Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
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OBJECTIVE: Chronic exercise and obesity both increase intramyocellular triglycerides (IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that chronically exercise-trained muscle would be characterized by lower skeletal muscle diacylglycerols (DAGs) and ceramides despite higher IMTGs and would account for its higher insulin sensitivity. We also hypothesized that the expression of key skeletal muscle proteins involved in lipid droplet hydrolysis, DAG formation, and fatty-acid partitioning and oxidation would be associated with the lipotoxic phenotype. RESEARCH DESIGN AND METHODS: A total of 14 normal-weight, endurance-trained athletes (NWA group) and 7 normal-weight sedentary (NWS group) and 21 obese sedentary (OBS group) volunteers were studied. Insulin sensitivity was assessed by glucose clamps. IMTGs, DAGs, ceramides, and protein expression were measured in muscle biopsies. RESULTS: DAG content in the NWA group was approximately twofold higher than in the OBS group and ~50% higher than in the NWS group, corresponding to higher insulin sensitivity. While certain DAG moieties clearly were associated with better insulin sensitivity, other species were not. Ceramide content was higher in insulin-resistant obese muscle. The expression of OXPAT/perilipin-5, adipose triglyceride lipase, and stearoyl-CoA desaturase protein was higher in the NWA group, corresponding to a higher mitochondrial content, proportion of type 1 myocytes, IMTGs, DAGs, and insulin sensitivity. CONCLUSIONS: Total myocellular DAGs were markedly higher in highly trained athletes, corresponding with higher insulin sensitivity, and suggest a more complex role for DAGs in insulin action. Our data also provide additional evidence in humans linking ceramides to insulin resistance. Finally, this study provides novel evidence supporting a role for specific skeletal muscle proteins involved in intramyocellular lipids, mitochondrial oxidative capacity, and insulin resistance.
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Diacylglycerol levels are higher in exercise-trained muscle corresponding to higher insulin sensitivity.
“As reported by Amati et al. (26), DAG levels are higher in exercise-trained muscle corresponding to higher insulin sensitivity”
From TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle (2019) · cites this paper as Amati et al. (26)
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Current Methods in Medical Image Segmentation
Pham, D. L., Xu, C., & Prince, J. L. (2000) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.2.1.315 · Cited by 2,352 · see citing works
Sphingosine-1-phosphate: an enigmatic signalling lipid
Spiegel, S., & Milstien, S. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1103 · Cited by 2,080 · see citing works
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
Cuvillier, O., Pirianov, G., Kleuser, B., Vanek, P. G., Coso, O. A., Gutkind, J. S., & Spiegel, S. (1996) · Nature · doi:10.1038/381800a0 · Cited by 1,532 · see citing works
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works
Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194 · see citing works
Self-citationSkeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 670 · see citing works
Bielawski, J., Szulc, Z. M., Hannun, Y. A., & Bielawska, A. E. (2006) · Methods · doi:10.1016/j.ymeth.2006.05.004 · Cited by 543 · see citing works
Intramuscular lipid content is increased in obesity and decreased by weight loss
Goodpaster, B. H., Theriault, R., Watkins, S. C., & Kelley, D. E. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80010-4 · Cited by 526 · see citing works
Self-citationDiacylglycerol-mediated insulin resistance
Erion, D. M., & Shulman, G. I. (2010) · Nature Medicine · doi:10.1038/nm0410-400 · Cited by 493 · see citing works
Schenk, S., & Horowitz, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30566 · Cited by 407 · see citing works
Kelley, D. E., & Goodpaster, B. H. (2001) · Diabetes Care · doi:10.2337/diacare.24.5.933 · Cited by 406 · see citing works
Self-citationHulver, M. W., Berggren, J. R., Carper, M. J., Miyazaki, M., Ntambi, J. M., Hoffman, E. P., Thyfault, J. P., Stevens, R., Dohm, G. L., Houmard, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.002 · Cited by 384 · see citing works
Dubé, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Sauers, S. E., & Goodpaster, B. H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00769.2007 · Cited by 378 · see citing works
Self-citationUssher, J. R., Koves, T. R., Cadete, V. J. J., Zhang, L., Jaswal, J. S., Swyrd, S. J., Lopaschuk, D. G., Proctor, S. D., Keung, W., Muoio, D. M., et al. (2010) · Diabetes · doi:10.2337/db09-1293 · Cited by 363 · see citing works
Sphingosine in apoptosis signaling
Cuvillier, O. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00336-0 · Cited by 330 · see citing works
Bruce, C. R., Thrush, A. B., Mertz, V. A., Bezaire, V., Chabowski, A., Heigenhauser, G. J. F., & Dyck, D. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00587.2005 · Cited by 328 · see citing works
Lee, J. S., Pinnamaneni, S. K., Eo, S. J., Cho, I. H., Pyo, J. H., Kim, C. K., Sinclair, A. J., Febbraio, M. A., & Watt, M. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01438.2005 · Cited by 325 · see citing works
OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization
Wolins, N. E., Quaynor, B. K., Skinner, J. R., Tzekov, A., Croce, M. A., Gropler, M. C., Varma, V., Yao‐Borengasser, A., Rasouli, N., Kern, P. A., et al. (2006) · Diabetes · doi:10.2337/db06-0399 · Cited by 324 · see citing works
Self-citationAltered Adipose and Plasma Sphingolipid Metabolism in Obesity
Samad, F., Hester, K. D., Yang, G., Hannun, Y. A., & Bielawski, J. (2006) · Diabetes · doi:10.2337/db06-0330 · Cited by 276 · see citing works
Ellis, B. A., Poynten, A., Lowy, A. J., Furler, S. M., Chisholm, D. J., Kraegen, E. W., & Cooney, G. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e554 · Cited by 273 · see citing works
Dubé, J. J., Amati, F., Toledo, F. G. S., Stefanović-Račić, M., Rossi, A. P., Coen, P. M., & Goodpaster, B. H. (2011) · Diabetologia · doi:10.1007/s00125-011-2065-0 · Cited by 272 · see citing works
Self-citationLSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues
Dalen, K. T., Dahl, T. B., Holter, E., Arntsen, B. M., Londos, C., Sztalryd, C., & Nebb, H. I. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.11.011 · Cited by 236 · see citing works
Biddinger, S. B., Almind, K., Miyazaki, M., Kokkotou, E. G., Ntambi, J. M., & Kahn, C. R. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1314 · Cited by 231 · see citing works
Coen, P. M., Dubé, J. J., Amati, F., Stefanović-Račić, M., Ferrell, R. E., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes · doi:10.2337/db09-0988 · Cited by 229 · see citing works
Self-citationIncreased skeletal muscle ceramide level in men at risk of developing type 2 diabetes
Strączkowski, M., Kowalska, I., Baranowski, M., Nikołajuk, A., Otziomek, E., Zabielski, P., Adamska, A., Blachnio, A., Górski, J., & Górska, M. (2007) · Diabetologia · doi:10.1007/s00125-007-0781-2 · Cited by 219 · see citing works
Toledo, F. G. S., Menshikova, E. V., Azuma, K., Radiková, Z., Kelley, C. A., Ritov, V. B., & Kelley, D. E. (2008) · Diabetes · doi:10.2337/db07-1429 · Cited by 218 · see citing works
Self-citationYamaguchi, T., Matsushita, S., Motojima, K., Hirose, F., & Osumi, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601682200 · Cited by 204 · see citing works
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells
Edsall, L. C., Cuvillier, O., Twitty, S., Spiegel, S., & Milstien, S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00164.x · Cited by 191 · see citing works
Bajaj, M., Suraamornkul, S., Romanelli, A., Cline, G. W., Mandarino, L. J., Shulman, G. I., & DeFronzo, R. A. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3148 · Cited by 181 · see citing works
Intramuscular lipid metabolism, insulin action, and obesity
Consitt, L. A., Bell, J. A., & Houmard, J. A. (2009) · IUBMB Life · doi:10.1002/iub.142 · Cited by 180 · see citing works
Exercise training increases intramyocellular lipid and oxidative capacity in older adults
Pruchnic, R., Katsiaras, A., He, J., Kelley, D. E., Winters, C., & Goodpaster, B. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00459.2003 · Cited by 177 · see citing works
Self-citationSphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
Stunff, H. L., Galve‐Roperh, I., Peterson, C. M., Milstien, S., & Spiegel, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203123 · Cited by 171 · see citing works
Russell, A. P., Gastaldi, G., Bobbioni-Harsch, E., Arboit, P., Gobelet, C., Dériaz, O., Golay, A., Witztum, J. L., & Giacobino, J.-P. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00875-5 · Cited by 166 · see citing works
Shah, C., Yang, G., Lee, I., Bielawski, J., Hannun, Y. A., & Samad, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709950200 · Cited by 155 · see citing works
Mitochondrial function as a determinant of life span
Lanza, I. R., & Nair, K. S. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0724-5 · Cited by 151 · see citing works
Taha, T. A., Kitatani, K., El‐Alwani, M., Bielawski, J., Hannun, Y. A., & Obeid, L. M. (2005) · The FASEB Journal · doi:10.1096/fj.05-4412fje · Cited by 143 · see citing works
Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
Alsted, T. J., Nybo, L., Schweiger, M., Fledelius, C., Jacobsen, P., Zimmermann, R., Zechner, R., & Kiens, B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90912.2008 · Cited by 135 · see citing works
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
Skovbro, M., Baranowski, M., Skov-Jensen, C., Flint, A., Dela, F., Górski, J., & Helge, J. W. (2008) · Diabetologia · doi:10.1007/s00125-008-1014-z · Cited by 133 · see citing works
Saltiel, A. R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10533 · Cited by 117 · see citing works
Minnaard, R., Schrauwen, P., Schaart, G., Jörgensen, J. A., Lenaers, E., Mensink, M., & Hesselink, M. K. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0352 · Cited by 104 · see citing works
Bergman, B. C., Perreault, L., Hunerdosse, D. M., Koehler, M. C., Samek, A. M., & Eckel, R. H. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00684.2009 · Cited by 103 · see citing works
Levin, M. C., Monetti, M., Watt, M. J., Sajan, M. P., Stevens, R. D., Bain, J. R., Newgard, C. B., Farese, R. V., & Farese, R. V. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00158.2007 · Cited by 99 · see citing works
Exercise and training effects on ceramide metabolism in human skeletal muscle
Helge, J. W., Dobrzyń, A., Saltin, B., & Górski, J. (2003) · Experimental Physiology · doi:10.1113/expphysiol.2003.002605 · Cited by 84 · see citing works
Zhang, D., Christianson, J., Liu, Z., Tian, L., Choi, C. S., Neschen, S., Dong, J., Wood, P. A., & Shulman, G. I. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.012 · Cited by 84 · see citing works
Intramuscular Lipid Metabolism in the Insulin Resistance of Smoking
Bergman, B. C., Perreault, L., Hunerdosse, D. M., Koehler, M. C., Samek, A. M., & Eckel, R. H. (2009) · Diabetes · doi:10.2337/db09-0481 · Cited by 65 · see citing works
Yao‐Borengasser, A., Varma, V., Coker, R. H., Ranganathan, G., Phanavanh, B., Rasouli, N., & Kern, P. A. (2010) · Metabolism · doi:10.1016/j.metabol.2010.10.005 · Cited by 59 · see citing works
Perreault, L., Bergman, B. C., Hunerdosse, D. M., & Eckel, R. H. (2010) · Obesity · doi:10.1038/oby.2010.76 · Cited by 53 · see citing works
The Role of Skeletal Muscle Sphingolipids in the Development of Insulin Resistance
Strączkowski, M., & Kowalska, I. (2008) · The Review of Diabetic Studies · doi:10.1900/rds.2008.5.13 · Cited by 41 · see citing works
Skeletal Muscle Lipase Content and Activity in Obesity and Type 2 Diabetes
Jocken, J. W. E., Moro, C., Goossens, G. H., Hansen, D., Mairal, A., Hesselink, M. K. C., Langin, D., van Loon, L. J. C., & Blaak, E. E. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0776 · Cited by 35 · see citing works
Turnover of endogenous ceramide in cultured normal and Farber fibroblasts
van Echten‐Deckert, G., Klein, A., Linke, T. A., Heinemann, T., Weisgerber, J., & Sandhoff, K. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30041-9 · Cited by 31 · see citing works
Sphingolipid Second Messengers: Tumor Suppressor Lipids
Hannun, Y. A. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5325-0_43 · Cited by 30 · see citing works
PAQRs: A Counteracting Force to Ceramides?
Holland, W. L., & Scherer, P. E. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.054817 · Cited by 30 · see citing works
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Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works
The role of estrogens in control of energy balance and glucose homeostasis
Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329 · see citing works
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
Shulman, G. I. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1011035 · Cited by 1,126 · see citing works
Metabolic Flexibility in Health and Disease
Goodpaster, B. H., & Sparks, L. M. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.015 · Cited by 995 · see citing works
Self-citationCusi, K. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.003 · Cited by 917 · see citing works
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 919 · see citing works
Metabolites as regulators of insulin sensitivity and metabolism
Yang, Q., Vijayakumar, A., & Kahn, B. B. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0044-8 · Cited by 681 · see citing works
Update on the effects of physical activity on insulin sensitivity in humans
Bird, S. R., & Hawley, J. A. (2017) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2016-000143 · Cited by 646 · see citing works
Ceramides – Lipotoxic Inducers of Metabolic Disorders
Chaurasia, B., & Summers, S. A. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.07.006 · Cited by 622 · see citing works
A Ceramide-Centric View of Insulin Resistance
Chavez, J. A., & Summers, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.002 · Cited by 620 · see citing works
Effects of Exercise and Aging on Skeletal MusclePreprint
Distéfano, G., & Goodpaster, B. H. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029785 · Cited by 493 · see citing works
Self-citationCorrea-de-Araujo, R., Addison, O., Miljkovic, I., Goodpaster, B. H., Bergman, B. C., Clark, R. V., Elena, J. W., Esser, K. A., Ferrucci, L., Harris-Love, M. O., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00963 · Cited by 468 · see citing works
Self-citationSphingolipids and phospholipids in insulin resistance and related metabolic disorders
Meikle, P. J., & Summers, S. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.169 · Cited by 426 · see citing works
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
Szendroedi, J., Yoshimura, T., Phielix, E., Koliaki, C., Marcucci, M., Zhang, D., Jelenik, T., Müller, J., Herder, C., Nowotny, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409229111 · Cited by 415 · see citing works
Decoding Insulin Resistance and Metabolic Syndrome for Promising Therapeutic Intervention
Guo, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0584 · Cited by 215 · see citing works
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
Funcke, J., & Scherer, P. E. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r094060 · Cited by 337 · see citing works
Wang, D. D., Toledo, E., Hruby, A., Rosner, B. A., Willett, W. C., Sun, Q., Razquin, C., Zheng, Y., Ruiz-Canela, M., Guasch-Ferré, M., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024261 · Cited by 327 · see citing works
Grevendonk, L., Connell, N. J., McCrum, C., Fealy, C. E., Bilet, L., Bruls, Y. M. H., Mevenkamp, J., Schrauwen-Hinderling, V. B., Jörgensen, J. A., Moonen-Kornips, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24956-2 · Cited by 298 · see citing works
New insights into ER stress-induced insulin resistance
Flamment, M., Hajduch, E., Ferré, P., & Foufelle, F. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.06.003 · Cited by 306 · see citing works
Metabolic Messengers: ceramides
Summers, S. A., Chaurasia, B., & Holland, W. L. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0134-8 · Cited by 304 · see citing works
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Sokołowska, E., & Błachnio-Zabielska, A. U. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00577 · Cited by 298 · see citing works
Kimmel, A. R., & Sztalryd, C. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105410 · Cited by 285 · see citing works
Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle
Greggio, C., Jha, P., Kulkarni, S. S., Lagarrigue, S., Broskey, N. T., Boutant, M., Wang, X., Conde Alonso, S., Ofori, E., Auwerx, J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.11.004 · Cited by 286 · see citing works
Self-citationHOCKING, S. L., Samocha‐Bonet, D., Milner, K., Greenfield, J. R., & Chisholm, D. J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1041 · Cited by 281 · see citing works
Brittain, E. L., Talati, M. H., Fessel, J. P., Zhu, H., Penner, N. L., Calcutt, M. W., West, J. D., Funke, M., Lewis, G. D., Gerszten, R. E., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.019351 · Cited by 252 · see citing works
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Coen, P. M., & Goodpaster, B. H. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.05.009 · Cited by 252 · see citing works
Self-citationEctopic lipid storage and insulin resistance: a harmful relationship
Borén, J., Taskinen, M., Olofsson, S. ‐., & Levin, M. C. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12071 · Cited by 230 · see citing works
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Meex, R. C. R., Blaak, E. E., & van Loon, L. J. C. (2019) · Obesity Reviews · doi:10.1111/obr.12862 · Cited by 218 · see citing works
Shepherd, S. O., Cocks, M., Tipton, K. D., Ranasinghe, A. M., Barker, T. A., Burniston, J. G., Wagenmakers, A. J. M., & Shaw, C. S. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240952 · Cited by 207 · see citing works
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Turner, N. A., Cooney, G. J., Kraegen, E. W., & Bruce, C. R. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0397 · Cited by 198 · see citing works
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Perreault, L., Newsom, S. A., Strauss, A., Kerege, A., Kahn, D. E., Harrison, K. A., Snell-Bergeon, J. K., Nemkov, T., D’Alessandro, A., Jackman, M. R., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.96805 · Cited by 184 · see citing works
Coen, P. M., Menshikova, E. V., Distéfano, G., Zheng, D., Tanner, C., Standley, R., Helbling, N., Dubis, G. S., Ritov, V., Xie, H., et al. (2015) · Diabetes · doi:10.2337/db15-0809 · Cited by 155 · see citing works
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Summers, S. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.003 · Cited by 184 · see citing works
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00484.x · Cited by 184 · see citing works
Targeting fatty acid metabolism to improve glucose metabolism
Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183 · see citing works
Tonks, K., Coster, A., Christopher, M., Chaudhuri, R., Xu, A., Gagnon-Bartsch, J., Chisholm, D., James, D. E., Meikle, P., Greenfield, J., et al. (2016) · Obesity · doi:10.1002/oby.21448 · Cited by 162 · see citing works
Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins
Morales, P. E., Bucarey, J. L., & Espinosa, A. (2017) · Journal of Diabetes Research · doi:10.1155/2017/1789395 · Cited by 171 · see citing works
Gallardo-Montejano, V. I., Saxena, G., Kusminski, C. M., Yang, C., McAfee, J. L., Hahner, L., Hoch, K. M., Dubinsky, W. P., Narkar, V. A., & Bickel, P. E. (2016) · Nature Communications · doi:10.1038/ncomms12723 · Cited by 166 · see citing works
Self-citationFarup, J., Madaro, L., Puri, P., & Mikkelsen, U. R. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.198 · Cited by 156 · see citing works
Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans
Bergman, B. C., Brozinick, J. T., Strauss, A., Bacon, S. D., Kerege, A. A., Bui, H. H., Sanders, P., Siddall, P., Kuo, M. S., & Perreault, L. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00134.2015 · Cited by 161 · see citing works
St‐Jean‐Pelletier, F., Pion, C. H., Leduc‐Gaudet, J., Sgarioto, N., Zovilé, I., Barbat‐Artigas, S., Reynaud, O., Alkaterji, F., Lemieux, F. C., Grenon, A., et al. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12139 · Cited by 156 · see citing works
Skeletal Muscle Mitochondria in the Elderly: Effects of Physical Fitness and Exercise Training
Broskey, N. T., Greggio, C., Boss, A., Boutant, M., Dwyer, A., Schlueter, L., Hans, D., Gremion, G., Kreis, R., Boesch, C., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3983 · Cited by 157 · see citing works
Self-citationExcess of free fatty acids as a cause of metabolic dysfunction in skeletal muscle
TUMOVA, J., ANDEL, M., & TRNKA, J. (2016) · Physiological Research · doi:10.33549/physiolres.932993 · Cited by 143 · see citing works
“Therefore, the role of this lipid species in muscle metabolism should be further examined, with emphasis on specific molecular species of DAG and their subcellular localization (Amati et al. 2011).”
BackgroundCeramides and Glucosylceramides Are Independent Antagonists of Insulin Signaling
Chavez, J. A., Siddique, M. M., Wang, S. T., Ching, J., Shayman, J. A., & Summers, S. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.522847 · Cited by 147 · see citing works
Watt, M. J., & Hoy, A. J. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00561.2011 · Cited by 142 · see citing works
Rivas, D. A., McDonald, D. J., Rice, N. P., Haran, P. H., Dolnikowski, G. G., & Fielding, R. A. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00198.2015 · Cited by 132 · see citing works
Kien, C. L., Bunn, J. Y., Poynter, M. E., Stevens, R., Bain, J. R., IIkayeva, O., Fukagawa, N. K., Champagne, C. M., Crain, K. I., Koves, T. R., et al. (2012) · Diabetes · doi:10.2337/db12-0363 · Cited by 138 · see citing works
Bosma, M., Sparks, L. M., Hooiveld, G. J. E. J., Jörgensen, J. A., Houten, S. M., Schrauwen, P., Kersten, S., & Hesselink, M. K. C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.007 · Cited by 135 · see citing works
Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function
Funai, K., Lodhi, I. J., Spears, L. D., Yin, L., Song, H., Klein, S., & Semenkovich, C. F. (2015) · Diabetes · doi:10.2337/db15-0659 · Cited by 130 · see citing works
Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism
Wicks, S. E., Vandanmagsar, B., Haynie, K. R., Fuller, S. E., Warfel, J. D., Stephens, J. M., Wang, M., Han, X., Zhang, J., Noland, R. C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418560112 · Cited by 131 · see citing works
Contribution of specific ceramides to obesity-associated metabolic diseases
Hammerschmidt, P., & Brüning, J. C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04401-3 · Cited by 127 · see citing works
Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity
Tsai, S., Sitzmann, J. M., Dastidar, S. G., Rodriguez, A. A., Vu, S. L., McDonald, C. E., Academia, E. C., O’Leary, M. N., Ashe, T. D., Spada, A. R. L., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77361 · Cited by 130 · see citing works
Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells
Bandet, C. L., Tan, S., Bourron, O., Stunff, H. L., & Hajduch, É. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030479 · Cited by 123 · see citing works
Noone, J., Mucinski, J. M., DeLany, J. P., Sparks, L. M., & Goodpaster, B. H. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.025 · Cited by 128 · see citing works
Self-citationLarsen, S., Danielsen, J., Søndergård, S. D., Søgaard, D., Vigelsø, A., Dybboe, R., Skaaby, S., Dela, F., & Helge, J. W. (2014) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12252 · Cited by 124 · see citing works
Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy
Roy, B., Curtis, M. E., Fears, L., Nahashon, S. N., & Fentress, H. M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00439 · Cited by 117 · see citing works
PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle
Mason, R. R., Mokhtar, R. A. M., Matzaris, M., Selathurai, A., Kowalski, G. M., Mokbel, N., Meikle, P. J., Bruce, C. R., & Watt, M. J. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.06.002 · Cited by 115 · see citing works
Zammit, V. A. (2013) · Biochemical Journal · doi:10.1042/bj20121689 · Cited by 115 · see citing works
Impact of Endurance and Resistance Training on Skeletal Muscle Glucose Metabolism in Older Adults
Consitt, L. A., Dudley, C., & Saxena, G. (2019) · Nutrients · doi:10.3390/nu11112636 · Cited by 116 · see citing works
Selathurai, A., Kowalski, G. M., Burch, M. L., Sepulveda, P. V., Risis, S., Lee, R. S., Lamon, S., Meikle, P. J., Genders, A. J., McGee, S. L., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.001 · Cited by 112 · see citing works
Arribat, Y., Broskey, N. T., Greggio, C., Boutant, M., Conde Alonso, S., Kulkarni, S. S., Lagarrigue, S., Carnero, E. A., Besson, C., Cantó, C., et al. (2019) · Acta Physiologica · doi:10.1111/apha.13179 · Cited by 112 · see citing works
Self-citationSphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease
Russo, S. B., Ross, J. S., & Cowart, L. A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-7091-1511-4_19 · Cited by 111 · see citing works
Ageing, adipose tissue, fatty acids and inflammation
Pararasa, C., Bailey, C. J., & Griffiths, H. R. (2015) · Biogerontology · doi:10.1007/s10522-014-9536-x · Cited by 110 · see citing works
Kasumov, T., Solomon, T. P. J., Hwang, C. E., Huang, H., Haus, J. M., Zhang, R., & Kirwan, J. P. (2015) · Obesity · doi:10.1002/oby.21117 · Cited by 110 · see citing works
Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis
Mahdaviani, K., Benador, I. Y., Su, S., Gharakhanian, R., Stiles, L., Trudeau, K. M., Cardamone, M. D., Enriquez-Zarralanga, V., Ritou, E., Aprahamian, T. R., et al. (2017) · EMBO Reports · doi:10.15252/embr.201643827 · Cited by 109 · see citing works
Aging-associated exacerbation in fatty degeneration and infiltration following rotator cuff tear
Gumucio, J., Korn, M. A., Saripalli, A., Flood, M. D., Phan, A. C., Roche, S. M., Lynch, E. B., Claflin, D., Bedi, A., & Mendias, C. (2013) · Journal of shoulder and elbow surgery · doi:10.1016/j.jse.2013.04.011 · Cited by 95 · see citing works
Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans
Nowotny, B., Zahiragic, L., Krog, D., Nowotny, P., Herder, C., Carstensen, M., Yoshimura, T., Szendroedi, J., Phielix, E., Schadewaldt, P., et al. (2013) · Diabetes · doi:10.2337/db12-1179 · Cited by 108 · see citing works
Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome
Hevener, A. L., Clegg, D. J., & Mauvais-Jarvis, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.020 · Cited by 112 · see citing works
Koh, J.-H., Johnson, M. L., Dasari, S., LeBrasseur, N. K., Vuckovic, I., Henderson, G. C., Cooper, S. A., Manjunatha, S., Ruegsegger, G. N., Shulman, G. I., et al. (2019) · Diabetes · doi:10.2337/db19-0088 · Cited by 92 · see citing works
Coen, P. M., Hames, K. C., Leachman, E. M., DeLany, J. P., Ritov, V. B., Menshikova, E. V., Dubé, J. J., Stefanović-Račić, M., Toledo, F. G. S., & Goodpaster, B. H. (2013) · Obesity · doi:10.1002/oby.20381 · Cited by 97 · see citing works
Self-citationKoves, T. R., Sparks, L. M., Kovalik, J., Mosedale, M., Arumugam, R., DeBalsi, K. L., Everingham, K., Thorne, L. B., Esther Phielix, E., Meex, R. C. R., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p028910 · Cited by 95 · see citing works
Targeting ceramide metabolism in obesity.
Aburasayn, H., Batran, R. A., & Ussher, J. (2016) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00133.2016 · Cited by 94 · see citing works
PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner
Summermatter, S., Shui, G., Maag, D., Santos, G., Wenk, M. R., & Handschin, C. (2012) · Diabetes · doi:10.2337/db12-0291 · Cited by 96 · see citing works
On ceramides, other sphingolipids and impaired glucose homeostasis
Larsen, P. J., & Tennagels, N. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.011 · Cited by 92 · see citing works
Goto‐Inoue, N., Yamada, K., Inagaki, A., Furuichi, Y., Ogino, S., Manabe, Y., Setou, M., & FUJII, N. L. (2013) · Scientific Reports · doi:10.1038/srep03267 · Cited by 93 · see citing works
Laurens, C., Bourlier, V., Mairal, A., Louche, K., Badin, P.-M., Mouisel, É., Montagner, A., Marette, A., Tremblay, A., Weisnagel, J. S., et al. (2016) · Scientific Reports · doi:10.1038/srep38310 · Cited by 92 · see citing works
Defect of insulin signal in peripheral tissues: Important role of ceramide
Hassan, R. H. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i3.244 · Cited by 90 · see citing works
Huang, T., Zheng, D., Houmard, J. A., Brault, J. J., Hickner, R. C., & Cortright, R. N. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00331.2016 · Cited by 90 · see citing works
Malin, S. K., Haus, J. M., Solomon, T. P. J., Blaszczak, A., Kashyap, S. R., & Kirwan, J. P. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00441.2013 · Cited by 89 · see citing works
Mesinovic, J., Fyfe, J. J., Talevski, J., Wheeler, M. J., Leung, G. K. W., George, E. S., Hunegnaw, M. T., Glavas, C., Jansons, P., Daly, R. M., et al. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0112 · Cited by 95 · see citing works
Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle
Smith, M. E., Tippetts, T. S., Brassfield, E. S., Tucker, B. J., Ockey, A., Swensen, A. C., Anthonymuthu, T. S., Washburn, T. D., Kane, D. A., Prince, J. T., et al. (2013) · Biochemical Journal · doi:10.1042/bj20130807 · Cited by 87 · see citing works
Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology
Tan, S., Guitton, J., Bourron, O., Stunff, H. L., & Hajduch, É. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00491 · Cited by 85 · see citing works
Mielke, M. M., Bandaru, V. V. R., Han, D., An, Y., Resnick, S. M., Ferrucci, L., & Haughey, N. J. (2015) · Aging Cell · doi:10.1111/acel.12369 · Cited by 85 · see citing works
Sphingolipid metabolism in non-alcoholic fatty liver diseases
Régnier, M., Polizzi, A., Guillou, H., & Loiseau, N. (2018) · Biochimie · doi:10.1016/j.biochi.2018.07.021 · Cited by 84 · see citing works
Unraveling the roles of PLIN5: linking cell biology to physiology
Mason, R. R., & Watt, M. J. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.01.005 · Cited by 84 · see citing works
Supruniuk, E., Mikłosz, A., & Chabowski, A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00923 · Cited by 83 · see citing works
The biology of lipid droplet-bound mitochondria
Veliova, M., Petcherski, A., Liesa, M., & Shirihai, O. S. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.04.013 · Cited by 81 · see citing works
Bonen, A., Jain, S. S., Snook, L. A., Han, X.-X., Yoshida, Y., Buddo, K. H., Lally, J., Pask, E. D., Paglialunga, S., Beaudoin, M., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3691-8 · Cited by 82 · see citing works
Peters, S. J., Samjoo, I. A., Devries, M. C., Stevic, I., Robertshaw, H. A., & Tarnopolsky, M. A. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-059 · Cited by 81 · see citing works
Dynamics of skeletal muscle lipid pools
Badin, P.-M., Langin, D., & Moro, C. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.08.001 · Cited by 80 · see citing works
Invited review: Sphingolipid biology in the dairy cow: The emerging role of ceramide
McFadden, J. W., & Rico, J. E. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-16095 · Cited by 80 · see citing works
Muscle protein anabolism in type 2 diabetes
Bassil, M. S., & Gougeon, R. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835a88ee · Cited by 77 · see citing works
Hansen, S., Svendsen, P., Jeppesen, J., Høeg, L. D., Andersen, N. R., Kristensen, J. M., Nilas, L., Lundsgaard, A., Wojtaszewski, J., Madsbad, S., et al. (2018) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2018-01771 · Cited by 69 · see citing works
How to diagnose a lipodystrophy syndrome
Vantyghem, M., Balavoine, A.-S., Douillard, C., Defrance, F., Dieudonne, L., Mouton, F., LEMAIRE, C., Bertrand-Escouflaire, N., Bourdelle-Hego, M. F., Devemy, F., et al. (2012) · Annales d Endocrinologie · doi:10.1016/j.ando.2012.04.010 · Cited by 75 · see citing works
Shepherd, S. O., Cocks, M. S., Meikle, P. J., Mellett, N. A., Ranasinghe, A. M., Barker, T. A., Wagenmakers, A. J. M., & Shaw, C. S. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.170 · Cited by 72 · see citing works
Lipid-mediated muscle insulin resistance: different fat, different pathways?
Ritter, O., Jelenik, T., & Roden, M. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1310-2 · Cited by 74 · see citing works
Chee, C., Shannon, C. E., Burns, A., Selby, A. L., Wilkinson, D., Smith, K., Greenhaff, P. L., & Stephens, F. B. (2016) · Diabetes · doi:10.2337/db15-1383 · Cited by 74 · see citing works
- Authors
- Amati, F., Dubé, J. J., Alvarez-Carnero, E., Edreira, M. M., Chomentowski, P., Coen, P. M., Switzer, G. E., Bickel, P. E., Stefanovic-Racic, M., Toledo, F. G. S., & Goodpaster, B. H.
- Affiliations
- University of Pittsburgh (US)
- Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
- Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (US)
- Department of Medicine, Division of Endocrinology and Metabolism, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
- Corresponding author
- Goodpaster, Bret H.
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2011-09-16
- Volume
- 60
- Issue
- 10
- Pages
- 2588-2597
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC3178290
- OpenAlex
- W2032345647
- Cited by
- 395
- References
- 54
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 13 · 2023: 17 · 2022: 18 · 2021: 16 · 2020: 28 · 2019: 27 · 2018: 38 · 2017: 32 · 2016: 41 · 2015: 41 · 2014: 29 · 2013: 35 · 2012: 27
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Funders
- University of Pittsburgh (UL1RR024153, RR024153)
- National Institutes of Health (5p30dk046204-15, RR024153, 1P30DK46204)
- National Institute on Aging (R01 AG20128, P30AG024827)
- National Institute of Diabetes and Digestive and Kidney Diseases (1P30DK-46204, R01DK068046, P30-DK046204)
- National Center for Research Resources (RR-024153, UL1RR024153)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- insulin resistance, intramyocellular triglyceride, diacylglycerol, ceramide, endurance athletes, obesity, perilipin 5, adipose triglyceride lipase, stearoyl-CoA desaturase, mitochondrial oxidative capacity, fatty acid oxidation
- MeSH terms
- Aged, Ceramides, Diglycerides, Female, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Mitochondria, Muscle, Obesity, Oxygen Consumption, Physical Endurance, Triglycerides, Muscle, Skeletal, Athletes
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