The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Progressive alterations in lipid and glucose metabolism during short-term fasting in young adult men
Abstract
Stable isotope tracers and indirect calorimetry were used to evaluate the progressive alterations in lipid and glucose metabolism after 12, 18, 24, 30, 42, 54, and 72 h of fasting in six healthy male volunteers. The rates of appearance (Ra) of glycerol and palmitic acid in plasma doubled from 2.08 +/- 0.22 and 1.63 +/- 0.20 mumol.kg-1 x min-1, respectively, after 12 h to 4.36 +/- 0.36 and 3.26 +/- 0.40 mumol.kg-1 x min-1, respectively, after 72 h of fasting (P < 0.01). Of the total increase in lipid kinetics, 60% occurred between 12 and 24 h of fasting; the greatest interval change occurred between 18 and 24 h of fasting. Glucose Ra and plasma concentration decreased by approximately 25% between 12 h (11.0 +/- 0.4 mumol.kg-1 x min-1 and 5.58 +/- 0.08 mmol/l, respectively) and 72 h (8.3 +/- 0.3 mumol.kg-1 x min-1 and 4.14 +/- 0.10 mmol/l, respectively) of fasting (P < 0.01), but no statistically significant changes occurred between 18 and 24 h of fasting. Plasma insulin decreased by approximately 50% between 12 h (64.6 +/- 12.9 pmol/l) and 72 h (30.1 +/- 7.9 pmol/l) of fasting (P < 0.001). Of the total decline in plasma insulin, 70% occurred within the first 24 h of fasting. These results demonstrate that the mobilization of adipose tissue triglycerides increases markedly between 18 and 24 h of fasting in young adult men. The early alterations in lipid metabolism are associated with a decline in circulating insulin but do not seem to be regulated by changes in glucose kinetics…
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“The exact length of the overnight fast may also be important: the steady state often supposed to exist after overnight fast is, in fact, a time of significant change in terms of falling plasma insulin concentrations and increasing lipolysis (Klein et al. 1993;Samra et al. 1996).”
From Glycaemic index methodology (2005) · cites this paper as Klein et al. 1993
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Metadata
- Authors
- Klein, S., Sakurai, Y., Romijn, J. A., & Carroll, R. M.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- ORCID
- Romijn, J. A.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1993-11-01
- Volume
- 265
- Issue
- 5
- Pages
- E801-E806
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1848960512
- Cited by
- 104
- References
- 21
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institutes of Health (5r29ca050330-05)
- U.S. Public Health Service (MO10073)
- National Cancer Institute (CA 50330)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- short-term fasting, lipid metabolism, glucose metabolism, plasma insulin, glucose kinetics, plasma glucose, young men
- MeSH terms
- Adult, Blood Glucose, Deuterium, Energy Metabolism, Fasting, Fatty Acids, Nonesterified, Glucose, Glycerol, Humans, Isotope Labeling, Lipolysis, Male, Palmitic Acids, Regression Analysis, Time Factors, Triglycerides, Palmitic Acid
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