Dietary protein recommendations and the prevention of sarcopenia

Paddon-Jones, Douglas; Rasmussen, Blake B

doi:10.1097/mco.0b013e32831cef8b

Cited by 823Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

Dietary protein recommendations and the prevention of sarcopenia

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Paddon-Jones, Douglas, Rasmussen, Blake B·2009·Current Opinion in Clinical Nutrition & Metabolic Care

DOI 10.1097/mco.0b013e32831cef8bPMC PMC2760315

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Abstract

PURPOSE OF REVIEW: To draw attention to recent work on the role of protein and the amount of protein needed with each meal to preserve skeletal muscle mass in ageing. RECENT FINDINGS: Ageing does not inevitably reduce the anabolic response to a high-quality protein meal. Ingestion of approximately 25-30 g of protein per meal maximally stimulates muscle protein synthesis in both young and older individuals. However, muscle protein synthesis is blunted in elderly when protein and carbohydrate are coingested or when the quantity of protein is less than approximately 20 g per meal. Supplementing regular mixed-nutrient meals with leucine may also enhance the muscle protein synthetic response in elders. SUMMARY: On the basis of recent work, we propose a novel and specific dietary approach to prevent or slow down muscle loss with ageing. Rather than recommending a large, global increase in the recommended dietary allowance (RDA) for protein for all elderly individuals, clinicians should stress the importance of ingesting a sufficient amount of protein with each meal. To maximize muscle protein synthesis while being cognizant of total energy intake, we propose a dietary plan that includes 25-30 g of high quality protein per meal.

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Older people have anabolic resistance, so a higher protein intake is needed to promote muscle protein synthesis.
“While in older people, a higher protein intake should be provided in order to promote muscle protein synthesis due to anabolic resistance.”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [151]
Increased dietary protein can prevent weight loss-induced sarcopenia.
“Increased dietary protein can prevent weight loss-induced sarcopenia.”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [151]

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Authors: Paddon-Jones, D., & Rasmussen, B. B.
Affiliations: The University of Texas Medical Branch at Galveston (US)
ORCID: Rasmussen, Blake B
Venue: Current Opinion in Clinical Nutrition & Metabolic Care
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-01
Volume: 12
Issue: 1
Pages: 86-90
ISSN: 1363-1950 (ISSN-L)
DOI: 10.1097/mco.0b013e32831cef8b
PMC: PMC2760315
OpenAlex: W2133222708
Cited by: 823
References: 57
Citations by year: 2026: 16 · 2025: 22 · 2024: 44 · 2023: 38 · 2022: 57 · 2021: 52 · 2020: 61 · 2019: 49 · 2018: 64 · 2017: 71 · 2016: 60 · 2015: 58 · 2014: 66 · 2013: 52 · 2012: 53
FWCI: 1.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P30AG024832)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049877)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: sarcopenia, dietary protein, muscle protein synthesis, aging, skeletal muscle mass, leucine supplementation, RDA
MeSH terms: Aged, Aging, Dietary Proteins, Humans, Leucine, Muscle Proteins, Muscular Atrophy, Protein Deficiency, Exercise, Nutrition Policy, Dietary Supplements

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Dietary protein recommendations and the prevention of sarcopenia

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