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The High-Fat Diet–Fed Mouse
Open accessAbstract
This study characterizes the high-fat diet–fed mouse as a model for impaired glucose tolerance (IGT) and type 2 diabetes. Female C57BL/6J mice were fed a high-fat diet (58% energy by fat) or a normal diet (11% fat). Body weight was higher in mice fed the high-fat diet already after the first week, due to higher dietary intake in combination with lower metabolic efficiency. Circulating glucose increased after 1 week on high-fat diet and remained elevated at a level of ∼1 mmol/l throughout the 12-month study period. In contrast, circulating insulin increased progressively by time. Intravenous glucose challenge revealed a severely compromised insulin response in association with marked glucose intolerance already after 1 week. To illustrate the usefulness of this model for the development of new treatment, mice were fed an orally active inhibitor of dipeptidyl peptidase-IV (LAF237) in the drinking water (0.3 mg/ml) for 4 weeks. This normalized glucose tolerance, as judged by an oral glucose tolerance test, in association with augmented insulin secretion. We conclude that the high-fat diet–fed C57BL/6J mouse model is a robust model for IGT and early type 2 diabetes, which may be used for studies on pathophysiology and development of new treatment.
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Evaluating the glucose tolerance test in mice
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Mouse models in non‐alcoholic fatty liver disease and steatohepatitis research
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Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver
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Metadata
- Authors
- Winzell, M. S., & Ahrén, B.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-12-01
- Volume
- 53
- Issue
- suppl_3
- Pages
- S215-S219
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2159581380
- Cited by
- 1,026
- References
- 2
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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