Cited by 413Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsInfant Health and Development

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V. Stress and irritable bowel syndrome

Mayer, Emeran A., Naliboff, Bruce D., Chang, Lin, Coutinho, Santosh V.·2001·American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI 10.1152/ajpgi.2001.280.4.g519

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Abstract

Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility and secretion and in alterations in the perception of visceral events. Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome.

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“과민성 장증 후군은 설사와 변비 등 장운동성의 변화가 전형적 증상이며, 장운동의 변화를 유발하는 생애초기의 부정적 사건, 장염과 같은 스트레스와 밀접한 관계를 보이고[31,32], 안정 시에 대”
during mental stress response in patients with irritable bowel syndrome Altered visceral perceptual and neuroendocrine
Posserud, I., Agerforz, P., Ekman, R., Björnsson, E. S., & Abrahamsson, H. (2006)
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Jacobus, D. J. (2014) · Cermin Dunia Kedokteran
Paradoxical Analgesic and Hyperalgesic Effects of Stress
Robbins, M. T., & Ness, T. J. (2009) · Springer eBooks · doi:10.1007/978-0-387-75269-3_28
Chapter 4 Estrogen Modulation of Visceral Nociception
Chaban, V. V. (2008)
Emotional Awareness for Pain
Schubiner, H. H. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1793-8.00084-4
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Tominaga, K., & Fujikawa, Y. (2018) · Springer eBooks · doi:10.1007/978-981-13-1074-4_4
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Sergueef, N., & Nelson, K. E. (2015) · Elsevier eBooks · doi:10.1016/b978-2-8101-0159-7.00011-6
Digestive System Dysfunction: Dietary Interventions
Iwu, M. M. (2016) · CRC Press eBooks · doi:10.1201/9781315371627-16
Emotional Awareness for Pain
Schubiner, H. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00102-x
Irritable Bowel Syndrome and Female Sexual Dysfunction
Cigna, S. T. (2020) · Wiley eBooks · doi:10.1002/9781119482598.ch39
Effects of Romantic Attachment and Partner Presence on Physiological Stress Reactivity
Douglas, S. M. (2015) · Digital WPI
MEASuRing symptoms in Irritable Bowel Syndrome
Vork, L. (2021) · Research Publications (Maastricht University) · doi:10.26481/dis.20210409lv
The interplay between pancreatic enzymes insufficiency and irritable bowel syndrome
Mari, A., Sbeit, W., Pellicano, R., & Khoury, T. (2021) · Minerva Gastroenterology · doi:10.23736/s2724-5985.20.02800-7
Psychological Determinants and Treatments for Chronic Abdominal Pain
Sweis, G. W. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1992-5_25
Irritable Bowel Syndrome
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Self-citation
Faculty Opinions recommendation of Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome.
Drossman, D. A. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718084718.793482228
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Digestive System Dysfunction: Dietary Interventions
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Authors: Mayer, E. A., Naliboff, B. D., Chang, L., & Coutinho, S. V.
Affiliations: University of California, Los Angeles (US)
ORCID: Mayer, Emeran A.
Naliboff, Bruce D.
Chang, Lin
Venue: American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher: American Physiological Society
Published: 2001-04-01
Volume: 280
Issue: 4
Pages: G519-G524
ISSN: 0193-1857 (ISSN-L)
1522-1547
DOI: 10.1152/ajpgi.2001.280.4.g519
OpenAlex: W1869460907
Cited by: 413
References: 41
Citations by year: 2026: 8 · 2025: 5 · 2024: 8 · 2023: 18 · 2022: 10 · 2021: 20 · 2020: 13 · 2019: 8 · 2018: 20 · 2017: 14 · 2016: 21 · 2015: 27 · 2014: 13 · 2013: 15 · 2012: 20
FWCI: 14.11
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r01nr004881-03)
National Institute of Nursing Research (NR-04881)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-48351, R01DK048351)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-46122, R01AR046122)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Keywords: irritable bowel syndrome, psychological stress, physical stress, gut-brain axis, autonomic nervous system, neuroendocrine response, visceral pain perception, gastrointestinal motility, gastrointestinal secretion, brain circuits
MeSH terms: Animals, Colonic Diseases, Functional, Digestive System, Humans, Stress, Psychological

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