A subset of Kupffer cells regulates metabolism through the expression of CD36
Open accessAbstract
Tissue macrophages are immune cells whose phenotypes and functions are dictated by origin and niches. However, tissues are complex environments, and macrophage heterogeneity within the same organ has been overlooked so far. Here, we used high-dimensional approaches to characterize macrophage populations in the murine liver. We identified two distinct populations among embryonically derived Kupffer cells (KCs) sharing a core signature while differentially expressing numerous genes and proteins: a major CD206 lo ESAM- population (KC1) and a minor CD206 hi ESAM+ population (KC2). KC2 expressed genes involved in metabolic processes, including fatty acid metabolism both in steady-state and in diet-induced obesity and hepatic steatosis. Functional characterization by depletion of KC2 or targeted silencing of the fatty acid transporter Cd36 highlighted a crucial contribution of KC2 in the liver oxidative stress associated with obesity. In summary, our study reveals that KCs are more heterogeneous than anticipated, notably describing a subpopulation wired with metabolic functions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
KCs, or at least their CD206+ESAM+ subset, actively participate in lipid metabolism.
“This may also have more direct consequences for metabolic injury in hepatocytes, since KCs, or at least their CD206+ESAM+ subset, actively participate in lipid metabolism.77”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [77]
Single-cell RNA sequencing has provided insights into hepatic immune cell heterogeneity, revealing striking alterations particularly in myeloid cells and macrophages in NAFLD.
“A series of elegant studies using single-cell RNA sequencing (scRNA-seq) has provided insights into hepatic immune cell heterogeneity that are unprecedented in their detail, revealing striking alterations, particularly in myeloid cells and macrophages in NAFLD,55–60”
From An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH (2023) · cites this paper as [56]
Kupffer cells comprise subsets/differentiation states, of which the CD206hi ESAM+ subtype in mice participates in fatty acid metabolism and may thereby directly drive NASH.
“Kupffer cells comprise subsets/differentiation states, of which the CD206hi ESAM+ subtype (in mice) participates in fatty acid metabolism and may thereby directly drive NASH.56”
From An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH (2023) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179 · see citing works
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453 · see citing works
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174 · see citing works
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781 · see citing works
Scenic: single-cell regulatory network inference and clustering.
Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520 · see citing works
Dimensionality reduction for visualizing single-cell data using UMAP
Becht, E., McInnes, L., Healy, J., Dutertre, C.-A., Kwok, I. W. H., Ng, L. G., Ginhoux, F., & Newell, E. W. (2019) · Nature Biotechnology · doi:10.1038/nbt.4314 · Cited by 5,358 · see citing works
Self-citationFull-length RNA-seq from single cells using Smart-seq2
Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137 · see citing works
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
The Tabula Muris Consortium, coordination, O., coordination, L., processing, O. C. A., sequencing, L. P. A., analysis, C. D., annotation, C. T., Writing group, Supplemental text writing group, & Principal investigators (2018) · Nature · doi:10.1038/s41586-018-0590-4 · Cited by 3,326 · see citing works
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
Picelli, S., Björklund, Å. K., Faridani, O. R., Sagasser, S., Winberg, G., & Sandberg, R. (2013) · Nature Methods · doi:10.1038/nmeth.2639 · Cited by 2,358 · see citing works
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · see citing works
Self-citationResolving the fibrotic niche of human liver cirrhosis at single-cell level
Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1631-3 · Cited by 1,784 · see citing works
Mapping the Mouse Cell Atlas by Microwell-Seq
Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.001 · Cited by 1,597 · see citing works
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552 · see citing works
Liver Macrophages in Tissue Homeostasis and Disease
Krenkel, O., & Tacke, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.11 · Cited by 1,424 · see citing works
Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377 · see citing works
Self-citationCD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Silverstein, R. L., & Febbraio, M. (2009) · Science Signaling · doi:10.1126/scisignal.272re3 · Cited by 1,247 · see citing works
A human liver cell atlas reveals heterogeneity and epithelial progenitors
Aizarani, N., Saviano, A., Sagar, Mailly, L., Durand, S., Herman, J. S., Pessaux, P., Baumert, T. F., & Grün, D. (2019) · Nature · doi:10.1038/s41586-019-1373-2 · Cited by 1,147 · see citing works
Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F. F., See, P., Beaudin, A. E., Lum, J., Low, I., Forsberg, E. C., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.011 · Cited by 1,135 · see citing works
Self-citationChakarov, S., Lim, H. Y., Tan, L., Lim, S. Y., See, P., Lum, J., Zhang, X.-M., Foo, S., Nakamizo, S., Duan, K., et al. (2019) · Science · doi:10.1126/science.aau0964 · Cited by 1,114 · see citing works
Self-citationKunjathoor, V., Febbraio, M., Podrez, E., Moore, K., Andersson, L., Koehn, S. L., Rhee, J. S., Silverstein, R., Hoff, H., & Freeman, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209649200 · Cited by 1,064 · see citing works
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
Halpern, K. B., Shenhav, R., Matcovitch-Natan, O., Tóth, B., Lemze, D., Golan, M., Massasa, E. E., Baydatch, S., Landen, S., Moor, A. E., et al. (2017) · Nature · doi:10.1038/nature21065 · Cited by 1,059 · see citing works
Cell-type-specific isolation of ribosome-associated mRNA from complex tissues
Sanz, E., Yang, L., Su, T., Morris, D. R., McKnight, G. S., & Amieux, P. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907143106 · Cited by 982 · see citing works
Specification of tissue-resident macrophages during organogenesis
Mass, E., Ballesteros, I., Farlik, M., Halbritter, F., Günther, P., Crozet, L., Jacome-Galarza, C. E., Händler, K., Klughammer, J., Kobayashi, Y., et al. (2016) · Science · doi:10.1126/science.aaf4238 · Cited by 891 · see citing works
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10321 · Cited by 860 · see citing works
Evaluating the glucose tolerance test in mice
Andrikopoulos, S., Blair, A. R., DeLuca, N., Fam, B. C., & Proietto, J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90617.2008 · Cited by 824 · see citing works
Xiong, X., Kuang, H., Ansari, S., Liu, T., Gong, J., Wang, S., Zhao, X.-Y., Ji, Y., Li, C., Guo, L., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.028 · Cited by 784 · see citing works
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells
Liu, Z., Gu, Y., Chakarov, S., Bleriot, C., Kwok, I., Chen, X., Shin, A., Huang, W., Dress, R. J., Dutertre, C.-A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.009 · Cited by 719 · see citing works
Self-citationCross-tissue single-cell landscape of human monocytes and macrophages in health and disease
Mulder, K., Patel, A. A., Kong, W. T., Piot, C., Halitzki, E., Dunsmore, G., Khalilnezhad, S., Irac, S. E., Dubuisson, A., Chevrier, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.07.007 · Cited by 678 · see citing works
Self-citationSharma, A., Seow, J. J. W., Dutertre, C.-A., Pai, R., Blériot, C., Mishra, A., Wong, R. M. M., Singh, G. S. N., Sudhagar, S., Khalilnezhad, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.040 · Cited by 677 · see citing works
Self-citationBonnardel, J., T’Jonck, W., Gaublomme, D., Browaeys, R., Scott, C. L., Martens, L., Vanneste, B., De Prijck, S., Nedospasov, S. A., Kremer, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.017 · Cited by 631 · see citing works
Metabolic zonation of the liver: Regulation and implications for liver function
Gebhardt, R. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90055-5 · Cited by 607 · see citing works
Remmerie, A., Martens, L., Thoné, T., Castoldi, A., Seurinck, R., Pavie, B., Roels, J., Vanneste, B., De Prijck, S., Vanhockerhout, M., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.004 · Cited by 592 · see citing works
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
Aouadi, M., Tesz, G. J., Nicoloro, S. M. C., Wang, M., Chouinard, M., Soto, E. R., Ostroff, G. R., & Czech, M. (2009) · Nature · doi:10.1038/nature07774 · Cited by 572 · see citing works
Self-citationWan, J., Benkdane, M., Teixeira-Clerc, F., Bonnafous, S., Louvet, A., Lafdil, F., Pecker, F., Tran, A., Gual, P., Mallat, A., et al. (2014) · Hepatology · doi:10.1002/hep.26607 · Cited by 558 · see citing works
Lewis, K. L. T., Caton, M. L., Bogunovic, M., Greter, M., Grajkowska, L. T., Ng, D., Klinakis, A., Charo, I. F., Jung, S., Gommerman, J. L., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.013 · Cited by 538 · see citing works
Wang, J., & Kubes, P. (2016) · Cell · doi:10.1016/j.cell.2016.03.009 · Cited by 537 · see citing works
Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
Rada, P., González‐Rodríguez, Á., García‐Monzón, C., & Valverde, Á. M. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03003-w · Cited by 522 · see citing works
A Mouse Model of Diet-Induced Obesity and Insulin Resistance
Wang, C., & Liao, J. K. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-430-8_27 · Cited by 519 · see citing works
Determinants of resident tissue macrophage identity and function
Blériot, C., Chakarov, S., & Ginhoux, F. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.014 · Cited by 507 · see citing works
Self-citationAnimal models of nonalcoholic fatty liver disease
Hebbard, L., & George, J. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.191 · Cited by 495 · see citing works
Blériot, C., Dupuis, T., Jouvion, G., Eberl, G., Disson, O., & Lecuit, M. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.020 · Cited by 471 · see citing works
Self-citationSeidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.001 · Cited by 443 · see citing works
Kim, K., Shim, D., Lee, J. S., Zaitsev, K., Williams, J. W., Kim, K.-W., Jang, M.-Y., Seok Jang, H., Yun, T. J., Lee, S. H., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.312804 · Cited by 434 · see citing works
Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.002 · Cited by 418 · see citing works
Does niche competition determine the origin of tissue-resident macrophages?
Guilliams, M., & Scott, C. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.42 · Cited by 409 · see citing works
Tran, S., Baba, I., Poupel, L., Dussaud, S., Moreau, M., Gélineau, A., Marcelin, G., Magréau-Davy, E., Ouhachi, M., Lesnik, P., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.003 · Cited by 400 · see citing works
Self-citationLim, H. Y., Lim, S. Y., Tan, C. K., Thiam, C. H., Goh, C. C., Carbajo, D., Chew, S. H. S., See, P., Chakarov, S., Wang, X. N., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.06.008 · Cited by 384 · see citing works
Self-citationLiposomes for Specific Depletion of Macrophages from Organs and Tissues
van Rooijen, N., & van Kesteren-Hendrikx, E. M. L. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-360-2_13 · Cited by 381 · see citing works
Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells
Halpern, K. B., Shenhav, R., Massalha, H., Toth, B., Egozi, A., Massasa, E. E., Medgalia, C., David, E., Giladi, A., Moor, A. E., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4231 · Cited by 368 · see citing works
Cytofkit: A Bioconductor Package for an Integrated Mass Cytometry Data Analysis Pipeline
Chen, H., Lau, M. C., Wong, M. T., Newell, E. W., Poidinger, M., & Chen, J. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005112 · Cited by 343 · see citing works
Self-citationHemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells
Gentek, R., Ghigo, C., Hoeffel, G., Bulle, M. J., Msallam, R., Gautier, G., Launay, P., Chen, J., Ginhoux, F., & Bajénoff, M. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.025 · Cited by 328 · see citing works
Self-citationKlein, I., Cornejo, J. C., Polakos, N. K., John, B., Wuensch, S. A., Topham, D. J., Pierce, R. H., & Crispe, I. N. (2007) · Blood · doi:10.1182/blood-2007-02-073841 · Cited by 326 · see citing works
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages
Scott, C. L., T’Jonck, W., Martens, L., Todorov, H., Sichien, D., Soen, B., Bonnardel, J., Prijck, S. D., Vandamme, N., Cannoodt, R., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.004 · Cited by 287 · see citing works
Phagocytosis imprints heterogeneity in tissue-resident macrophages
A-González, N., Quintana, J. A., Garcı́a-Silva, S., Mazariegos, M. S., de la Aleja, A. G., Nicolás-Ávila, J. Á., Walter, W., Adrover, J. M., Crainiciuc, G., Kuchroo, V. K., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161375 · Cited by 282 · see citing works
Beattie, L., Sawtell, A. K., Mann, J., Frame, T. C. M., Teal, B. E., Rivera, F. D. L., Brown, N., Walwyn-Brown, K., Moore, J. W. J., Macdonald, S. J., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.037 · Cited by 258 · see citing works
Sierro, F., Evrard, M., Rizzetto, S., Melino, M., Mitchell, A. J., Flórido, M., Beattie, L., Walters, S. B., Tay, S. S., Lü, B., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.018 · Cited by 256 · see citing works
Self-citationLonardo, A., Byrne, C. D., Caldwell, S. H., Cortez‐Pinto, H., & Targher, G. (2016) · Hepatology · doi:10.1002/hep.28584 · Cited by 243 · see citing works
Heterogeneity of liver parenchymal cells
Jungermann, K. A., & Sasse, D. (1978) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(78)91764-4 · Cited by 221 · see citing works
Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies
Haimon, Z., Volaski, A., Orthgiess, J., Boura-Halfon, S., Varol, D., Shemer, A., Yona, S., Zuckerman, B., David, E., Chappell-Maor, L., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0110-6 · Cited by 209 · see citing works
David, B. A., Rezende, R. M., Antunes, M. M., Santos, M. M., Lopes, M. A. F., Diniz, A. B., Pereira, R. V. S., Marchesi, S. C., Alvarenga, D. M., Nakagaki, B. N., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.08.024 · Cited by 205 · see citing works
Han, Y., Kim, H., Na, H., Nam, M.-W., Kim, J.-Y., Kim, J.-S., Koo, S., & Lee, M.-O. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.017 · Cited by 150 · see citing works
Acute liver failure is regulated by MYC- and microbiome-dependent programs
Kolodziejczyk, A. A., Federici, S., Zmora, N., Mohapatra, G., Dori-Bachash, M., Hornstein, S., Leshem, A., Reuveni, D., Zigmond, E., Tobar, A., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1102-2 · Cited by 148 · see citing works
Simone, G. D., Andreata, F., Blériot, C., Fumagalli, V., Laura, C., Garcia-Manteiga, J., Lucia, P. D., Gilotto, S., Ficht, X., Ponti, F. F. D., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.005 · Cited by 139 · see citing works
Self-citationLiver macrophages regulate systemic metabolism through non-inflammatory factors
Morgantini, C., Jager, J., Li, X., Levi, L., Azzimato, V., Sulen, A., Barreby, E., Xu, C., Tencerová, M., Näslund, E. B., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0044-9 · Cited by 113 · see citing works
Self-citationGlucan particles for selective delivery of siRNA to phagocytic cells in mice
Tesz, G. J., Aouadi, M., Prot, M., Nicoloro, S. M. C., Boutet, E., Amano, S. U., Goller, A., Wang, M., Guo, C., Salomon, W. E., et al. (2011) · Biochemical Journal · doi:10.1042/bj20110352 · Cited by 111 · see citing works
Self-citation(2020) · doi:10.1016/j.celrep.2020.03.063 · Cited by 111 · see citing works
Self-citationUnderstanding the heterogeneity of resident liver macrophages
Blériot, C., & Ginhoux, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02694 · Cited by 107 · see citing works
Self-citationNon-alcoholic steatohepatitis induces transient changes within the liver macrophage pool
Devisscher, L., Scott, C. L., Lefere, S., Raevens, S., Bogaerts, E., Paridaens, A., Verhelst, X., Geerts, A. M., Guilliams, M., & Vlierberghe, H. V. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.10.006 · Cited by 104 · see citing works
Isolation of Kupffer Cells and Hepatocytes from a Single Mouse Liver
Aparicio-Vergara, M., Tencerová, M., Morgantini, C., Barreby, E., & Aouadi, M. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7163-3_16 · Cited by 102 · see citing works
Self-citationCheng, Y., Wong, M. T., van der Maaten, L., & Newell, E. W. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501928 · Cited by 67 · see citing works
Self-citationActivated Kupffer cells inhibit insulin sensitivity in obese mice
Tencerová, M., Aouadi, M., Vangala, P., Nicoloro, S. M. C., Yawe, J. C., Cohen, J. L., Shen, Y., Garcia‐Menendez, L., Pedersen, D. J., Gallagher-Dorval, K. A., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-270496 · Cited by 65 · see citing works
Self-citationCOMBAT: A Combined Association Test for Genes Using Summary Statistics
Wang, M., Huang, J., Liu, Y., Ma, L., Potash, J. B., & Han, S. (2017) · Genetics · doi:10.1534/genetics.117.300257 · Cited by 60 · see citing works
Azzimato, V., Jager, J., Chen, P., Morgantini, C., Levi, L., Barreby, E., Sulen, A., Oses, C., Willerbrords, J., Xu, C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw9709 · Cited by 55 · see citing works
Self-citationLynch, R. W., Hawley, C. A., Pellicoro, A., Bain, C. C., Iredale, J. P., & Jenkins, S. J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ta0517-169r · Cited by 53 · see citing works
Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice
Jourdan, T., Nicoloro, S. M. C., Zhou, Z., Shen, Y., Liu, J., Coffey, N. J., Çınar, R., Godlewski, G., Gao, B., Aouadi, M., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.08.011 · Cited by 49 · see citing works
Self-citationHuman Liver Macrophage Subsets Defined by CD32
Wu, X., Hollingshead, N., Roberto, J. B., Knupp, A., Kenerson, H. L., Chen, A., Strickland, I., Horton, H., Yeung, R. S. W., Soysa, R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02108 · Cited by 34 · see citing works
Okada, T., Kimura, A., Kanki, K., Nakatani, S., Nagahara, Y., Hiraga, M., & Watanabe, Y. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12402 · Cited by 13 · see citing works
Barreby, E., Sulen, A., & Aouadi, M. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9130-3_4 · Cited by 10 · see citing works
Self-citationKupffer Cell Characterization by Mass Cytometry
Blériot, C., Li, S., Kairi, M. F. B. M., Newell, E. W., & Ginhoux, F. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0704-6_10 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
Guilliams, M., Bonnardel, J., Haest, B., Vanderborght, B., Wagner, C., Remmerie, A., Bujko, A., Martens, L., Thoné, T., Browaeys, R., et al. (2022) · Cell · doi:10.1016/j.cell.2021.12.018 · Cited by 985 · see citing works
Hepatic inflammatory responses in liver fibrosis
Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803 · see citing works
Macrophages in health and disease
Park, M. D., Silvin, A., Ginhoux, F., & Merad, M. (2022) · Cell · doi:10.1016/j.cell.2022.10.007 · Cited by 644 · see citing works
Self-citationTissue-specific macrophages: how they develop and choreograph tissue biology
Mass, E., Nimmerjahn, F., Kierdorf, K., & Schlitzer, A. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00848-y · Cited by 621 · see citing works
Peiseler, M., Schwabe, R., Hampe, J., Kubes, P., Heikenwälder, M., & Tacke, F. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.06.012 · Cited by 564 · see citing works
Liver macrophages in health and disease
Guilliams, M., & Scott, C. L. (2022) · Immunity · doi:10.1016/j.immuni.2022.08.002 · Cited by 395 · see citing works
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371 · see citing works
Self-citationRoles of macrophages in tumor development: a spatiotemporal perspective
Bied, M., Ho, W. W., Ginhoux, F., & Blériot, C. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01061-6 · Cited by 360 · see citing works
Self-citationLiver diseases: epidemiology, causes, trends and predictions
Gan, C., Yuan, Y., Shen, H., Gao, J., Kong, X., Che, Z., Guo, Y., Wang, H., Dong, E., & Xiao, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02072-z · Cited by 370 · see citing works
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH
Tacke, F., Puengel, T., Loomba, R., & Friedman, S. L. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.038 · Cited by 321 · see citing works
Macrophage functional diversity in NAFLD — more than inflammation
Barreby, E., Chen, P., & Aouadi, M. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00675-6 · Cited by 246 · see citing works
Self-citationLiver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies
Parola, M., & Pinzani, M. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101231 · Cited by 226 · see citing works
Simone, G. D., Andreata, F., Blériot, C., Fumagalli, V., Laura, C., Garcia-Manteiga, J., Lucia, P. D., Gilotto, S., Ficht, X., Ponti, F. F. D., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.005 · Cited by 139 · see citing works
Self-citationPeriportal macrophages protect against commensal-driven liver inflammation
Miyamoto, Y., Kikuta, J., Matsui, T., Hasegawa, T., Fujii, K., Okuzaki, D., Liu, Y.-C., Yoshioka, T., Seno, S., Motooka, D., et al. (2024) · Nature · doi:10.1038/s41586-024-07372-6 · Cited by 135 · see citing works
Guillot, A., Winkler, M., Silva Afonso, M., Aggarwal, A., Lopez, D., Berger, H., Kohlhepp, M. S., Liu, H., Özdirik, B., Eschrich, J., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000270 · Cited by 116 · see citing works
Understanding the cellular interactome of non-alcoholic fatty liver disease
Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100524 · Cited by 116 · see citing works
Qian, Y., Yin, Y., Zheng, X., Liu, Z., & Wang, X. (2024) · Biomarker Research · doi:10.1186/s40364-023-00549-7 · Cited by 115 · see citing works
Self-citationGuo, W., Li, Z., Anagnostopoulos, G., Kong, W. T., Zhang, S., Chakarov, S., Shin, A., Qian, J., Zhu, Y., Bai, W., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.08.016 · Cited by 109 · see citing works
Self-citationHeterogeneity and Function of Kupffer Cells in Liver Injury
Li, W., Chang, N., & Li, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940867 · Cited by 102 · see citing works
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity
Zhao, J., Andreev, I., & Silva, H. M. (2024) · Science Immunology · doi:10.1126/sciimmunol.add1967 · Cited by 104 · see citing works
Lipid-associated macrophages between aggravation and alleviation of metabolic diseases
Xu, R., Vujić, N., Bianco, V., Reinisch, I., Kratky, D., Krstić, J., & Prokesch, A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.04.009 · Cited by 103 · see citing works
Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease
Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052668 · Cited by 95 · see citing works
The Multifaceted Roles of Macrophages in NAFLD Pathogenesis
Vonderlin, J., Chavakis, T., Sieweke, M., & Tacke, F. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.03.002 · Cited by 96 · see citing works
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair
De Ponti, F. F., Bujko, A., Liu, Z., Collins, P. J., Schuermans, S., Maueroder, C., Amstelveen, S., Thoné, T., Martens, L., McKendrick, J. G., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.01.002 · Cited by 94 · see citing works
Self-citationRole of adipose tissue macrophages in obesity-related disorders
Chakarov, S., Blériot, C., & Ginhoux, F. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211948 · Cited by 86 · see citing works
Self-citationImmunopathogenic mechanisms and immunoregulatory therapies in MASLD
He, Y., Chen, Y., Qian, S., van Der Merwe, S., Dhar, D., Brenner, D. A., & Tacke, F. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01307-5 · Cited by 81 · see citing works
“…population (KC1) and a minor CD206 high ESAM + population (KC2), only KC2-expressing genes are involved in liver metabolism regulation, including fatty acid metabolism both in steady-state and in diet-induced obesity in mice, as well as steatosis induction via the fatty acid transporter CD36 [52].”
Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils
Ng, L. G., Liu, Z., Kwok, I., & Ginhoux, F. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-081022-113627 · Cited by 85 · see citing works
Self-citationMacrophage heterogeneity in the single-cell era: facts and artifacts
Hume, D. A., Millard, S. M., & Pettit, A. R. (2023) · Blood · doi:10.1182/blood.2023020597 · Cited by 78 · see citing works
The nuclear factor ID3 endows macrophages with a potent anti-tumour activity
Deng, Z., Loyher, P.-L., Lazarov, T., Li, L., Shen, Z., Bhinder, B., Yang, H., Zhong, Y., Alberdi, A., Massagué, J., et al. (2024) · Nature · doi:10.1038/s41586-023-06950-4 · Cited by 75 · see citing works
Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury
Li, W., Yang, Y., Yang, L., Chang, N., & Li, L. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113164 · Cited by 74 · see citing works
Liu, C., Schönke, M., Spoorenberg, B., Lambooij, J. M., van der Zande, H. J. P., Zhou, E., Tushuizen, M. E., Andréasson, A., Park, A., Oldham, S. N., et al. (2023) · eLife · doi:10.7554/elife.83075 · Cited by 72 · see citing works
Mejía-Guzmán, J. E., Belmont-Hernández, R. A., Chávez-Tapia, N. C., Uribe, M., & Nuño‐Lámbarri, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072959 · Cited by 72 · see citing works
In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
Kaur, S., Kidambi, S., Ortega‐Ribera, M., Thủy, L. T. T., Nieto, N., Cogger, V. C., Xie, W., Tacke, F., & Gracia‐Sancho, J. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.11.008 · Cited by 67 · see citing works
Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection
Heieis, G. A., Patente, T. A., Almeida, L., Vrieling, F., Tak, T., Perona‐Wright, G., Maizels, R. M., Stienstra, R., & Everts, B. (2023) · Nature Communications · doi:10.1038/s41467-023-41353-z · Cited by 65 · see citing works
Systemic mechanisms of necrotic cell debris clearance
Schuermans, S., Kestens, C., & Marques, P. E. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06947-5 · Cited by 63 · see citing works
Spatially resolved multi-omics of human metabolic dysfunction-associated steatotic liver disease
Li, Z., Luo, G., Gan, C., Zhang, H., Li, L., Zhang, X., Xing, X., Hu, S., Tan, X., Ding, J., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02407-8 · Cited by 61 · see citing works
Self-citationBiology of resident tissue macrophages
Lee, C., & Ginhoux, F. (2022) · Development · doi:10.1242/dev.200270 · Cited by 62 · see citing works
Self-citationReprogramming of Hepatic Metabolism and Microenvironment in Nonalcoholic Steatohepatitis
Rui, L., & Lin, J. D. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-105200 · Cited by 56 · see citing works
Autophagy Dysregulation in Metabolic Associated Fatty Liver Disease: A New Therapeutic Target
Chen, C., & Lin, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710055 · Cited by 57 · see citing works
Locally sourced: site-specific immune barriers to metastasis
Correia, A. L. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00836-2 · Cited by 58 · see citing works
Treating inflammation to combat non-alcoholic fatty liver disease
Wiering, L., & Tacke, F. (2022) · Journal of Endocrinology · doi:10.1530/joe-22-0194 · Cited by 58 · see citing works
The roles of tissue resident macrophages in health and cancer
Cao, M., Wang, Z., Lan, W., Xiang, B., Liao, W., Zhou, J., Liu, X., Wang, Y., Zhang, S., Lu, S., et al. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00469-0 · Cited by 56 · see citing works
Liebold, I., Meyer, S., Heine, M., Kuhl, A., Witt, J., Eissing, L., Fischer, A., Koop, A., Kluwe, J., Schulze zur Wiesch, J., et al. (2023) · Cells · doi:10.3390/cells12030341 · Cited by 55 · see citing works
Priming and Maintenance of Adaptive Immunity in the Liver
Kawashima, K., Andreata, F., Beccaría, C. G., & Iannacone, M. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090122-041354 · Cited by 55 · see citing works
Self-citationMacrophages as key regulators of liver health and disease
Papachristoforou, E., & Ramachandran, P. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.04.006 · Cited by 55 · see citing works
Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke
Li, R., Wei, R., Liu, C., Zhang, K., He, S., Liu, Z., Huang, J., Tang, Y., An, Q., Lin, L., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.007 · Cited by 53 · see citing works
Self-citationInflammatory and immune etiology of type 2 diabetes
Blériot, C., Dalmas, É., Ginhoux, F., & Venteclef, N. (2023) · Trends in Immunology · doi:10.1016/j.it.2022.12.004 · Cited by 51 · see citing works
Self-citationCheng, S. G., Zou, Y., Zhang, M., Bai, S., Tao, K., Wu, J., Shi, Y., Wu, Y., Lu, Y., He, K., et al. (2023) · MedComm · doi:10.1002/mco2.378 · Cited by 50 · see citing works
Liver macrophages: development, dynamics, and functions
Nusse, Y., & Kubes, P. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01298-3 · Cited by 50 · see citing works
Meyer, M., Schwärzler, J., Jukic, A., & Tilg, H. (2024) · Biomolecules · doi:10.3390/biom14040476 · Cited by 50 · see citing works
Adipose tissue macrophage dysfunction is associated with a breach of vascular integrity in NASH
Boesch, M., Lindhorst, A., Feio‐Azevedo, R., Brescia, P., Silvestri, A., Lannoo, M., Deleus, E., Jaekers, J., Topal, H., Topal, B., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.10.039 · Cited by 48 · see citing works
Understanding the complex macrophage landscape in MASLD
Ponti, F. F. D., Liu, Z., & Scott, C. L. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101196 · Cited by 51 · see citing works
Self-citationAn Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche
Elchaninov, A. V., Vishnyakova, P., Menyailo, E., Sukhikh, G. T., & Fatkhudinov, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179868 · Cited by 47 · see citing works
Antifibrotic therapies for metabolic dysfunction-associated steatotic liver disease
Schwabe, R. F., Tacke, F., Sugimoto, A., & Friedman, S. L. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101421 · Cited by 50 · see citing works
Guillot, A., & Tacke, F. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000491 · Cited by 45 · see citing works
The Gut–Liver Axis in Chronic Liver Disease: A Macrophage Perspective
Muynck, K. D., Vanderborght, B., Vlierberghe, H. V., & Devisscher, L. (2021) · Cells · doi:10.3390/cells10112959 · Cited by 47 · see citing works
Inflammation in MASLD progression and cancer
Kim, Y., Park, Y., Rho, H., Yao, T., Gao, B., & Hwang, S. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101414 · Cited by 61 · see citing works
The Dual Role of Innate Immune Response in Acetaminophen-Induced Liver Injury
Yang, T., Wang, H., Wang, X., Li, J., & Jiang, L. (2022) · Biology · doi:10.3390/biology11071057 · Cited by 45 · see citing works
Programmed cell death and lipid metabolism of macrophages in NAFLD
Xiao, Z., Liu, M., Yang, F., Liu, G., Liu, J., Zhao, W., Ma, S., & Duan, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1118449 · Cited by 41 · see citing works
Spatial dimension of macrophage heterogeneity in liver diseases
Guillot, A., & Tacke, F. (2023) · eGastroenterology · doi:10.1136/egastro-2023-000003 · Cited by 40 · see citing works
Hu, S., Yang, Z., Li, L., Yan, Q.-W., Hu, Y., Zhou, F., Tan, Y., & Pei, G. (2024) · Molecules · doi:10.3390/molecules29010236 · Cited by 40 · see citing works
Resident macrophages of the lung and liver: The guardians of our tissues
Kulle, A., Thanabalasuriar, A., Cohen, T. S., & Szydlowska, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1029085 · Cited by 39 · see citing works
Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression
Li, J., Karakas, D., Xue, F., Chen, Y., Zhu, G., Yücel, Y. H., MacParland, S. A., Zhang, H., Semple, J. W., Freedman, J. J., et al. (2023) · Research · doi:10.34133/research.0236 · Cited by 37 · see citing works
TREM2 macrophages mediate the beneficial effects of bariatric surgery against MASH
Fredrickson, G., Florczak, K. L., Barrow, F., Mahmud, S., DIETSCHE, K. B., Wang, H., Parthiban, P., Hakeem, A. N., Almutlaq, R. N., Adeyi, O. A., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000001098 · Cited by 37 · see citing works
The versatility of macrophage heterogeneity in liver fibrosis
Gao, C.-C., Bai, J., Han, H., & Qin, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.968879 · Cited by 37 · see citing works
Macrophages and the development and progression of non-alcoholic fatty liver disease
Alabdulaali, B., Al‐Rashed, F., Al‐Onaizi, M., Kandari, A., Razafiarison, J., Tonui, D., Williams, M. R., Blériot, C., Ahmad, R., & Alzaïd, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1195699 · Cited by 35 · see citing works
Self-citationDecoding the multiple functions of ZBP1 in the mechanism of sepsis-induced acute lung injury
Gong, T., Fu, Y., Wang, Q., Loughran, P., Li, Y., Billiar, T. R., Wen, Z., Liu, Y., & Fan, J. (2024) · Communications Biology · doi:10.1038/s42003-024-07072-x · Cited by 35 · see citing works
Septal LYVE1 + macrophages control adipocyte stem cell adipogenic potential
Yu, X., Hu, Y., Lim, H. Y., Li, Z., Jaitin, D. A., Yang, K. L., Kong, W. T., Xu, J., Bejarano, D. A., Bied, M., et al. (2025) · Science · doi:10.1126/science.adg1128 · Cited by 35 · see citing works
Self-citationEicosanoids and other oxylipins in liver injury, inflammation and liver cancer development
Alba, M. M., Ebright, B., Hua, B., Slarve, I., Zhou, Y., Jia, Y., Louie, S. G., & Stiles, B. L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1098467 · Cited by 32 · see citing works
Therapeutic modulation of the liver immune microenvironment
Tilg, H., Adolph, T. E., & Tacke, F. (2023) · Hepatology · doi:10.1097/hep.0000000000000386 · Cited by 31 · see citing works
Regulation of systemic metabolism by tissue-resident immune cell circuits
Li, J. H., Hepworth, M. R., & O’Sullivan, T. E. (2023) · Immunity · doi:10.1016/j.immuni.2023.05.001 · Cited by 34 · see citing works
Kim, S. H., White, Z., Gainullina, A., Kang, S., Kim, J., Dominguez, J. R., Choi, Y., Cabrera, I., Plaster, M., Takahama, M., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.004 · Cited by 34 · see citing works
Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells
Hume, D. A., Offermanns, S., & Bonnavion, R. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.010 · Cited by 31 · see citing works
Efferocytosis in liver disease
Shi, H., Moore, M. P., Wang, X., & Tabas, I. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2023.100960 · Cited by 30 · see citing works
The diverse roles of macrophages in metabolic inflammation and its resolution
Guha-Ray, A., Odum, O., Wiseman, D., & Weinstock, A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147434 · Cited by 29 · see citing works
Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells
Li, Z., Ruan, B., Yang, P., Liu, J., Song, P., Duan, J., & Wang, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01621-2 · Cited by 29 · see citing works
Kohlhepp, M. S., Liu, H., Tacke, F., & Guillot, A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1129831 · Cited by 27 · see citing works
The role of macrophages in liver fibrosis: composition, heterogeneity, and therapeutic strategies
Ma, X., Qiu, J., Zou, S., Tan, L., & Miao, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1494250 · Cited by 26 · see citing works
Romeo, M., Silvestrin, A., Senese, G., Nardo, F. D., Napolitano, C., Vaia, P., Coppola, A., Federico, P., Dallio, M., & Federico, A. (2025) · Biomedicines · doi:10.3390/biomedicines13082004 · Cited by 28 · see citing works
Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis
Araujo David, B., Atif, J., Vargas e Silva Castanheira, F., Yasmin, T., Guillot, A., Ait Ahmed, Y., Peiseler, M., Hommes, J. W., Salm, L., Brundler, M.-A., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adq9704 · Cited by 25 · see citing works
Self-citationKupffer cells, the limelight in the liver regeneration
Zhao, Y., Zhao, S., Liu, S., Ye, W., & Chen, W. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113808 · Cited by 25 · see citing works
Key role of macrophages in the progression of hepatic fibrosis
Ran, J., Yin, S., Issa, R., Zhao, Q., Zhu, G., Zhang, H., Zhang, Q., Wu, C., & Li, J. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000602 · Cited by 24 · see citing works
Chen, D., Lü, Z., Zhao, Y., Xia, L., Liu, C., Zuo, S., Jin, M., Jia, H., Li, S., Zhang, S., et al. (2024) · Advanced Science · doi:10.1002/advs.202306066 · Cited by 23 · see citing works
Liu, H., Yin, G., Franco Leonardi, B., Lan, T., Ait Ahmed, Y., Berger, H., Kohlhepp, M. S., Amiridze, N., Martagón Calderón, N., Frau, C., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334425 · Cited by 23 · see citing works
Macrophage metabolism in nonalcoholic fatty liver disease
Zhang, W., & Lang, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1257596 · Cited by 24 · see citing works
Metabolic homeostasis of tissue macrophages across the lifespan
Wculek, S. K., Forisch, S., Miguel, V., & Sancho, D. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.04.017 · Cited by 23 · see citing works
Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers
David, B. A., Andreata, F., Blériot, C., Ginhoux, F., Kubes, P., & Iannacone, M. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01288-0 · Cited by 22 · see citing works
Self-citationOntogeny, functions and reprogramming of Kupffer cells upon infectious disease
Musrati, M. A., BAETSELIER, P. D., Movahedi, K., & Ginderachter, J. A. V. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1238452 · Cited by 22 · see citing works
Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis
Shimizu, J., Murao, A., Lee, Y., Aziz, M., & Wang, P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1411930 · Cited by 21 · see citing works
Jang, J. H., Sung, J. H., & Huh, J. Y. (2025) · Immune Network · doi:10.4110/in.2025.25.e12 · Cited by 23 · see citing works
Dissecting the mechanisms of MASLD fibrosis in the era of single-cell and spatial omics
Colella, F., Henderson, N. C., & Ramachandran, P. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186421 · Cited by 22 · see citing works
Decoding liver fibrogenesis with single-cell technologies
Zhou, T., Musunuru, K., Lui, K. O., & Ding, Q. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac040 · Cited by 21 · see citing works
Responses of hepatic sinusoidal cells to liver ischemia–reperfusion injury
Ito, Y., Hosono, K., & Amano, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1171317 · Cited by 21 · see citing works
Wu, Y., He, Y., Liu, C., Ehle, C., Iyer-Bierhoff, A., Liu, B., Heinzel, T., & Xing, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512448 · Cited by 20 · see citing works
Physical exercise in liver diseases
Zhang, Y., Cao, C., Li, C., Witt, R. G., Huang, H., Tsung, A., & Zhang, H. (2024) · Hepatology · doi:10.1097/hep.0000000000000941 · Cited by 18 · see citing works
Myeloid cells in chronic liver inflammation
Patseas, D., El-Masry, A., Liu, Z., Ramachandran, P., & Triantafyllou, E. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01324-4 · Cited by 17 · see citing works
Self-citationZhou, Z., Pan, X., & Li, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1070208 · Cited by 17 · see citing works
ScRNA-seq and ST-seq in liver research
He, J., Deng, C., Krall, L., & Shan, Z. (2023) · Cell Regeneration · doi:10.1186/s13619-022-00152-5 · Cited by 17 · see citing works
Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Nunzio, G. D., Hellberg, S., Zhang, Y., Osman, A., Wang, J., Zhang, X., Björck, H. M., Chizh, V., Schipper, R., Aulin, H., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00448-6 · Cited by 17 · see citing works
Self-citationHuman resident liver myeloid cells protect against metabolic stress in obesity
Barreby, E., Strunz, B., Nock, S., Naudet, L., Shen, J. X., Johansson, H., Sönnerborg, I., Ma, J., Urgard, E., Pallett, L. J., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00834-7 · Cited by 15 · see citing works
Self-citation
- Authors
- Blériot, C., Barreby, E., Dunsmore, G., Ballaire, R., Chakarov, S., Ficht, X., De Simone, G., Andreata, F., Fumagalli, V., Guo, W., Wan, G., Gessain, G., Khalilnezhad, A., Zhang, X. M., Ang, N., Chen, P., Morgantini, C., Azzimato, V., Kong, W. T., Liu, Z., Pai, R., Lum, J., Shihui, F., Low, I., Xu, C., Malleret, B., Kairi, M. F. M., Balachander, A., Cexus, O., Larbi, A., Lee, B., Newell, E. W., Ng, L. G., Phoo, W. W., Sobota, R. M., Sharma, A., Howland, S. W., Chen, J., Bajenoff, M., Yvan-Charvet, L., Venteclef, N., Iannacone, M., Aouadi, M., & Ginhoux, F.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Karolinska Institutet (SE)
- Inserm (FR)
- IRCCS Ospedale San Raffaele (IT)
- Vita-Salute San Raffaele University (IT)
- Shanghai Jiao Tong University (CN)
- Genome Institute of Singapore (SG)
- University of Surrey (GB)
- Corresponding author
- Blériot, Camille
- Ginhoux, Florent
- ORCID
- Blériot, Camille
- Barreby, Emelie
- Dunsmore, Garett
- Chakarov, Svetoslav
- Ficht, Xenia
- Andreata, Francesco
- Fumagalli, Valeria
- Guo, Wei
- Khalilnezhad, Ahad
- Zhang, Xiao Meng
- Ang, Nicholas
- Chen, Ping
- Morgantini, Cecilia
- Azzimato, Valerio
- Kong, Wan Ting
- Liu, Zhaoyuan
- Lum, Josephine
- Low, Ivy
- Xu, Connie
- Balachander, Akhila
- Cexus, Olivier
- Larbi, Anis
- Lee, Bernett
- Newell, Evan W.
- Ng, Lai Guan
- Phoo, Wint Wint
- Sobota, Radoslaw M.
- Sharma, Ankur
- Howland, Shanshan W.
- Chen, Jinmiao
- Venteclef, Nicolas
- Iannacone, Matteo
- Aouadi, Myriam
- Ginhoux, Florent
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 54
- Issue
- 9
- Pages
- 2101-2116.e6
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W3198090726
- Cited by
- 236
- References
- 84
- Citations by year
- 2026: 35 · 2025: 56 · 2024: 51 · 2023: 59 · 2022: 31 · 2021: 4
- FWCI
- 13.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 378 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Agency for Science, Technology and Research (NUHSRO/ 2018/006/SU/01, NRFI2017-02)
- Biomedical Research Council (IAF311006, H16/99/b0/011, 16/99/b0/011)
- Horizon 2020 Framework Programme (ERC-EpiFAT 725790, 864788)
- European Molecular Biology Organization
- European Research Council
- Horizon 2020
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Kupffer cells, CD36, fatty acid metabolism, macrophage heterogeneity, hepatic macrophages, CD206, ESAM, diet-induced obesity, hepatic steatosis, oxidative stress
- MeSH terms
- Animals, Kupffer Cells, Liver, Obesity, Oxidative Stress, CD36 Antigens, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
