Chronic high fat feeding attenuates load‐induced hypertrophy in mice

Sitnick, Mitchell; Bodine, Sue C.; Rutledge, John C.

doi:10.1113/jphysiol.2009.180174

Cited by 104Muscle Physiology and DisordersMuscle metabolism and nutritionMetabolism, Diabetes, and Cancer

Chronic high fat feeding attenuates load‐induced hypertrophy in mice

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Sitnick, Mitchell, Bodine, Sue C., Rutledge, John C.·2009·The Journal of Physiology

DOI 10.1113/jphysiol.2009.180174PMC PMC2805383

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Abstract

The incidence of obesity and obesity‐related conditions, such as metabolic syndrome and insulin resistance, is on the increase. The effect of obesity on skeletal muscle function, especially the regulation of muscle mass, is poorly understood. In this study we investigated the effect of diet‐induced obesity on the ability of skeletal muscle to respond to an imposed growth stimulus, such as increased load. Male C57BL/6 mice were randomized into two diet groups: a low fat, high carbohydrate diet (LFD) and a high fat, low carbohydrate diet (HFD) fed ad libitum for 14 weeks. Mice from each diet group were divided into two treatment groups: sedentary control or bilateral functional overload (FO) of the plantaris muscle. Mice were evaluated at 3, 7, 14 or 30 days following FO. By 14 days of FO, there was a 10% reduction (P< 0.05) in absolute growth of the plantaris in response to overload in HFD mice vs.LFD mice. By 30 days the attenuation in growth increased to 16% in HFD mice compared to LFD mice. Following FO, there was a reduction in the formation of polysomes in the HFD mice relative to the LFD mice, suggesting a decrease in protein translation. Further, activation of Akt and S6K1, in response to increased mechanical loading, was significantly attenuated in the HFD mice relative to the LFD mice. In conclusion, chronic high fat feeding impairs the ability of skeletal muscle to hypertrophy in response to increased mechanical load. This failure coincided with a failure to activate key members of the Akt/mTOR signalling pathway and increase protein translation.

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A high-fat diet impairs muscle hypertrophy.
“both endurance exercise [2] and a high-fat diet [61] impair muscle hypertrophy”
From Using Molecular Biology to Maximize Concurrent Training (2014) · cites this paper as [61]

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Authors: Sitnick, M., Bodine, S. C., & Rutledge, J. C.
Affiliations: University of California, Davis (US)
ORCID: Bodine, Sue C.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2009-11-30
Volume: 587
Issue: 23
Pages: 5753-5765
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.2009.180174
PMC: PMC2805383
OpenAlex: W2100431456
Cited by: 104
References: 97
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 9 · 2013: 16 · 2012: 5
FWCI: 2.42
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
University of California, Davis
National Heart, Lung, and Blood Institute (HL55667, R01HL055667)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: diet-induced obesity, high-fat diet, skeletal muscle hypertrophy, mechanical loading, functional overload, plantaris muscle, Akt/mTOR signaling, S6K1, mRNA translation, polysomes, muscle growth
MeSH terms: Glycogen Synthase Kinase 3 beta, Animals, Body Composition, Centrifugation, Density Gradient, Diet, Dietary Fats, Electrophoresis, Polyacrylamide Gel, Insulin, Male, Mice, Inbred C57BL, Obesity, Protein Biosynthesis, Blotting, Western, Signal Transduction, Protein Serine-Threonine Kinases, Muscle, Skeletal, Glycogen Synthase Kinase 3, Ribosomal Protein S6 Kinases, 90-kDa, Intracellular Signaling Peptides and Proteins, Oncogene Protein v-akt, Mice, Muscle Strength, TOR Serine-Threonine Kinases

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Chronic high fat feeding attenuates load‐induced hypertrophy in mice

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