The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
V. Stress and irritable bowel syndrome
Abstract
Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility and secretion and in alterations in the perception of visceral events. Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome.
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“Although the cause of the disorder remains essentially unknown, IBS is currently conceptualized as a bio-psychosocial disorder with disturbances of motor function, heightened visceral sensitivity, and possibly central nervous system disturbances (4–6).”
From Psychosocial Distress and Somatic Symptoms in Community Subjects With Irritable Bowel Syndrome: A Psychological Component Is the Rule (2009) · cites this paper as [5]
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Sorted by citations
Gut/brain axis and the microbiota
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Self-citation
Metadata
- Authors
- Mayer, E. A., Naliboff, B. D., Chang, L., & Coutinho, S. V.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2001-04-01
- Volume
- 280
- Issue
- 4
- Pages
- G519-G524
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W1869460907
- Cited by
- 413
- References
- 41
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 18 · 2022: 10 · 2021: 20 · 2020: 13 · 2019: 8 · 2018: 20 · 2017: 14 · 2016: 21 · 2015: 27 · 2014: 13 · 2013: 15 · 2012: 20
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7r01nr004881-03)
- National Institute of Nursing Research (NR-04881)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-48351, R01DK048351)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-46122, R01AR046122)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Keywords
- irritable bowel syndrome, psychological stress, physical stress, gut-brain axis, autonomic nervous system, neuroendocrine response, visceral pain perception, gastrointestinal motility, gastrointestinal secretion, brain circuits
- MeSH terms
- Animals, Colonic Diseases, Functional, Digestive System, Humans, Stress, Psychological
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