Cited by 413Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsInfant Health and Development

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V. Stress and irritable bowel syndrome

Mayer, Emeran A., Naliboff, Bruce D., Chang, Lin, Coutinho, Santosh V.·2001·American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI 10.1152/ajpgi.2001.280.4.g519

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Abstract

Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility and secretion and in alterations in the perception of visceral events. Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome.

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“…dysregulation of brain-body interactions (Monga et al., 1997; Fass et al., 1998 and 2000; Mayer et al., 1998; Wessely et al., 1999; Henningsen et al., 2003; Spiegel et al., 2004), including alterations in neuroendocrine, autonomic nervous system, and pain modulatory systems (Mayer et al., 2001).”
BackgroundSelf-citation
Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats
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Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors
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“However, the few studies that have examined the effects of stress on mucosal immune responses have focused on inflammatory bowel disease and colitis (Mawdsley and Rampton, 2005; Mayer, 2000; Mayer et al., 2001), and on the secretion of IgA in saliva (Bosch et al.”
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Authors: Mayer, E. A., Naliboff, B. D., Chang, L., & Coutinho, S. V.
Affiliations: University of California, Los Angeles (US)
ORCID: Mayer, Emeran A.
Naliboff, Bruce D.
Chang, Lin
Venue: American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher: American Physiological Society
Published: 2001-04-01
Volume: 280
Issue: 4
Pages: G519-G524
ISSN: 0193-1857 (ISSN-L)
1522-1547
DOI: 10.1152/ajpgi.2001.280.4.g519
OpenAlex: W1869460907
Cited by: 413
References: 41
Citations by year: 2026: 8 · 2025: 5 · 2024: 8 · 2023: 18 · 2022: 10 · 2021: 20 · 2020: 13 · 2019: 8 · 2018: 20 · 2017: 14 · 2016: 21 · 2015: 27 · 2014: 13 · 2013: 15 · 2012: 20
FWCI: 14.11
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r01nr004881-03)
National Institute of Nursing Research (NR-04881)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-48351, R01DK048351)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-46122, R01AR046122)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Keywords: irritable bowel syndrome, psychological stress, physical stress, gut-brain axis, autonomic nervous system, neuroendocrine response, visceral pain perception, gastrointestinal motility, gastrointestinal secretion, brain circuits
MeSH terms: Animals, Colonic Diseases, Functional, Digestive System, Humans, Stress, Psychological

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