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Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind

Pecháňová, O., & Šimko, F. (2009) · Journal of Hypertension · doi:10.1097/01.hjh.0000358835.25934.5e · Cited by 47 · see citing works

NADPH Oxidase Plays a Role on Ethanol-Induced Hypertension and Reactive Oxygen Species Generation in the Vasculature

Marchi, K. C., Ceron, C. S., Muniz, J. J., Martinis, B. S. D., Tanus-Santos, J. E., & Tirapelli, C. R. (2016) · Alcohol and Alcoholism · doi:10.1093/alcalc/agw043 · Cited by 43 · see citing works

Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury

Iketani, M., Ohshiro, J., Urushibara, T., Takahashi, M. M., Arai, T., Kawaguchi, H., & Ohsawa, I. (2016) · Shock · doi:10.1097/shk.0000000000000810 · Cited by 43 · see citing works

Hypertrophic Remodeling of Subcutaneous Small Resistance Arteries in Patients with Cushing’s Syndrome

Rizzoni, D., Porteri, E., Ciuceis, C. D., Rodella, L. F., Paiardi, S., Rizzardi, N., Platto, C., Boari, G. E. M., Pilu, A., Tiberio, G. A. M., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1588 · Cited by 41 · see citing works

Deleterious combined effects of salt-loading and endothelial cell restricted endothelin-1 overexpression on blood pressure and vascular function in mice

Amiri, F., Ko, E. A., Javeshghani, D., Reudelhuber, T. L., & Schiffrin, E. L. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e328338bb8b · Cited by 38 · see citing works

Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats

Shirakura, T., Nomura, J., Matsui, C., Kobayashi, T., Tamura, M., & Masuzaki, H. (2016) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-016-1239-1 · Cited by 36 · see citing works

Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications

Tracy, E. P., Hughes, W. E., Beare, J. E., Rowe, G., Beyer, A., & LeBlanc, A. J. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0031 · Cited by 38 · see citing works

End O' The Line Revisited: Moving on from nitric oxide to CGRP

Mey, J. G. R. D., & Vanhoutte, P. M. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.04.012 · Cited by 36 · see citing works

The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney Disease

Ravarotto, V., Bertoldi, G., Innico, G., Gobbi, L., & Calò, L. A. (2021) · Antioxidants · doi:10.3390/antiox10071041 · Cited by 35 · see citing works

Nicotinamide nucleotide transhydrogenase activity impacts mitochondrial redox balance and the development of hypertension in mice

Leskov, I. L., Neville, A., Shen, X., Pardue, S., Kevil, C. G., Granger, D. N., & Krzywanski, D. M. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.12.002 · Cited by 34 · see citing works

Cardiovagal Modulation, Oxidative Stress, and Cardiovascular Risk Factors in Prehypertensive Subjects: Cross-Sectional Study

Thiyagarajan, R., Pal, P., Pal, G. K., Subramanian, S. K., Bobby, Z., Das, A. K., & Trakroo, M. (2013) · American Journal of Hypertension · doi:10.1093/ajh/hpt025 · Cited by 33 · see citing works

A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats

Chien, S., Chang, W., Lin, P.-H., Chang, W.-P., Hsu, S., Chang, J., Wu, Y.-C., Pei, J.-K., & Lin, C. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/217525 · Cited by 33 · see citing works

Intrarenal Dopamine Attenuates Deoxycorticosterone Acetate/High Salt–Induced Blood Pressure Elevation in Part Through Activation of a Medullary Cyclooxygenase 2 Pathway

Yao, B., Harris, R. C., & Zhang, M. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.137174 · Cited by 32 · see citing works

Endothelin-1 impairs coronary arteriolar dilation: Role of p38 kinase-mediated superoxide production from NADPH oxidase

Thengchaisri, N., Hein, T. W., Ren, Y., & Kuo, L. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.07.014 · Cited by 31 · see citing works

l ‐Carnitine Attenuates Cardiac Remodelling rather than Vascular Remodelling in Deoxycorticosterone Acetate‐Salt Hypertensive Rats

O’Brien, D. R., Chunduri, P., Iyer, A., & Brown, L. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00480.x · Cited by 29 · see citing works

Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension

Oliveira‐Paula, G. H., Pinheiro, L. C., Guimarães, D. A., Conde-Tella, S. O., Blanco, A. L. F., de Angelis, C. D., Schechter, A. N., & Tanus-Santos, J. E. (2016) · Redox Biology · doi:10.1016/j.redox.2016.04.001 · Cited by 27 · see citing works

Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia

Piechota-Polańczyk, A., & Gorąca, A. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70941-6 · Cited by 26 · see citing works

Thromboxane Prostanoid Receptors Enhance Contractions, Endothelin-1, and Oxidative Stress in Microvessels From Mice With Chronic Kidney Disease

Wang, C., Luo, Z., Kohan, D. E., Wellstein, A., José, P. A., Welch, W. J., Wilcox, C. S., & Wang, D. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05244 · Cited by 26 · see citing works

Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders

Hu, X., & Zhang, L. (2022) · Antioxidants · doi:10.3390/antiox11122432 · Cited by 22 · see citing works

Pioglitazone Modulates the Vascular Contractility in Hypertension by Interference with ET-1 Pathway

Palacios, R., Hernanz, R., Martín, Á., Pérez-Girón, J. V., Barrús, M. T., González-Carnicero, Z., Aguado, A., Jaisser, F., Briones, A. M., Salaíces, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52839-6 · Cited by 25 · see citing works

Endothelin-1 Downregulates Sulfur Dioxide/Aspartate Aminotransferase Pathway via Reactive Oxygen Species to Promote the Proliferation and Migration of Vascular Smooth Muscle Cells

Tian, X., Zhang, Q., Huang, Y., Chen, S. Y., Tang, C., Sun, Y. K., Du, J., & Jin, H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9367673 · Cited by 24 · see citing works

MMPT as a reactive oxygen species generator induces apoptosis via the depletion of intracellular GSH contents in A549 cells

Yun-feng, Z., Zhang, C., & Suo, Y. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.05.003 · Cited by 22 · see citing works

Lipid Peroxidation and Antioxidants in Arterial Hypertension

Sousa, T., Afonso, J., Carvalho, F., & Albino‐Teixeira, A. (2012) · InTech eBooks · doi:10.5772/50346 · Cited by 19 · see citing works

High Serum Uric Acid is Highly Associated with a Reduced Left Ventricular Ejection Fraction Rather than Increased Plasma B-type Natriuretic Peptide in Patients with Cardiovascular Diseases

Oki, Y., Kawai, M., Minai, K., Ogawa, K., Inoue, Y., Morimoto, S., Tanaka, T. D., Nagoshi, T., Ogawa, T., & Yoshimura, M. (2019) · Scientific Reports · doi:10.1038/s41598-018-37053-0 · Cited by 19 · see citing works

Human mitochondrial MIA40 (CHCHD4) is a component of the Fe–S cluster export machinery

Murari, A., Thiriveedi, V., Mohammad, F., Vengaldas, V., Gorla, M., Tammineni, P., Krishnamoorthy, T., & Sepuri, N. B. V. (2015) · Biochemical Journal · doi:10.1042/bj20150012 · Cited by 17 · see citing works

Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow

Sharma, S., Kumar, S., Wiseman, D. A., Kallarackal, S., Ponnala, S., Elgaish, M., Tian, J., Fineman, J. R., & Black, S. M. (2010) · Vascular Pharmacology · doi:10.1016/j.vph.2010.03.005 · Cited by 15 · see citing works

Reactive Oxygen Species and the Cardiovascular System

Montezano, A. C. I., & Touyz, R. M. (2012) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00043ed1v01y201112isp032 · Cited by 13 · see citing works

Long-Term Inhibition of Xanthine Oxidase by Febuxostat Does Not Decrease Blood Pressure in Deoxycorticosterone Acetate (DOCA)-Salt Hypertensive Rats

Szasz, T., Davis, R. P., Garver, H. S., Burnett, R. J., Fink, G. D., & Watts, S. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056046 · Cited by 13 · see citing works

Uric Acid Does Not Affect the Acetylcholine-Induced Relaxation of Aorta from Normotensive and Deoxycorticosterone Acetate-Salt Hypertensive Rats

Szasz, T., & Watts, S. W. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.160184 · Cited by 13 · see citing works

Lack of Reactive Oxygen Species Deteriorates Blood Pressure Regulation in Acute Stress

Bernátová, I., Bališ, P., GOGA, R., Behuliak, M., Zicha, J., & Sekaj, I. (2016) · Physiological Research · doi:10.33549/physiolres.933433 · Cited by 13 · see citing works

Transcriptomic analysis reveals inflammatory and metabolic pathways that are regulated by renal perfusion pressure in the outer medulla of Dahl-S rats

Evans, L. C., Dayton, A., Yang, C., Liu, P., Kurth, T. M., Ahn, K. W., Komas, S., Stingo, F. C., Laud, P. W., Vannucci, M., et al. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00034.2018 · Cited by 13 · see citing works

Scurrula atropurpurea increases nitric oxide and decreases malondialdehyde in hypertensive rats

Nour Athiroh, A. S., & Sulistyowati, E. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.18051/univmed.2013.v32.44 · Cited by 12 · see citing works

Chronic stress effects in contralateral medial pterygoid muscle of rats with occlusion alteration

Loyola, B. M., Nascimento, G. C., Fernández, R. A. R., Iyomasa, D. M., Pereira, Y. C. L., Leite‐Panissi, C. R. A., Issa, J. P. M., & Iyomasa, M. M. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.06.028 · Cited by 12 · see citing works

Oxidative Stress and Essential Hypertension

Rodrigo, R., Brito, R., & González, J. (2016) · InTech eBooks · doi:10.5772/64079 · Cited by 11 · see citing works

Allopurinol Does Not Decrease Blood Pressure or Prevent the Development of Hypertension in the Deoxycorticosterone Acetate-Salt Rat Model

Szasz, T., Linder, A. E., Davis, R. P., Burnett, R. J., Fink, G. D., & Watts, S. W. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181f80194 · Cited by 11 · see citing works

Metabolic Changes in Masseter Muscle of Rats Submitted to Acute Stress Associated with Exodontia

Iyomasa, M. M., Fernandes, F. S., Iyomasa, D. M., Pereira, Y. C. L., Fernández, R. A. R., Calzzani, R. A. J., Nascimento, G. C., Leite‐Panissi, C. R. A., & Issa, J. P. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128397 · Cited by 10 · see citing works

ROS Suppression by Egg White Hydrolysate in DOCA-Salt Rats—An Alternative Tool against Vascular Dysfunction in Severe Hypertension

Abreu, E. D. L., Moro, C. R., Kanaan, S. H. H., de Paula, R. B., Herrera, C. T., Costa, P. H. D., Peçanha, F. M., Vassallo, D. V., Rossoni, L. V., Miguel, M., et al. (2022) · Antioxidants · doi:10.3390/antiox11091713 · Cited by 10 · see citing works

Management of hypertension addressing hyperuricaemia: introduction of nano-based approaches

Girigoswami, K., Arunkumar, R., & Girigoswami, A. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2352022 · Cited by 10 · see citing works

Metabolic and vascular pattern in medial pterygoid muscle is altered by chronic stress in an animal model of hypodontia

Fernández, R. A. R., Pereira, Y. C. L., Iyomasa, D. M., Calzzani, R. A. J., Leite‐Panissi, C. R. A., Iyomasa, M. M., & Nascimento, G. C. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.12.026 · Cited by 9 · see citing works

Endothelium, the Blood–Brain Barrier, and Hypertension

Silva, T. M. D., Silva, R. A. P., & Faraci, F. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-25616-0_8 · Cited by 9 · see citing works

The Melatonin Derivative ITH13001 Prevents Hypertension and Cardiovascular Alterations in Angiotensin II-Infused Mice

Martínez‐Casales, M., Hernanz, R., González-Carnicero, Z., Barrús, M. T., Martín, Á., Briones, A. M., Michalska, P., Leon, R. M., Pinilla, E., Simonsen, U., et al. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.001586 · Cited by 7 · see citing works

Influence of Hypoxia on Endothelium-Derived NO-Mediated Relaxation in Rat Carotid, Mesenteric and Iliac Arteries

Tawa, M., Shimosato, T., Geddawy, A., Imamura, T., & Okamura, T. (2013) · Pharmacology · doi:10.1159/000351706 · Cited by 6 · see citing works

Involvement of the Endothelin Receptor Type A in the Cardiovascular Inflammatory Response Following Scorpion Envenomation

Sifi, A., Adi-Bessalem, S., & Laraba‐Djebari, F. (2020) · Toxins · doi:10.3390/toxins12060389 · Cited by 6 · see citing works

Role of Oxidative Stress in Hypertension

Chrissobolis, S., Dinh, Q. N., Drummond, G. R., & Sobey, C. G. (2016) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4899-7693-2_4 · Cited by 5 · see citing works

Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease

Angelini, A., Pi, X., & Xie, L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01044 · Cited by 6 · see citing works

PVAT-induced aortic hypercontractility in acute sepsis: Role of ROS and COX-2 signaling

Ribeiro, N. D. A. R., Nóbrega, N. R. C., de Araújo, N. F., Costa, D. E. F. D. R., Capettini, L. D. S. A., & Bonaventura, D. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123745 · Cited by 4 · see citing works

Role of Glyceraldehyde-Derived AGEs and Mitochondria in Superoxide Production in Femoral Artery of OLETF Rat and Effects of Pravastatin

Hori, E., Kikuchi, C., Nagami, C., Kajikuri, J., Itoh, T., Takeuchi, M., & Matsunaga, T. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00411 · Cited by 4 · see citing works

NADPH Oxidases: Structure and Function

Quinn, M. T. (2013) · Wiley eBooks · doi:10.1002/9781118355886.ch7 · Cited by 3 · see citing works

Reactive Oxygen Species, Oxidative Stress, and Hypertension

Touyz, R. M., Chignalia, A. Z., & Sedeek, M. H. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_15 · Cited by 2 · see citing works

Minocycline treatment attenuates high-refined carbohydrate diet-induced gut bacterial dysbiosis, anxiety-like behaviour, and cardiac damage in mice

Silva, A. O., Ribeiro, J. M., Soares, N. P., de Oliveira, K., Espuri, P. F., Belo, T. C. A., dos Reis, L. F. C., de Aguiar, D. C., Paula, F. B. D. A., Ruginsk, S. G., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177552 · Cited by 2 · see citing works

Estimation of Some Oxidative Stress Parameters and Blood Pressure After Administration of Endothelin-1 (ET-1) in Rats

Kleniewska, P., Kowalczyk, A., Cieśla, W., & Gorąca, A. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0371-0 · Cited by 2 · see citing works

Oxidative Stress at the Crossroads Between Osteoarthritis and Metabolic Syndrome

Katz, J. D., & Velasquez, M. T. (2012) · Springer eBooks · doi:10.1007/978-1-4614-6166-1_12 · Cited by 1 · see citing works

Iatrogenic, Congenic, and Transgenic Models of Hypertension

Gross, D. R. (2009) · Springer eBooks · doi:10.1007/978-0-387-95962-7_11 · Cited by 1 · see citing works

Papel del estrés oxidativo en la patogénesis de la hipertensión arterial

Gutiérrez, Y. P., Gutiérrez, A. P., León, A. R., & García, K. C. (2014) · CorSalud · Cited by 1 · see citing works

Esomeprazole vs pantoprazole effects on cyclosporine levels in kidney transplantation: A randomized clinical trial

El‐Bohy, D., Elsharkawy, M. M., Abo‐Elazm, S., Shahin, S. M., Bchari, W., Mancy, A., & Hamamsy, M. E. (2019) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.13464 · Cited by 1 · see citing works

Reactive Oxygen Species, Vascular Disease, and Hypertension

Montezano, A. C. I., & Touyz, R. M. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_56 · Cited by 1 · see citing works

Update on Essential Hypertension

Salazar‐Sánchez, L. (2016) · InTech eBooks · doi:10.5772/61565 · Cited by 1 · see citing works

Interferon-stimulated gene 15, a common link of vascular damage in hypertension, obesity and aortic aneurysms

González‐Amor, M., & García‐Redondo, A. B. (2022) · Anales de la Real Academia Nacional de Farmacia · doi:10.53519/analesranf.2022.88.02.04 · Cited by 1 · see citing works

Signaling in Atherosclerosis

Marı́n-Garcı́a, J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9461-5_18 · Cited by 1 · see citing works

PROGRAMA DE PÓS-GRADUAÇÃO EM FARMACOLOGIA

Amaral, L. M. (2012) · Cited by 1 · see citing works

Avaliação morfofisiológica do músculo pterigóideo lateral e da sensibilidade nociceptiva orofacial em ratos com hipofunção mastigatória

Iyomasa, D. M. (2014) · doi:10.11606/d.58.2014.tde-12052014-141658

Papel del estrés oxidativo y nitrosativo en la hipertrofia cardiaca y remodelación ventricular

Giraldo, A. (2019) · Acta Médica Colombiana · doi:10.36104/amc.2010.1570

Efeitos morfofisiológicos do estresse crônico e exodontia em músculo masseter de ratos

Calzzani, R. A. J. (2013) · doi:10.11606/d.58.2013.tde-16122013-115458

Efeitos da inibição da sintase induzida do óxido nítrico na fisiopatologia da pré-eclâmpsia experimental

Amaral, L. M. (2012) · doi:10.11606/t.17.2012.tde-26092013-200202

NADH/NADPH Oxidase and Enhanced Superoxide Production in the Mineralocorticoid Hypertensive Rat

Beswick, R. A., Dorrance, A. M., Leite, R., & Webb, R. C. (2001) · Hypertension · doi:10.1161/hy1101.093423 · Cited by 346 · see citing works

Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms

Callera, G. E., Tostes, R. C., Yogi, Á., Montezano, A. C. I., & Touyz, R. M. (2006) · Clinical Science · doi:10.1042/cs20050307 · Cited by 121 · see citing works

ET A Receptor Blockade Decreases Vascular Superoxide Generation in DOCA-Salt Hypertension

Callera, G. E., Touyz, R. M., Teixeira, S. A., Muscará, M. N., de Carvalho, M. H. C., Fortes, Z. B., Nigro, D., Schiffrin, E. L., & Tostes, R. C. (2003) · Hypertension · doi:10.1161/01.hyp.0000088363.65943.6c · Cited by 140 · see citing works

Endothelin-1 Increases Vascular Superoxide via Endothelin A –NADPH Oxidase Pathway in Low-Renin Hypertension

Li, L., Fink, G. D., Watts, S. W., Northcott, C. A., Galligan, J. J., Pagano, P. J., & Chen, A. F. (2003) · Circulation · doi:10.1161/01.cir.0000051459.74466.46 · Cited by 317 · see citing works

NADPH Oxidase–Derived Superoxide Augments Endothelin-1–Induced Venoconstriction in Mineralocorticoid Hypertension

Li, L., Watts, S. W., Banes, A. K., Galligan, J. J., Fink, G. D., & Chen, A. F. (2003) · Hypertension · doi:10.1161/01.hyp.0000084853.47326.f2 · Cited by 89 · see citing works