Insulin secretion and action and the response of endogenous glucose production to a lack of glucagon suppression in nondiabetic subjects

Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution Method

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The essential role of glucagon in the pathogenesis of diabetes mellitus

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Lack of Suppression of Glucagon Contributes to Postprandial Hyperglycemia in Subjects with Type 2 Diabetes Mellitus¹

Shah, P., Vella, A., Basu, A., Basu, R., Schwenk, W. F., & Rizza, R. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6993 · Cited by 368 · see citing works

Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans

Meier, J. J., Veldhuis, J. D., & Butler, P. C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1649 · Cited by 261 · see citing works

Insulin Resistance Is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation

Færch, K., Vistisen, D., Pacini, G., Torekov, S. S., Johansen, N. B., Witte, D. R., Jonsson, A., Pedersen, O., Hansen, T., Lauritzen, T., et al. (2016) · Diabetes · doi:10.2337/db16-0240 · Cited by 217 · see citing works

The Oral Minimal Model Method

Cobelli, C., Dalla Man, C., Toffolo, G., Basu, R., Vella, A., & Rizza, R. (2014) · Diabetes · doi:10.2337/db13-1198 · Cited by 216 · see citing works

Insulin Sensitivity from Meal Tolerance Tests in Normal Subjects: A Minimal Model Index

Caumo, A., Bergman, R. N., & Cobelli, C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6982 · Cited by 206 · see citing works

Use of a novel triple-tracer approach to assess postprandial glucose metabolism

Basu, R., Di Camillo, B., Toffolo, G., Basu, A., Shah, P., Vella, A., Rizza, R., & Cobelli, C. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2001 · Cited by 189 · see citing works

Impact of lack of suppression of glucagon on glucose tolerance in humans

Shah, P., Basu, A., Basu, R., & Rizza, R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.2.e283 · Cited by 166 · see citing works

Postprandial Suppression of Glucagon Secretion Depends on Intact Pulsatile Insulin Secretion

Meier, J. J., Kjems, L. L., Veldhuis, J. D., Lefèbvre, P., & Butler, P. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1449 · Cited by 144 · see citing works

Regulation of glucagon secretion by incretins

Holst, J. J., Christensen, M., Lund, A., de Heer, J., Svendsen, B., Kielgast, U. L., & Knop, F. K. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01452.x · Cited by 143 · see citing works

Differential effects of oral, peripheral intravenous, and intraportal glucose on hepatic glucose uptake and insulin and glucagon extraction in conscious dogs.

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Contribution to Postprandial Hyperglycemia and Effect on Initial Splanchnic Glucose Clearance of Hepatic Glucose Cycling in Glucose-Intolerant or NIDDM Patients

Butler, P. C., & Rizza, R. A. (1991) · Diabetes · doi:10.2337/diab.40.1.73 · Cited by 127 · see citing works

Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes.

Vella, A. V., Shah, P., Basu, R., Basu, A., Holst, J. J., & Rizza, R. A. (2000) · Diabetes · doi:10.2337/diabetes.49.4.611 · Cited by 119 · see citing works

Familiality of Quantitative Metabolic Traits in Finnish Families with Non-Insulin-Dependent Diabetes mellitus

Watanabe, R. M., Valle, T. T., Hauser, E. R., Ghosh, S., Eriksson, J. G., Kohtamäki, K., Ehnholm, C., Tuomilehto, J., Collins, F. S., Bergman, R. N., et al. (1999) · Human Heredity · doi:10.1159/000022865 · Cited by 117 · see citing works

Glucagon Resistance at the Level of Amino Acid Turnover in Obese Subjects With Hepatic Steatosis

Suppli, M. P., Bagger, J. I., Lund, A., Demant, M., van Hall, G., Strandberg, C., Kønig, M. J., Rigbolt, K. T. G., Langhoff, J. L., Albrechtsen, N. J. W., et al. (2020) · Diabetes · doi:10.2337/db19-0715 · Cited by 97 · see citing works

Association of fasting glucagon and proinsulin concentrations with insulin resistance

Ferrannini, E., Muscelli, E., Natali, A., Gabriel, R., Mitrakou, A., Flyvbjerg, A., Golay, A., Højlund, K., & The Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) Project Investigators (2007) · Diabetologia · doi:10.1007/s00125-007-0806-x · Cited by 90 · see citing works

Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance.

Basu, A., Alzaid, A., Dinneen, S. F., Caumo, A., Cobelli, C., & Rizza, R. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118678 · Cited by 90 · see citing works

Application of Isotopic Techniques Using Constant Specific Activity or Enrichment to the Study of Carbohydrate Metabolism

Vella, A., & Rizza, R. A. (2009) · Diabetes · doi:10.2337/db09-0318 · Cited by 67 · see citing works

Quantitation of measurement error with Optimal Segments: basis for adaptive time course smoothing

Bradley, D. C., Steil, G. M., & Bergman, R. N. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.6.e902 · Cited by 64 · see citing works

TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes

Shah, M., Varghese, R. T., Miles, J. M., Piccinini, F., Man, C. D., Cobelli, C., Bailey, K. R., Rizza, R. A., & Vella, A. V. (2015) · Diabetes · doi:10.2337/db15-1233 · Cited by 57 · see citing works

A concerted decline in insulin secretion and action occurs across the spectrum of fasting and postchallenge glucose concentrations

Sathananthan, A., Man, C. D., Zinsmeister, A. R., Camilleri, M., Rodeheffer, R. J., TOFFOLO, G. M., Cobelli, C., Rizza, R. A., & Vella, A. V. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04159.x · Cited by 43 · see citing works

HOMA and Matsuda indices of insulin sensitivity: poor correlation with minimal model-based estimates of insulin sensitivity in longitudinal settings

Xiang, A., Watanabe, R. M., & Buchanan, T. (2013) · Diabetologia · doi:10.1007/s00125-013-3121-8 · Cited by 42 · see citing works

Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling

Galsgaard, K. D., Winther‐Sørensen, M., Pedersen, J., Kjeldsen, S. A. S., ROSENKILDE, M. M., Albrechtsen, N. J. W., & Holst, J. J. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00410.2018 · Cited by 35 · see citing works

Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans

Sharma, A. R., Varghese, R. T., Shah, M., Man, C. D., Cobelli, C., Rizza, R. A., Bailey, K. R., & Vella, A. V. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01197 · Cited by 34 · see citing works

Assessment of individual and standardized glucagon kinetics in healthy humans

LAURENTI, M. C., Vella, A. V., Adams, J. D., Wismayer, D. S., Egan, A. M., & Man, C. D. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2020 · Cited by 28 · see citing works

Modeling hepatic insulin sensitivity during a meal: validation against the euglycemic hyperinsulinemic clamp

Man, C. D., Piccinini, F., Basu, R., Basu, A., Rizza, R. A., & Cobelli, C. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00482.2012 · Cited by 26 · see citing works

Fasting glucagon concentrations are associated with longitudinal decline of β-cell function in non-diabetic humans

Adams, J. D., Man, C. D., LAURENTI, M. C., Andrade, M. D. H., Cobelli, C., Rizza, R. A., Bailey, K. R., & Vella, A. V. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154175 · Cited by 26 · see citing works

Diabetes-Associated Variation in <i>TCF7L2</i> Is Not Associated With Hepatic or Extrahepatic Insulin Resistance

Varghese, R. T., Viegas, I., Barosa, C., Marques, C., Shah, M., Rizza, R. A., Jones, J. G., & Vella, A. (2016) · Diabetes · doi:10.2337/db15-1593 · Cited by 25 · see citing works

Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp–derived insulin sensitivity in a mixed-age cohort

Rasmussen‐Torvik, L. J., Pankow, J. S., Jacobs, D. R., & Sinaiko, A. R. (2009) · Metabolism · doi:10.1016/j.metabol.2009.04.023 · Cited by 13 · see citing works

A simple method for converting an odds ratio to effect size for use in meta-analysis

Chinn, S. (2000) · Statistics in Medicine · doi:10.1002/1097-0258(20001130)19:22

The Effect of Diabetes-Associated Variation in TCF7L2 on Postprandial Glucose Metabolism When Glucagon and Insulin Concentrations Are Matched

Adams, J. D., Egan, A. M., LAURENTI, M. C., Wismayer, D. S., Bailey, K. R., Cobelli, C., Man, C. D., & Vella, A. V. (2022) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2021.0136 · Cited by 8 · see citing works

The relationship between insulin and glucagon concentrations in non‐diabetic humans

LAURENTI, M. C., Arora, P., Man, C. D., Andrews, J. C., Rizza, R. A., Matveyenko, A. V., Bailey, K. R., Cobelli, C., & Vella, A. V. (2022) · Physiological Reports · doi:10.14814/phy2.15380 · Cited by 7 · see citing works

Diabetes-associated Genetic Variation in MTNR1B and Its Effect on Islet Function

Vella, M., Mohan, S., Christie, H. E., Bailey, K. R., Cobelli, C., Man, C. D., Matveyenko, A. V., Egan, A. M., & Vella, A. V. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae130 · Cited by 1 · see citing works

Immunological profile of diabetic foot ulcers: update review

Jassim, M. M. A. (2023) · Muthanna Medical Journal · doi:10.52113/1/1/2023-38-43 · Cited by 1 · see citing works

Modeling the effect of glucagon on endogenous glucose production in healthy individuals under meal-like conditions

Faggionato, E., Tonello, A., Laurenti, M. C., Vella, A., & Dalla Man, C. (2025) · American Journal of Physiology - Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00172.2025

The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes

Arble, D. M., Hutch, C. R., Hafner, H., Stelmak, D., Leix, K., Sorrell, J. E., Pressler, J. W., Gregg, B. E., & Sandoval, D. A. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00152.2022 · Cited by 1 · see citing works

Homeostasis Model Assessment (Beta Cell Function) of a Type 2 Diabetes Nigerian Population

Odewusi, O. O., Ihueze, C. L., Obadire, S. O., Omon, E. A., Amadi, V. H., Olaifa, B. B., Oguntuase, M. O., & Alake, O. A. (2024) · International Journal of Pharmaceutical and Bio-Medical Science · doi:10.47191/ijpbms/v4-i1-03

Enhanced quantification of α-cell suppression by hyperglycemia using a high-sensitivity glucagon assay

Dyer, R. B., LAURENTI, M. C., Christie, H. E., Mohan, S., Egan, A. M., Man, C. D., & Vella, A. V. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00301.2024

Pathogenesis of type 2 diabetes

Honka, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00376-9

Glucagon Synthesis, Secretion, and Mechanisms of Action

Mohan, S., & Vella, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-11985-9.00005-6

259-OR: The Effect of Impaired Glucagon Suppression on Endogenous Glucose Production Is Independent of Insulin Action

LAURENTI, M. C., Egan, A. M., Wismayer, D. S., Cobelli, C., Man, C. D., & Vella, A. V. (2021) · Diabetes · doi:10.2337/db21-259-or · Cited by 1 · see citing works

1564-P: Impaired Insulin Secretion Increases Glucagon Action on the Liver

Tonello, A., LAURENTI, M. C., Cobelli, C., Vella, A. V., & Man, C. D. (2023) · Diabetes · doi:10.2337/db23-1564-p

1831-P: Delayed Glucagon Suppression Contributes to Postprandial Hyperglycemia Independently of the Degree of Insulin Secretion

ADAMS, J. D., LAURENTI, M. C., Rizza, R. A., Egan, A. M., Cobelli, C., Man, C. D., & Vella, A. V. (2019) · Diabetes · doi:10.2337/db19-1831-p

Impact of lack of suppression of glucagon on glucose tolerance in humans

Shah, P., Basu, A., Basu, R., & Rizza, R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.2.e283 · Cited by 166 · see citing works

1682-P: Factors Associated with Postprandial Suppression of Endogenous Glucose Production in People without Diabetes

Mohan, S., Christie, H. E., Boscolo, F. S., LAURENTI, M. C., Egan, A. M., Man, C. D., & Vella, A. V. (2025) · Diabetes · doi:10.2337/db25-1682-p