The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Slow to fast alterations in skeletal muscle fibers caused by clenbuterol, a beta 2-receptor agonist
Abstract
Chronic treatment of rats with clenbuterol, a beta 2-receptor agonist (8–12 wk), caused hypertrophy of histochemically identified fast- but not slow-twitch fibers within the soleus, while the mean areas of both fiber types were increased in the extensor digitorum longus (EDL). In contrast, treatment with the beta 2-receptor antagonist, butoxamine, reduced fast-twitch fiber size in both muscles. In the solei and to a lesser extent in the EDLs, the ratio of the number of fast- to slow-twitch fibers was increased by clenbuterol, while the opposite was observed with butoxamine. The muscle fiber hypertrophy observed in the EDL was accompanied by parallel increases in maximal tetanic tension and muscle cross-sectional area, while in the solei, progressive increases in rates of force development and relaxation toward values typical of fast-twitch muscles were also observed. Our results suggest a role of beta 2-receptors in regulating muscle fiber type composition as well as growth.
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Citations
Cites
Dynamic properties of mammalian skeletal muscles.
Close, R. I. (1972) · Physiological Reviews · doi:10.1152/physrev.1972.52.1.129 · Cited by 1,890
Izumo, S., Nadal-Ginard, B., & Mahdavi, V. (1986) · Science · doi:10.1126/science.3945800 · Cited by 621
Use of a β-Agonist to Alter Fat and Muscle Deposition in Steers1
Ricks, C. A., Dalrymple, R. H., Baker, P. K., & Ingle, D. L. (1984) · Journal of Animal Science · doi:10.2527/jas1984.5951247x · Cited by 294
Cited by
Hughes, S. M., Taylor, J. M., Tapscott, S. J., Gurley, C. M., Carter, W. J., & Peterson, C. A. (1993) · Development · doi:10.1242/dev.118.4.1137 · Cited by 422
Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410
Scherrer, U., & Sartori, C. (1997) · Circulation · doi:10.1161/01.cir.96.11.4104 · Cited by 371
Sympathetic overactivity in hypertension. A moving target
JULIUS, S., & NESBITT, S. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(96)00287-7 · Cited by 237
Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle
Louard, R. J., Fryburg, D. A., Gelfand, R. A., & Barrett, E. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116124 · Cited by 169
Metadata
- Authors
- Zeman, R. J., Ludemann, R., Easton, T. G., & Etlinger, J. D.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1988-06-01
- Volume
- 254
- Issue
- 6
- Pages
- E726-E732
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1770040190
- Cited by
- 195
- References
- 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Slow to fast alterations in skeletal muscle fibers caused by clenbuterol, a beta 2-receptor agonist. https://app.cochat.ai/papers/10.1152/ajpendo.1988.254.6.e726
- The paper
- Zeman, R. J., Ludemann, R., Easton, T. G., & Etlinger, J. D. (1988). Slow to fast alterations in skeletal muscle fibers caused by clenbuterol, a beta 2-receptor agonist. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1988.254.6.e726
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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