A. F., Liu, H., Qiao, L., Deng, H., & Han, J. (2025) · Nutrients · doi:10.3390/nu17132069 · Cited by 22 · see citing works

Alteration of chromatin high‐order conformation associated with oxaliplatin resistance acquisition in colorectal cancer cells

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Selenium nanoparticles alleviate deoxynivalenol-induced intestinal epithelial barrier dysfunction by regulating endoplasmic reticulum stress in IPEC-J2 cells

Song, X., Qiao, L., Dou, X., Chang, J., Zhang, Y., & Xu, C. (2023) · Toxicology · doi:10.1016/j.tox.2023.153593 · Cited by 22 · see citing works

Extracellular Vesicles Derived from Selenium-Deficient MAC-T Cells Aggravated Inflammation and Apoptosis by Triggering the Endoplasmic Reticulum (ER) Stress/PI3K-AKT-mTOR Pathway in Bovine Mammary Epithelial Cells

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Selenium Nanoparticles as Versatile Delivery Tools

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The Potential of Selenium-Based Therapies for Ocular Oxidative Stress

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Unveiling the Role of Selenium in Child Development: Impacts on Growth, Neurodevelopment and Immunity

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How neurons cope with oxidative stress

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Multi-omic Profiling Reveals that Intra-abdominal-Hypertension-Induced Intestinal Damage Can Be Prevented by Microbiome and Metabolic Modulations with 5-Hydroxyindoleacetic Acid as a Diagnostic Marker

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Cross-Talk Between Selenium Nanoparticles and Cancer Treatment Through Autophagy

Ali, W., Chen, Y., Gandahi, J. A., Qazi, I. H., Sun, J. G., Wang, T., Liu, Z., & Zou, H. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03886-8 · Cited by 20 · see citing works

Biosynthesis, Engineering, and Delivery of Selenoproteins

Wright, D., & O’Donoghue, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010223 · Cited by 20 · see citing works

Learning from Nature to Expand the Genetic Code

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Identification and preparation of selenium‐containing peptides from selenium‐enriched Pleurotus eryngii and their protective effect on lead‐induced oxidative damage in NCTC1469 hepatocytes

Yu, A., Ji, Y., Ma, G., Xu, J., & Hu, Q. (2023) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12529 · Cited by 19 · see citing works

Selenium Deficiency in COVID-19—A Possible Long-Lasting Toxic Relationship

Schomburg, L. (2022) · Nutrients · doi:10.3390/nu14020283 · Cited by 18 · see citing works

Biology and Roles in Diseases of Selenoprotein I Characterized by Ethanolamine Phosphotransferase Activity and Antioxidant Potential

Li, F., Shi, Z., Cheng, M., Zhou, Z., Chu, M., Sun, L., & Zhou, J. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.03.023 · Cited by 18 · see citing works

Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer

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Selenomethionine-Dominated Selenium-Enriched Peanut Protein Ameliorates Alcohol-Induced Liver Disease in Mice by Suppressing Oxidative Stress

Gao, L., Yuan, J., Cheng, Y., Chen, M., Zhang, G., & Wu, J. (2021) · Foods · doi:10.3390/foods10122979 · Cited by 17 · see citing works

Functions of dehydroepiandrosterone in relation to breast cancer

Chatterton, R. T. (2022) · Steroids · doi:10.1016/j.steroids.2022.108970 · Cited by 17 · see citing works

Molecular docking analysis of mosquito ribosomal protein in selenium nanoparticle bio-synthesis: Implications for pest and pathogen mitigation

Kandasamy, C., Balasubramanian, B., Prakash, P., Baskaran, R., Kamyab, H., Chelliapan, S., & Arjunan, N. (2024) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2024.105602 · Cited by 17 · see citing works

Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice

Agudelo, F. A. G., Leblanc, N., Bourdeau‐Julien, I., St‐Arnaud, G., Lacroix, S., Martin, C., Flamand, N., Veilleux, A., Marzo, V. D., & Raymond, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1028412 · Cited by 16 · see citing works

Preliminary Study to Assess the Impact of Dietary Rutin on Growth, Antioxidant Capacity, and Intestinal Health of Yellow Catfish, Pelteobagrus fulvidraco

Liu, A., Lü, X., Ji, Z., Dong, L., Jiang, J., Tian, J., Wen, H., Xu, Z., Xu, G., & Jiang, M. (2023) · Animals · doi:10.3390/ani13213386 · Cited by 16 · see citing works

tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory

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PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells

He, L., Zhao, T., Leong, W. Z., Sharda, A., Mayerhofer, C., Mei, S., Bonilla, G. M., Menendez-Gonzalez, J. B., Gustafsson, K. M., Fukushima, T., et al. (2025) · Blood · doi:10.1182/blood.2024026040 · Cited by 19 · see citing works

Supranutritional Maternal Organic Selenium Supplementation during Different Trimesters of Pregnancy Affects the Muscle Gene Transcriptome of Newborn Beef Calves in a Time-Dependent Manner

Diniz, W. J. S., Bobe, G., Klopfenstein, J. J., Gultekin, Y., Davis, T. Z., Ward, A. K. K., & Hall, J. A. (2021) · Genes · doi:10.3390/genes12121884 · Cited by 16 · see citing works

Selenoproteins and the senescence-associated epitranscriptome

Lee, M. Y., Ojeda-Britez, S., Ehrbar, D. J., Samwer, A., Begley, T. J., & Melendez, J. A. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221116592 · Cited by 15 · see citing works

Effects of selenoprotein extracts from Cardamine hupingshanensis on growth, selenium metabolism, antioxidant capacity, immunity and intestinal health in largemouth bass Micropterus salmoides

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Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling

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Opposite Effects of Small and Large Diameter Selenium Nanoparticles on the Redox-Status and Survival of Cortical Cells in Toxic Models In Vitro

Varlamova, E. G., Gudkov, S. V., & Turovsky, E. A. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04682-2 · Cited by 15 · see citing works

Alert to US physicians: DHEA, widely used as an OTC androgen supplement, may exacerbate COVID-19

Nyce, J. W. (2020) · Endocrine Related Cancer · doi:10.1530/erc-20-0439 · Cited by 15 · see citing works

Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA ‐183/ 135b‐FOXO1 / TXNIP / NLRP3 inflammasome axis

Gao, P., Chen, X., Chu, J., Li, L., Wang, Z., & Fan, R. (2022) · Environmental Toxicology · doi:10.1002/tox.23463 · Cited by 15 · see citing works

Vitamin E and selenium partially prevent cytotoxicity, oxidative stress and DNA damage induced by T-2 toxin in bovine Leydig cells

Yang, J., Du, J., Zhang, Y. F., & Li, Y. X. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.06.028 · Cited by 15 · see citing works

Organic di-selenide hydrogel microspheres for multimodal treatment of osteoarthritis

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Essential trace element selenium and redox regulation: its metabolism, physiological function, and related diseases

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Selenium, a Micronutrient That Modulates Cardiovascular Health via Redox Enzymology

Handy, D. E., Joseph, J., & Loscalzo, J. (2021) · Nutrients · doi:10.3390/nu13093238 · Cited by 106 · see citing works

Regulation of Redox Signaling by Selenoproteins

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Selenoproteins: Antioxidant selenoenzymes and beyond

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