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Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction
Open accessAbstract
Heart failure (HF) with preserved ejection fraction (HFPEF) is the most common form of HF in older persons. The primary chronic symptom in HFPEF is severe exercise intolerance, and its pathophysiology is poorly understood. To determine whether skeletal muscle abnormalities contribute to their severely reduced peak exercise O 2 consumption (V̇o 2), we examined 22 older HFPEF patients (70 ± 7 yr) compared with 43 age-matched healthy control (HC) subjects using needle biopsy of the vastus lateralis muscle and cardiopulmonary exercise testing to assess muscle fiber type distribution and capillarity and peak V̇o 2. In HFPEF versus HC patients, peak V̇o 2(14.7 ± 2.1 vs. 22.9 ± 6.6 ml·kg−1·min−1, P < 0.001) and 6-min walk distance (454 ± 72 vs. 573 ± 71 m, P < 0.001) were reduced. In HFPEF versus HC patients, the percentage of type I fibers (39.0 ± 11.4% vs. 53.7 ± 12.4%, P < 0.001), type I-to-type II fiber ratio (0.72 ± 0.39 vs. 1.36 ± 0.85, P = 0.001), and capillary-to-fiber ratio (1.35 ± 0.32 vs. 2.53 ± 1.37, P = 0.006) were reduced, whereas the percentage of type II fibers was greater (61 ± 11.4% vs. 46.3 ± 12.4%, P < 0.001). In univariate analyses, the percentage of type I fibers ( r = 0.39, P = 0.003), type I-to-type II fiber ratio ( r = 0.33, P = 0.02), and capillary-to-fiber ratio ( r = 0.59, P < 0.0001) were positively related to peak V̇o 2. In multivariate analyses, type I fibers and the capillary-to-fiber ratio remained significantly related to peak V̇o 2. We conclude that older HFPEF patients have significant abnormalities in skeletal muscle, characterized by a shift in muscle fiber type distribution with reduced type I oxidative muscle fibers and a reduced capillary-to-fiber ratio, and these may contribute to their severe exercise intolerance. This suggests potential new therapeutic targets in this difficult to treat disorder.
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Citations
Cites
Irbesartan in patients with heart failure and preserved ejection fraction
Massie, B. M., Carson, P. E., McMurray, J. J., Komajda, M., McKelvie, R., Zile, M. R., Anderson, S., Donovan, M., Iverson, E., Staiger, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0805450 · Cited by 1,960
Kitzman, D. W. (2002) · JAMA · doi:10.1001/jama.288.17.2144 · Cited by 883
Self-citationKitzman, D. W., Brubaker, P. H., Herrington, D. M., Morgan, T. M., Stewart, K. P., Hundley, W. G., Abdelhamed, A., & Haykowsky, M. J. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.04.033 · Cited by 369
Self-citationHaykowsky, M. J., Brubaker, P. H., Stewart, K. P., Morgan, T. M., Eggebeen, J., & Kitzman, D. W. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.055 · Cited by 358
Self-citationCoen, P. M., Jubrias, S. A., Distefano, G., Amati, F., Mackey, D. C., Glynn, N. W., Manini, T. M., Wohlgemuth, S. E., Leeuwenburgh, C., Cummings, S. R., et al. (2013) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gls196 · Cited by 323 · cited 1×
“(8) recently reported that thigh muscle oxidative capacity (measured as maximal stage 3 respiration of permeabilized fibers) is a major determinant of peak V̇O2 in healthy older sedentary adults, and, in a preliminary report, Bhella et al.”
Abnormal Haemodynamic Response to Exercise in Heart Failure with Preserved Ejection Fraction
Bhella, P. S., Prasad, A., Heinicke, K., Hastings, J. L., Arbab-Zadeh, A., Adams-Huet, B., Pacini, E. L., Shibata, S., Palmer, M. D., Newcomer, B. R., et al. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr133 · Cited by 238
Haykowsky, M. J., Brubaker, P. H., Morgan, T. M., Kritchevsky, S., Eggebeen, J., & Kitzman, D. W. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt011 · Cited by 189
Self-citationSchaufelberger, M., Andersson, G., Eriksson, B. O., Grimby, G., Held, P., & Swedberg, K. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014751 · Cited by 55
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Shah, S. J., Kitzman, D. W., Borlaug, B. A., van Heerebeek, L., Zile, M. R., Kass, D. A., & Paulus, W. J. (2016) · Circulation · doi:10.1161/circulationaha.116.021884 · Cited by 1,003
Self-citationKitzman, D. W., Brubaker, P., Morgan, T., Haykowsky, M., Hundley, G., Kraus, W. E., Eggebeen, J., & Nicklas, B. J. (2016) · JAMA · doi:10.1001/jama.2015.17346 · Cited by 921
Self-citationExercise and the Cardiovascular System: Clinical Science and Cardiovascular Outcomes
Lavie, C. J., Arena, R., Swift, D. L., Johannsen, N. M., Sui, X., Lee, D.-C., Earnest, C. P., Church, T. S., O’Keefe, J. H., Milani, R. V., et al. (2015) · Circulation Research · doi:10.1161/circresaha.117.305205 · Cited by 782
The pathophysiology of heart failure with preserved ejection fraction
Borlaug, B. A. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.83 · Cited by 726
Heart Failure With Preserved Ejection Fraction
Borlaug, B. A., Sharma, K., Shah, S. J., & Ho, J. E. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.01.049 · Cited by 742
Heart Failure With Preserved Ejection Fraction: Mechanisms, Clinical Features, and Therapies
Sharma, K., & Kass, D. A. (2014) · Circulation Research · doi:10.1161/circresaha.115.302922 · Cited by 508
Borlaug, B. A., Jensen, M. D., Kitzman, D. W., Lam, C. S. P., Obokata, M., & Rider, O. J. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac120 · Cited by 450
Self-citationShah, S. J., Borlaug, B. A., Kitzman, D. W., McCulloch, A. D., Blaxall, B. C., Agarwal, R., Chirinos, J. A., Collins, S., Deo, R. C., Gladwin, M. T., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.041886 · Cited by 436
Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction
Zamani, P., Rawat, D., Shiva-Kumar, P., Geraci, S., Bhuva, R., Konda, P., Doulias, P.-T., Ischiropoulos, H., Townsend, R. R., Margulies, K. B., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.012957 · Cited by 307
Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction
Kumar, A. A., Kelly, D. P., & Chirinos, J. A. (2019) · Circulation · doi:10.1161/circulationaha.118.036259 · Cited by 298
Lai, Y.-C., Tabima, D. M., Dube, J. J., Hughan, K. S., Vanderpool, R. R., Goncharov, D. A., St. Croix, C. M., Garcia-Ocaña, A., Goncharova, E. A., Tofovic, S. P., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.018935 · Cited by 270
Cardiovascular Phenotype in HFpEF Patients With or Without Diabetes
Lindman, B. R., Dávila-Román, V. G., Mann, D. L., McNulty, S., Semigran, M. J., Lewis, G. D., de las Fuentes, L., Joseph, S. M., Vader, J., Hernandez, A. F., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.05.030 · Cited by 209
Eggebeen, J., Kim-Shapiro, D. B., Haykowsky, M., Morgan, T. M., Basu, S., Brubaker, P., Rejeski, J., & Kitzman, D. W. (2016) · JACC: Heart Failure · doi:10.1016/j.jchf.2015.12.013 · Cited by 190
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Pandey, A., Shah, S. J., Butler, J., Kellogg, D. L., Lewis, G. D., Forman, D. E., Mentz, R. J., Borlaug, B. A., Simon, M. A., Chirinos, J. A., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.07.014 · Cited by 184
Self-citationHaykowsky, M. J., Nicklas, B. J., Brubaker, P. H., Hundley, W. G., Brinkley, T. E., Upadhya, B., Becton, J. T., Nelson, M. D., Chen, H., & Kitzman, D. W. (2018) · JACC: Heart Failure · doi:10.1016/j.jchf.2018.06.002 · Cited by 179
Self-citationObesity-Related Heart Failure With a Preserved Ejection Fraction
Packer, M., & Kitzman, D. W. (2018) · JACC: Heart Failure · doi:10.1016/j.jchf.2018.01.009 · Cited by 172
Self-citationBowen, T. S., Rolim, N. P. L., Fischer, T., Bækkerud, F. H., Medeiros, A., Werner, S., Brønstad, E., Rognmo, O., Mangner, N., Linke, A., et al. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.239 · Cited by 165
Withaar, C., Lam, C. S. P., Schiattarella, G. G., de Boer, R. A., & Meems, L. M. G. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab389 · Cited by 150
Adiponectin resistance in skeletal muscle: Pathophysiological implications in chronic heart failure
Sente, T., Van Berendoncks, A. M., Hoymans, V. Y., & Vrints, C. J. (2016) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12086 · Cited by 95
Microvascular endothelial dysfunction in heart failure with preserved ejection fraction
Lam, C. S. P., & Lund, L. H. (2016) · Heart · doi:10.1136/heartjnl-2015-308852 · Cited by 81
Reduced lymphatic reserve in heart failure with preserved ejection fraction
Rossitto, G., Mary, S., McAllister, C., Neves, K. B., Haddow, L., Rocchiccioli, J. P., Lang, N. N., Murphy, C. L., Touyz, R. M., Petrie, M. C., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.022 · Cited by 77
Dietary nitrate supplementation in cardiovascular health: an ergogenic aid or exercise therapeutic?
Woessner, M. N., McIlvenna, L. C., Ortiz de Zevallos, J., Neil, C. J., & Allen, J. D. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00414.2017 · Cited by 50
Dietary Nitrate and Skeletal Muscle Contractile Function in Heart Failure
Coggan, A. R., & Peterson, L. R. (2016) · Current Heart Failure Reports · doi:10.1007/s11897-016-0293-9 · Cited by 20
Metadata
- Authors
- Kitzman, D. W., Nicklas, B., Kraus, W. E., Lyles, M. F., Eggebeen, J., Morgan, T. M., & Haykowsky, M.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2014-05-01
- Volume
- 306
- Issue
- 9
- Pages
- H1364-H1370
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2143676228
- Cited by
- 342
- References
- 8
- FWCI
- 64.68
- Type
- journal article
- Language
- en
- Open access
- green
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