Cited by 104Dietary Effects on HealthLipid metabolism and biosynthesisDiabetes, Cardiovascular Risks, and Lipoproteins

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Progressive alterations in lipid and glucose metabolism during short-term fasting in young adult men

Klein, S., Sakurai, Y., Romijn, J. A., Carroll, R. M.·1993·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1993.265.5.e801

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Abstract

Stable isotope tracers and indirect calorimetry were used to evaluate the progressive alterations in lipid and glucose metabolism after 12, 18, 24, 30, 42, 54, and 72 h of fasting in six healthy male volunteers. The rates of appearance (Ra) of glycerol and palmitic acid in plasma doubled from 2.08 +/- 0.22 and 1.63 +/- 0.20 mumol.kg-1 x min-1, respectively, after 12 h to 4.36 +/- 0.36 and 3.26 +/- 0.40 mumol.kg-1 x min-1, respectively, after 72 h of fasting (P < 0.01). Of the total increase in lipid kinetics, 60% occurred between 12 and 24 h of fasting; the greatest interval change occurred between 18 and 24 h of fasting. Glucose Ra and plasma concentration decreased by approximately 25% between 12 h (11.0 +/- 0.4 mumol.kg-1 x min-1 and 5.58 +/- 0.08 mmol/l, respectively) and 72 h (8.3 +/- 0.3 mumol.kg-1 x min-1 and 4.14 +/- 0.10 mmol/l, respectively) of fasting (P < 0.01), but no statistically significant changes occurred between 18 and 24 h of fasting. Plasma insulin decreased by approximately 50% between 12 h (64.6 +/- 12.9 pmol/l) and 72 h (30.1 +/- 7.9 pmol/l) of fasting (P < 0.001). Of the total decline in plasma insulin, 70% occurred within the first 24 h of fasting. These results demonstrate that the mobilization of adipose tissue triglycerides increases markedly between 18 and 24 h of fasting in young adult men. The early alterations in lipid metabolism are associated with a decline in circulating insulin but do not seem to be regulated by changes in glucose kinetics…

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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Calculation of substrate oxidation rates in vivo from gaseous exchange.
Frayn, K. N. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.628 · Cited by 2,365
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680
Brain Metabolism during Fasting*
Owen, O. E., Morgan, A. P., Kemp, H. G., Sullivan, J. M., Herrera, M. G., & Cahill, G. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105650 · Cited by 1,662
The theoretical bases of indirect calorimetry: A review
Ferrannini, E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90110-2 · Cited by 1,604
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
Effects of arterial versus venous sampling on analysis of glucose kinetics in man
McGuire, E. A., Helderman, J. H., Tobin, J. D., Andres, R., & Berman, M. D. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.41.4.565 · Cited by 704
Quantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With 13 C NMR
Rothman, D. L., Magnusson, I., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1991) · Science · doi:10.1126/science.1948033 · Cited by 546
Glycerol Utilization and its Regulation in Mammals
Lin, E. C. C. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004001 · Cited by 421
Insulin Regulation of Lipolysis in Nondiabetic and IDDM Subjects
Jensen, M. D., Caruso, M., Heiling, V. J., & Miles, J. M. (1989) · Diabetes · doi:10.2337/diab.38.12.1595 · Cited by 331

Show all 21 references

Research works printed but not linked: 8

Hultman E, 1978, FL: Symposia Specialist, 99
Jahoor F., 1992, Metab. 25), E353
Klein S., 1990, Metab. 21), E32
Klein S., 1992, Metab. 25), E631
Owen 0., 1988, PA: Saunders, 35
Peters E. J., 1991, Metab. 24), E500
Simonson D. C., 1990, Metab. 21), E399
Wolfe R. R., 1987, Metab. 15), E189

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Boaz, M., Iskhakov, A., Tsivian, A., Shimonov, M., Berkenstadt, H., Izakson, A., Szmuk, P., Evron, S., Muggia‐Sullam, M., & Ezri, T. (2011) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-011-9299-8 · Cited by 7
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Lankelma, J., Kooi, B. W., Krab, K., Dorsman, J. C., Joenje, H., & Westerhoff, H. V. (2014) · Biosystems · doi:10.1016/j.biosystems.2014.11.001 · Cited by 7
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Toth, M. J., Sites, C. K., Poehlman, É. T., & Tchernof, A. (2002) · Metabolism · doi:10.1053/meta.2002.30496 · Cited by 6
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Lladó, I., Palou, A., & Pons, A. (1998) · Annals of Nutrition and Metabolism · doi:10.1159/000012731 · Cited by 5
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Gluconeogenesis and fasting in cerebral malaria.
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Herbst, E. A. F. (2011)
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櫻井, 洋., 長谷川, 由., 難波, 秀., & 王堂, 哲. (2018) · 静脈経腸栄養 · doi:10.11244/jspen.33.753
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Alpers, D., & Cashman, K. D. (2015) · Yamada's Textbook of Gastroenterology · doi:10.1002/9781118512074.ch27
Hypoxia-induced muscle atrophy
Theye, C. C. D. (2016) · Research Publications (Maastricht University) · doi:10.26481/dis.20160122cd

Authors: Klein, S., Sakurai, Y., Romijn, J. A., & Carroll, R. M.
Affiliations: The University of Texas Medical Branch at Galveston (US)
ORCID: Romijn, J. A.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1993-11-01
Volume: 265
Issue: 5
Pages: E801-E806
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1993.265.5.e801
OpenAlex: W1848960512
Cited by: 104
References: 21
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 4
FWCI: 1.11
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: National Institutes of Health (5r29ca050330-05)
U.S. Public Health Service (MO10073)
National Cancer Institute (CA 50330)
Topics: Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: short-term fasting, lipid metabolism, glucose metabolism, plasma insulin, glucose kinetics, plasma glucose, young men
MeSH terms: Adult, Blood Glucose, Deuterium, Energy Metabolism, Fasting, Fatty Acids, Nonesterified, Glucose, Glycerol, Humans, Isotope Labeling, Lipolysis, Male, Palmitic Acids, Regression Analysis, Time Factors, Triglycerides, Palmitic Acid

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Progressive alterations in lipid and glucose metabolism during short-term fasting in young adult men

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