The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
V. Stress and irritable bowel syndrome
Abstract
Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility and secretion and in alterations in the perception of visceral events. Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome.
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“Although the cause of the disorder remains essentially unknown, IBS is currently conceptualized as a bio-psychosocial disorder with disturbances of motor function, heightened visceral sensitivity, and possibly central nervous system disturbances (4–6).”
From Psychosocial Distress and Somatic Symptoms in Community Subjects With Irritable Bowel Syndrome: A Psychological Component Is the Rule (2009) · cites this paper as [5]
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BackgroundResultInfluentialSelf-citationDysfunction of stress responsive systems as a risk factor for functional somatic syndromes
Tak, L. M., & Rosmalen, J. G. M. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.12.004 · Cited by 112
“Psychosocial stress is widely believed to be involved in the development of functional somatic syndromes or disorders (FSDs), such as chronic fatigue syndrome (CFS), fibromyalgia (FM), and irritable bowel syndrome (IBS) [1– 3].”
BackgroundPsychological Stress, Intestinal Barrier Dysfunctions, and Autoimmune Disorders: An Overview
Ilchmann-Diounou, H., & Ménard, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01823 · Cited by 125
Ponferrada, Á., Caso, J. R., Alou, L., Rodríguez, A. C., Sevillano, D., Moro, M. Á., Lizasoaín, I., Menchén, P. L., Gómez-Lus, M. L., Lorenzo, P. L., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.032 · Cited by 112
Mechanisms of Stress-induced Visceral Pain
Meerveld, B. G., & Johnson, A. C. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17137 · Cited by 109
“Although IBS is not an inflammatory disorder, the immune system plays a role in the pathogenesis of IBS in at least a subset of patients and likely contributes to the etiology of IBS symptoms.22,23 A subset of IBS patients display a low grade chronic inflammation, and there is also evidence that following an enteric i…”
BackgroundInfluentialValdez-Morales, E. E., Overington, J., Guerrero-Alba, R., Ochoa-Cortes, F., Ibeakanma, C. O., Spreadbury, I., Bunnett, N. W., Beyak, M., & Vanner, S. J. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.241 · Cited by 107
Million, M., Grigoriadis, D. E., Sullivan, S., Crowe, P. D., McRoberts, J. A., Zhou, H., Saunders, P. R., Maillot, C., Mayer, E. A., & Taché, Y. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03027-0 · Cited by 107
Self-citationKennedy, P. J., Clarke, G., O‘Neill, A., Groeger, J. A., Quigley, E. M. M., Shanahan, F., Cryan, J. F., & Dinan, T. G. (2014) · Psychological Medicine · doi:10.1017/s0033291713002171 · Cited by 106
“Nonetheless, these results add to the well-acknowledged view that HPA-axis dysfunction is a key feature of IBS (Mayer et al. 2001).”
Childhood functional abdominal pain: mechanisms and management
Korterink, J., Devanarayana, N. M., Rajindrajith, S., Vlieger, A. M., & Benninga, M. A. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.21 · Cited by 106
Hong, J. Y., Kilpatrick, L. A., Labus, J. S., Gupta, A., Jiang, Z., Ashe-McNalley, C., Stains, J., Heendeniya, N., Ebrat, B., Smith, S. E., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5733-12.2013 · Cited by 106
“…in visceral perception, in the autonomic nervous system, and in brain responses to visceral stimuli or their expectation have been demonstrated (Mayer et al., 2001; Chang and Heitkemper, 2002; Mayer et al., 2004; Mayer et al., 2005; Mayer et al., 2006; Lieberman et al., 2007; Wang et al.,…”
BackgroundSelf-citationEffect of Yoga in the Therapy of Irritable Bowel Syndrome: A Systematic Review
Schumann, D., Anheyer, D., Lauche, R., Dobos, G. J., Langhorst, J., & Cramer, H. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.04.026 · Cited by 108
Savignac, H. M., Finger, B. C., Pizzo, R., O’Leary, O. F., Dinan, T. G., & Cryan, J. F. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.054 · Cited by 105
“Abbreviations: IBS, irritable bowel syndrome; SD, social defeat; SD-L, c social defeat-long; SD-S, social defeat-short; SI, social interaction; TPH, tryptophan hydroxylase; 5-HT, serotonin.”
BackgroundInfluentialA Microbial Signature of Psychological Distress in Irritable Bowel Syndrome
Peter, J., Fournier, C., Durdević, M., Knoblich, L., Keip, B., Dejaco, C., Trauner, M., & Moser, G. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000630 · Cited by 100
Duloxetine in the treatment of irritable bowel syndrome: an open‐label pilot study
Brennan, B. P., Fogarty, K. V., Roberts, J. L., Reynolds, K. A., Pope, H. G., & Hudson, J. I. (2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1038 · Cited by 101
Boyd, C., Abraham, S., & Kellow, J. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510015836 · Cited by 113
The gut microbiota as a key regulator of visceral pain
O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2016) · Pain · doi:10.1097/j.pain.0000000000000779 · Cited by 104
Sex‐based differences in gastrointestinal pain
Mayer, E. A., Berman, S. M., Chang, L., & Naliboff, B. D. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2004.01.006 · Cited by 98
“As discussed above we have recently presented a biobehavioral model which integrates central autonomic, pain modulation, and cognitive mechanisms underlying the symptoms of IBS and other functional disorders (Mayer, 2000; Mayer et al., 2001).”
BackgroundSelf-citationEarly Experience Modifies the Postnatal Assembly of Autonomic Emotional Motor Circuits in Rats
Card, J. P., Levitt, P. R., Gluhovsky, M. Y., & Rinaman, L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2345-05.2005 · Cited by 97
“Autonomic responses to stimuli that elicit fear, anxiety, or other strong emotions typically include significant alterations of autonomic outflow, including gastrointestinal function (Kaplan et al., 1996; Punyabati et al., 2000; Mayer et al., 2001).”
Jarrett, M. E., Burr, R. L., Cain, K. C., Hertig, V., Weisman, P., & Heitkemper, M. M. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1021904216312 · Cited by 94
Schwetz, I., Bradesi, S., McRoberts, J. A., Sablad, M., Miller, J. C., Zhou, H., Ohning, G., & Mayer, E. A. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00358.2003 · Cited by 92
Self-citationBraak, B., Klooker, T. K., Wouters, M. M., Welting, O., van der Loos, C. M., Stanisor, O. I., van Diest, S., van den Wijngaard, R. M., & Boeckxstaens, G. E. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.54 · Cited by 93
Rosztoczy, A. I., Fioramonti, J., Jármay, K., Barreau, F., Wittmann, T., & Bueno, L. P. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1350-1925.2003.00451.x · Cited by 91
Volatility as a Concept to Understand the Impact of Stress on the Microbiome
Bastiaanssen, T. F. S., Gururajan, A., van de Wouw, M., Moloney, G. M., Ritz, N. L., Long-Smith, C. M., Wiley, N., Murphy, A., Lyte, J. M., Fouhy, F., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105047 · Cited by 93
Stress-Related Alterations of Visceral Sensation: Animal Models for Irritable Bowel Syndrome Study
Larauche, M. H., Mulak, A., & Taché, Y. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.3.213 · Cited by 92
Labus, J. S., Hubbard, C. S., Bueller, J. A., Ebrat, B., Tillisch, K., Chen, M., Stains, J., Dukes, G. E., Kelleher, D. L., Naliboff, B. D., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.016 · Cited by 90
Self-citationCamilleri, M., Kim, D.-Y., McKinzie, S., Kim, H. J., Thomforde, G. M., Burton, D. D., Low, P. A., & Zinsmeister, A. R. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1053/cgh.2003.50019 · Cited by 90
Lane, R. D., Waldstein, S. R., Critchley, H., Derbyshire, S. W. G., Drossman, D. A., Wager, T. D., Schneiderman, N., Chesney, M. A., Jennings, J. R., Lovallo, W. R., et al. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318198a11f · Cited by 96
Metadata
- Authors
- Mayer, E. A., Naliboff, B. D., Chang, L., & Coutinho, S. V.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2001-04-01
- Volume
- 280
- Issue
- 4
- Pages
- G519-G524
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W1869460907
- Cited by
- 413
- References
- 41
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 18 · 2022: 10 · 2021: 20 · 2020: 13 · 2019: 8 · 2018: 20 · 2017: 14 · 2016: 21 · 2015: 27 · 2014: 13 · 2013: 15 · 2012: 20
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7r01nr004881-03)
- National Institute of Nursing Research (NR-04881)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-48351, R01DK048351)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-46122, R01AR046122)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Keywords
- irritable bowel syndrome, psychological stress, physical stress, gut-brain axis, autonomic nervous system, neuroendocrine response, visceral pain perception, gastrointestinal motility, gastrointestinal secretion, brain circuits
- MeSH terms
- Animals, Colonic Diseases, Functional, Digestive System, Humans, Stress, Psychological
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