Flagellin-mediated activation of IL-33-ST2 signaling by a pathobiont promotes intestinal fibrosis
Open accessAbstract
Intestinal fibrosis is a severe complication in patients with Crohn's disease (CD). Unfortunately, the trigger leading to the development of intestinal fibrosis in the context of CD remains elusive. Here, we show that colonization by a CD-associated pathobiont adherent-invasive Escherichia coli (AIEC) promotes the development of intestinal fibrosis. Exogenously inoculated AIEC strain LF82 and commensal E. coli HS were gradually eradicated from the intestine in healthy mice. In Salmonella- or dextran sodium sulfate-induced colitis models, AIEC exploited inflammation and stably colonize the gut. Consequently, persistent colonization by AIEC LF82 led to substantial fibrosis. In contrast, commensal E. coli HS was unable to derive a growth advantage from inflammation, thereby failing to colonize the inflamed intestine or promote intestinal fibrosis. AIEC colonization potentiated the expression of the IL-33 receptor ST2 in the intestinal epithelium, which is crucial for the development of intestinal fibrosis. The induction of ST2 by AIEC LF82 was mediated by flagellin, as the ΔfliC mutant failed to induce ST2. These observations provide novel insights into pathobiont-driven intestinal fibrosis and can lead to the development of novel therapeutic approaches for the treatment of intestinal fibrosis in the context of CD that target AIEC and/or its downstream IL-33-ST2 signaling.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Deletion of TRIF in a diet-induced NASH mouse model reduced hepatic steatosis but increased hepatic fibrosis, and TRIF−/− HSCs expressed higher levels of CXCL1 and C-C motif chemokine ligands in response to LPS.
“Deletion of TRIF in a diet-induced NASH mouse model reduced hepatic steatosis but increased hepatic fibrosis, and TRIF−/− HSCs expressed higher levels of CXCL1 and C-C motif chemokine ligands in response to LPS”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [165]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works
Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,701 · see citing works
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256 · see citing works
Self-citationEpidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741 · see citing works
Control of pathogens and pathobionts by the gut microbiota
Kamada, N., Chen, G. Y., Inohara, N., & Núñez, G. (2013) · Nature Immunology · doi:10.1038/ni.2608 · Cited by 1,625 · see citing works
Self-citationDarfeuille-Michaud, A., Boudeau, J., Bulois, P., Neut, C., Glasser, A.-L., Barnich, N., Bringer, M.-A., Swidsinski, A., Beaugerie, L., & Colombel, J.-F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.061 · Cited by 1,566 · see citing works
Self-citationSimultaneous Identification of Bacterial Virulence Genes by Negative Selection
Hensel, M., Shea, J. E., Gleeson, C., Jones, M. D., Dalton, E. C., & Holden, D. W. (1995) · Science · doi:10.1126/science.7618105 · Cited by 1,200 · see citing works
Moussion, C., Ortega, N., & Girard, J.-P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003331 · Cited by 1,179 · see citing works
Host-Derived Nitrate Boosts Growth of <i>E. coli</i> in the Inflamed Gut
Winter, S. E., Winter, M. G., Xavier, M. N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R. C., Gomez, G., Wu, J., Lawhon, S. D., et al. (2013) · Science · doi:10.1126/science.1232467 · Cited by 1,019 · see citing works
Rasko, D. A., Rosovitz, M. J., Myers, G. S. A., Mongodin, E. F., Fricke, W. F., Gajer, P., Crabtree, J., Sebaihia, M., Thomson, N. R., Chaudhuri, R. R., et al. (2008) · Journal of Bacteriology · doi:10.1128/jb.00619-08 · Cited by 881 · see citing works
Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808 · see citing works
Adherent-invasive Escherichia coli in inflammatory bowel disease
Palmela, C., Chevarin, C., Xu, Z., Torres, J., Sevrin, G., Hirten, R. P., Barnich, N., Ng, S. C., & Colombel, J. (2017) · Gut · doi:10.1136/gutjnl-2017-314903 · Cited by 541 · see citing works
Self-citationMechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases
Rieder, F., Fiocchi, C., & Rogler, G. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.047 · Cited by 534 · see citing works
Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis
Mchedlidze, T., Waldner, M., Zopf, S., Walker, J., Rankin, A. L., Schuchmann, M., Voehringer, D., McKenzie, A. N. J., Neurath, M. F., Pflanz, S., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.018 · Cited by 502 · see citing works
Pastorelli, L., Garg, R. R., Hoang, S. B., Spina, L., Mattioli, B., Scarpa, M., Fiocchi, C., Vecchi, M. L., & Pizarro, T. T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912678107 · Cited by 418 · see citing works
Adherent-invasive Escherichia coli in inflammatory bowel disease
Rolhion, N., & Darfeuille–Michaud, A. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20176 · Cited by 299 · see citing works
Vancamelbeke, M., Vanuytsel, T., Farré, R., Verstockt, S., Ferrante, M., Assche, G. V., Rutgeerts, P. J., Schuit, F. C., Vermeire, S., Arijs, I., et al. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001246 · Cited by 270 · see citing works
Nagao‐Kitamoto, H., Shreiner, A. B., Gillilland, M. G., Kitamoto, S., Ishii, C., Hirayama, A., Kuffa, P., Zaatari, M. E., Grasberger, H., Seekatz, A. M., et al. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.02.003 · Cited by 248 · see citing works
Self-citationCharacterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease
Beltrán, C. J., Núñez, L. E., Díaz-Jiménez, D., Farfán, N., Candía, E., Heine, C., López, F., González, M. J., Quera, R., & Hermoso, M. A. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21175 · Cited by 239 · see citing works
AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition
Chassaing, B., Koren, O., Carvalho, F. A., Ley, R. E., & Gewirtz, A. T. (2013) · Gut · doi:10.1136/gutjnl-2013-304909 · Cited by 219 · see citing works
Sedhom, M. A. K., Pichery, M., Murdoch, J. R., Foligné, B., Ortéga, N., Normand, S., Mertz, K. D., Sanmugalingam, D., Brault, L., Grandjean, T., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301785 · Cited by 211 · see citing works
Fichtner‐Feigl, S., Fuss, I. J., Young, C. A., Watanabe, T., Geissler, E. K., Schlitt, H. J., Kitani, A., & Strober, W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5859 · Cited by 201 · see citing works
Small, C.-L. N., Reid‐Yu, S. A., McPhee, J. B., & Coombes, B. K. (2013) · Nature Communications · doi:10.1038/ncomms2957 · Cited by 187 · see citing works
Mechanisms of initiation and progression of intestinal fibrosis in IBD
Latella, G., Gregorio, J. D., Flati, V., Rieder, F., & Lawrance, I. C. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2014.968863 · Cited by 183 · see citing works
Dreux, N., Denizot, J., Martínez-Medina, M., Mellmann, A., Billig, M., Kisiela, D., Chattopadhyay, S., Sokurenko, E. V., Neut, C., Gower‐Rousseau, C., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003141 · Cited by 177 · see citing works
Self-citationChronic Enteric Salmonella Infection in Mice Leads to Severe and Persistent Intestinal Fibrosis
Graßl, G. A., Valdez, Y., Bergstrom, K., Vallance, B. A., & Finlay, B. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.12.043 · Cited by 157 · see citing works
Denney, L., Byrne, A. J., Shea, T. J., Buckley, J., Pease, J. E., Herledan, G., Walker, S. A., Gregory, L. G., & Lloyd, C. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.012 · Cited by 153 · see citing works
Barnich, N., Boudeau, J., Claret, L., & Darfeuille–Michaud, A. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03468.x · Cited by 148 · see citing works
Self-citationRieder, F., Kessler, S., Sans, M., & Fiocchi, C. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00059.2012 · Cited by 135 · see citing works
Carvalho, F. A., Barnich, N., Sauvanet, P., Darcha, C., Gelot, A., & Darfeuille–Michaud, A. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20423 · Cited by 130 · see citing works
Self-citationRolhion, N., Carvalho, F. A., & Darfeuille–Michaud, A. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05638.x · Cited by 125 · see citing works
Isolation of flagellated bacteria implicated in Crohnʼs disease
Duck, W. L., Walter, M. R., Novák, J., Kelly, D., Tomasi, M., Cong, Y., & Elson, C. O. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20237 · Cited by 121 · see citing works
Seo, D. H., Che, X., Kwak, M. S., Kim, S., Kim, J. H., Ma, H. W., Kim, D. H., Kim, T. I., Kim, W. H., Kim, S. W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00840-2 · Cited by 107 · see citing works
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis
Mindt, B. C., Fritz, J. H., & Duerr, C. U. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00840 · Cited by 93 · see citing works
Sevrin, G., Massier, S., Chassaing, B., Agus, A., Delmas, J., Denizot, J., Billard, E., & Barnich, N. (2018) · Gut Microbes · doi:10.1080/19490976.2017.1421886 · Cited by 91 · see citing works
Self-citationLo, B. C., Gold, M. J., Hughes, M. R., Antignano, F., Valdez, Y., Zaph, C., Harder, K. W., & McNagny, K. M. (2016) · Science Immunology · doi:10.1126/sciimmunol.aaf8864 · Cited by 90 · see citing works
Interleukin‐33 exacerbates acute colitis via interleukin‐4 in mice
Pushparaj, P. N., Li, D., Komai‐Koma, M., Guabiraba, R., Alexander, J. K., McSharry, C. P., & Xu, D. (2013) · Immunology · doi:10.1111/imm.12111 · Cited by 82 · see citing works
Buckner, M. M. C., Croxen, M. A., Arena, E. T., & Finlay, B. B. (2011) · Virulence · doi:10.4161/viru.2.3.15894 · Cited by 59 · see citing works
Wu, L., Luo, Z., Zheng, J., Yao, P., Yuan, Z., Lv, X., Zhao, J., & Wang, M. (2018) · Inflammation · doi:10.1007/s10753-018-0742-6 · Cited by 48 · see citing works
Small, C. L., Xing, L., McPhee, J. B., Law, H. T., & Coombes, B. K. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005907 · Cited by 45 · see citing works
TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice
Son, A., Oshio, T., Kawamura, Y. I., Hagiwara, T., YAMAZAKI, M., Inagaki-Ohara, K., Okada, T., Wu, P., Iseki, M., Takaki, S., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.10 · Cited by 44 · see citing works
The IL-33 gene is related to increased susceptibility to systemic sclerosis
Koca, S. S., Pehlivan, Y., Kara, M., Alıbaz-Öner, F., Öztuzcu, S., Yilmaz, N., Çetin, G. Y., Kısacık, B., Özgen, M., Pamuk, Ö. N., et al. (2016) · Rheumatology International · doi:10.1007/s00296-015-3417-8 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
Chen, Y., Cui, W., Xiao, L., & Yang, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.761981 · Cited by 286 · see citing works
Revisiting fibrosis in inflammatory bowel disease: the gut thickens
D’Alessio, S., Ungaro, F., Noviello, D., Lovisa, S., Peyrin‐Biroulet, L., & Danese, S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00543-0 · Cited by 258 · see citing works
Fibrosis in IBD: from pathogenesis to therapeutic targets
Rieder, F., Mukherjee, P. K., Massey, W. J., Wang, Y., & Fiocchi, C. (2024) · Gut · doi:10.1136/gutjnl-2023-329963 · Cited by 205 · see citing works
Raftar, S. K. A., Ashrafian, F., Yadegar, A., Lari, A., Moradi, H. R., Shahryari, A., Azimirad, M., Alavifard, H., Mohsenifar, Z., Davari, M., et al. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00484-21 · Cited by 166 · see citing works
Dietary l-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut
Kitamoto, S., Alteri, C. J., Rodrigues, M., Nagao‐Kitamoto, H., Sugihara, K., Himpsl, S. D., Bazzi, M., Miyoshi, M., Nishioka, T., Hayashi, A., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0591-6 · Cited by 154 · see citing works
Self-citationDysbiotic microbiota interactions in Crohn’s disease
Caparrós, E., Wiest, R., Scharl, M. M., Rogler, G., Gutiérrez, A., Yılmaz, B., Wawrzyniak, M., & Francés, R. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1949096 · Cited by 123 · see citing works
Novel mechanisms and clinical trial endpoints in intestinal fibrosis*
Wang, J., Lin, S., Brown, J. M., Wagoner, D. R. V., Fiocchi, C., & Rieder, F. (2021) · Immunological Reviews · doi:10.1111/imr.12974 · Cited by 119 · see citing works
Intestinal Fibrosis in Inflammatory Bowel Disease and the Prospects of Mesenchymal Stem Cell Therapy
Wang, Y., Huang, B., Jin, T., Ocansey, D. K. W., Jiang, J., & Mao, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.835005 · Cited by 110 · see citing works
Diet–Microbiota Interactions in Inflammatory Bowel Disease
Sugihara, K., & Kamada, N. (2021) · Nutrients · doi:10.3390/nu13051533 · Cited by 109 · see citing works
Self-citationFibrostenotic strictures in Crohn’s disease
Yoo, J. H., Holubar, S. D., & Rieder, F. (2020) · Intestinal Research · doi:10.5217/ir.2019.09148 · Cited by 105 · see citing works
Fibrosis: cross-organ biology and pathways to development of innovative drugs
Rieder, F., Nagy, L. E., Maher, T. M., Distler, J. H. W., Kramann, R., Hinz, B., & Prunotto, M. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01158-9 · Cited by 117 · see citing works
Pathogenesis of fibrostenosing Crohn's disease
Li, J., Mao, R., Kurada, S. V., Wang, J., Lin, S., Chandra, J., & Rieder, F. (2019) · Translational research · doi:10.1016/j.trsl.2019.03.005 · Cited by 102 · see citing works
Adherent-Invasive E. coli: Update on the Lifestyle of a Troublemaker in Crohn’s Disease
Chervy, M., Barnich, N., & Denizot, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103734 · Cited by 90 · see citing works
Self-citationLin, S., Mao, R., Qian, C., Bettenworth, D., Wang, J., Li, J., Bruining, D. H., Jairath, V., Feagan, B. G., Chen, M., et al. (2021) · Physiological Reviews · doi:10.1152/physrev.00005.2021 · Cited by 83 · see citing works
Saadh, M. J., Mikhailova, M. V., Rasoolzadegan, S., Falaki, M., Akhavanfar, R., Gonzáles, J. L. A., Rigi, A. M., & Kiasari, B. A. (2023) · European journal of medical research · doi:10.1186/s40001-023-01008-7 · Cited by 77 · see citing works
Therapeutic Targeting of Intestinal Fibrosis in Crohn’s Disease
Santacroce, G., Lenti, M. V., & Sabatino, A. D. (2022) · Cells · doi:10.3390/cells11030429 · Cited by 73 · see citing works
Microbial adaptation to the healthy and inflamed gut environments
Guo, Y., Kitamoto, S., & Kamada, N. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1857505 · Cited by 63 · see citing works
Self-citationIL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential
Sheng, F., Mi, L., Yu, J.-M., Yang, S., Zou, L., Yang, G., & Zhang, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1533335 · Cited by 62 · see citing works
Zhao, S., Dejanovic, D., Yao, P., Bhilocha, S., Sadler, T., Schirbel, A., West, G., Doyon, G., Lopez, R., Mao, R., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0259-9 · Cited by 59 · see citing works
Immunological Regulation of Intestinal Fibrosis in Inflammatory Bowel Disease
Bamias, G., Pizarro, T. T., & Cominelli, F. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab251 · Cited by 56 · see citing works
Sugihara, K., Kitamoto, S., Saraithong, P., Nagao‐Kitamoto, H., Hoostal, M. J., McCarthy, C., Rosevelt, A., Muraleedharan, C. K., Gillilland, M. G., Imai, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111093 · Cited by 54 · see citing works
Self-citationGut Microbiome and Organ Fibrosis
Costa, C. F. F. A., Sampaio‐Maia, B., Araújo, R., Nascimento, D. S., Ferreira‐Gomes, J., Pestana, M., Azevedo, M. J., & Alencastre, I. S. (2022) · Nutrients · doi:10.3390/nu14020352 · Cited by 51 · see citing works
Cellular and Molecular Mechanisms of Intestinal Fibrosis
Wu, X., Lin, X., Tan, J., Liu, Z., He, J., Hu, F., Wang, Y., Chen, M., Liu, F., & Mao, R. (2023) · Gut and Liver · doi:10.5009/gnl220045 · Cited by 50 · see citing works
Xu, Y., Qian, W., Huang, L., Wen, W., Li, Y., Guo, F., Zhu, Z., Li, Z., Gong, J., Yu, Z., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2193115 · Cited by 39 · see citing works
The effect of chronic inflammation on female fertility
Ameho, S., & Klutstein, M. (2025) · Reproduction · doi:10.1530/rep-24-0197 · Cited by 39 · see citing works
Intestinal Fibrosis and Gut Microbiota: Clues From Other Organs
Zhan, S., Li, N., Liu, C., Mao, R., Wu, D., Li, T., Chen, M., Zhuang, X., & Zeng, Z. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.694967 · Cited by 34 · see citing works
Gut Microbiota, Macrophages and Diet: An Intriguing New Triangle in Intestinal Fibrosis
Amamou, A., O’Mahony, C., Leboutte, M., Savoye, G., Ghosh, S. K., & Marion‐Letellier, R. (2022) · Microorganisms · doi:10.3390/microorganisms10030490 · Cited by 36 · see citing works
Kittana, H., Neto, J. C. G., Heck, K., Juritsch, A. F., Sughroue, J. A., Xian, Y., Mantz, S., Muñoz, R. R. S., Cody, L. A., Schmaltz, R. J., et al. (2023) · mSphere · doi:10.1128/msphere.00478-22 · Cited by 34 · see citing works
Inflammation accelerating intestinal fibrosis: from mechanism to clinic
Xin, S., Liu, X., He, C., Gao, H., Wang, B., Hua, R., Gao, L., Shang, H., Sun, F., & Xu, J. (2024) · European journal of medical research · doi:10.1186/s40001-024-01932-2 · Cited by 35 · see citing works
Palmieri, V., Ebel, J., Phuong, N. N. T., Klopfleisch, R., Vu, V. P., Adamczyk, A., Zöller, J., Riedel, C. U., Buer, J., Krebs, P., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00386-7 · Cited by 30 · see citing works
Recent advances in intestinal fibrosis
Lenti, M. V., Santacroce, G., Broglio, G., Rossi, C. M., & Sabatino, A. D. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101251 · Cited by 29 · see citing works
Intestinal strictures in Crohn's disease: An update from 2023
Liu, Z., Huang, Z., Wang, Y., Xiong, S., Lin, S., He, J., Tan, J., Liu, C., Wu, X., Nie, J., et al. (2024) · United European Gastroenterology Journal · doi:10.1002/ueg2.12568 · Cited by 29 · see citing works
Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease
Ahn, J.-H., Pedrosa, M. D. S., Lopez, L. R., Tibbs, T., Jeyachandran, J. N., Vignieri, E. E., Rothemich, A., Cumming, I., Irmscher, A. D., Haswell, C. J., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.11.012 · Cited by 28 · see citing works
The role of cytokine and immune responses in intestinal fibrosis
Yang, B., Zhang, G., Elias, M. G., Zhu, Y., & Wang, J. (2020) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12879 · Cited by 26 · see citing works
Huang, Q., Li, C., Yang, Y. R., Qin, X. F., Wang, J. J., Zhang, X., Du, X., Yang, X., Wang, Y., Li, L., et al. (2021) · Thorax · doi:10.1136/thoraxjnl-2020-214712 · Cited by 26 · see citing works
Contribution of the Gut Microbiota to Intestinal Fibrosis in Crohn's Disease
Watanabe, D., & Kamada, N. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.826240 · Cited by 23 · see citing works
Self-citationStromal Cell Regulation of Intestinal Inflammatory Fibrosis
Yang, W., Yu, T., & Cong, Y. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.01.007 · Cited by 21 · see citing works
Intestinal fibrosis associated with inflammatory bowel disease: Known and unknown
Zhang, Y., Zhuang, H., Chen, K., Zhao, Y., Wang, D., Ran, T., & Zou, D. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003545 · Cited by 21 · see citing works
Waddell, A., Vallance, J. E., Fox, S. R., & Rosen, M. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-89119-1 · Cited by 20 · see citing works
Tan, X., Jing, H., & Ma, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.792897 · Cited by 20 · see citing works
Intestinal stricture in Crohn's disease: A 2020 update
Lin, X., Qiu, Y., Zhuang, X. J., Liu, F., Wu, X. M., Chen, M. H., & Mao, R. (2021) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13022 · Cited by 19 · see citing works
Tissue Niches Formed by Intestinal Mesenchymal Stromal Cells in Mucosal Homeostasis and Immunity
Pásztói, M., & Ohnmacht, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095181 · Cited by 21 · see citing works
Zhou, L., Lin, S., Rieder, F., Chen, M., Zhang, S., & Mao, R. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa321 · Cited by 19 · see citing works
Motyka, N. I., Stewart, S. R., Hollifield, I. E., Kyllo, T. R., Mansfield, J. A., Norton, E. B., Clements, J. D., & Bitoun, J. P. (2021) · Infection and Immunity · doi:10.1128/iai.00707-20 · Cited by 16 · see citing works
Mechanisms and therapeutic research progress in intestinal fibrosis
Liu, Y., Zhang, T., Pan, K., & He, W. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1368977 · Cited by 15 · see citing works
Muscular hyperplasia in Crohn’s disease strictures: through thick and thin
Veisman, I., Massey, W. J., Goren, I., Liu, W. W., Chauhan, G., & Rieder, F. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00307.2024 · Cited by 14 · see citing works
Touny, A. A., Venkataraman, B., Ojha, S. K., Pessia, M., Subramanian, V. S., gowdru, S. N. H., & Subramanya, S. B. (2024) · Nutrients · doi:10.3390/nu16213633 · Cited by 14 · see citing works
Molecular Basis of Chronic Intestinal Wall Fibrosis in Inflammatory Bowel Diseases
Sputa-Grzegrzółka, P., Socha‐Banasiak, A., Dzięgiel, P., & Kempisty, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125754 · Cited by 14 · see citing works
Flores, E. M., Dutta, S., Bosserman, R. E., van Hoof, A., & Krachler, A. M. (2023) · mSphere · doi:10.1128/msphere.00512-23 · Cited by 12 · see citing works
Li, Y., Xu, F., Fang, Y., Cui, Y., Zhu, Z., Wu, Y., Tong, Y., Hu, J., Zhu, L., & Shen, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1530797 · Cited by 11 · see citing works
A Deep View of the Biological Property of Interleukin-33 and Its Dysfunction in the Gut
Wang, Y., He, C., Xin, S., Liu, X., Zhang, S., Qiao, B., Shang, H., Gao, L., & Xu, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713504 · Cited by 12 · see citing works
Shen, J., Du, S., Zhang, Y. J., Li, H., Liu, X., & Jing, J. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s538988 · Cited by 14 · see citing works
Intestinal Fibrosis in Crohn’s Disease: Pathophysiology, Diagnosis, and New Therapeutic Targets
Fousekis, F. S., Mpakogiannis, K., Mastorogianni, I. N., Lianos, G. D., Christodoulou, D. K., & Katsanos, K. H. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124060 · Cited by 10 · see citing works
Tanaka, R., Imai, J., Tsugawa, H., Eap, K. B., Yazawa, M., Kaneko, M., Ohno, M., Sugihara, K., Kitamoto, S., Nagao‐Kitamoto, H., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1031997 · Cited by 10 · see citing works
Self-citationPreventing fibrosis in IBD: update on immune pathways and clinical strategies
Wang, J., Yang, B., Chandra, J., Ivanov, A. I., Brown, J. M., & Rieder, F. (2024) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2024.2330604 · Cited by 9 · see citing works
Srivastava, R., González-Prieto, C., Lynch, J. P., Muscolo, M. E., Lin, C. Y., Brown, M. A., Lemos, L., Shrestha, A., Osburne, M. S., Leong, J. M., et al. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae374 · Cited by 9 · see citing works
Abdulla, M., & Chew, T. S. (2021) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000729 · Cited by 9 · see citing works
Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease
Liu, C., Li, R., Nie, J., He, J., Lin, Z., Wu, X., Tan, J., Liu, Z., Zhou, L., Li, X., et al. (2025) · United European Gastroenterology Journal · doi:10.1002/ueg2.70027 · Cited by 8 · see citing works
Zhou, C., Zhou, X., Wen, Z., Zai-bo, Y., Mu, R., Song, Y., Mei, X., & Rothenberg, D. O. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/8832554 · Cited by 7 · see citing works
Diet in Intestinal Fibrosis: A Double-Edged Sword
Marion‐Letellier, R., Leboutte, M., Amamou, A., Raman, M., Savoye, G., & Ghosh, S. K. (2021) · Nutrients · doi:10.3390/nu13093148 · Cited by 7 · see citing works
Fang, L., Peng, H., Tan, Z., Deng, N., & Peng, X. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s504827 · Cited by 7 · see citing works
Chronic Salmonella Infection Induced Intestinal Fibrosis
Lo, B. C., Shin, S. B., Messing, M., & McNagny, K. M. (2019) · Journal of Visualized Experiments · doi:10.3791/60068 · Cited by 7 · see citing works
Ma, N., Xu, M., Dong, Y., Yu, F., Zhang, X., Gao, X., Meng, Y., Gao, P. H., Zhou, J. J., Yuan, M., et al. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.104983 · Cited by 6 · see citing works
Mi, J., Wu, X., Bai, X., Yang, Y., & Yang, H. (2022) · Clinical and Translational Science · doi:10.1111/cts.13442 · Cited by 6 · see citing works
Kanno, T., Katano, T., Shimura, T., Tanaka, M., Nishie, H., Fukusada, S., Ozeki, K., Ogawa, I., Iwao, T., Matsunaga, T., et al. (2024) · Medicina · doi:10.3390/medicina60050713 · Cited by 5 · see citing works
Profound Defect of Amphiregulin Secretion by Regulatory T Cells in the Gut of HIV-Treated Patients
Tariq, M., Gallien, S., Surénaud, M., Wiedemann, A., Jean‐Louis, F., Lacabaratz, C., Zaragoza, J. L. L., Zeitoun, J., Ysmail-Dalhouk, S., Lelièvre, J., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100725 · Cited by 5 · see citing works
Tanaka, R., Imai, J., Sugiyama, E., Tsubaki, S., Hozumi, K., & Tsugawa, H. (2024) · Gut Pathogens · doi:10.1186/s13099-024-00600-4 · Cited by 5 · see citing works
Self-citationThe aryl hydrocarbon receptor: A promising target for intestinal fibrosis therapy
Pan, Y., Deng, Y., Yang, H., & Yu, M. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107909 · Cited by 6 · see citing works
Guan, Y.-C., Zhang, M., Wang, Y., Liu, Z., Zhao, Z.-L., Wang, H., An, D., Qian, A., Kang, Y., Sun, W., et al. (2022) · The Journal of Microbiology · doi:10.1007/s12275-022-2373-8 · Cited by 4 · see citing works
Kittana, H., Neto, J. C. G., Heck, K., Sughroue, J. A., Xian, Y., Mantz, S., Muñoz, R. R. S., Cody, L. A., Schmaltz, R. J., Anderson, C. L., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/772012 · Cited by 4 · see citing works
Epicutaneous Immunotherapy with CBir1 Alleviates Intestinal Inflammation
Chen, X., Elson, C. O., & Dunkin, D. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac261 · Cited by 3 · see citing works
Zhang, C., Tang, X., Chen, S., Akanyibah, F. A., & Mao, F. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1760517 · Cited by 2 · see citing works
Ahn, J. A. O. K., Hazelton, A., Nguyen, J., & Arthur, J. C. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01725-z · Cited by 2 · see citing works
Hai, S., Chen, Y., Zhang, M., Liu, W., & Sun, X. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01984-8 · Cited by 2 · see citing works
[Research frontier of inflammatory bowel disease].
Fan, Y., & Lü, B. (2019) · PubMed Central · doi:10.3785/j.issn.1008-9292.2019.06.15 · Cited by 2 · see citing works
The P2X7 Receptor Promotes Intestinal Fibrosis by Modulating the Gut Microbiota and the Inflammasome
Ribeiro, B. E., de Lima, I. S., Souza, K. C. D. S. E., Rosas, S. L. B., Santana, P. T., Amaral, G. R. S., Machado, J. C., de Oliveira, R. P., Leal, C. V., Thompson, C. C., et al. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101718 · Cited by 1 · see citing works
Yoo, J. H., Choi, Y. J., Pinchuk, I. V., Powell, D. W., Zachos, N. C., & Donowitz, M. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1764088 · Cited by 1 · see citing works
Role of microbiome in development of systemic inflammatory response syndrome and sepsis (review)
Khomyakova, T. I., Khomyakov, Y. N., & Makarova, O. V. (2023) · Epidemiology and Infectious Diseases · doi:10.17816/eid451025 · Cited by 1 · see citing works
Flores, E. M., Dutta, S., Bosserman, R. E., van Hoof, A., & Krachler, A. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.07.556695 · Cited by 1 · see citing works
Tanaka, R., Imai, J., Sugiyama, E., Tsubaki, S., Hozumi, K., & Tsugawa, H. (2023) · Research Square · doi:10.21203/rs.3.rs-3323664/v1 · Cited by 1 · see citing works
Self-citationSFB flagellin mediates cell adhesion, endocytosis and immune regulation in germ-free mice
Chen, H., Liu, W., Cao, X., Li, Z., Zhu, R., Wang, X., Li, J., Wei, Z., Yang, D., & Yin, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1624092
Tanaka, R., Imai, J., Sugiyama, E., Tsubaki, S., Hozumi, K., & Tsugawa, H. (2024) · Figshare · doi:10.6084/m9.figshare.26672415
Self-citationLe récepteur minéralocorticoide : une cible potentielle dans la fibrose intestinale ?
Amamou, A. (2020) · theses.fr (ABES) · doi:10.70675/ec2e0df7z8ae1z4feczaf08z10bcbd86d2f3
Fibrose intestinale, récepteur minéralocorticoide,alimentation.
Leboutte, M. (2023) · theses.fr (ABES) · doi:10.70675/a47cb697z212az4a17za4d6zeaf9d5cbaf24
Molecular mechanisms of persistence of adherent-invasive Escherichia coli in the host organism
Pobeguts, O. V., Avshalumov, A. S., Mikhailycheva, M. V., & Gorbachev, A. Y. (2026) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2026-11.2.8
Barendregt, D. M. H., Zhao, Q., Samsom, J. N., & Elson, C. O. (2026) · Mucosal Immunology · doi:10.1016/j.mucimm.2026.100365
Bai, X., Ihara, E., & Akiho, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40306-4.00016-8
Anorectal fibrosis in 3 murine models of chronic intestinal fibrosis: a comparative analysis
Ge, Y., Li, M. T., Li, T., Guo, D., Yu, M., Yue, J., Liu, X., Liu, Y., Leng, Q., & Ding, K. (2026) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izag138
Wei, H., Yang, W., Zhang, T., Xu, W., Wu, K., Kong, L., Li, H., Wang, K., Yan, W., Yang, M., et al. (2026) · mBio · doi:10.1128/mbio.01899-26
- Authors
- Imai, J., Kitamoto, S., Sugihara, K., Nagao-Kitamoto, H., Hayashi, A., Morhardt, T. L., Kuffa, P., Higgins, P. D. R., Barnich, N., & Kamada, N.
- Affiliations
- Tokai University (JP)
- University of Michigan (US)
- Inserm (FR)
- Corresponding author
- Kamada, Nobuhiko
- ORCID
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 12
- Issue
- 3
- Pages
- 632-643
- ISSN
- 1933-0219 (ISSN-L)
- PMC
- PMC6462251
- OpenAlex
- W2912821148
- Cited by
- 91
- References
- 42
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 14 · 2023: 12 · 2022: 11 · 2021: 19 · 2020: 8 · 2019: 5
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- Crohn's and Colitis Foundation of America
- Prevent Cancer Foundation
- University of Michigan
- Uehara Memorial Foundation
- Kenneth Rainin Foundation
- Crohn's and Colitis Foundation (632826)
- Georgia Clinical and Translational Science Alliance
- Mitsukoshi Health and Welfare Foundation
- National Institutes of Health (DK108901)
- University of Michigan Center for Gastrointestinal Research (5 P30 DK034933)
- Japan Society for the Promotion of Science
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034933, R21DK110146, T32DK094775, R01DK108901)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- intestinal fibrosis, Crohn's disease, adherent-invasive Escherichia coli, pathobionts, flagellin, IL-33, ST2 receptor, commensal Escherichia coli, intestinal colonization, DSS-induced colitis, intestinal epithelium
- MeSH terms
- Interleukin-33, Interleukin-1 Receptor-Like 1 Protein, Animals, Cells, Cultured, Colitis, Crohn Disease, Disease Models, Animal, Escherichia coli, Escherichia coli Infections, Fibrosis, Flagellin, Humans, Intestinal Mucosa, Mice, Inbred C57BL, Mutation, Salmonella, Salmonella Infections, Signal Transduction, Dextran Sulfate, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
