Effect of hypercorticism on regulation of skeletal muscle glycogen metabolism by insulin
Abstract
The effects of hypercorticism on the regulation of glycogen metabolism by insulin in skeletal muscles was examined by using the hindlimb perfusion technique. Rats were injected daily with either saline or dexamethasone (0.4 mg.kg-1.day-1) for 14 days and were studied in the fed or fasted (24 h) state under saline or insulin (1 mU/ml) treatment. In fed controls, insulin resulted in glycogen synthase activation and in enhanced glycogen synthesis. In dexamethasone-treated animals, basal muscle glycogen concentration remained normal, but glycogen synthase activity ratio was decreased in white and red gastrocnemius and plantaris muscles. Furthermore, insulin failed to activate glycogen synthase and glycogen synthesis. In the controls, fasting was associated with decreased glycogen concentrations and with increased glycogen synthase activity ratio in all four groups of muscles (P less than 0.01). Dexamethasone treatment, however, completely abolished the decrease in muscle glycogen content as well as the augmented glycogen synthase activity ratio associated with fasting. Insulin infusion stimulated glycogen synthesis in fasted controls but not in dexamethasone-treated rats. These data therefore indicate that dexamethasone treatment inhibits the stimulatory effect of insulin on glycogen synthase activity and on glycogen synthesis. Furthermore, hypercorticism suppresses the decrease in muscle glycogen content associated with fasting.
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Dexamethasone treatment inhibits insulin-stimulated glycogen synthesis and glycogen synthase activation.
“Dexamethasone treatment, in addition, inhibits insulin-stimulated glycogen synthesis and glycogen synthase activation [18,19].”
Cites
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770 · see citing works
Thomas, J. A., Schlender, K. K., & Larner, J. (1968) · Analytical Biochemistry · doi:10.1016/0003-2697(68)90127-9 · Cited by 1,198 · see citing works
RIZZA, R. A., MANDARINO, L. J., & GERICH, J. E. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-131 · Cited by 696 · see citing works
Glycogen Synthetase Activity in Skeletal Muscle
Danforth, W. H. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45214-8 · Cited by 435 · see citing works
Radioactive method for the assay of glycogen phosphorylases
Gilboe, D. P., Larson, K., & Nuttall, F. Q. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90274-6 · Cited by 402 · see citing works
Effects of glucocorticoids on carbohydrate metabolism
Mcmahon, M., Gerich, J., & Rizza, R. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040105 · Cited by 390 · see citing works
Adrenal glucocorticoids after twenty years
David, D. S., Grieco, M. H., & Cushman, P. (1970) · Journal of Chronic Diseases · doi:10.1016/0021-9681(70)90078-0 · Cited by 209 · see citing works
Effects of increased plasma fatty acids on glycogen utilization and endurance
Hickson, R. C., Rennie, M. J., Conlee, R. K., Winder, W. W., & Holloszy, J. O. (1977) · Journal of Applied Physiology · doi:10.1152/jappl.1977.43.5.829 · Cited by 179 · see citing works
Charron, M. J., & Kahn, B. B. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39029-5 · Cited by 144 · see citing works
Skeletal muscle glycogen content: diurnal variation and effects of fasting
Conlee, R. K., Rennie, M. J., & Winder, W. W. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.231.2.614 · Cited by 131 · see citing works
Jenkins, A. B., Storlien, L. H., Chisholm, D. J., & Kraegen, E. W. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113586 · Cited by 119 · see citing works
Challiss, R. A. J., Espinal, J., & Newsholme, E. A. (1983) · Bioscience Reports · doi:10.1007/bf01172878 · Cited by 71 · see citing works
Dietz, M. R., Chiasson, J. L., Soderling, T. R., & Exton, J. H. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85890-8 · Cited by 70 · see citing works
Self-citationGarvey, W. T., Huecksteadt, T. P., Monzon, R. I., & MARSHALL, S. (1989) · Endocrinology · doi:10.1210/endo-124-5-2063 · Cited by 64 · see citing works
In Vivo Regulation of Non-Insulin-Mediated and Insulin-Mediated Glucose Uptake by Cortisol
Baron, A. D., Wallace, P., & Brechtel, G. (1987) · Diabetes · doi:10.2337/diab.36.11.1230 · Cited by 56 · see citing works
Effects of adrenalectomy on the amino acid and glucose metabolism of perfused rat hindlimbs.
Caldwell, M. D., LACY, W. W., & Exton, J. H. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37996-6 · Cited by 43 · see citing works
Karasik, A., & Kahn, C. R. (1988) · Endocrinology · doi:10.1210/endo-123-5-2214 · Cited by 31 · see citing works
Leighton, B., Challiss, R. A. J., Lozeman, F. J., & Newsholme, E. A. (1987) · Biochemical Journal · doi:10.1042/bj2460551 · Cited by 31 · see citing works
Chap, Z., Jones, R. H., Chou, J., Hartley, C. J., Entman, M. L., & Field, J. B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112722 · Cited by 21 · see citing works
Tan, M. H., & Bonen, A. (1985) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y85-185 · Cited by 18 · see citing works
Effects of glucocorticoids on carbohydrate metabolism
Hers, H. G. (1986) · Inflammation Research · doi:10.1007/bf01982615 · Cited by 17 · see citing works
Differential response of rat cardiac and skeletal muscle glycogen to glucocorticoids
Poland, J. L., Poland, J. W., & Honey, R. N. (1982) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y82-086 · Cited by 7 · see citing works
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Glucocorticoids, metabolism and metabolic diseases
Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535 · see citing works
Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
Beaupere, C., Liboz, A., Fève, B., Blondeau, B., & Guillemain, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020623 · Cited by 271 · see citing works
Ruzzin, J., Wagman, A. S., & Jensen, J. (2005) · Diabetologia · doi:10.1007/s00125-005-1886-0 · Cited by 243 · see citing works
- Authors
- Coderre, L., Srivastava, A. K., & Chiasson, J. L.
- Affiliations
- Montreal Clinical Research Institute (CA)
- ORCID
- Srivastava, A. K.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1992-04-01
- Volume
- 262
- Issue
- 4
- Pages
- E427-E433
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W4246986591
- Cited by
- 17
- References
- 22
- Citations by year
- 2021: 2 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- hypercortisolism, insulin, glycogen synthase, dexamethasone, fasting, muscle glycogen, glucocorticoids, insulin resistance
- MeSH terms
- Adrenocortical Hyperfunction, Animals, Dexamethasone, Glucose, Glucosephosphates, Glycogen, Phosphorylases, Hormones, Insulin, Male, Muscles, Rats, Inbred Strains, Glucose-6-Phosphate, Rats
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