The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Experimental validation of measurements of glucose turnover in nonsteady state.
Abstract
The aim of the present experiments is to validate, in conscious dogs, the tracer infusion methods of measuring nonsteady turnover rates. This was done in nine experiments performed in four normal dogs by infusing isotopically labeled glucose (2-3H, 6-3H, 1-14C) and monitoring the concentrations of both the labeled and unlabeled substances. The validation is based on the observation that a high exogenous infusion of glucose will suppress endogenous glucose production and become the sole source of glucose in the body. By infusing glucose at a high, time-varying rate, calculating its rate of appearance, (Ra) and comparing it to the infused rate, the method can be verified. The calculations were based on: a) a single-compartment model with a modified volume of distribution; b) a two-compartment model; and c) a generalized dispersion model. The absolute values of the areas of the deviations of the calculated from the infused curves were found to be, respectively, 9.5, 8.4, and 7.8 percent of the total area under the infused curve. It was concluded that the tracer infusion method can reliably measure Ra of glucose when it is changing rapidly, and the system is out of steady state.
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“Rates of glucose production and glucose utilization were estimated by means of Steele's equations for nonsteady-state conditions (19) as validated for the glucose system (20).”
From Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. (1980) · cites this paper as [20]
Citations
Cites
Somogyi, M. (1926) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84465-9 · Cited by 5,601
Somogyi, M. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50870-5 · Cited by 5,310
Immunoassay of insulin with insulin-antibody precipitate
Hales, C. N., & Pj, R. (1963) · Biochemical Journal · doi:10.1042/bj0880137 · Cited by 2,640
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680
Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution Method
Steele, R., Wall, J. S., de Bodo, R. C., & Altszuler, N. (1956) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1956.187.1.15 · Cited by 816
A model of the kinetics of insulin in man
Sherwin, R. S., Kramer, K. J., Tobin, J. D., Insel, P. A., Liljenquist, J. E., Berman, M., & Andres, R. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107697 · Cited by 460
Jefferson, L. S., Exton, J. H., Butcher, R. W., Sutherland, E. W., & Park, C. R. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93618-5 · Cited by 324
Glucoregulatory responses in normal and diabetic dogs recorded by a new tracer method
Cowan, J. S., & Hetenyi, G., Jr. (1971) · Metabolism · doi:10.1016/0026-0495(71)90098-9 · Cited by 239
The Hormonal Control of Hepatic Gluconeogenesis
EXTON, J. H., MALLETTE, L. E., JEFFERSON, L. S., WONG, E. H. A., FRIEDMANN, N., MILLER, T. B., & PARK, C. R. (1970) · Proceedings of the 1969 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571126-5.50014-5 · Cited by 222
Quantitative Estimation of the Cori Cycle in the Human
Reichard, G., Moury, N. F., Hochella, N. J., Patterson, A., & Weinhouse, S. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81288-1 · Cited by 215
Research works printed but not linked: 13
- ALTSZULEEL N., I., 1968, Ann. N.Y. Acad. Sci., 148, 411
- L., 1967, J. Bill. Chem., 42, 1354
- COWAN J. S., 1969, MetaboZism, 18, 319
- EXTON J, H, 1970, Recent Progr. Hormone Res., 26, 411
- HETENYI G., 1973, PhysioZ., 224, 635
- HETENYI G, 1966, J. NucZ. Med., 7, 454
- INSEL P. A., 1974, Federation PFOC., 33, 1865
- PAYNE J. A, 1970, G. Hayes. London: Aihlone, 98
- RADZIUK J, 1977, Eng., 11, 729
- RADZIUK J., K., 1974, Federation Proc., 33, 1855
- STEELE R., J., 1965, Am. J. PJlysioZ., 208, 301
- STEINER G., S., 1974, Diabetes, 23, 338
- VRANIC M., J., 1973, S. Iberall and A. C. Guyton. Pittsburgh: Instrument Society of America, 487
Cited by
Sorted by citations
Assessment of Insulin Sensitivityin Vivo*
Bergman, R. N., Finegood, D. T., & Ader, M. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-1-45 · Cited by 1,072
A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test
Mari, A., Pacini, G., Murphy, E., Ludvik, B. H., & Nolan, J. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.539 · Cited by 805
Bergman, R. N., Prager, R., Volund, A., & Olefsky, J. M. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112886 · Cited by 772
Influence of body fat distribution on free fatty acid metabolism in obesity.
Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113997 · Cited by 683
Clutter, W. E., Bier, D. M., Shah, S. D., & Cryer, P. E. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109840 · Cited by 576
Metadata
- Authors
- Radziuk, J., Norwich, K. H., & Vranic, M.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1978-01-01
- Volume
- 234
- Issue
- 1
- Pages
- E84
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2153716175
- Cited by
- 277
- References
- 36
- Citations by year
- 2023: 2 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- glucose turnover, tracer infusion, glucose appearance rate, compartmental modeling, glucose kinetics, dogs
- MeSH terms
- Animals, Dogs, Glucose, Infusions, Parenteral, Mathematics, Models, Biological
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