Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models

Ostler, Joseph E.; Maurya, Santosh K.; Dials, Justin; Roof, Steve R.; Devor, Steven T.; Ziolo, Mark T.; Periasamy, Muthu

doi:10.1152/ajpendo.00277.2013

Cited by 102Muscle Physiology and DisordersMuscle metabolism and nutritionMetabolism, Diabetes, and Cancer

Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models

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Ostler, Joseph E., Maurya, Santosh K., Dials, Justin, Roof, Steve R., Devor, Steven T., Ziolo, Mark T., Periasamy, Muthu·2014·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00277.2013PMC PMC3948983

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Abstract

Type 2 diabetes mellitus is associated with an accelerated muscle loss during aging, decreased muscle function, and increased disability. To better understand the mechanisms causing this muscle deterioration in type 2 diabetes, we assessed muscle weight, exercise capacity, and biochemistry in db/ db and TallyHo mice at prediabetic and overtly diabetic ages. Maximum running speeds and muscle weights were already reduced in prediabetic db/ db mice when compared with lean controls and more severely reduced in the overtly diabetic db/ db mice. In contrast to db/ db mice, TallyHo muscle size dramatically increased and maximum running speed was maintained during the progression from prediabetes to overt diabetes. Analysis of mechanisms that may contribute to decreased muscle weight in db/ db mice demonstrated that insulin-dependent phosphorylation of enzymes that promote protein synthesis was severely blunted in db/ db muscle. In addition, prediabetic (6-wk-old) and diabetic (12-wk-old) db/ db muscle exhibited an increase in a marker of proteasomal protein degradation, the level of polyubiquitinated proteins. Chronic treadmill training of db/ db mice improved glucose tolerance and exercise capacity, reduced markers of protein degradation, but only mildly increased muscle weight. The differences in muscle phenotype between these models of type 2 diabetes suggest that insulin resistance and chronic hyperglycemia alone are insufficient to rapidly decrease muscle size and function and that the effects of diabetes on muscle growth and function are animal model-dependent.

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Excess intramyocellular lipids are associated with impaired muscle function in Type 2 diabetes and obesity.
“excess IMCLs, largely in the form of lipid droplets (LDs), are associated with impaired muscle function in conditions such as Type 2 diabetes and obesity”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [58]

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American College of Sports Medicine position stand
Otis, C. L. (1997) · Medical Entomology and Zoology · Cited by 4,407 · see citing works
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works
Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · cited 2× · see citing works
“When muscle loss progresses to a pathological extreme, it is termed “sarcopenia” and contributes to physical disability (22) and prolonged hospitalizations (49).”
Background
The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · cited 3× · see citing works
“AS HUMANS AGE, IT IS COMMON for skeletal muscle mass and function to deteriorate (14, 22, 36).”
Background
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760 · see citing works
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.
Stitt, T. N., Drujan, D., Clarke, B. A., Panaro, F., Timofeyva, Y., Kline, W. O., Gonzalez, M., Yancopoulos, G. D., & Glass, D. J. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00211-4 · Cited by 1,964 · see citing works
Exercise and Type 2 Diabetes
Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., Chasan-Taber, L., Albright, A. L., & Braun, B. (2010) · Diabetes Care · doi:10.2337/dc10-9990 · Cited by 1,955 · see citing works
OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
INGALLS, A. M., DICKIE, M. M., & SNELL, G. D. (1950) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a106073 · Cited by 1,090 · see citing works
Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in <i>ob/ob</i> Mice
Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904 · see citing works
Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes
Park, S. W., Goodpaster, B. H., Lee, J. S., Kuller, L. H., Boudreau, R., de Rekeneire, N., Harris, T. B., Kritchevsky, S., Tylavsky, F. A., Nevitt, M., et al. (2009) · Diabetes Care · doi:10.2337/dc09-0264 · Cited by 778 · see citing works
Accelerated Loss of Skeletal Muscle Strength in Older Adults With Type 2 Diabetes
Park, S. W., Goodpaster, B. H., Strotmeyer, E. S., Kuller, L. H., Broudeau, R., Kammerer, C., de Rekeneire, N., Harris, T. B., Schwartz, A. V., Tylavsky, F. A., et al. (2007) · Diabetes Care · doi:10.2337/dc06-2537 · Cited by 766 · see citing works
Exercise and Type 2 Diabetes
(2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200007000-00024 · Cited by 604 · see citing works
Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling
Wang, X., Hu, Z., Hu, J., Du, J., & Mitch, W. E. (2006) · Endocrinology · doi:10.1210/en.2006-0251 · Cited by 600 · see citing works
Prevalence and Determinant Factors of Sarcopenia in Patients With Type 2 Diabetes
Kim, T. N., Park, M. S., Yang, S. J., Yoo, H. J., Kang, H. J., Song, W., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2010) · Diabetes Care · doi:10.2337/dc09-2310 · Cited by 585 · see citing works
Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury.
Chow, F. Y. F., Ozols, E., Nikolic-Paterson, D., Atkins, R., & Tesch, G. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00367.x · Cited by 560 · see citing works
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals
Bal, N. C., Maurya, S. K., Sopariwala, D. H., Sahoo, S. K., Gupta, S. C., Shaikh, S. A., Pant, M., Rowland, L. A., Bombardier, É., Goonasekera, S. A., et al. (2012) · Nature Medicine · doi:10.1038/nm.2897 · Cited by 553 · see citing works
Self-citation
Diabetes and physical disability among older U.S. adults.
Gregg, E. W., Beckles, G. L., Williamson, D. F., Leveille, S. G., Langlois, J. A., Engelgau, M. M., & Narayan, K. M. V. (2000) · Diabetes Care · doi:10.2337/diacare.23.9.1272 · Cited by 521 · see citing works
Sarcopenia: Diagnosis and treatment
Morley, J. E. (2008) · The journal of nutrition health & aging · doi:10.1007/bf02982705 · Cited by 398 · see citing works
Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice
Izumiya, Y., Hopkins, T., Morris, C., Sato, K., Zeng, L., Viereck, J., Hamilton, J. A., Ouchi, N., LeBrasseur, N. K., & Walsh, K. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.003 · Cited by 395 · see citing works
Nontraumatic Fracture Risk With Diabetes Mellitus and Impaired Fasting Glucose in Older White and Black Adults
Strotmeyer, E. S., Cauley, J. A., Schwartz, A. V., Nevitt, M. C., Resnick, H. E., Bauer, D. C., Tylavsky, F. A., de Rekeneire, N., Harris, T. B., & Newman, A. B. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.14.1612 · Cited by 373 · see citing works
Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.
Price, S. R., Bailey, J. L., Wang, X., Jurkovitz, C. T., England, B. K., Ding, X., Phillips, L. S., & Mitch, W. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118968 · Cited by 348 · see citing works
Unraveling the Temporal Pattern of Diet-Induced Insulin Resistance in Individual Organs and Cardiac Dysfunction in <scp>c57bl/6</scp> Mice
Park, S.-Y., Cho, Y.-R., Kim, H.-J., Higashimori, T., Danton, C., Lee, M.-K., Dey, A., Rothermel, B., Kim, Y.-B., Kalinowski, A., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3530 · Cited by 286 · see citing works
Diabetes Mellitus Is Associated With an Increased Risk of Falls in Elderly Residents of a Long-Term Care Facility
Maurer, M. S., Burcham, J. L., & Cheng, H. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.9.1157 · Cited by 281 · see citing works
Effects of an Intervention by a Diabetes Team in Hospitalized Patients With Diabetes
Koproski, J., Pretto, Z. E., & Poretsky, L. (1997) · Diabetes Care · doi:10.2337/diacare.20.10.1553 · Cited by 224 · see citing works
Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation
Wing, S. S., Haas, A. L., & Goldberg, A. L. (1995) · Biochemical Journal · doi:10.1042/bj3070639 · Cited by 222 · see citing works
Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice
Hu, Z., Wang, H., Lee, I. H., Du, J., & Mitch, W. E. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38770 · Cited by 205 · see citing works
Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca 2+ Control, and SR Ca 2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy
Stølen, T., Høydal, M. A., Kemi, O. J., Catalucci, D., Ceci, M., Aasum, E., Larsen, T. S., Rolim, N. P. L., Condorelli, G., Smith, G. L., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.199810 · Cited by 205 · see citing works
Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways
Long, Y.-C., Cheng, Z.-Y., Copps, K. D., & White, M. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00983-10 · Cited by 186 · see citing works
Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance
Turpin, S. M., Lancaster, G. I., Darby, I., Febbraio, M. A., & Watt, M. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00095.2006 · Cited by 164 · see citing works
The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice
Hamrick, M. W., Herberg, S., Arounleut, P., He, H.-Z., Shiver, A. L., Qi, R.-Q., Zhou, L., Isales, C. M., & Mi, Q. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.079 · Cited by 157 · see citing works
Diabetes Is Associated With Subclinical Functional Limitation in Nondisabled Older Individuals
de Rekeneire, N., Resnick, H. E., Schwartz, A. V., Shorr, R. I., Kuller, L. H., Simonsick, E. M., Vellas, B. J., & Harris, T. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3257 · Cited by 156 · see citing works
Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice
Shao, J., Yamashita, H., Qiao, L., & Friedman, J. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1670107 · Cited by 148 · see citing works
Synthesis Rate of Muscle Proteins, Muscle Functions, and Amino Acid Kinetics in Type 2 Diabetes
Halvatsiotis, P., Short, K. R., Bigelow, M. L., & Nair, K. S. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2395 · Cited by 143 · see citing works
Hyperinsulinemia in pre-weaning diabetes (db) mice
Coleman, D. L., & Hummel, K. P. (1974) · Diabetologia · doi:10.1007/bf01221993 · Cited by 141 · see citing works
Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice
Yokota, T., Kinugawa, S., Hirabayashi, K., Matsushima, S., Inoue, N., Ohta, Y., Hamaguchi, S., Sobirin, M. A., Ono, T., Suga, T., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00267.2009 · Cited by 139 · see citing works
Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice
Sáinz, N., Rodríguez, A., Catalán, V., Becerril, S., Ramírez, B., Gómez-Ambrosi, J., & Frühbeck, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006808 · Cited by 135 · see citing works
General characteristics of protein degradation in diabetes and starvation.
Dice, J. F., Walker, C. D., Byrne, B., & Cardiel, A. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.5.2093 · Cited by 129 · see citing works
Impaired Muscle Regeneration in Ob/ob and Db/db Mice
Nguyen, M.-H., Cheng, M., & Koh, T. J. (2011) · The Scientific World JOURNAL · doi:10.1100/tsw.2011.137 · Cited by 129 · see citing works
Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats
Pepato, M. T., Migliorini, R. H., Goldberg, A. L., & Kettelhut, Í. D. C. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e340 · Cited by 114 · see citing works
Examination of ‘lipotoxicity’ in skeletal muscle of high‐fat fed and ob / ob mice
Turpin-Nolan, S. M., Ryall, J. G., Southgate, R. J., Darby, I. A., Hevener, A. L., Febbraio, M. A., Kemp, B. E., Lynch, G. S., & Watt, M. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.166033 · Cited by 110 · see citing works
Chronic high fat feeding attenuates load‐induced hypertrophy in mice
Sitnick, M., Bodine, S. C., & Rutledge, J. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.180174 · Cited by 104 · see citing works
Phenotypic characterization of polygenic type 2 diabetes in TALLYHO/JngJ mice
Kim, J. H., Stewart, T. P., Soltani‐Bejnood, M., Wang, L., Fortuna, J. M., Mostafa, O. A., Moustaïd‐Moussa, N., Shoieb, A. M., McEntee, M. F., Wang, Y., et al. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06647 · Cited by 104 · see citing works
Excess Physical Limitations Among Adults With Diabetes in the U.S. Population, 1997–1999
Ryerson, A. B., Tierney, E. F., Thompson, T. J., Engelgau, M. M., Wang, J., Gregg, E. W., & Geiss, L. S. (2003) · Diabetes Care · doi:10.2337/diacare.26.1.206 · Cited by 99 · see citing works
Structural and functional analysis of pancreatic islets preserved by pioglitazone in <i>db/db</i> mice
Kawasaki, F., Matsuda, M., Kanda, Y., Inoue, H., & Kaku, K. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00128.2004 · Cited by 99 · see citing works
Peripheral neuropathy in mutant diabetic mouse [C57BL/Ks (db/db)]
Sima, A. A. F., & Robertson, D. M. (1978) · Acta Neuropathologica · doi:10.1007/bf00689757 · Cited by 98 · see citing works
Protein metabolism in skeletal muscle, diaphragm, and heart of diabetic rats
Pain, V. M., Albertse, E. C., & Garlick, P. J. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.245.6.e604 · Cited by 90 · see citing works
Glycolytic fast‐twitch muscle fiber restoration counters adverse age‐related changes in body composition and metabolism
Akasaki, Y., Ouchi, N., Izumiya, Y., Bernardo, B. L., LeBrasseur, N. K., & Walsh, K. (2013) · Aging Cell · doi:10.1111/acel.12153 · Cited by 88 · see citing works
Methodology and Baseline Characteristics for the Sarcopenia and Hip Fracture Study: A 5-Year Prospective Study
Singh, M. A. F., Singh, N. A., Hansen, R., FINNEGAN, T. P., Allen, B., DIAMOND, T. H., Diwan, A. D., Lloyd, B. D., Williamson, D. A., Smith, E. U. R., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp002 · Cited by 86 · see citing works
The TALLYHO Mouse as a Model of Human Type 2 Diabetes
Kim, H. J., & Saxton, A. M. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-068-7_6 · Cited by 75 · see citing works
Pancreatic Islets of Obese Hyperglycemic Mice (ob/ob)
Tomita, T., Doull, V., POLLOCK, H. G., & Krizsan, D. (1992) · Pancreas · doi:10.1097/00006676-199205000-00015 · Cited by 75 · see citing works
Functional and histological characteristics of skeletal muscle and the effects of leptin in the genetically obese (ob/ob) mouse
Warmington, S. A., Tolan, R., & McBennett, S. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801357 · Cited by 66 · see citing works
Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse
Kemp, J. G., Blazev, R., Stephenson, D. G., & Stephenson, G. M. M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.100 · Cited by 62 · see citing works
Skeletal Muscle Proteolysis in Rats With Acute Streptozocin-Induced Diabetes
Smith, O. L. K., Wong, C., & Gelfand, R. (1989) · Diabetes · doi:10.2337/diab.38.9.1117 · Cited by 57 · see citing works
PTEN Expression Contributes to the Regulation of Muscle Protein Degradation in Diabetes
Hu, Z., Lee, I. H., Wang, X., Sheng, H., Zhang, L., Du, J., & Mitch, W. E. (2007) · Diabetes · doi:10.2337/db06-1731 · Cited by 57 · see citing works
Skeletal muscle protein anabolic response to increased energy and insulin is preserved in poorly controlled type 2 diabetes
Bell, J. A., Volpi, E., Fujita, S., Cadenas, J. G., Sheffield-Moore, M., & Rasmussen, B. B. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.5.1249 · Cited by 53 · see citing works
Muscle mass and functional correlates of insulin sensitivity in lean young Indian men
Unni, U., Ramakrishnan, G., Raj, T., Kishore, R., Thomas, T., Vaz, M., & Kurpad, A. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.32 · Cited by 51 · see citing works
Temporal changes in pancreatic islet composition in c57bl/6j-db/db (diabetes) mice
Gapp, D. A., Leiter, E. H., Coleman, D., & Schwizer, R. W. (1983) · Diabetologia · doi:10.1007/bf00282525 · Cited by 50 · see citing works
Animal Models in Diabetes Research
(2012) · Methods in molecular biology · doi:10.1007/978-1-62703-068-7 · Cited by 49 · see citing works
Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using (C57BL/6J × TALLYHO/JngJ) F2 mice
Stewart, T. P., Kim, H. Y., Saxton, A. M., & Kim, J. H. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-713 · Cited by 45 · see citing works
Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation
O'Neill, E. D., Wilding, J. P. H., Kahn, C. R., Remmen, H. V., McArdle, A., Jackson, M. J., & Close, G. L. (2010) · AGE · doi:10.1007/s11357-009-9125-0 · Cited by 42 · see citing works
Studies in the diabetic mutant mouse: V. Glucose tolerance in mice homozygous and heterozygous for the diabetes (db) gene
Chick, W. L., Lavine, R. L., & LIKE, A. A. (1970) · Diabetologia · doi:10.1007/bf01212235 · Cited by 40 · see citing works
Regulation of myoplasmic Ca 2+ in genetically obese ( ob/ob ) mouse single skeletal muscle fibres
Bruton, J. D., Katz, A., Lännergren, J., Abbate, F., & Westerblad, H. (2002) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0882-1 · Cited by 30 · see citing works
The Muscle Protein Synthetic Response to Carbohydrate and Protein Ingestion Is Not Impaired in Men with Longstanding Type 2 Diabetes3
MANDERS, R. J. F., Koopman, R., Beelen, M., Gijsen, A. P., Wodzig, W. K. W. H., Saris, W. H. M., & van Loon, L. J. C. (2008) · Journal of Nutrition · doi:10.1093/jn/138.6.1079 · Cited by 29 · see citing works
A histochemical and morphological study of skeletal muscle from obese hyperglycaemic ob/ob mice
Almond, R., & Enser, M. B. (1984) · Diabetologia · doi:10.1007/bf00304859 · Cited by 25 · see citing works
Inability of muscles in the obese mouse (ob/ob) to respond to changes in body weight and activity.
Stickland, N. C., Batt, R. A., Crook, A. R., & Sutton, C. M. (1994) · Europe PMC (PubMed Central) · Cited by 21 · see citing works
Muscle Growth and Satellite Cell Proliferative Activity in Obese (OB/OB) Mice
Purchas, R. W., Romsos, D. R., Allen, R. E., & Merkel, R. A. (1985) · Journal of Animal Science · doi:10.2527/jas1985.603644x · Cited by 18 · see citing works

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Perry, B. D., Caldow, M. K., Brennan‐Speranza, T. C., Sbaraglia, M., Jerums, G., GARNHAM, A. P., Wong, C. Y., Levinger, P., Haq, M. A. U., Hare, D. L., et al. (2016) · PubMed · Cited by 240 · see citing works
Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes
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Tata, V. D. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00138 · Cited by 144 · see citing works
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Petrosino, J. M., Silfee, V., Maurya, S. K., Kalyanasundaram, A., Periasamy, M., LaFountain, R. A., Wilson, J. M., Simonetti, O. P., & Ziouzenkova, O. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148010 · Cited by 103 · see citing works
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Chavanelle, V., Boisseau, N., Otero, Y. F., Combaret, L., Dardevet, D. P., Montaurier, C., Delcros, G., Peltier, S. L., & Sirvent, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-00276-8 · Cited by 103 · see citing works
Diabetes pharmacotherapy and effects on the musculoskeletal system
Kalaitzoglou, E., Fowlkes, J. L., Popescu, I. R., & Thrailkill, K. M. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3100 · Cited by 101 · see citing works
Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints
Zingarelli, B., Coopersmith, C. M., Drechsler, S., Efron, P. A., Marshall, J. C., Moldawer, L. L., Wiersinga, W. J., Xiao, X., Osuchowski, M. F., & Thiemermann, C. (2018) · Shock · doi:10.1097/shk.0000000000001243 · Cited by 86 · see citing works
Heart failure with preserved ejection fraction: present status and future directions
Yoon, S., & Eom, G. H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0323-2 · Cited by 84 · see citing works
Emerging awareness on the importance of skeletal muscle in liver diseases: time to dig deeper into mechanisms!
Nachit, M., & Leclercq, I. A. (2019) · Clinical Science · doi:10.1042/cs20180421 · Cited by 72 · see citing works
SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism
Kumar, A., Xie, L., Ta, C. M., Hinton, A. O., Jr., Gunasekar, S. K., Minerath, R. A., Shen, K. C., Maurer, J. M., Grueter, C. E., Abel, E. D., et al. (2020) · eLife · doi:10.7554/elife.58941 · Cited by 69 · see citing works
The Impact of Bariatric Surgery on the Muscle Mass in Patients with Obesity: 2-Year Follow-up
Comas, M., Fidilio, E., Palmas-Candia, F. X., Filippi-Arriaga, F., Vilallonga, R., Cordero-Vázquez, E., Hernández, I., Eguinoa, A. Z., Burgos, R., Vila‐Martí, A., et al. (2021) · Obesity Surgery · doi:10.1007/s11695-021-05815-x · Cited by 68 · see citing works
Sarcolipin overexpression improves muscle energetics and reduces fatigue
Sopariwala, D. H., Pant, M., Shaikh, S. A., Goonasekera, S. A., Molkentin, J. D., Weisleder, N. L., Ma, J., Pan, Z., & Periasamy, M. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01066.2014 · Cited by 63 · see citing works
Self-citation
The role of TGF-β signaling in muscle atrophy, sarcopenia and cancer cachexia
Lan, X., Deng, C., Wang, Q., Zhao, L., Jiao, B., & Xiang, Y. (2024) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2024.114513 · Cited by 56 · see citing works
Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes
Ward, M. S., Flemming, N., Gallo, L. A., Fotheringham, A. K., McCarthy, D. A., Zhuang, A., Tang, P., Borg, D. J., Shaw, H., Harvie, B. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15589-x · Cited by 46 · see citing works
Skeletal muscle and fiber type-specific intramyocellular lipid accumulation in obese mice
Umek, N., Horvat, S., & Cvetko, E. (2021) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2021.5876 · Cited by 41 · see citing works
Metformin Treatment Prevents Sedentariness Related Damages in Mice
Senesi, P., Montesano, A., Luzi, L., Codella, R., Benedini, S., & Terruzzi, I. M. (2015) · Journal of Diabetes Research · doi:10.1155/2016/8274689 · Cited by 40 · see citing works
Permittivity of ex vivo healthy and diseased murine skeletal muscle from 10 kHz to 1 MHz
Nagy, J. A., DiDonato, C. J., Rutkove, S. B., & Sanchez, B. (2019) · Scientific Data · doi:10.1038/s41597-019-0045-2 · Cited by 38 · see citing works
Mulberry (Morus alba L.) Leaf Extract and 1-Deoxynojirimycin Improve Skeletal Muscle Insulin Resistance via the Activation of IRS-1/PI3K/Akt Pathway in db/db Mice
Kang, C., Park, M., & Lee, H. (2022) · Life · doi:10.3390/life12101630 · Cited by 37 · see citing works
The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats
Rahmati, M., & Taherabadi, S. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-89106-6 · Cited by 35 · see citing works
Transplanting old organs promotes senescence in young recipients
Iske, J., Roesel, M. J., Martin, F., Schroeter, A., Matsunaga, T., Maenosono, R., Tripathi, U., Xiao, Y., Nian, Y., Caldarone, B. J., et al. (2023) · American Journal of Transplantation · doi:10.1016/j.ajt.2023.10.013 · Cited by 35 · see citing works
Brief report of the effects of the aerobic, resistance, and high-intensity interval training in type 2 diabetes mellitus individuals
Sousa, R. A. L. D. (2017) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-017-0582-1 · Cited by 35 · see citing works
The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice
Hansen, L., Gupta, D., Joseph, G., Weiss, D., & Taylor, W. R. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2016.113 · Cited by 33 · see citing works
Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF
Pepin, M. E., Konrad, P. J. M., Nazir, S., Bazgir, F., Maack, C., Nickel, A. G., Gorham, J., Hohl, M., Schreiter, F. C., Dewenter, M., et al. (2025) · Circulation Research · doi:10.1161/circresaha.125.326154 · Cited by 30 · see citing works
Dysfunction of muscle contraction with impaired intracellular Ca2+handling in skeletal muscle and the effect of exercise training in maledb/dbmice
Eshima, H., Tamura, Y., Kakehi, S., Nakamura, K., Kurebayashi, N., Murayama, T., Kakigi, R., Sakurai, T., Kawamori, R., & Watada, H. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00048.2018 · Cited by 30 · see citing works
Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography
Pan, G., Munukutla, S., Kar, A., Gardinier, J. D., Thandavarayan, R. A., & Palaniyandi, S. S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195796 · Cited by 28 · see citing works
Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension
Onken, B., Kalinava, N., & Driscoll, M. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008982 · Cited by 26 · see citing works
Association of the gut microbiota and fecal short‐chain fatty acids with skeletal muscle mass and strength in children
Chen, F., Li, Q., Chen, Y., Wei, Y., Liang, J., Song, Y., Shi, L., Wang, J., Mao, L., Zhang, B., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002697rrr · Cited by 27 · see citing works
Dulaglutide Protects Mice against Diabetic Sarcopenia-Mediated Muscle Injury by Inhibiting Inflammation and Regulating the Differentiation of Myoblasts
Deng, F., Wu, W., Fan, X., Zhong, X., Wang, N., Wang, Y., Pan, T., & Du, Y. (2023) · International Journal of Endocrinology · doi:10.1155/2023/9926462 · Cited by 26 · see citing works
Role of exercise intensity on GLUT4 content, aerobic fitness and fasting plasma glucose in type 2 diabetic mice
Cunha, V. N., Lima, M. D. P., Motta‐Santos, D., Pesquero, J. L., de Andrade, R. V., de Almeida, J. A., Araújo, R. C., Campbell, C. S. G., Lewis, J. E., & Simões, H. G. (2015) · Cell Biochemistry and Function · doi:10.1002/cbf.3128 · Cited by 24 · see citing works
The joint association of insulin sensitivity and physical activity on the skeletal muscle mass and performance in community-dwelling older adults
Yang, C., Li, C.-I., Li, T., Liu, C.-S., Lin, C., Lin, C., & Lin, C. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.05.006 · Cited by 24 · see citing works
Psoas and paraspinous muscle index as a predictor of mortality in African American men with type 2 diabetes mellitus
Murea, M., Lenchik, L., Register, T. C., Russell, G. B., Xu, J., Smith, S. C., Bowden, D. W., Divers, J., & Freedman, B. I. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.03.004 · Cited by 22 · see citing works
Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob/ob Mice with Sarcopenia
Choi, E. B., Jeong, J. H., Jang, H. M., Ahn, Y. J., Kim, K. H., An, H. S., Lee, J. Y., Jeong, E. A., Lee, J., Shin, H. J., et al. (2021) · Antioxidants · doi:10.3390/antiox10050758 · Cited by 22 · see citing works
Effects of exercise on brain functions in diabetic animal models
Yi, S. S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i4.583 · Cited by 22 · see citing works
Whole grains beyond fibre: what can metabolomics tell us about mechanisms?
Ross, A. B. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114001542 · Cited by 21 · see citing works
Age and Sex Differences in Heart Failure With Preserved Ejection Fraction
Kobak, K. A., Zarzycka, W., & Chiao, Y. A. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.811436 · Cited by 21 · see citing works
Predicting myofiber cross‐sectional area and triglyceride content with electrical impedance myography: A study in db/db mice
Pandeya, S. R., Nagy, J. A., Riveros, D., Semple, C., Taylor, R. S., Mortreux, M., Sanchez, B., Kapur, K., & Rutkove, S. B. (2020) · Muscle & Nerve · doi:10.1002/mus.27095 · Cited by 20 · see citing works
Validation of Candidate Phospholipid Biomarkers of Chronic Kidney Disease in Hyperglycemic Individuals and Their Organ-Specific Exploration in Leptin Receptor-Deficient db/db Mouse
Huang, J., Covic, M., Huth, C., Rommel, M., Adam, J., Zukunft, S., Prehn, C. P., Wang, L., Nano, J., Scheerer, M. F., et al. (2021) · Metabolites · doi:10.3390/metabo11020089 · Cited by 18 · see citing works
Whole genome sequence analysis of the TALLYHO/Jng mouse
Denvir, J., Bošković, G., Fan, J., Primerano, D. A., Parkman, J. K., & Kim, J. H. (2016) · BMC Genomics · doi:10.1186/s12864-016-3245-6 · Cited by 20 · see citing works
Insulin-like growth factor-1 status is associated with insulin resistance in young patients with spinal muscular atrophy
Brener, A., Sagi, L., Shtamler, A., Levy, S., Fattal‐Valevski, A., & Lebenthal, Y. (2020) · Neuromuscular Disorders · doi:10.1016/j.nmd.2020.09.025 · Cited by 20 · see citing works
High glucose promotes IL-17A-induced gene expression through histone acetylation in retinal pigment epithelium cells
Wu, J., Hu, J., Zhang, F., Jin, Q., & Sun, X. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108893 · Cited by 19 · see citing works
Impaired healing of fragility fractures in type 2 diabetes: clinical and radiographic assessments and serum cytokine levels
Liuni, F. M., Rugiero, C., Feola, M., Rao, C., Pistillo, P., Terracciano, C., Giganti, M. G., & Tarantino, U. (2015) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0422-4 · Cited by 19 · see citing works
Sarco/Endoplasmic Reticulum Ca2+ ATPase 2 Activator Ameliorates Endothelial Dysfunction; Insulin Resistance in Diabetic Mice
Kimura, T., Kagami, K., Sato, A., Osaki, A., Ito, K., Horii, S., Toya, T., Masaki, N., Yasuda, R., Nagatomo, Y., et al. (2022) · Cells · doi:10.3390/cells11091488 · Cited by 18 · see citing works
Long-term consequences of COVID-19 on mental health and the impact of a physically active lifestyle: a narrative review
Roever, L., Cavalcante, B. R. R., & Caria, A. C. I. (2023) · Annals of General Psychiatry · doi:10.1186/s12991-023-00448-z · Cited by 18 · see citing works
Moderate/high resistance exercise is better to reduce blood glucose and blood pressure in middle-aged diabetic subjects
Sousa, R. A. L. D., Hagenbeck, K. F., Arsa, G., & Pardono, E. (2020) · Revista Brasileira de Educação Física e Esporte · doi:10.11606/issn.1981-4690.v34i1p165-175 · Cited by 17 · see citing works
Precision medicine approach: Empagliflozin for diabetic cardiomyopathy in mice with aldehyde dehydrogenase (ALDH) 2 * 2 mutation, a specific genetic mutation in millions of East Asians
Pan, G., Deshpande, M., Pang, H., & Palaniyandi, S. S. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.09.021 · Cited by 17 · see citing works
Ubiquitin Proteasome System Role in Diabetes-Induced Cardiomyopathy
Nahum, O., Kurtzwald-Josefson, E., Ciechanover, A. J., Waldman, M., Rohaker, O. S., Hochhauser, E., Meyer, J. S., Aravot, D. J., Phillip, M., & Barac, Y. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015376 · Cited by 16 · see citing works
Lespedeza bicolor extract supplementation reduced hyperglycemia-induced skeletal muscle damage by regulation of AMPK/SIRT/PGC1α–related energy metabolism in type 2 diabetic mice
Lee, H., Kim, S. Y., & Lim, Y. (2022) · Nutrition Research · doi:10.1016/j.nutres.2022.12.007 · Cited by 17 · see citing works
Effect of Aerobic Exercise and Time‐Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High‐Fat Diet
Raza, G. S., Kaya, Y., Stenbäck, V., Sharma, R., Sodum, N., Mutt, S. J., Gagnon, D. D., Tulppo, M. P., Järvelin, M., Herzig, K., et al. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300465 · Cited by 15 · see citing works
Effects of Ecklonia stolonifera extract on the obesity and skeletal muscle regeneration in high-fat diet-fed mice
Jin, H., Oh, H., Kim, J., Lee, K., Han, X., Lee, O., & Lee, B.-Y. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104511 · Cited by 15 · see citing works
Insulin resistance and the role of gamma-aminobutyric acid
Rezazadeh, H., Sharifi, M., & Soltani, N. (2021) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_374_20 · Cited by 15 · see citing works
Targeting Intramyocellular Lipids to Improve Aging Muscle Function
Russ, D. W., Manickam, R., & Tipparaju, S. M. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02622-6 · Cited by 15 · see citing works
“…of lipid droplets (LDs), are associated with impaired muscle function in conditions such as Type 2 diabetes and obesity, which have been described as accelerating aging, leading to increased adipose tissue combined with decreased muscle and bone content that can impair quality of life [58, 59].”
Dynamic transcriptome profile in db/db skeletal muscle reveal critical roles for long noncoding RNA regulator
Zhang, N., Zhou, Y., Yuan, Q., Gao, Y., Wang, Y., Wang, X., Cui, X., Xu, P., Ji, C., Guo, X., et al. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.08.013 · Cited by 13 · see citing works
Are TallyHo Mice A True Mouse Model for Type 2 Diabetes and Alzheimer’s Disease?
Ramasubramanian, B., & Reddy, P. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190613 · Cited by 13 · see citing works
Effect of a Single Bout of Exercise on Autophagy Regulation in Skeletal Muscle of High-Fat High-Sucrose Diet-Fed Mice
Zhang, D., Lee, J. H., Kwak, S. E., Shin, H. E., Zhang, Y., Moon, H. Y., Shin, D. M., Seong, J. K., Tang, L. V., & Song, W. J. (2019) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2019.28.3.175 · Cited by 13 · see citing works
Aerobic Exercise Modulates Proteomic Profiles in Gastrocnemius Muscle of db/db Mice, Ameliorating Sarcopenia
Huang, Y., Sanotra, M. R., Huang, C., Hsu, Y.-J., & Liao, C. (2024) · Life · doi:10.3390/life14030412 · Cited by 11 · see citing works
Integrated Remodeling of Gut–Liver Metabolism Induced by Moderate Protein Restriction Contributes to Improvement of Insulin Sensitivity
Zhang, X., Qiu, K., Wang, L., Xu, D., & Yin, J. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800637 · Cited by 10 · see citing works
Association of muscle mass measured by D3-Creatine (D3Cr), sarcopenic obesity, and insulin-glucose homeostasis in postmenopausal women
Banack, H. R., LaMonte, M. J., Manson, J. E., Zhu, K., Evans, W. J., Shankaran, M., & Wactawski‐Wende, J. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278723 · Cited by 10 · see citing works
Insights into the progressive impact of high-fat-diet induced insulin resistance on skeletal muscle and myocardium: A comprehensive study on C57BL6 mice
Wang, J., Dai, L., Yu, T., & Xiao, J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0310458 · Cited by 9 · see citing works
Retracted
Cuban Policosanol Prevents the Apoptosis and the Mitochondrial Dysfunction Induced by Lipopolysaccharide in C2C12 Myoblast via Activation of Akt and Erk Pathways
Jo, A. L., Ji Won, H. A. N., Ji In, A. N., Cho, K., & Jeoung, N. H. (2022) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.68.79 · Cited by 9 · see citing works
Impaired fatigue resistance, sarcoplasmic reticulum function, and mitochondrial activity in soleus muscle of db/db mice
Yamamoto, H., Eshima, H., Kakehi, S., Kawamori, R., Watada, H., & Tamura, Y. (2022) · Physiological Reports · doi:10.14814/phy2.15478 · Cited by 9 · see citing works
Animal Models of Type 2 Diabetes, Obesity and Nonalcoholic Steatohepatitis – Clinical Translatability and Applicability in Preclinical Drug Development
Hansen, H. H., Hansen, G., Secher, T., Feigh, M., Veidal, S. S., Fosgerau, K., Jelsing, J., & Vrang, N. (2019) · Springer eBooks · doi:10.1007/978-3-030-11748-1_14 · Cited by 9 · see citing works
Analysis of the Molecular Signaling Signatures of Muscle Protein Wasting Between the Intercostal Muscles and the Gastrocnemius Muscles in db/db Mice
Kim, K. W., Baek, M., Choi, J., Son, K. H., & Yoon, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236062 · Cited by 9 · see citing works
Trehalose Ameliorates Nonalcoholic Fatty Liver Disease by Regulating IRE1α–TFEB Signaling Pathway
Su, S., Liu, X., Zhu, M., Liu, W., Liu, J., Yuan, Y., Fu, F., Rao, Z., Liu, J., Lu, Y., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c08669 · Cited by 8 · see citing works
Type 2 diabetes-related sarcopenia: role of nitric oxide
Bahadoran, Z., Mirmiran, P., & Ghasemi, A. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00883-z · Cited by 8 · see citing works
Effect of insulin insufficiency on ultrastructure and function in skeletal muscle
Kopecky, C., Haug, M., Reischl, B., Deshpande, N., Manandhar, B., King, T. W., Lee, V., Wilkins, M. R., Morris, M. J., Polly, P., et al. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13380 · Cited by 8 · see citing works
Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease
Shastry, A., Wilkinson, M., Miller, D. M., Kuriakose, M., Veeneman, J., Smith, M. R., Hindmarch, C. C. T., & Dunham‐Snary, K. J. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103541 · Cited by 8 · see citing works
RNA sequencing reveals potential interacting networks between the altered transcriptome and ncRNome in the skeletal muscle of diabetic mice
Kesharwani, D., Kumar, A., Poojary, M., Scaria, V., & Datta, M. (2021) · Bioscience Reports · doi:10.1042/bsr20210495 · Cited by 9 · see citing works
Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders
Li, T., Wu, C.-W., Li, C., Wu, F.-Y., Liao, L.-N., Liu, C.-S., Lin, C., Wang, M.-C., Yang, C., & Lin, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239530 · Cited by 8 · see citing works
Peripheral and cognitive benefits of physical exercise in a mouse model of midlife metabolic syndrome
Gaamouch, F. E., Lin, H., Wang, Q., Zhao, W., Pan, J., Liu, K., Wong, J., Wu, C., Yuan, C., Cheng, H. M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-07252-x · Cited by 7 · see citing works
In vitro skeletal muscle models for type 2 diabetes
Sheng, C. Y., Son, Y. H., Jang, J., & Park, S. (2022) · Biophysics Reviews · doi:10.1063/5.0096420 · Cited by 7 · see citing works
Genetic Loss of Nicotinamide Nucleotide Transhydrogenase Prevents from Cardiometabolic Heart Failure with Preserved Ejection FractionPreprint
Pepin, M. E., Nazir, S., Konrad, P. J. M., Schreiter, F. C., Dewenter, M., & Backs, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.21.537792 · Cited by 7 · see citing works
Bioactive Nutritional Components Within the Planetary Health Diet for Preventing Sarcopenic Obesity and Diabetic Sarcopenia: A Systematic Review
Elvina, L., Chen, C., Nguyen, D. H. N., Wei, C.-C., Su, C., Fang, T., Sutanto, F., & Li, S. (2025) · Nutrients · doi:10.3390/nu17233656 · Cited by 6 · see citing works
Investigating the Effects of Diet-Induced Prediabetes on Skeletal Muscle Strength in Male Sprague Dawley Rats
Dlamini, M., & Khathi, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074076 · Cited by 6 · see citing works
Computed Tomography-Derived Skeletal Muscle Radiodensity Predicts Peak Weight-Corrected Jump Power in Older Adults: The Korean Urban Rural Elderly (KURE) Study
Choi, H., Hong, N., Park, N., Kim, C. O., Kim, H. C., Choi, J., Youm, Y., & Rhee, Y. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00812-9 · Cited by 6 · see citing works
Long‐term wheel‐running prevents reduction of grip strength in type 2 diabetic rats
Takada, Y., Hanaoka, T., Imagita, H., Yasui, T., Takeshita, D., Abe, M., Kawata, S., Yamakami, T., Okada, K., Washio, H., et al. (2021) · Physiological Reports · doi:10.14814/phy2.15046 · Cited by 6 · see citing works
Regulation of Ferroptosis in Obesity: Muscle Type-Specific Effects of Dietary Restriction and ExercisePreprint
Ji, F., Lee, H., & Kim, J. H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.04.605473 · Cited by 5 · see citing works
Role of Skeletal Muscle in the Pathogenesis and Management of Type 2 Diabetes: A Special Focus on Asian Indians
Sambashivaiah, S., Bhadra, R., Bhattacharya, S., & Kurpad, A. (2023) · Journal of the Indian Institute of Science · doi:10.1007/s41745-022-00349-2 · Cited by 3 · see citing works
Impact of Aerobic Exercise on Expression of OPN and OPG Genes and Bmal1 Protein in the Bone Tissue of Diabetic Rats During Two Phases of Light and Dark Circadian Rhythm
Janbozorgi, M., Hosseinzadeh, M., Taheri, A., & Ghafaripur, S. (2024) · RESEARCH RESULTS IN BIOMEDICINE · doi:10.18413/2658-6533-2024-10-4-0-3 · Cited by 3 · see citing works
Sexual dimorphism in animal models of heart failure with preserved ejection fraction
Bauer, M., Gadkari, M., Yus, M. M., Santhanam, L., & Steppan, J. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00595.2024 · Cited by 2 · see citing works
Association between serum glycated albumin and the risk of sarcopenia and dynapenia in a community-dwelling older Japanese population: the Hisayama Study
Ninomiya, T., Konishi, H., Ueda, E., Sakata, S., Oishi, E., Furuta, Y., Ohmae, S., Hoshiko, H., Tateishi, N., Shibata, M., et al. (2025) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2025.109199 · Cited by 2 · see citing works
The relationship between estimated glucose disposal rate and sarcopenia among middle-aged and older adults
Chen, Y., Gao, L., Song, X., Wu, M., Li, R., Su, K., Lv, Z., Gao, J., & Feng, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-31091-1 · Cited by 2 · see citing works
Experimental models in diabetes research
Dewalkar, L. P. (2026) · Laboratory Animal Research · doi:10.1186/s42826-026-00286-6 · Cited by 2 · see citing works
Mitigation of high-fat diet-induced sarcopenia by Toona sinensis fruit extracts via autophagic flux and mitochondrial quality control
Chen, Y., Chan, Y., Chang, Y., Liu, H., Cheng, C.-C., & Chang, S. (2024) · Food Science and Biotechnology · doi:10.1007/s10068-024-01610-3 · Cited by 2 · see citing works
Sex-specific associations between type 2 diabetes and muscle health in middle-aged adults
Wang, Y., Gao, S., Xu, Q., & Zhu, Z. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01963-7 · Cited by 1 · see citing works
Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China
Bei, Y., Zhong, D., Lu, J., Qiu, Y., Bowen, T. S., Chen, N., Dun, Y., Gao, F., Huang, Y., Li, G., et al. (2025) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2025.101103 · Cited by 1 · see citing works
Modeling heart failure with preserved ejection fraction in rodents: Where do we stand?
Chou, C., & Chin, M. T. (2022) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2022.948407 · Cited by 1 · see citing works
Exploring Protein O-GlcNAcylation as a Novel Diagnostic Tool for Type II Mellitus and the Impact of Exercise on Cardiac Protein O-GlcNAcylation
Myslicki, J. P. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/26098
Efeitos da suplementação de leucina e do treinamento de força sobre a miopatia diabética em modelo experimental de diabetes mellitus induzido por estreptozotocina
Martins, C. E. C. (2017) · doi:10.11606/d.9.2017.tde-04072016-094630
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Okun, J. G., Rusu, P. M., Chan, A. Y., Yap, Y. W., Sharkie, T., Schumacher, J., Schmidt, K. V., Zota, A., Hille, S. S., Jungmann, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.25.115709
The effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways gastrocnemius muscle of type 2 diabetic rats
Faezi, G., Moghadam, M. S., Shadmehri, S., & Fathalipour, M. (2020) · فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران · doi:10.29252/iau.30.2.120
Efeitos do exercício físico sobre o metabolismo oxidativo hepático e muscular em camundongos obesos e nocautes para adiponectina.
Spagnol, A. R. (2022) · doi:10.11606/t.42.2022.tde-16112022-160054
The Effect of Combined Exercise on the Expression of FoxO and Atrogin Pathway Genes in the Gastrocnemius and Soleus Muscles of Elderly Rats
Pahlevanzadeh, M., Shabani, R., & Elmieh, A. (2024) · مجله دانشگاه علوم پزشکی جیرفت. · doi:10.61186/jjums.11.1.1512
Single‐Cell RNA Sequencing Shows Exercise Protects db/db Mouse Pancreatic Injuries by Regulating Endothelial Cell Homeostasis
Weng, W., Li, M., Wang, Z., Peng, M., Fan, G. W., Jiang, S., Zhang, C., & Lu, X. (2025) · Journal of Diabetes Research · doi:10.1155/jdr/9676094
Pathological Mechanism and Drug Prevention and Treatment of Skeletal Muscle Atrophy
李, 雯. (2025) · Pharmacy Information · doi:10.12677/pi.2026.151004
Chiglitazar prevents diabetes-induced skeletal muscle loss by enhancing myogenic differentiation through the MEK/ERK pathway
Song, W., Dong, Y., Wang, X., Xu, F., Jiang, B., Zhou, Y., & Li, Q. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153768
Pilot study: The effect of eight weeks of aerobic training in the two phases of light and dark circadian rhythm on genes (OCT4, NANOG, SOX2, REX1) in bone tissue of diabetic mice
Janbozorgi, M., Taheri, A., Hosseinzadeh, M., & Ghafaripur, S. (2026) · PLoS ONE · doi:10.1371/journal.pone.0353987

Muscle Growth and Function in Mouse Models of Type 2 Diabetes Mellitus
Ostler, J. E. (2013) · OhioLink ETD Center (Ohio Library and Information Network)
Self-citation
Effect of type 2 diabetes (T2DM) on muscle protein metabolism in older subjects
Fujita, S., Rasmussen, B. B., Cadenas, J. G., Bell, J. A., & Volpi, E. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.4.a556
doi: 10.1210/en.2006-0251 Insulin Resistance Accelerates Muscle Protein Degradation: Activation of the Ubiquitin-Proteasome Pathway by Defects in Muscle Cell Signaling
Wang, X., Hu, Z., Hu, J., Du, J., & Mitch, W. E. (2006)
Type 2 diabetes causes skeletal muscle atrophy but does not impair resistance training‐mediated myonuclear accretion and muscle mass gain in rats
Ato, S., Kido, K., Sato, K., & Fujita, S. (2019) · Experimental Physiology · doi:10.1113/ep087585 · Cited by 26 · see citing works
The impact of type 2 diabetes on tendon material properties and locomotor function in the db / db mouse
Charles, J. P., Chen, E., Hart, J., Bell, A., Geraghty, B., & Kissane, R. W. P. (2026) · Experimental Physiology · doi:10.1113/ep093650

Authors: Ostler, J. E., Maurya, S. K., Dials, J., Roof, S. R., Devor, S. T., Ziolo, M. T., & Periasamy, M.
Affiliations: The Ohio State University (US)
Corresponding author: Periasamy, Muthu
ORCID: Maurya, Santosh K.
Roof, Steve R.
Ziolo, Mark T.
Periasamy, Muthu
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2014-03-15
Volume: 306
Issue: 6
Pages: E592-E605
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00277.2013
PMC: PMC3948983
OpenAlex: W2047831763
Cited by: 102
References: 66
Citations by year: 2026: 5 · 2025: 12 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 12 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 3
FWCI: 2.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL088555)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: insulin resistance, type 2 diabetes, skeletal muscle growth, exercise capacity, db/db mice, prediabetes, muscle atrophy, protein synthesis, protein degradation, polyubiquitinated proteins, treadmill training, glucose tolerance, hyperglycemia, animal model comparison
MeSH terms: Animals, Diabetes Mellitus, Type 2, Disease Models, Animal, Hypoglycemic Agents, Insulin, Insulin Resistance, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Motor Activity, Phosphorylation, Physical Endurance, Prediabetic State, Protein Processing, Post-Translational, Muscle, Skeletal, Animals, Outbred Strains, Muscle Development, Proteasome Endopeptidase Complex, Mice, Sarcopenia

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Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models

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