Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption
Abstract
Redox modification of mitochondrial proteins is thought to play a key role in regulating cellular function, although direct evidence to support this hypothesis is limited. Using an in vivo model of mitochondrial redox stress, ethanol hepatotoxicity, the modification of mitochondrial protein thiols was examined using a proteomics approach. Specific labeling of reduced thiols in the mitochondrion from the livers of control and ethanol-fed rats was achieved by using the thiol reactive compound (4-iodobutyl)triphenylphosphonium (IBTP). This molecule selectively accumulates in the organelle and can be used to identify thiol-containing proteins. Mitochondrial proteins that have been modified are identified by decreased labeling with IBTP using two-dimensional SDS-PAGE followed by immunoblotting with an antibody directed against the triphenylphosphonium moiety of the IBTP molecule. Analyses of these data showed a significant decrease in IBTP labeling of thiols present in specific mitochondria matrix proteins from ethanol-fed rats compared with their corresponding controls. These proteins were identified as the low-K(m) aldehyde dehydrogenase and glucose-regulated protein 78. The decrease in IBTP labeling in aldehyde dehydrogenase was accompanied by a decrease in specific activity of the enzyme. These data demonstrate that mitochondrial protein thiol modification is associated with chronic alcohol intake and might contribute to the pathophysiology associated with hepatic injury. Taken together, we have developed a protocol to chemically tag and select thiol-modified proteins that will greatly enhance efforts to establish posttranslational redox modification of mitochondrial protein in in vivo models of oxidative or nitrosative stress.
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Oxidative modification and suppression of ALDH2 in alcohol-exposed rodents were consistently observed by other groups.
“Oxidative modification and suppression of ALDH2 in alcohol-exposed rodents were consistently observed by other groups [44], [45].”
Cites
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,499 · see citing works
The Feeding of Alcohol in Liquid Diets: Two Decades of Applications and 1982 Update
Lieber, C. S., & DeCarli, L. M. (1982) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1982.tb05017.x · Cited by 713 · see citing works
Alcohol and mitochondria: a dysfunctional relationship
Hoek, J. B., Cahill, A., & Pastorino, J. G. (2002) · Gastroenterology · doi:10.1053/gast.2002.33613 · Cited by 553 · see citing works
Ji, C., & Kaplowitz, N. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00276-2 · Cited by 539 · see citing works
Reversible Glutathionylation of Complex I Increases Mitochondrial Superoxide Formation
Taylor, E. R., Hurrell, F., Shannon, R. J., Lin, T., Hirst, J., & Murphy, M. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209359200 · Cited by 389 · see citing works
Bailey, S. M., & CUNNINGHAM, C. C. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00769-9 · Cited by 301 · see citing works
Kevin, L. G., Camara, A. K. S., Riess, M. L., Novalija, E., & Stowe, D. F. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00711.2002 · Cited by 272 · see citing works
Thiols in Cellular Redox Signalling and Control
Moran, L. K., Gutteridge, J. M. C., & Quinlan, G. J. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013372904 · Cited by 256 · see citing works
Oxidative modifications in nitrosative stress
Stamler, J. S., & Hausladen, A. (1998) · Nature Structural Biology · doi:10.1038/nsb0498-247 · Cited by 249 · see citing works
Tuma, D. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00742-0 · Cited by 211 · see citing works
Bailey, S. M., & CUNNINGHAM, C. C. (1998) · Hepatology · doi:10.1002/hep.510280521 · Cited by 205 · see citing works
Pastorino, J. G., & Hoek, J. B. (2000) · Hepatology · doi:10.1053/he.2000.7013 · Cited by 197 · see citing works
Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury,
Niemelä, O. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00744-4 · Cited by 181 · see citing works
Specific Modification of Mitochondrial Protein Thiols in Response to Oxidative Stress
Lin, T., Hughes, G., Muratovska, A., Blaikie, F. H., Brookes, P. S., Darley-Usmar, V. M., Smith, R. A. J., & Murphy, M. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110797200 · Cited by 180 · see citing works
Patterson, S. D., Spahr, C. S., Daugas, É., Susín, S. A., Irinopoulou, T., Koehler, C. M., & Kroemer, G. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400640 · Cited by 176 · see citing works
THE EFFECTS OF CHRONIC ETHANOL CONSUMPTION ON HEPATIC MITOCHONDRIAL ENERGY METABOLISM
CUNNINGHAM, C. C., Coleman, W. B., & Spach, P. I. (1990) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a044987 · Cited by 170 · see citing works
Bailey, S. M., Patel, V. B., Young, T. A., Asayama, K., & CUNNINGHAM, C. C. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02273.x · Cited by 162 · see citing works
Farrés, J., Wang, T. T. Y., Cunningham, S. J., & Weiner, H. (1995) · Biochemistry · doi:10.1021/bi00008a025 · Cited by 150 · see citing works
Ethanol Consumption and Liver Mitochondria Function
CUNNINGHAM, C. C., & Bailey, S. M. (2001) · Neurosignals · doi:10.1159/000046892 · Cited by 121 · see citing works
THAYER, W. S., & Rubin, E. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)36005-8 · Cited by 118 · see citing works
Proteomic analysis of human lysosomes: Application to monocytic and breast cancer cells
Journet, A., Chapel, A., Kieffer‐Jaquinod, S., Roux‐Dalvai, F., & Garin, J. (2002) · PROTEOMICS · doi:10.1002/1615-9861(200208)2:8 · Cited by 117 · see citing works
Hendershot, L. M., Valentine, V. A., Lee, A. S., Morris, S. W., & Shapiro, D. N. (1994) · Genomics · doi:10.1006/geno.1994.1166 · Cited by 101 · see citing works
Mallis, R. J., Hamann, M. J., Zhao, W. M., Zhang, T., Hendrich, S., & Thomas, J. A. (2002) · Biological Chemistry · doi:10.1515/bc.2002.067 · Cited by 94 · see citing works
Bailey, S. M. (2003) · Free Radical Research · doi:10.1080/1071576031000091711 · Cited by 93 · see citing works
Comparative subcellular distribution of aldehyde dehydrogenase in rat, mouse and rabbit liver
Lindahl, R. G., & Evces, S. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90109-6 · Cited by 81 · see citing works
Protein S-Thiolation in Hepatocytes Stimulated by t-Butyl Hydroperoxide, Menadione, and Neutrophils
Chai, Y. C., Hendrich, S., & Thomas, J. A. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1166 · Cited by 73 · see citing works
Zheng, C., Wang, T. T. Y., & Weiner, H. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00849.x · Cited by 67 · see citing works
Venditti, P., Masullo, P., & Meo, S. D. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000793 · Cited by 66 · see citing works
Venkatraman, A., Shiva, S., Davis, A. J., Bailey, S. M., Brookes, P. S., & Darley-Usmar, V. M. (2003) · Hepatology · doi:10.1053/jhep.2003.50293 · Cited by 55 · see citing works
Self-citationSpach, P. I., Bottenus, R. E., & CUNNINGHAM, C. C. (1982) · Biochemical Journal · doi:10.1042/bj2020445 · Cited by 53 · see citing works
Vendemiale, G., Grattagliano, I., Signorile, A., & Altomare, E. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80201-8 · Cited by 45 · see citing works
Subcellular Localization of Acetaldehyde Oxidation in Livera
Weiner, H. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb48650.x · Cited by 34 · see citing works
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Cited by
Sorted by citations
Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683 · see citing works
Ross, M. F., Kelso, G. F., Blaikie, F. H., James, A. M., Cochemé, H. M., Filipovska, A., Ros, T. D., Hurd, T. R., Smith, R. A. J., & Murphy, M. P. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0104-5 · Cited by 495 · see citing works
Integration of cellular bioenergetics with mitochondrial quality control and autophagy
Hill, B. G., Benavides, G. A., Lancaster, J. R., Ballinger, S. W., Dell’Italia, L., Zhang, J., & Darley-Usmar, V. M. (2012) · Biological Chemistry · doi:10.1515/hsz-2012-0198 · Cited by 481 · see citing works
Mantena, S. K., King, A. L., Andringa, K. K., Eccleston, H. B., & Bailey, S. M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.029 · Cited by 429 · see citing works
Molecular Mechanisms of Alcoholic Fatty Liver
Purohit, V., Gao, B., & Song, B. (2009) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00827.x · Cited by 312 · see citing works
Mantena, S. K., Vaughn, D. P., Andringa, K. K., Eccleston, H. B., King, A. L., Abrams, G. A., Doeller, J. E., Kraus, D. W., Darley-Usmar, V. M., & Bailey, S. M. (2009) · Biochemical Journal · doi:10.1042/bj20080868 · Cited by 265 · see citing works
Levonen, A., Hill, B. G., Kansanen, E., Zhang, J., & Darley-Usmar, V. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.025 · Cited by 232 · see citing works
Invited Review: Toxicoproteomics: Proteomics Applied to Toxicology and Pathology
Wetmore, B. A., & Merrick, B. A. (2004) · Toxicologic Pathology · doi:10.1080/01926230490518244 · Cited by 207 · see citing works
Venkatraman, A., Landar, A., Davis, A. J., Chamlee, L., Sanderson, T., Kim, H., Page, G., Pompilius, M., Ballinger, S., Darley-Usmar, V., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402245200 · Cited by 170 · see citing works
Redox Regulation of Tumor Necrosis Factor Signaling
Han, D., Ybanez, M. D., Ahmadi, S., Yeh, K., & Kaplowitz, N. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2611 · Cited by 169 · see citing works
The Disulfide Proteome and Other Reactive Cysteine Proteomes: Analysis and Functional Significance
Lindahl, M., Mata-Cabana, A., & Kieselbach, T. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3551 · Cited by 141 · see citing works
Oxidative stress in alcoholic liver disease: Role of NADPH oxidase complex
Minicis, S. D., & Brenner, D. A. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05277.x · Cited by 139 · see citing works
Song, B.-J., Akbar, M., Abdelmegeed, M. A., Byun, K., Lee, B., Yoon, S. K., & Hardwick, J. P. (2014) · Redox Biology · doi:10.1016/j.redox.2014.10.004 · Cited by 123 · see citing works
“sistently observed by other groups [44,45].”
Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis
Chacko, B. K., Srivastava, A., Johnson, M. S., Benavides, G. A., Chang, M. J., Ye, Y., Jhala, N., Murphy, M. P., Kalyanaraman, B., & Darley-Usmar, V. M. (2011) · Hepatology · doi:10.1002/hep.24377 · Cited by 122 · see citing works
Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats
Moon, K.-H., Hood, B. L., Kim, B.-J., Hardwick, J. P., Conrads, T. P., Veenstra, T. D., & Song, B. J. (2006) · Hepatology · doi:10.1002/hep.21372 · Cited by 120 · see citing works
Shiva, S., Oh, J.-Y., Landar, A. L., Ulasova, E., Venkatraman, A., Bailey, S. M., & Darley-Usmar, V. M. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.037 · Cited by 112 · see citing works
S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver
Bailey, S. M., Robinson, G., Pinner, A. L., Chamlee, L., Ulasova, E., Pompilius, M., Page, G. P., Chhieng, D., Jhala, N. C., Landar, A. L., et al. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00044.2006 · Cited by 110 · see citing works
Hovenia dulcis– An Asian Traditional Herb
Hyun, T. K., Eom, S. H., Yu, C. M., & Roitsch, T. G. (2010) · Planta Medica · doi:10.1055/s-0030-1249776 · Cited by 107 · see citing works
Total Thiols: Biomedical Importance And Their Alteration In Various DisordersPreprint
Prakash, M., Shetty, M. S., Tilak, P., & Anwar, N. (2009) · CogPrints (University of Southampton) · Cited by 104 · see citing works
Perrelli, A., Goitre, L., Salzano, A. M., Moglia, A., Scaloni, A., & Retta, S. F. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6015351 · Cited by 90 · see citing works
Thiols: Role in Oxidative Stress-Related Disorders
Kükürt, A., Gelen, V., Başer, Ö. F., Deveci, H. A., & Karapehlivan, M. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96682 · Cited by 88 · see citing works
Suh, S., Hood, B. L., Kim, B., Conrads, T. P., Veenstra, T. D., & Song, B. J. (2004) · PROTEOMICS · doi:10.1002/pmic.200400971 · Cited by 76 · see citing works
Mechanisms of MDMA (Ecstasy)-Induced Oxidative Stress, Mitochondrial Dysfunction, and Organ Damage
Song, B., Moon, K., Upreti, V. V., Eddington, N. D., & Lee, I. J. (2010) · Current Pharmaceutical Biotechnology · doi:10.2174/138920110791591436 · Cited by 73 · see citing works
Mitochondrial proteomics in free radical research
Bailey, S. M., Landar, A. L., & Darley-Usmar, V. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.011 · Cited by 73 · see citing works
Szczęsny-Małysiak, E., Stojak, M., Campagna, R., Grosicki, M., Jamrozik, M., Kaczara, P., & Chłopicki, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4678252 · Cited by 70 · see citing works
Song, B.-J., Abdelmegeed, M. A., Henderson, L. E., Yoo, S.-H., Wan, J., Purohit, V., Hardwick, J. P., & Moon, K.-H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/781050 · Cited by 67 · see citing works
Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes
Zelickson, B. R., Benavides, G. A., Johnson, M. S., Chacko, B. K., Venkatraman, A., Landar, A. L., Betancourt, A. M., Bailey, S. M., & Darley-Usmar, V. M. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.09.011 · Cited by 66 · see citing works
Landar, A. L., Shiva, S., Levonen, A., Oh, J., Zaragoza, C., Johnson, M. S., & Darley-Usmar, V. M. (2006) · Biochemical Journal · doi:10.1042/bj20051259 · Cited by 63 · see citing works
Moon, K., Upreti, V. V., Yu, L., Lee, I. J., Ye, X., Eddington, N. D., Veenstra, T. D., & Song, B. (2008) · PROTEOMICS · doi:10.1002/pmic.200800215 · Cited by 62 · see citing works
Mantena, S. K. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i37.4967 · Cited by 59 · see citing works
Redox regulation of hepatitis C in nonalcoholic and alcoholic liver
Seronello, S., Sheikh, M. Y., & Choi, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.036 · Cited by 58 · see citing works
Mitchell, T., Chacko, B., Ballinger, S. W., Bailey, S. M., Zhang, J., & Darley-Usmar, V. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120231 · Cited by 57 · see citing works
Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis
Li, H., Toth, E. L., & Cherrington, N. J. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy106 · Cited by 57 · see citing works
Andringa, K. K., King, A. L., Eccleston, H. B., Mantena, S. K., Landar, A. L., Jhala, N. C., Dickinson, D. A., Squadrito, G. L., & Bailey, S. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00332.2009 · Cited by 54 · see citing works
Andringa, K. K., Udoh, U. S., Landar, A. L., & Bailey, S. M. (2014) · Redox Biology · doi:10.1016/j.redox.2014.09.006 · Cited by 52 · see citing works
Rhodanese–thioredoxin system and allyl sulfur compounds
Sabelli, R., Iorio, E., Martino, A. D., Podo, F., Ricci, A., Viticchiè, G., Rotilio, G., Paci, M., & Melino, S. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06535.x · Cited by 53 · see citing works
Andringa, K. K., Bajt, M. L., Jaeschke, H., & Bailey, S. M. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.01.010 · Cited by 51 · see citing works
Song, B., Akbar, M. D., Jo, I., Hardwick, J. P., & Abdelmegeed, M. A. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.002 · Cited by 49 · see citing works
Buonvino, S., Arciero, I., & Melino, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158452 · Cited by 49 · see citing works
Wang, X., Luo, J., Chen, R., Zha, X., & Wang, H. (2014) · Food & Function · doi:10.1039/c3fo60629e · Cited by 46 · see citing works
King, A. L., Mantena, S. K., Andringa, K. K., Millender-Swain, T., Dunham‐Snary, K. J., Oliva, C. R., Griguer, C. E., & Bailey, S. M. (2016) · Redox Biology · doi:10.1016/j.redox.2016.08.005 · Cited by 45 · see citing works
Landar, A. L., Oh, J., Giles, N. M., Isom, A., KIRK, M. C., Barnes, S., & Darley-Usmar, V. M. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.046 · Cited by 45 · see citing works
Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis
Çakır, Y., Yang, Z., Knight, C. A., Pompilius, M., Westbrook, D. G., Bailey, S. M., Pinkerton, K. E., & Ballinger, S. W. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.07.015 · Cited by 45 · see citing works
Piplani, H., Marek‐Iannucci, S., Sin, J., Hou, J., Takahashi, T., Sharma, A., Germano, J. D. F., Waldron, R. T., Saadaeijahromi, H., Song, Y., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.08.006 · Cited by 41 · see citing works
Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria
Guo, J., Prókai-Tátrai, K., Nguyen, V., Rauniyar, N., Ughy, B., & Prókai, L. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.07.009 · Cited by 38 · see citing works
The Complete Pathway for Thiosulfate Utilization in Saccharomyces cerevisiae
Chen, Z., Zhang, X., Li, H., Liu, H., Xia, Y., & Xun, L. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.01241-18 · Cited by 37 · see citing works
HepatoProteomics: Applying proteomic technologies to the study of liver function and disease
Diamond, D. L., Proll, S. C., Jacobs, J., Chan, E. Y., Camp, D., Smith, R. D., & Katze, M. G. (2006) · Hepatology · doi:10.1002/hep.21318 · Cited by 37 · see citing works
King, A. L., Swain, T. M., Dickinson, D. A., Lesort, M. J., & Bailey, S. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00246.2010 · Cited by 35 · see citing works
Detection of electrophile-sensitive proteins
Wall, S. B., Smith, M. R., Ricart, K. C., Zhou, F., Vayalil, P. K., Oh, J., & Landar, A. L. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.09.003 · Cited by 31 · see citing works
Mitochondrial Glutathione and Chemically Induced Stress Including Ethanol
Reed, D. J. (2004) · Drug Metabolism Reviews · doi:10.1081/dmr-200033449 · Cited by 31 · see citing works
Malekinejad, H., Janbazacyabar, H., Razi, M., & Varasteh, S. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.06.011 · Cited by 30 · see citing works
Tsou, P., Page, N. A., Lee, S. G., Fung, S. M., Keung, W. M., & Fung, H. L. (2011) · The AAPS Journal · doi:10.1208/s12248-011-9295-4 · Cited by 23 · see citing works
Harris, P. S., McGinnis, C. D., Michel, C. R., Marentette, J., Reisdorph, R. M., Roede, J. R., & Fritz, K. S. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102792 · Cited by 21 · see citing works
Oxidative and nitrosative stress in experimental rat liver fibrosis: Protective effect of taurine
Devi, S. L., & Anuradha, C. V. (2009) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2009.11.005 · Cited by 21 · see citing works
Oxidative stress response: a proteomic view
Rabilloud, T., Chevallet, M., Luche, S., & Leize‐Wagner, E. (2005) · Expert Review of Proteomics · doi:10.1586/14789450.2.6.949 · Cited by 20 · see citing works
Song, B.-J., Suh, S.-K., & Moon, K.-H. (2010) · Methods in Enzymology · doi:10.1016/s0076-6879(10)73013-5 · Cited by 18 · see citing works
Smith, M. R., Vayalil, P. K., Zhou, F., Benavides, G. A., Beggs, R. R., Golzarian, H., Nijampatnam, B., Oliver, P. G., Smith, R. A. J., Murphy, M. P., et al. (2016) · Redox Biology · doi:10.1016/j.redox.2016.01.002 · Cited by 17 · see citing works
Dikalov, S., Mayorov, V., & Panov, A. V. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00907 · Cited by 17 · see citing works
Bailey, S. M., Andringa, K. K., Landar, A. L., & Darley-Usmar, V. M. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-242-7_24 · Cited by 16 · see citing works
A Glance At … ethanol consumption, GSH suppression, and oxidative liver damage
Glade, M. J., & Meguid, M. M. (2016) · Nutrition · doi:10.1016/j.nut.2016.07.003 · Cited by 15 · see citing works
Saraswathy, S., & Rao, N. A. (2011) · PubMed Central · Cited by 13 · see citing works
Nieto, N. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02573.x · Cited by 13 · see citing works
Vayalil, P. K., Oh, J., Zhou, F., Diers, A. R., Smith, M. R., Golzarian, H., Oliver, P. G., Smith, R. A. J., Murphy, M. P., Velu, S. E., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120460 · Cited by 12 · see citing works
Mitochondrial proteomics and its application in biomedical research
Ruíz‐Romero, C., & Blanco, F. J. (2009) · Molecular BioSystems · doi:10.1039/b906296n · Cited by 12 · see citing works
Ohtake, K., Shimada, N., Uchida, H., & Kobayashi, J. (2009) · Journal of Proteomics · doi:10.1016/j.jprot.2009.03.001 · Cited by 11 · see citing works
Assessment of Mitochondrial Dysfunction Arising from Treatment with Hepatotoxicants
King, A. L., & Bailey, S. M. (2010) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx1408s44 · Cited by 10 · see citing works
Proteomics‐based investigations of animal models of disease
Bousette, N., Gramolini, A. O., & Kislinger, T. (2008) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200780043 · Cited by 10 · see citing works
Scaloni, A., Codarin, E., Maso, V. D., Arena, S., Renzone, G., Tiribelli, C., Quadrifoglio, F., & Tell, G. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800169 · Cited by 10 · see citing works
An, J. H., Kim, D.-S., Lee, Y., Ho, J., Kim, H. K., Kang, O.-J., Shin, I.-S., & Cho, H. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2009.0017 · Cited by 8 · see citing works
Mitochondrial Proteome: Toward the Detection and Profiling of Disease Associated Alterations
Herrmann, P. C., & Herrmann, E. (2011) · Methods in molecular biology · doi:10.1007/978-1-60327-216-2_17 · Cited by 7 · see citing works
French, S. W. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_35 · Cited by 6 · see citing works
Blue Native-Gel Electrophoresis Proteomics
Andringa, K. K., King, A. L., & Bailey, S. M. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-281-6_15 · Cited by 6 · see citing works
Qin, F., Zhao, N., Xia, W., Liang, C., Dai, G., Yang, J. Z., Jingxia, S., Liu, L., Luo, L., & Yang, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27397 · Cited by 5 · see citing works
Akinloye, D. I., Ugbaja, R. N., & IDOWU, O.-M. O. (2023) · Comparative Clinical Pathology · doi:10.1007/s00580-023-03444-7 · Cited by 4 · see citing works
Andringa, K. K., & Bailey, S. M. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)74006-4 · Cited by 4 · see citing works
Genomics in Pathogenesis of Cirrhosis
Shackel, N. A., Patel, K., & McHutchison, J. G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374934-5.00050-7 · Cited by 3 · see citing works
Does Ethanol Play a Pro-Oxidant Role during Oxidative Stress in the Liver?
Obih, P., Soblosky, J. S., & Potter, B. J. (2015) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2015.38001 · Cited by 1 · see citing works
Shackel, N. A., Patel, K., & McHutchison, J. G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382227-7.00078-1 · Cited by 1 · see citing works
Genomics, Gene Arrays and Proteomics in the Study of Liver Disease
McCaughan, G. W., Shackel, N. A., Williams, R. B. H., Seth, D., Haber, P., & Gorrell, M. D. (2007) · Wiley eBooks · doi:10.1002/9780470691861.ch3f
Cirrhosis in the Era of Genomic Medicine
Shackel, N. A., Patel, K., & McHutchison, J. G. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-369420-1.00093-7
Buonvino, S., Cinotti, G., & Melino, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18827-5.00006-6
Madan, E., Jain, V., & Singh, V. P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.05.652328
Opposing Roles of CYP2E1 and ALDH2 in Binge Alcohol-Mediated Cerebellar Damage
Ruiter-Lopez, L., Rungratanawanich, W., & Song, B. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156825
- Authors
- Venkatraman, A., Landar, A., Davis, A. J., Ulasova, E., Page, G., Murphy, M. P., Darley-Usmar, V., & Bailey, S. M.
- Affiliations
- University of Alabama at Birmingham (US)
- ORCID
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2004-04
- Volume
- 286
- Issue
- 4
- Pages
- G521-G527
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2131656539
- Cited by
- 85
- References
- 32
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21aa013682-03)
- National Institute on Alcohol Abuse and Alcoholism (AA13682, R01AA013395, AA-13395)
- National Cancer Institute (P30CA013148)
- National Center for Research Resources (S10RR011329)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- redox modification, chronic alcohol consumption, ethanol-induced hepatotoxicity, oxidative stress, mitochondrial matrix proteins, aldehyde dehydrogenase, GRP78, thiol labeling, liver injury
- MeSH terms
- Ethanol, Aldehyde Dehydrogenase, Animals, Central Nervous System Depressants, Chronic Disease, Electrophoresis, Polyacrylamide Gel, Energy Metabolism, Image Processing, Computer-Assisted, Male, Mitochondria, Liver, Molecular Weight, Oxidation-Reduction, Proteins, Sulfhydryl Compounds, Immunoblotting, Rats, Sprague-Dawley, Reactive Oxygen Species, Reactive Nitrogen Species, Rats, In Vitro Techniques
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