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Cited by 108Cardiac Ischemia and ReperfusionCardiac Fibrosis and RemodelingCardiovascular Function and Risk Factors

Myocardial infarction and heart failure in the db/db diabetic mouse

Greer, James J. M., Ware, Derek P., Lefer, David J.·2006·American Journal of Physiology-Heart and Circulatory Physiology
DOI 10.1152/ajpheart.00583.2005
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Abstract

Clinical studies have reported that the incidence and severity of myocardial infarction is significantly greater in diabetics compared with nondiabetics after correction for all other risk factors. The majority of studies investigating the pathophysiology of myocardial ischemia-reperfusion injury have focused on otherwise healthy animals. At present, there is a paucity of experimental investigations on the pathophysiology of heart failure in diabetic animals. We hypothesized that the severity of myocardial reperfusion injury and the development of congestive heart failure would be markedly enhanced in the db/db diabetic mouse. Accordingly, we studied the effects of varying durations of in vivo myocardial ischemia and reperfusion on the incidence of heart failure in db/db diabetic mice. Nondiabetic and db/db diabetic mice (10 wk of age) were subjected to 30, 45, or 60 min of left coronary artery occlusion and 28 days of reperfusion. Survival at 24 h of reperfusion was 100% in nondiabetic mice subjected to 30 min of myocardial ischemia and 88% in nondiabetic mice subjected to 45 min of myocardial ischemia. In contrast, survival was 53% in db/db diabetic mice subjected to 30 min of myocardial ischemia and 44% in db/db mice after 45 min of myocardial ischemia. Prolonged survival in nondiabetic mice was not significantly attenuated when compared during the 28-day follow-up period with all groups experiencing >90% survival. Prolonged survival was significantly decreased in db/db mice after both 30 and 45 min of myocardial ischemia compared with sham controls. Furthermore, we observed a significant degree or left ventricular dilatation, cardiac hypertrophy, and cardiac contractile dysfunction in db/db mice subjected to 45 min of myocardial ischemia and 28 days reperfusion. In nondiabetic mice subjected to 45 min of myocardial ischemia, we failed to observe any changes in left ventricular dimensions or fractional shortening. These studies provide a feasible experimental model system for the investigation of heart failure secondary to acute myocardial infarction in the db/db diabetic mouse.

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Crossref · 10.1152/ajpheart.00583.2005

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  • Studies performed in vivo using coronary artery ligation show that obesity and insulin resistance are associated with impaired recovery of cardiac function in genetic models such as Zucker rats, db/db mice, and mice with diet-induced obesity.

    “Studies performed in vivo using coronary artery ligation show that obesity and insulin resistance are associated with impaired recovery of cardiac function. This is true in genetic models such as Zucker rats, db/db mice, and mice with diet-induced obesity (119, 146, 346).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [119]

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Related

Authors
Greer, J. J. M., Ware, D. P., & Lefer, D. J.
Affiliations
Louisiana State University Health Sciences Center Shreveport (US)
ORCID
Lefer, David J.
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Published
2006-01
Volume
290
Issue
1
Pages
H146-H153
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
DOI
10.1152/ajpheart.00583.2005
OpenAlex
W2135874575
Cited by
108
References
46
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 8 · 2012: 13
FWCI
4.04
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (2R01 HL-060849, R01HL060849)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P01 DK-43785, P01DK043785)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
myocardial infarction, heart failure, type 2 diabetes, myocardial ischemia-reperfusion injury, coronary artery occlusion, left ventricular dilatation, cardiac hypertrophy, cardiac contractile dysfunction, diabetic cardiomyopathy, animal models
MeSH terms
Animals, Blood Glucose, Diabetes Mellitus, Cardiomegaly, Heart Failure, Glycated Hemoglobin, Insulin, Mice, Obese, Myocardial Infarction, Pulmonary Edema, Myocardial Reperfusion Injury, Ventricular Dysfunction, Left, Diabetes Complications, Mice

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