The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Evaluating the glucose tolerance test in mice
Abstract
The objective of this study was to determine the optimal conditions under which to assess glucose tolerance in chow- and high-fat-fed C57BL/6J mice. Mice were fed either chow or high-fat diet for 8 wk. Variables tested were fasting duration (0-, 3-, 6-, and 24-h and overnight fasting), route of administration (intraperitoneal vs. oral) load of glucose given (2, 1, or 0.5 g/kg and fixed 50-mg dose), and state of consciousness. Basal glucose concentrations were increased in high-fat- compared with chow-fed mice following 6 h of fasting (9.1 ± 0.3 vs. 7.9 ± 0.4 mmol/l P = 0.01). Glucose tolerance was most different and therefore significant ( P = 0.001) in high-fat-fed mice after 6 h of fasting (1,973 ± 96 vs. 1,248 ± 83 mmol·l−1·120 min−1). The difference in glucose tolerance was greater following an OGTT (142%), in contrast to an IPGTT, with a 127% difference between high fat and chow. We also found that administering 2 g/kg of glucose resulted in a greater level of significance ( P = 0.0008) in glucose intolerance in high-fat- compared with chow-fed mice. A fixed dose of 50 mg glucose regardless of body weight was enough to show glucose intolerance in high-fat- vs. chow-fed mice. Finally, high-fat-fed mice showed glucose intolerance compared with their chow-fed counterparts whether they were tested under conscious or anesthetized conditions. We conclude that 2 g/kg glucose administered orally following 6 h of fasting is best to assess glucose tolerance in mice under these conditions.
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Mechanisms linking obesity to insulin resistance and type 2 diabetes
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Antibiotics in early life alter the murine colonic microbiome and adiposity
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In vivo imaging of glucose uptake and metabolism in tumors
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A subset of Kupffer cells regulates metabolism through the expression of CD36
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Metadata
- Authors
- Andrikopoulos, S., Blair, A. R., Deluca, N., Fam, B. C., & Proietto, J.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2008-12
- Volume
- 295
- Issue
- 6
- Pages
- E1323-E1332
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1995375315
- Cited by
- 819
- References
- 32
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- closed
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