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Cited by 121Cardiac Fibrosis and RemodelingCardiovascular Function and Risk FactorsCardiac Ischemia and Reperfusion

Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction

Thakker, Geeta D., Frangogiannis, Nikolaos G., Bujak, Marcin, Zymek, Paul, Gaubatz, John W., Reddy, Anilkumar K., Taffet, George, Michael, Lloyd H. +2 more·2006·American Journal of Physiology-Heart and Circulatory Physiology
DOI 10.1152/ajpheart.00322.2006
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Abstract

Epidemiological studies indicate that obesity, insulin resistance, and diabetes are important comorbidities of patients with ischemic heart disease and increase mortality and development of congestive heart failure after myocardial infarction. Although ob/ob and db/db mice are commonly used to study obesity with insulin resistance or diabetes, mutations in the leptin gene or its receptor are rarely the cause of obesity in humans, which is, instead, primarily a consequence of dietary and lifestyle factors. Therefore, we used a murine model of diet-induced obesity to examine the physiological effects of obesity and the inflammatory and healing response of diet-induced obese (DIO) mice after myocardial ischemia-reperfusion injury. DIO mice developed hyperinsulinemia and insulin resistance and hepatic steatosis, with significant ectopic lipid deposition in the heart and cardiac hypertrophy in the absence of significant changes in blood pressure. The mRNA levels of chemokines at 24 h and cytokines at 24 and 72 h of reperfusion were higher in DIO than in lean mice. In granulation tissue at 72 h of reperfusion, macrophage density was significantly increased, whereas neutrophil density was reduced, in DIO mice compared with lean mice. At 7 days of reperfusion, collagen deposition in the scar was significantly reduced and left ventricular (LV) dilation and cardiac hypertrophy were increased, indicative of adverse LV remodeling, in infarcted DIO mice. Characterization of a murine diet-induced model of obesity and insulin resistance that satisfies many aspects commonly observed in human obesity allows detailed examination of the adverse cardiovascular effects of diet-induced obesity at the molecular level.

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Crossref · 10.1152/ajpheart.00322.2006

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  • A commonly described feature of most animal models of obesity is increased accumulation of intramyocellular triglycerides in the heart.

    “A commonly described feature of most animal models of obesity is increased accumulation of intramyocellular triglycerides in the heart. This has been reported in the hearts of genetic models such as ob/ob and db/db mice (29, 31, 34, 53), Zucker or fa/fa rats (394), and following high-fat feeding (346).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [346]

  • Studies performed in vivo using coronary artery ligation show that obesity and insulin resistance are associated with impaired recovery of cardiac function in genetic models such as Zucker rats, db/db mice, and mice with diet-induced obesity.

    “Studies performed in vivo using coronary artery ligation show that obesity and insulin resistance are associated with impaired recovery of cardiac function. This is true in genetic models such as Zucker rats, db/db mice, and mice with diet-induced obesity (119, 146, 346).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [346]

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Authors
Thakker, G. D., Frangogiannis, N. G., Bujak, M., Zymek, P., Gaubatz, J. W., Reddy, A. K., Taffet, G., Michael, L. H., Entman, M. L., & Ballantyne, C. M.
Affiliations
  • Baylor College of Medicine (US)
  • Jagiellonian University (PL)
  • Houston Methodist (US)
ORCID
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Published
2006-11
Volume
291
Issue
5
Pages
H2504-H2514
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
DOI
10.1152/ajpheart.00322.2006
OpenAlex
W2138201763
Cited by
121
References
57
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 8 · 2012: 12
FWCI
4.98
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Cincinnati
  • National Heart, Lung, and Blood Institute (P01HL42550, K25HL073041, R01HL-76246, T32HL007812, P01HL042550, R01HL076246)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords
diet-induced obesity, myocardial infarction, inflammation, cardiac remodeling, insulin resistance, hyperinsulinemia, ischemia-reperfusion injury, cardiac hypertrophy, macrophage infiltration, neutrophils, chemokines, cytokines, collagen deposition, left ventricular dilatation, hepatic steatosis
MeSH terms
Animals, Diet, Female, Inflammation, Male, Mice, Inbred C57BL, Myocardial Infarction, Obesity, Myocardial Reperfusion Injury, Ventricular Remodeling, Mice

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