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The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
Open accessAbstract
High-capacity mitochondrial ATP production is essential for normal function of the adult heart, and evidence is emerging that mitochondrial derangements occur in common myocardial diseases. Previous overexpression studies have shown that the inducible transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is capable of activating postnatal cardiac myocyte mitochondrial biogenesis. Recently, we generated mice deficient in PGC-1alpha (PGC-1alpha(-/-) mice), which survive with modestly blunted postnatal cardiac growth. To determine if PGC-1alpha is essential for normal cardiac energy metabolic capacity, mitochondrial function experiments were performed on saponin-permeabilized myocardial fibers from PGC-1alpha(-/-) mice. These experiments demonstrated reduced maximal (state 3) palmitoyl-l-carnitine respiration and increased maximal (state 3) pyruvate respiration in PGC-1alpha(-/-) mice compared with PGC-1alpha(+/+) controls. ATP synthesis rates obtained during maximal (state 3) respiration in permeabilized myocardial fibers were reduced for PGC-1alpha(-/-) mice, whereas ATP produced per oxygen consumed (ATP/O), a measure of metabolic efficiency, was decreased by 58% for PGC-1alpha(-/-) fibers. Ex vivo isolated working heart experiments demonstrated that PGC-1alpha(-/-) mice exhibited lower cardiac power, reduced palmitate oxidation, and increased reliance on glucose oxidation, with the latter likely a compensatory response. (13)C NMR revealed that hearts from PGC-1alpha(-/-) mice exhibited a limited capacity to recruit triglyceride as a source for lipid oxidation during beta-adrenergic challenge. Consistent with reduced mitochondrial fatty acid oxidative enzyme gene expression, the total triglyceride content was greater in hearts of PGC-1alpha(-/-) mice relative to PGC-1alpha(+/+) following a fast. Overall, these results demonstrate that PGC-1alpha is essential for the maintenance of maximal, efficient cardiac mitochondrial fatty acid oxidation, ATP synthesis, and myocardial lipid homeostasis.
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“Functionally, decreases in ATP levels, state 3 respiration, and metabolic efficiency are seen, and cardiac and skeletal muscle performance is reduced in response to stress.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [61]
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“These mice consistently display 30 -60% reductions in OXPHOS gene expression in muscle, normal to decreased mitochondrial density in skeletal muscle, and decreased cristae density in heart.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [61]
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“For example, decreased metabolic efficiency (61), defined as decreased ATP produced per unit of oxidized fuel and/or oxygen, may lead to enhanced whole-body fuel utilization and thus a leaner, more insulin-sensitive phenotype.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [61]
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Metadata
- Authors
- Lehman, J. J., Boudina, S., Banke, N. H., Sambandam, N., Han, X., Young, D. M., Leone, T. C., Gross, R. W., Lewandowski, E. D., Abel, E. D., & Kelly, D. P.
- Affiliations
- Washington University in St. Louis (US)
- University of Utah (US)
- University of Illinois Chicago (US)
- ORCID
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2008-07
- Volume
- 295
- Issue
- 1
- Pages
- H185-H196
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC2494758
- OpenAlex
- W2099192357
- Cited by
- 158
- References
- 64
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 16 · 2019: 4 · 2018: 8 · 2017: 15 · 2016: 6 · 2015: 2 · 2014: 12 · 2013: 6 · 2012: 16
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (K08AG024844)
- National Heart, Lung, and Blood Institute (R01HL073167, R01-HL-73167, R37HL049244, R01HL058493, R01-HL-3749244)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056341, P30DK052574)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- PGC-1α, myocardial energy metabolism, mitochondrial biogenesis, palmitate oxidation, triglyceride mobilization, beta-adrenergic stimulation, cardiac power output
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adenosine Triphosphate, Adrenergic beta-Agonists, Animals, Energy Metabolism, Fatty Acids, Female, Glucose, Homeostasis, Isoproterenol, Male, Mitochondria, Heart, Myocardial Contraction, Myocardium, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Oxidative Phosphorylation, Oxygen Consumption, Palmitoylcarnitine, Transcription Factors, Triglycerides, Trans-Activators, Mice, Knockout, Pyruvic Acid, Mice, In Vitro Techniques
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