Cited by 116Regulation of Appetite and ObesityDietary Effects on HealthHypothalamic control of reproductive hormones

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Possible entrainment of ghrelin to habitual meal patterns in humans

Frecka, Julie M., Mattes, Richard D.·2008·American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI 10.1152/ajpgi.00448.2007

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Abstract

Ghrelin is reportedly a meal-initiation signal based on observations that concentrations increase before meals coincident with rising hunger. However, evidence that ghrelin peaks vary with feeding schedules suggests that it rises in anticipation of an expected meal, rather than eliciting feeding. To explore the entrainment of ghrelin profiles, this study investigated the association between varying habitual meal patterns and plasma ghrelin concentrations. Lean and obese adults following either a short intermeal interval (SII) pattern, with 2.5–3.5 h between their habitual breakfast and lunch times, or a long intermeal interval (LII) pattern, with 5.5–6.5 h between these eating occasions, participated. Food intake and appetite were recorded for 2 baseline days. On the subsequent test day, blood samples were collected over 8 h while participants ate a breakfast and lunch matched to their customary meals and pattern. Appetite ratings were obtained and ghrelin, insulin, glucose, and leptin concentrations were measured. Peak ghrelin concentrations differed significantly by group and occurred prior to each group's respective lunch time. Ghrelin concentrations directly correlated with subjective hunger. This association was stronger when hunger preceded ghrelin, a pattern inconsistent with ghrelin causing the hunger rise. Ghrelin concentrations were inversely correlated with insulin, and peak insulin concentrations preceded nadir ghrelin concentrations postprandially. Ghrelin concentrations periprandially, and over the entire test session, did not differ by meal group, likely because of similar intakes between groups. These data demonstrate that the timing of ghrelin peaks is related to habitual meal patterns and may rise in anticipation of eating rather than eliciting feeding.

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Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · cited 2×
“Furthermore, its orexigenic actions are rapid and transient, characteristic of a signal acutely influencing prandial behavior (28, 43).”
Background
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · cited 3×
“The periprandial ghrelin changes in this study are consistent with other reported profiles (7, 8, 33) and did not vary by habitual eating schedule.”
BackgroundResult
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Marina, K., Dellinger, E. P., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,271
Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans
Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M. S., Suganuma, T., Matsukura, S., Kangawa, K., & Nakazato, M. (2000) · Endocrinology · doi:10.1210/endo.141.11.7757 · Cited by 1,916
The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion
Wren, A. M., Small, C. J., Ward, H. L., Murphy, K. G., Dakin, C. L., Taheri, S., Kennedy, A. R., Roberts, G. H., Morgan, D. G. A., Ghatei, M. A., et al. (2000) · Endocrinology · doi:10.1210/endo.141.11.7873 · Cited by 1,593

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Delzenne, N. M., Blundell, J. E., Brouns, F. J. P. H., Cunningham, K., de Graaf, K. C., Erkner, A., Lluch, A., Mars, M., Peters, H. P. F., & Westerterp‐Plantenga, M. S. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00707.x · Cited by 172
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Ratliff, J. C., Leite, J. O. M., de Ogburn, R., Puglisi, M. J., VanHeest, J. L., & Fernández, M. L. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.01.002 · Cited by 136
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Merkestein, M., Brans, M. A. D., Luijendijk, M. C. M., de Jong, J. W., Egecioglu, E., Dickson, S. L., & Adan, R. A. H. (2012) · Obesity · doi:10.1038/oby.2011.389 · Cited by 95
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Cognitive and neuronal systems underlying obesity
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The Effects of Increased Protein Intake on Fullness: A Meta-Analysis and Its Limitations
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The cephalic phase insulin response to nutritive and low-calorie sweeteners in solid and beverage form
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Authors: Frecka, J. M., & Mattes, R. D.
Affiliations: Purdue University West Lafayette (US)
ORCID: Mattes, Richard D.
Venue: American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher: American Physiological Society
Published: 2008-03
Volume: 294
Issue: 3
Pages: G699-G707
ISSN: 0193-1857 (ISSN-L)
1522-1547
DOI: 10.1152/ajpgi.00448.2007
OpenAlex: W2128855912
Cited by: 116
References: 48
Citations by year: 2026: 3 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 8 · 2020: 3 · 2019: 4 · 2018: 23 · 2017: 7 · 2016: 8 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 9
FWCI: 3.27
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: ghrelin, meal patterns, intermeal interval, meal timing, subjective hunger, insulin, leptin, plasma ghrelin concentration, appetite, postprandial ghrelin, obesity
MeSH terms: Adolescent, Adult, Anthropometry, Appetite, Blood Glucose, Eating, Feeding Behavior, Female, Humans, Insulin, Male, Middle Aged, Obesity, Body Mass Index, Leptin, Ghrelin

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Possible entrainment of ghrelin to habitual meal patterns in humans

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