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Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction
Abstract
Muscle protein synthesis and breakdown and amino acid transport were measured in 7 healthy young (30 ± 2 yr) and 8 healthy elderly (71 ± 2 yr) volunteers in the postabsorptive state and during the oral administration of an amino acid mixture withl-[ ring-2 H 5]phenylalanine infusion, femoral artery and vein catheterization, and muscle biopsies. Phenylalanine first-pass splanchnic extraction was measured by addingl-[ ring-13 C 6]phenylalanine to the mixture. In the postabsorptive state, no differences in muscle amino acid kinetics were detected between young and elderly volunteers. Phenylalanine first-pass splanchnic extraction was significantly higher in the elderly ( P < 0.003) during ingestion of amino acids, but the delivery to the leg increased to the same extent in both groups. Phenylalanine transport into the muscle, muscle protein synthesis, and net balance increased significantly ( P < 0.01) and similarly in both the young and the elderly. We conclude that, despite an increased splanchnic first-pass extraction, muscle protein anabolism can be stimulated by oral amino acids in the elderly as well as in the young.
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“Aging has been shown to reduce the appearance of dietary amino acids in the systemic circulation during the postprandial period [24, 25], which could reduce their availability for uptake by skeletal muscle.”
From Protein Requirements for Master Athletes: Just Older Versions of Their Younger Selves (2021) · cites this paper as [24]
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Metadata
- Authors
- Volpi, E., Mittendorfer, B., Wolf, S. E., & Wolfe, R. R.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1999-09-01
- Volume
- 277
- Issue
- 3
- Pages
- E513-E520
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2137048653
- Cited by
- 418
- References
- 4
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
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