The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Mechanotransduction in bone: role of strain rate
Abstract
Bone tissue can detect and respond to its mechanical environment, but there is no consensus for how bone cells detect mechanical loads. Some think that cells sense tissue deformation (strain) and respond when strain is abnormally high. However, strains in bone tissue are usually very small, and it is questionable whether bone cells are sensitive enough to detect them. Another theory suggests that mechanical loads are coupled to the bone cells by stress-generated fluid flow within the bone tissue, which is dependent on the rate of change of bone strain. We applied bending loads to the tibiae of adult rats to create equivalent peak strains in the bone tissue but with varied rates of strain. Bone formation was significantly increased in the two experimental groups when the highest strain rates were compared with lower strain rates (P < 0.01), and the amount of new bone formation was directly proportional to the rate of strain in the bone tissue. These results suggest that relatively large strains alone are not sufficient to activate bone cells. High strain rates and possibly stress-generated fluid flow are required to stimulate new bone formation.
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Citations
Cites
Regulation of bone mass by mechanical strain magnitude
Rubin, C. T., & Lanyon, L. E. (1985) · Calcified Tissue International · doi:10.1007/bf02553711 · Cited by 1,294
A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
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Static vs dynamic loads as an influence on bone remodelling
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Mechanical loading thresholds for lamellar and woven bone formation
Dr. Turner, C. H., Forwood, M. R., Rho, J.-Y., & Yoshikawa, T. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090113 · Cited by 475
Mechanotransduction in bone: do bone cells act as sensors of fluid flow?
Turner, C. H., Forwood, M. R., & Otter, M. W. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.11.8070637 · Cited by 411
Self-citationJournal of Bone and Mineral Research
Lanyon, L. E. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650071403 · Cited by 355
Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo
Skerry, T. M., Lanyon, L. E., Bitensky, L., & Chayen, J. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040519 · Cited by 352
Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production
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Mechanoelectrical Transduction by Hair Cells
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Cited by
BIOMECHANICAL AND MOLECULAR REGULATION OF BONE REMODELING
Robling, A. G., Castillo, A. B., & Turner, C. H. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095721 · Cited by 1,343
Self-citationMechanotransduction and the functional response of bone to mechanical strain
Duncan, R. L., & Turner, C. H. (1995) · Calcified Tissue International · doi:10.1007/bf00302070 · Cited by 1,048
Self-citationVerschueren, S. M., Roelants, M., Delecluse, C., Swinnen, S., Vanderschueren, D., & Boonen, S. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301245 · Cited by 833
The aging of Wolff’s “law”: Ontogeny and responses to mechanical loading in cortical bone
Pearson, O. M., & Lieberman, D. E. (2004) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20155 · Cited by 745
Mechanical Strain and Bone Cell Function: A Review
Ehrlich, P. J., & Lanyon, L. E. (2002) · Osteoporosis International · doi:10.1007/s001980200095 · Cited by 512
Metadata
- Authors
- Turner, C. H., Owan, I., & Takano, Y.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1995-09-01
- Volume
- 269
- Issue
- 3
- Pages
- E438-E442
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1811174311
- Cited by
- 358
- References
- 16
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Turner, C. H., Owan, I., & Takano, Y. (1995). Mechanotransduction in bone: role of strain rate. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1995.269.3.e438
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
