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Cited by 277Diabetes Management and ResearchPancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Experimental validation of measurements of glucose turnover in nonsteady state.

Radziuk, J, Norwich, K H, Vranic, M·1978·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1978.234.1.e84
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Abstract

The aim of the present experiments is to validate, in conscious dogs, the tracer infusion methods of measuring nonsteady turnover rates. This was done in nine experiments performed in four normal dogs by infusing isotopically labeled glucose (2-3H, 6-3H, 1-14C) and monitoring the concentrations of both the labeled and unlabeled substances. The validation is based on the observation that a high exogenous infusion of glucose will suppress endogenous glucose production and become the sole source of glucose in the body. By infusing glucose at a high, time-varying rate, calculating its rate of appearance, (Ra) and comparing it to the infused rate, the method can be verified. The calculations were based on: a) a single-compartment model with a modified volume of distribution; b) a two-compartment model; and c) a generalized dispersion model. The absolute values of the areas of the deviations of the calculated from the infused curves were found to be, respectively, 9.5, 8.4, and 7.8 percent of the total area under the infused curve. It was concluded that the tracer infusion method can reliably measure Ra of glucose when it is changing rapidly, and the system is out of steady state.

Overview

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Crossref · 10.1152/ajpendo.1978.234.1.e84

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36 of 36 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 13

  1. ALTSZULEEL N., I., 1968, Ann. N.Y. Acad. Sci., 148, 411
  2. L., 1967, J. Bill. Chem., 42, 1354
  3. COWAN J. S., 1969, MetaboZism, 18, 319
  4. EXTON J, H, 1970, Recent Progr. Hormone Res., 26, 411
  5. HETENYI G., 1973, PhysioZ., 224, 635
  6. HETENYI G, 1966, J. NucZ. Med., 7, 454
  7. INSEL P. A., 1974, Federation PFOC., 33, 1865
  8. PAYNE J. A, 1970, G. Hayes. London: Aihlone, 98
  9. RADZIUK J, 1977, Eng., 11, 729
  10. RADZIUK J., K., 1974, Federation Proc., 33, 1855
  11. STEELE R., J., 1965, Am. J. PJlysioZ., 208, 301
  12. STEINER G., S., 1974, Diabetes, 23, 338
  13. VRANIC M., J., 1973, S. Iberall and A. C. Guyton. Pittsburgh: Instrument Society of America, 487

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Metadata

Authors
Radziuk, J., Norwich, K. H., & Vranic, M.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1978-01-01
Volume
234
Issue
1
Pages
E84
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1978.234.1.e84
OpenAlex
W2153716175
Cited by
277
References
36
Citations by year
2023: 2 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 3
FWCI
5.22
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
glucose turnover, tracer infusion, glucose appearance rate, compartmental modeling, glucose kinetics, dogs
MeSH terms
Animals, Dogs, Glucose, Infusions, Parenteral, Mathematics, Models, Biological

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