The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction
Abstract
Muscle protein synthesis and breakdown and amino acid transport were measured in 7 healthy young (30 ± 2 yr) and 8 healthy elderly (71 ± 2 yr) volunteers in the postabsorptive state and during the oral administration of an amino acid mixture withl-[ ring-2 H 5]phenylalanine infusion, femoral artery and vein catheterization, and muscle biopsies. Phenylalanine first-pass splanchnic extraction was measured by addingl-[ ring-13 C 6]phenylalanine to the mixture. In the postabsorptive state, no differences in muscle amino acid kinetics were detected between young and elderly volunteers. Phenylalanine first-pass splanchnic extraction was significantly higher in the elderly ( P < 0.003) during ingestion of amino acids, but the delivery to the leg increased to the same extent in both groups. Phenylalanine transport into the muscle, muscle protein synthesis, and net balance increased significantly ( P < 0.01) and similarly in both the young and the elderly. We conclude that, despite an increased splanchnic first-pass extraction, muscle protein anabolism can be stimulated by oral amino acids in the elderly as well as in the young.
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“Aging has been shown to reduce the appearance of dietary amino acids in the systemic circulation during the postprandial period [24, 25], which could reduce their availability for uptake by skeletal muscle.”
From Protein Requirements for Master Athletes: Just Older Versions of Their Younger Selves (2021) · cites this paper as [24]
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Biolo, G., Declan Fleming, R. Y., & Wolfe, R. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117731 · Cited by 442
Exogenous amino acids stimulate net muscle protein synthesis in the elderly.
Volpi, E., Ferrando, A. A., Yeckel, C. W., Tipton, K. D., & Wolfe, R. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci939 · Cited by 390
Self-citationTestosterone injection stimulates net protein synthesis but not tissue amino acid transport
Ferrando, A. A., Tipton, K. D., Doyle, D., Phillips, S. M., Cortiella, J., & Wolfe, R. R. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e864 · Cited by 256
Self-citationTipton, K. (1999) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(98)00087-4 · Cited by 231
Cited by
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553
Self-citationAnabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211
Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives
Rolland, Y., Czerwinski, S., van Kan, G. A., Morley, J. E., Cesari, M., Onder, G., Woo, J., Baumgartner, R., Pillard, F., Boirie, Y., et al. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982704 · Cited by 1,071
Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846
Self-citationDietary protein recommendations and the prevention of sarcopenia
Paddon-Jones, D., & Rasmussen, B. B. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef8b · Cited by 823
Metadata
- Authors
- Volpi, E., Mittendorfer, B., Wolf, S. E., & Wolfe, R. R.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1999-09-01
- Volume
- 277
- Issue
- 3
- Pages
- E513-E520
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2137048653
- Cited by
- 418
- References
- 4
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Volpi, E., Mittendorfer, B., Wolf, S. E., & Wolfe, R. R. (1999). Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1999.277.3.e513
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
